Climara Pro Alternatives

(estradiol / levonorgestrel patch)

Alternatives

Compare Climara Pro (estradiol / levonorgestrel patch) to alternatives

These medications are comparable to Climara Pro (estradiol / levonorgestrel patch) or used for similar purposes.

Climara Pro
(estradiol / levonorgestrel patch)

Angeliq
(drospirenone / estradiol)

Combipatch
(estradiol / norethindrone patch)

Estrace
(Estradiol)

Aygestin
(norethindrone)

Prefest
(Estradiol / Norgestimate)

Relieves hot flashes and lowers your risk of osteoporosis. The Climara Pro (estradiol / levonorgestrel patch) is effective at treating menopause symptoms, and it can be a good choice for women who need estrogen/progestin combination medications but prefer to use a patch once a week instead of pills every day.Relieves hot flashes and vaginal dryness due to menopause. Angeliq (drospirenone / estradiol) helps relieve menopausal symptoms. There can be many side effects, so it's important to think through the benefits and potential hassles of this drug before using it.Treats low estrogen and relieves menopause symptoms. Combipatch (estradiol / norethindrone patch) is a twice weekly patch that effectively treats menopause and causes less blood clots or stroke than combination pills.Treats low estrogen, relieves menopause symptoms, and lowers your risk of osteoporosis. Estrace (Estradiol) relieves menopausal symptoms and prevents bone loss. It's an oral hormone replacement, so it can have a lot of side effects, and it's important to think through the benefits and potential hassles of this drug before using it.Regulates your menstrual cycle and treats irregular bleeding. Aygestin (norethindrone) regulates the menstrual cycle and treats heavy or irregular vaginal bleeding. It's easy to take and isn't expensive.Relieves menopause symptoms and lowers your risk of osteoporosis. Prefest (Estradiol / Norgestimate) is effective at treating symptoms related to menopause and bone loss. It has a difficult dosing schedule to follow, but doesn't affect your cholesterol and triglyceride levels as much as other estrogen products.
Reviews & ratings
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Have you used Climara Pro (estradiol / levonorgestrel patch)?
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Have you used Angeliq (drospirenone / estradiol)?
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Have you used Combipatch (estradiol / norethindrone patch)?
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Have you used Estrace (Estradiol)?
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Reviews for Aygestin
40%
+31% better vs. Climara Pro
23%
+48% better vs. Climara Pro
23%
+9% better vs. Climara Pro
Have you used Aygestin (norethindrone)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Prefest (Estradiol / Norgestimate)?
Worth itNot sureNot worth it
Side effects
Climara ProAngeliqCombipatchEstraceAygestinPrefest
  • Rash 2%
  • Vaginal inflammation 2%
  • Accidental injury 3%
  • Infection 3%
  • High blood pressure 3%
  • Weight gain 3%
  • Bladder infection 3%
  • Stomach pain 4%
  • Gas 4%
  • Swelling of arms and legs 4%
More Climara Pro side effects »
  • Diarrhea 1%
  • Swelling of arms and legs 1%
  • Breast pain 2%
  • Nausea 2%
  • Stomach pain 3%
  • Headache 1%
  • Yeast infections 5%
  • Vaginal Bleeding 14%
More Angeliq side effects »
  • Nervousness 2%
  • Sore throat 2%
  • Vaginal discharge 2%
More Combipatch side effects »

The Estrace FDA package insert doesn’t have numbers about how common side effects are.

More about Estrace side effects »

The Aygestin FDA package insert doesn’t have numbers about how common side effects are.

