Prescription onlyNo lower cost generic available

Climara Pro

(Estradiol / Levonorgestrel Patch)

  • Patch
  • Hot flashes and night sweats
  • Prevention of postmenopausal osteoporosis
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Relieves hot flashes and lowers your risk of osteoporosis.

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Prescription onlyNo lower cost generic available

Our pharmacists’ bottom line

The Climara Pro (Estradiol / Levonorgestrel Patch) is effective at treating menopause symptoms, and it can be a good choice for women who need estrogen/progestin combo medications, but prefer to use a patch once a week instead of pills every day.

  • Once-a-week patch. Good for people who don't want to take daily pills.
  • The Climara Pro (Estradiol / Levonorgestrel Patch) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, vaginal dryness).
  • Fewer side effects than pills since patches contain lower amounts of hormones.
  • Good for women with an intact uterus. The levonorgestrel (a progestin) protects against the risk of cancer in the uterus caused by estrogen treatment.
  • More potential side effects than single-ingredient medications since it exposes your whole body to two hormones, estrogen and levonorgestrel (a progestin).
  • Increases your risk of developing blood clots and stroke.
  • You may get irregular bleeding and spotting that can last a few months to a year.
  • Patch can fall off.
  • Can be expensive since it's only available as a brand name product.
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Side effects for Climara Pro (Estradiol / Levonorgestrel Patch)

From clinical trials of Climara Pro / Postmenopausal hormone replacement (0.045/0.015 mg) ( 212)

  • Application site reactionApplication site reaction41% for Climara Pro patch vs.0% for placebo
  • Vaginal bleedingVaginal bleeding37% for Climara Pro patch vs.0% for placebo
  • Breast painBreast pain19% for Climara Pro patch vs.0% for placebo
  • Upper respiratory infectionUpper respiratory infection13% for Climara Pro patch vs.0% for placebo
  • Application site reactionApplication site reaction9% for Climara Pro patch vs.0% for placebo
  • Low mood disorderLow mood disorder6% for Climara Pro patch vs.0% for placebo
  • Back painBack pain6% for Climara Pro patch vs.0% for placebo
  • Flu syndromeFlu syndrome5% for Climara Pro patch vs.0% for placebo
  • PainPain5% for Climara Pro patch vs.0% for placebo
  • HeadacheHeadache5% for Climara Pro patch vs.0% for placebo

What to expect when you start Climara Pro (Estradiol / Levonorgestrel Patch)

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Tips from our pharmacists
  • Remove the patch by tearing the package by hand and not with scissors. Never cut the patch.
  • Apply the sticky side of the patch to clean, dry, hairless skin below your waistline on areas as instructed by the manufacturer (never on your breast).
  • Replace the patch weekly on a different area of your skin to lower your risk of skin irritation.
  • Fold together the sticky sides of used patches before throwing them away to avoid exposing others to the medicine. Don't flush them down the toilet.
  • Shouldn't be used forever. Talk to your doctor regularly to see if you still need treatment.
  • Can cause nausea, dizziness, bloating, and breast tenderness.
  • Tell your doctor about any unusual vaginal bleeding.
  • Get emergency care if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.

Risks and Warnings for Climara Pro (Estradiol / Levonorgestrel Patch)

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    • Higher risk if:
    • Using estrogen for more than one year

    Vaginal bleeding after menopause can be a warning sign of uterus (endometrial) cancer, so let your doctor know if you notice any unusual bleeding. When estrogen is prescribed to women after menopause who still have a uterus, progestin should be used with it to lower the risk of cancer. Low-dose vaginal estrogen products are often a better choice than oral pills for women 65 years or older who have vaginal symptoms.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Climara Pro (Estradiol / Levonorgestrel Patch)

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The FDA category for this medication is X. It is advised that you: Unsafe