Prescription onlyLower-cost generic available


(Estradiol Patch)

  • Patch
  • Hot flashes and night sweats
  • Vaginal dryness and inflammation
  • Low estrogen
  • Primary ovarian failure
  • Prevention of postmenopausal osteoporosis
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Treats low estrogen, relieves menopause symptoms, and lowers your risk of osteoporosis.

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Prescription onlyLower-cost generic available

Our pharmacists’ bottom line

You only have to think about the Climara (Estradiol Patch) once a week, and it may have fewer side effects than oral estrogen pills.

  • The Climara (Estradiol Patch) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen, like hot flashes and vaginal dryness.
  • The patch is good for people who don't want to take daily pills.
  • Can be worn while swimming, bathing, and showering.
  • By using a patch instead of a pill, there's a lower risk of side effects such as blood clots and stroke since lower amounts of estrogen are used in patches.
  • Lowers your risk of fractures by keeping your bones healthy. Make sure you also get enough calcium and Vitamin D.
  • Improves mood, energy, and mental alertness for some people.
  • Patch can fall off.
  • Increases your risk of uterine and breast cancer.
  • If you have your uterus, you have to use the Climara (Estradiol Patch) with another hormone called progestin to lower your risk of uterine cancer.
  • Increases your risk of developing blood clots and stroke.
  • Can worsen other health conditions, like high cholesterol, asthma, diabetes, fluid retention, and migraines.
  • Can't be used in people with liver problems.
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Side effects for Climara (Estradiol Patch)

From clinical trials of Climara / Estrogen replacement postmenopause (0.1 mg/day) ( 266)

  • Breast painBreast pain28% for Climara patch vs.4% for placebo
  • Ear, nose, or throat infectionEar, nose, or throat infection17% for Climara patch vs.8% for placebo
  • Abdominal painAbdominal pain16% for Climara patch vs.8% for placebo
  • HeadacheHeadache13% for Climara patch vs.10% for placebo
  • PainPain11% for Climara patch vs.7% for placebo
  • Swelling due to excess fluidSwelling due to excess fluid10% for Climara patch vs.6% for placebo
  • Back painBack pain9% for Climara patch vs.6% for placebo
  • Low mood disorderLow mood disorder8% for Climara patch vs.0% for placebo
  • Passing gasPassing gas7% for Climara patch vs.1% for placebo
  • Thick vaginal dischargeThick vaginal discharge7% for Climara patch vs.1% for placebo

What to expect when you start Climara (Estradiol Patch)

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Tips from our pharmacists
  • Remove the patch by tearing the package by hand and not with scissors. Never cut the patch.
  • Apply the sticky side of the patch to clean, dry, hairless skin below your waistline on areas as instructed by the manufacturer (never on your breast).
  • Replace the patch every 7 days on a different area of your skin to lower your risk of skin irritation.
  • Fold together the sticky sides of used patches before throwing them away to avoid exposing others to the medicine. Don't flush them down the toilet.
  • Shouldn't be used forever. Talk to your doctor regularly to see if you still need treatment.
  • Can cause nausea, dizziness, bloating, and breast tenderness.
  • Tell your doctor about any unusual vaginal bleeding.
  • Get emergency care if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.

Risks and Warnings for Climara (Estradiol Patch)

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    • Higher risk if:
    • Using estrogen for more than one year

    Vaginal bleeding after menopause can be a warning sign of uterus (endometrial) cancer, so let your doctor know if you notice any unusual bleeding. When estrogen is prescribed to women after menopause who still have a uterus, progestin should be used with it to lower the risk of cancer. Low-dose vaginal estrogen products are often a better choice than oral pills for women 65 years or older who have vaginal symptoms.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Climara (Estradiol Patch)

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The FDA category for this medication is X. It is advised that you: Unsafe