More about Aygestin side effects »
  • Flatulence 5%
  • Tooth disorder 5%
  • Myalgia 5%
  • Dizziness 5%
  • Depression 5%
  • Coughing 5%
  • Fatigue 6%
  • Pain 6%
  • Nausea 6%
  • Viral infection 6%
More Prefest side effects »
How it works
Climara ProAngeliqCombipatchEstraceAygestinPrefest
Climara Pro (estradiol / levonorgestrel patch) is an estrogen/progestin combination patch that works to balance hormone changes in your body during and after menopause. Estrogen reduces hot flashes, reduces night sweats, and prevents bone loss. Progestin protects the uterus from damage.Angeliq (drospirenone / estradiol) is a combination medicine that works to balance hormone changes in your body during and after menopause. Estradiol (an estrogen) reduces hot flashes and night sweats. Drospirenone (a progestin) protects the uterus from damage.Combipatch (estradiol / norethindrone patch) is a combination patch that works to balance hormone changes in your body during and after menopause. Estradiol (an estrogen) reduces hot flashes and night sweats. Norethindrone (a progestin) protects the uterus from damage.Estrace (Estradiol) is an oral medication that replaces an estrogen hormone, estradiol, that your body loses during and after menopause. Higher levels of estradiol relieve symptoms of low estrogen and menopause and prevent bone loss.Aygestin (norethindrone) contains norethindrone, a synthetic progesterone hormone. It regulates your period, treats irregular vaginal bleeding, and eases the pain of endometriosis (a condition where tissue that lines your uterus is found in other parts of the body).Prefest (Estradiol / Norgestimate) is a combination oral medicine that works to balance hormone changes in your body during and after menopause. Estradiol (an estrogen) reduces hot flashes and night sweats and prevents bone loss, but can also harm cells in the uterus after menopause. Norgestimate (a progestin) protects the uterus from damage.
Type of medication
Climara ProAngeliqCombipatchEstraceAygestinPrefest
Prescription onlyNo lower cost generic availablePrescription onlyNo lower cost generic availablePrescription onlyNo lower cost generic availablePrescription onlyLower-cost generic availablePrescription onlyLower-cost generic availablePrescription onlyNo lower cost generic available
Available as
Climara ProAngeliqCombipatchEstraceAygestinPrefest
  • Patch
  • Pill
  • Patch
  • Pill
  • Pill
  • Pill
Used for
Climara ProAngeliqCombipatchEstraceAygestinPrefest
  • Hot Flashes And Night Sweats
  • Hot Flashes And Night Sweats
  • Pain Caused By Endometriosis
  • Hot Flashes And Night Sweats
Risk factors for serious side effects
Climara ProAngeliqCombipatchEstraceAygestinPrefest
  • Using estrogen for more than one year
  • Personal or family history of breast cancer
  • Personal or family history of blood clots
  • Smoking
Detailed Climara Pro (estradiol / levonorgestrel patch) risks & warnings »
  • Using estrogen for more than one year
  • Personal or family history of breast cancer
  • Personal or family history of blood clots
  • Smoking
Detailed Angeliq (drospirenone / estradiol) risks & warnings »
  • Using estrogen for more than one year
  • Personal or family history of breast cancer
  • Personal or family history of blood clots
  • Smoking
Detailed Combipatch (estradiol / norethindrone patch) risks & warnings »
  • Using estrogen for more than one year
  • Personal or family history of breast cancer
  • Duration of use
  • Personal or family history of blood clots
  • Obesity
Detailed Estrace (Estradiol) risks & warnings »
  • Personal or family history of blood clots
  • Smoking
  • Obesity
  • Systemic lupus erythematosus (SLE)
  • History of depression
Detailed Aygestin (norethindrone) risks & warnings »
  • Using estrogen for more than one year
  • Personal or family history of breast cancer
  • Duration of use
  • Personal or family history of blood clots
  • Obesity
Detailed Prefest (Estradiol / Norgestimate) risks & warnings »
Pregnancy

