Prescription onlyClass: Autoimmune

CimziaAlternatives

(certolizumab)

Prescription onlyClass: Autoimmune
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Compare Cimzia (certolizumab) to alternatives

These medications are comparable to Cimzia (certolizumab) or used for similar purposes.

Cimzia
(certolizumab)

Enbrel
(etanercept)

Humira
(adalimumab)

Remicade
(infliximab)

Reduces inflammation. Cimzia (Certolizumab) is an effective medicine to calm down your immune system, but it can be expensive and it requires a lot of monitoring while you're taking it.Calms down your immune system. Enbrel (Etanercept) is very effective at calming down your immune system, but it's expensive, you have to take into account the hassle of injections and traveling with the medication.Calms down the immune system. Humira (adalimumab) is good for treating many autoimmune conditions, but it can also cause serious side effects.Calms down your immune system. Remicade (Infliximab) is very effective at calming down your immune system, but you have to get each dose at your doctor's office and watch out for serious side effects.
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Reviews & ratings
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Have you used Cimzia (certolizumab)?
Worth itNot sureNot worth it
Reviews for Enbrel (etanercept)
62%
-5% worse vs. Cimzia (certolizumab)
53%
-5% worse vs. Cimzia (certolizumab)
17%
-17% worse vs. Cimzia (certolizumab)
Have you used Enbrel (etanercept)?
Worth itNot sureNot worth it
Reviews for Humira (adalimumab)
60%
-7% worse vs. Cimzia (certolizumab)
51%
-7% worse vs. Cimzia (certolizumab)
26%
-26% worse vs. Cimzia (certolizumab)
182 reviews
Have you used Humira (adalimumab)?
Worth itNot sureNot worth it
Reviews for Remicade (infliximab)
76%
+9% better vs. Cimzia (certolizumab)
62%
+4% better vs. Cimzia (certolizumab)
15%
-15% worse vs. Cimzia (certolizumab)
Have you used Remicade (infliximab)?
Worth itNot sureNot worth it
Side effects
CimziaEnbrelHumiraRemicade
  • Any side effect 1%
  • Upper respiratory infections 7%
  • Urinary tract infections 1%
  • Joint pain 2%
  • Ear, nose, or throat infection 4%
  • Headache 1%
  • High blood pressure 3%
  • Common cold 4%
  • Back pain 3%
  • Fever 1%
More Cimzia side effects »
  • Positive anti-double-stranded dna antibodies 11%
  • Antibodies to etanercept 6%
  • Crithidia luciliae 3%
  • Anticardiolipin 3%
  • Mild or moderate skin reactions 15%
  • Any infection 11%
  • Upper respiratory infections 8%
  • Injection site reactions 26%
  • Non-upper respiratory infections 6%
  • Positive ana 6%
More Enbrel side effects »
  • Upper airway infection 4%
  • Rash 6%
  • Headache 4%
  • Sinus infection 2%
  • Nausea 1%
  • Injection site reactions 7%
  • Urinary tract infection 3%
  • Flu syndrome 1%
  • Stomach pain 3%
  • High cholesterol 2%
More Humira side effects »
  • Infections 11%
  • Infusion reaction 13%
More Remicade side effects »
How it works
CimziaEnbrelHumiraRemicade
Cimzia (Certolizumab) is a monoclonal antibody. It lowers inflammation in the body by blocking a protein called TNF (tumor necrosis factor).Enbrel (Etanercept) is a biologic response modifier. It works in the immune system to block a protein called TNF (tumor necrosis factor). Blocking TNF relieves symptoms and prevents disease progression.Humira (adalimumab) is a TNF blocker which stops inflammation.Remicade (Infliximab) is a biologic response modifier. It works in the immune system to block a protein called TNF (tumor necrosis factor). Blocking TNF relieves symptoms and prevents disease progression.
Type of medication
CimziaEnbrelHumiraRemicade
Prescription only
Prescription only
Prescription only
Prescription only
Available as
CimziaEnbrelHumiraRemicade
  • Injection
  • Injection
  • Injection
  • Injection
Used for
CimziaEnbrelHumiraRemicade
Risk factors for serious side effects
CimziaEnbrelHumiraRemicade
  • Medications that lower immune system function
  • Younger age
      • History of heart failure
        Detailed Cimzia (certolizumab) risks & warnings »
          • History of heart failure
          • Taking other immunosuppressant drugs
          • Age 60 or older
          • Taking other immunosuppressant drugs
          • History of malignancy
          • History of neurologic condition
            Detailed Enbrel (etanercept) risks & warnings »
            • Taking other immunosuppressant medications such as Kineret or Orencia
            • Age 65 or older
            • Active, chronic, or recurrent infection
            • Comorbidities
            • Taking other immunosuppressant medications, such as azathiprine or 6-mercaptopurine, at the same time as Humira (adalimumab)
            • History of malignancy
            • Adolescent age
            • COPD with significant smoking history
              • History of heart failure
              • Preexisting or recently acquired neurologic condition
                Detailed Humira (adalimumab) risks & warnings »
                  • History of heart failure
                  • Taking other immunosuppressant drugs
                  • Age 60 or older
                  • Taking other immunosuppressant drugs
                  • History of malignancy
                  • History of neurologic condition
                      Detailed Remicade (infliximab) risks & warnings »
                      Pregnancy

