Prescription onlyClass: Respiratory

Clarinex D 

(desloratadine / pseudoephedrine)

Prescription onlyClass: Respiratory
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Treats allergy symptoms and clears up congestion.

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Our bottom line

Clarinex D (Desloratadine / Pseudoephedrine) works well to relieve allergy symptoms and nasal congestion, but it's not a good choice for people with high blood pressure.

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  • Combines the benefits of two medications to relieve congestion and allergy symptoms.
  • Desloratidine (the antihistamine) is useful for itchy eyes, runny nose, or constant sneezing.
  • Pseudoephedrine (the decongestant) is good for relieving congestion.
  • Doesn't make people feel sleepy like other antihistamine-containing products.


  • If you don't need both of the medications in this combination, you'd be taking extra medicine and can have extra side effects for no reason.
  • Pseudoephedrine (the decongestant) can make your heart race or make you feel anxious and restless.
  • Not for kids age 12 years or less.
  • Not a good medication for pregnant women to take.
How it works

Clarinex D (Desloratadine / Pseudoephedrine) is a combination medicine with an antihistamine (Desloratidine) and a decongestant (Pseudoephedrine). The antihistamine relieves allergy symptoms and the decongestant clears congestion.

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Side effect rates for Clarinex D (desloratadine / pseudoephedrine)

414 From clinical trials of Clarinex D / Seasonal allergies
  • Sleep difficulty
  • Mouth dry
  • Headache
  • Any side effect
  • Fatigue
  • Drowsiness
  • Dizziness
  • Sore throat
  • Nausea
  • Loss of appetite

Risks and Warnings for Clarinex D (desloratadine / pseudoephedrine)

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    • Higher risk if:
    • History of high blood pressure

    Clarinex D (Desloratadine / Pseudoephedrine) works by narrowing blood vessels. It can cause or worsen high blood pressure. If you feel dizzy or have a headache that won't go away, Clarinex D (Desloratadine / Pseudoephedrine) might not be the best option for you.

Common concerns from people taking Clarinex D (desloratadine / pseudoephedrine)

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  • While taking this, avoid alcohol and other drugs that make you drowsy.