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Kidneys and liver
Climara ProAngeliqCombipatchEstraceAygestinPrefest
No kidneys and liver related info.No kidneys and liver related info.No kidneys and liver related info.No kidneys and liver related info.
  • Aygestin (norethindrone) is broken down by the liver, so if the liver is damaged, the drug can build up in your body. Tell your doctor if you've had liver disease or damage. Your doctor will have to change Aygestin (norethindrone) to a different medicine.
No kidneys and liver related info.
Pain
Climara ProAngeliqCombipatchEstraceAygestinPrefest
No pain related info.No pain related info.No pain related info.
  • Estrogens like Estrace (Estradiol) can increase the risk of gallbladder disease, sometimes needing surgery. Let your doctor know if you have nausea, vomiting, bloating, or severe stomach pain that won't go away.
  • Aygestin (norethindrone) can raise your risk of blood clots, which can be very dangerous. You're more likely to have them if you smoke tobacco, are obese, or if you or your family have ever had blood clots. Get medical care right away if you have pain in your legs or arms, bad headaches, trouble breathing, or sudden changes in your speech or vision.
  • Tell your doctor about any severe stomach pain or yellowing of your eyes or skin.
No pain related info.
Weight
Climara ProAngeliqCombipatchEstraceAygestinPrefest
  • Can cause nausea, dizziness, bloating, and breast tenderness. Tell your doctor right away if you have unusual vaginal bleeding.
No weight related info.No weight related info.
  • Can cause nausea, dizziness, bloating and breast tenderness.
  • Aygestin (norethindrone) can cause cramps, bloating, trouble sleeping, acne, weight gain, or irregular periods.
  • Can make you gain weight.
  • Prefest (Estradiol / Norgestimate) is a mixture of estrogen and progestin. It could cause a higher risk of ovarian cancer, especially if you have a family history of it. Your doctor can help you weigh the risks versus the benefits of this medication.
  • Can cause nausea, dizziness, bloating, and breast tenderness.
Upsides and benefits
Climara ProAngeliqCombipatchEstraceAygestinPrefest
  • Once-a-week patch. Good for people who don't want to take daily pills.
  • Replaces estrogen in your body and relieves multiple symptoms from low estrogen, such as hot flashes and vaginal dryness.
  • Fewer side effects than pills since patches contain lower amounts of hormones.
  • Good for women with an intact uterus. The progestin in the patch protects against the risk of cancer in the uterus.
  • The Climara Pro (estradiol / levonorgestrel patch) patch has a lower risk of causing blood clots and stroke compared to other forms containing the same medicines.
  • Angeliq (drospirenone / estradiol) replaces estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, night sweats, vaginal dryness).
  • Useful for women who experience moderate to severe symptoms of menopause.
  • Improves mood, energy, and mental alertness for some people.
  • Good for women with an intact uterus. The drospirenone (a progestin) protects against the risk of cancer in the uterus from estrogen treatment.
  • Twice weekly patch. Good for people who don't want to take daily pills.
  • Replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, vaginal dryness).
  • Less likely to cause blood clots or stroke than pills since patches contain a lower amount of hormones.
  • Good for women with an intact uterus.
  • You can bathe, shower, and swim while wearing the patch, as long as you don't rub the patch.
  • Estrace (Estradiol) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen, like hot flashes and vaginal dryness.
  • Lowers your risk of fractures by keeping your bones healthy. Make sure you also get enough calcium and Vitamin D.
  • Improves mood, energy, and mental alertness for some people.
  • Doesn't expose your partner to estrogen during sexual acitivities like the vaginal estrogen creams.
  • Can help relieve symptoms of advanced prostate or breast cancer in some people.
  • Helps to regulate your period.
  • Decreases bleeding from hormone imbalance.
  • Available as a generic medication, so it costs less.
  • Prefest (Estradiol / Norgestimate) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, night sweats, vaginal dryness).
  • Lowers your risk of fractures by keeping your bones healthy. Make sure you also get enough calcium and Vitamin D.
  • Improves mood, energy, and mental alertness for some people.
  • Good for women with an intact uterus. The norgestimate (a progestin) protects against the risk of cancer in the uterus caused by estrogen treatment.
  • Doesn't affect your cholesterol levels as much as other estrogen treatments.
Downsides and risks
Climara ProAngeliqCombipatchEstraceAygestinPrefest
  • More potential side effects than medications with one ingredient since Climara Pro (estradiol / levonorgestrel patch) exposes your whole body to two hormones.
  • Increases your risk of developing blood clots and stroke.
  • You may get irregular bleeding and spotting that can last a few months to a year.
  • The patch can fall off, especially if you like to regularly swim, take baths, or use saunas.
  • Can be expensive since it's only available as a brand name product.
  • There are more possible side effects since it exposes your whole body to two hormones.