                      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

                      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

                      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

                      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

                      Weight
                      CimziaEnbrelHumiraRemicade
                      No weight related info.No weight related info.No weight related info.
                      • Although rare, Remicade (Infliximab) can cause serious liver injury. You'll need to have your liver enzymes tested regularly. If liver enzymes are significantly elevated and you have appetite/weight loss, stomach discomfort, vomiting, and notice dark urine, yellowing of skin/eyes, change in stool color, and skin rash you should stop treatment with Remicade (Infliximab) until you can be completely assessed,
                      Upsides and benefits
                      CimziaEnbrelHumiraRemicade
                      • In studies, people with RA (rheumatoid arthritis) taking methotrexate had improved symptoms when Cimzia (Certolizumab) was added to methotrexate.
                      • Cimzia (Certolizumab) is as effective as other similar medicines for Crohn's disease. It can be an option for people taking other RA medications that have too many side effects of don't work anymore.
                      • Cimzia (Certolizumab) lasts longer in the body than other RA medications, letting it work longer.
                      • Available in a prefilled syringe. This can make it easier to give yourself the injection.
                      • Treats certain types of arthritis conditions caused by an overactive immune system.
                      • Enbrel is the first biologic approved for moderate to severe rheumatoid arthritis.
                      • It has an established safety profile for treatment of rheumatoid arthritis (RA).
                      • Available as a single-use syringe and SureClick auto-injector pen which may be more convenient and easier for some people to use.
                      • People taking Enbrel for rheumatoid arthritis showed significant improvement and were able to reduce the dose or stop immunosuppressant medicines.
                      • Humira (adalimumab) is effective in reducing symptoms in all of its approved indications.
                      • You can give yourself Humira (adalimumab) on your own at home rather than visiting a clinic or hospital.
                      • Humira (adalimumab) treats many different autoimmune conditions.
                      • Available in a single-use pen (Humira Pen) that may be more convenient and easier for some people to use.
                      • Treats certain types of arthritis and gastrointestinal conditions caused by an overactive immune system.
                      • Remicade has almost two decades of clinical trial data and real-life experience with millions of people who have used it.
                      • Initial dosing to introduce Remicade to your body might be a hassle, but then you only need to take it every 6-8 weeks depending on your condition.
                      Downsides and risks
                      CimziaEnbrelHumiraRemicade
                      • Can lower your immune system's ability to fight infections. You can get serious infections such as TB (tuberculosis) and infections caused by viruses, fungi, or bacteria.
                      • Can have a higher risk for causing bladder infections, rash, and upper respiratory infections (cold or flu) compared to other similar medicines.
                      • Cimzia (Certolizumab) can increase the risk of lymphoma, leukemia, and other cancers.
                      • Requires routine tests to check for infections.
                      • Not a good choice if you have a history of heart failure, nervous system problems, or hepatitis B.
                      • There's no generic available and it can be very expensive.
                      • It's an injection.
                      • It's expensive because there's no generic available yet.
                      • Enbrel lowers your ability to fight infection and can cause serious life-threatening illness. The risk is greater if you take other drugs that lower your immune system, have an active infection, diabetes, or had tuberculosis (TB) in the past.
                      • You're first dose of Enbrel will need to be given at your doctor's office. If you decide not to self-inject and don't have someone to do it for you, you'll need to continue to see your doctor for each dose.
                      • You'll need to properly dispose of the needle, syringes, or Pen in a special (FDA-approved) sharps container.
                      • Because it needs to be refrigerated until you use it, if you're traveling, you'll need to carry it in a cooler with an ice pack.
                      • Not first-choice treatment for rheumatoid arthritis.
                      • Humira (adalimumab) is an injection and not an oral medication.
                      • Humira (adalimumab) is expensive because there's no generic available yet.
                      • Humira (adalimumab) lowers your ability to fight infection and in some cases can cause serious life-threatening illness. The risk is greater if you take other drugs that lower your immune system, have an active infection, diabetes, or had tuberculosis (TB) in the past.
                      • You'll need to properly dispose of the needle, syringes, or Pen in a sharps container.
                      • Humira (adalimumab) needs to be refrigerated until you use it, so if you're traveling, you'll need to carry it in a cooler with an ice pack.
                      • You have to get every dose through an IV infusion at your doctor's office.
                      • It's expensive because there's no generic available yet.
                      • Remicade has a higher risk of serious infusion-related side effects during or after it's given since it's injected right into your veins. Your doctor can prescribe medication before your dose that may lower this risk.
                      • Remicade lowers your ability to fight infection and can cause serious life-threatening illness. The risk is greater if you take other drugs that lower your immune system, have an active infection, diabetes, or had tuberculosis (TB) in the past.
                      • Not the best choice if you have heart failure.
                      • Talk to your baby's doctor if you're pregnant or breast-feeding. When women in a study took Remicade (Infliximab), the medicine was found in their breast milk 2 to 3 days after each dose, and in the baby's blood 6 months after they were born.
                      Tips from our pharmacists for people taking the medication
                      CimziaEnbrelHumiraRemicade
                      • Cimzia (Certolizumab) is a medicine that's injected just under the skin (subcutaneous). It can be given in your doctor's office or you can do it yourself at home.
                      • It can take multiple doses before you start to see any effects, so don't change your dose without talking to your doctor.
                      • Tell your doctor if you have night sweats, persistent fever, fatigue, weight loss, or swollen lymph nodes.
                      • You'll need to have a TB (tuberculosis) test before you start Cimzia (Certolizumab) and periodically during treatment.
                      • Don't get any live vaccines while you're taking Cimzia (Certolizumab) since they may not work as well. Wait at least 3 months after you've stopped taking Cimzia (Certolizumab) before getting a live vaccine.
                      • Enbrel (Etanercept) is available as a single-use prefilled syringe, single-use prefilled SureClick Autoinjector, and multiple-use vial. You and your doctor can discuss which is best for you.
                      • The autoinjector can be stored at room temperature for up to 14 days and can't be refrigerated again.
                      • Enbrel (Etanercept) is a medication that's injected under the skin (subcutaneous). Your doctor can give you your first dose, then let you self-inject it once so you learn how to do it correctly.
                      • Enbrel (Etanercept) lowers the your immune system's ability to fight infections, so it's important to let your doctor know if you come down with a fever, cough, or notice flu-like symptoms.
                      • You'll need to have a TB test before you start using Enbrel (Etanercept).
                      • Tell your doctor if you have an allergy to latex since the syringe needle cover has latex in it.
                      • Don't inject Enbrel (Etanercept) into skin that's red, bruised, or irritated. Rotate your injection areas to avoid skin reactions.
                      • As with all injection medicines, store away from children and throw used syringes away in a protective container, and not in the trash.
                      • Humira (adalimumab) is a medication that's injected under the skin. Your doctor can give you your first dose, then you can inject yourself at home once you feel comfortable doing so on your own.
                      • Humira (adalimumab) lowers your ability to fight infections, so it's important to let your doctor know if you have a fever, cough, or flu-like symptoms.
                      • Tell your doctor if you have an allergy to latex since the syringe needle cover has latex in it.
                      • Each time you use Humira (adalimumab), it's important to rotate the sites you chose to inject it in. Don't inject Humira (adalimumab) into skin that's red, bruised, or irritated.
                      • As with all injection medicines, store securely away from children and throw away used syringes in an FDA-approved sharps disposal container, and not in the trash.
                      • Remicade (Infliximab) is a medication that's given as an infusion at your doctor's office or clinic.
                      • It's very important to read the patient Medication Guide when you first start using Remicade (Infliximab).
                      • It's possible to get an allergic reaction to Remicade (Infliximab) either immediately during the treatment or a several days after stopping it. Your doctor can give you medicines that'll lower this risk.
                      • You'll need to have a TB test before you start taking Remicade (Infliximab) and periodically during treatment.
                      • Remicade (Infliximab) lowers your immune system's ability to fight infections, so it's important to let your doctor know if you notice a fever, cough, or flu-like symptoms. Children seem to get more infections than adults, so keep a close eye on them.
                      • If you have a young child, let their doctor know if you were on Remicade (Infliximab) while pregnant or nursing. It can increase their risk of infections for several months after your last dose and can delay their vaccine schedule.
                      Learn more
                      More about CimziaSide effectsReviews & ratingsAlternativesFDA package insert
                      Have you used Cimzia (certolizumab)?
                      Worth itNot sureNot worth it
                      More about EnbrelSide effectsReviews & ratingsFDA package insert
                      Have you used Enbrel (etanercept)?
                      Worth itNot sureNot worth it
                      More about HumiraSide effectsReviews & ratingsFDA package insert
                      Have you used Humira (adalimumab)?
                      Worth itNot sureNot worth it
                      More about RemicadeSide effectsReviews & ratingsFDA package insert
                      Have you used Remicade (infliximab)?
                      Worth itNot sureNot worth it