  • Angeliq (drospirenone / estradiol) can't be used by women who have had their uterus removed.
  • You may get irregular bleeding and spotting that can last a few months to a year.
  • Compared to other estrogen-progestin combination medicines, you might be more likely to have blood clots with Angeliq (drospirenone / estradiol).
  • Angeliq (drospirenone / estradiol) might increase your potassium, which can be dangerous if you're taking other medicines that do the same.
  • More potential side effects than single ingredient medications since it exposes your whole body to two hormones.
  • You may get irregular bleeding and spotting that can last a few months to a year.
  • The patch can't be exposed to direct sunlight for long periods of time.
  • Can be expensive since it's only available as a brand name product.
  • More potential side effects than estrogen creams since it exposes your whole body to estrogen.
  • Increases your risk of uterine and breast cancer.
  • If you have your uterus, you have to take Estrace (Estradiol) with another hormone called progestin to lower your risk of uterine cancer.
  • Increases your risk of developing blood clots and stroke.
  • Can't be used in people with liver problems.
  • Can be expensive since it's only available as a brand name product.
  • Can make you gain weight.
  • Higher risk of blood clots.
  • Not for people who are post-menopausal, pregnant, or breast-feeding.
  • Can cause a lot of side effects.
  • More potential side effects since it exposes your whole body to two hormones, estrogen and norgestimate (a progestin).
  • Dosing schedule can be hard to follow with the 2 different kind of pills (estrogen-only and estrogen/progestin pills).
  • Increases your risk of developing blood clots and stroke.
  • You may get irregular bleeding and spotting that can last a few months to a year.
Tips from our pharmacists for people taking the medication
Climara ProAngeliqCombipatchEstraceAygestinPrefest
  • Remove the patch by tearing the package by hand and not with scissors. Never cut the patch.
  • Apply the sticky side of the patch to clean, dry, hairless skin on your lower belly or the upper areas of your buttocks as directed by the manufacturer. Don't put it on your waistline or on your breasts. Press the patch firmly in place for 10 seconds, especially around the edges.
  • Replace the patch every 7 days on a different area of your skin to prevent skin irritation.
  • Fold together the sticky sides of used patches before throwing them away to avoid exposing others to the medicine. Don't flush them down the toilet.
  • Should not be used forever. Talk to your doctor regularly to see if you still need treatment.
  • Can cause nausea, dizziness, bloating, and breast tenderness. Tell your doctor right away if you have unusual vaginal bleeding.
  • You can get some bleeding if you miss several doses in a row.
  • If you miss a pill and it's been more than 24 hours since you were supposed to take it, skip it and continue your normal dose. Don't ever take a double dose.
  • You and your doctor should regularly talk about how long to use Angeliq (drospirenone / estradiol). The longer you are on it, the more likely you are to have problems from it.
  • Can cause nausea, dizziness, and breast tenderness.
  • Tell your doctor about any unusual vaginal bleeding.
  • Tell your doctor or go to an emergency room if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.
  • Remove the patch by tearing the package by hand and not with scissors. Never cut the patch.
  • Apply the sticky side of the patch to clean, dry, hairless skin on your lower belly as directed by the manufacturer. Press the patch firmly in place for 10 seconds, especially around the edges. Don't place it at your waistline or on your breasts.
  • Replace the patch twice a week (every 3-4 days) on a different area of your skin to help prevent skin irritation.
  • Fold together the sticky sides of used patches before throwing them away to avoid exposing others to the medicine. Don't flush them down the toilet.
  • Combipatch (estradiol / norethindrone patch) is not intended to be used forever. Talk to your doctor regularly to see if you still need treatment.
  • Take Estrace (Estradiol) exactly the way your doctor tells you since the dose and dosing cycle may be different depending on what you're being treated for.
  • Shouldn't be used forever. Talk to your doctor regularly to see if you still need treatment. If you’re taking Estrace (Estradiol) only for vaginal symptoms or to prevent bone loss, there are other medicines that can work better with fewer side effects (like a vaginal cream for menopause or non-estrogen medicine for bone loss).
  • Can cause nausea, dizziness, bloating and breast tenderness.
  • Tell your doctor about any unusual vaginal bleeding.
  • Get emergency care if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.
  • The dose of Aygestin (norethindrone) will be different depending on what you’re using it for, so take it exactly the way your doctor tells you.
  • It's important to take it at the same time every day.
  • Talk to your doctor every few months about using the lowest possible dose of Aygestin (norethindrone). Since there can be a lot of long-term side effects, take it only as long as you need it.
  • If you're taking Aygestin (norethindrone) to regulate your period, you'll get withdrawal bleeding 3 to 7 days after stopping Aygestin (norethindrone).
  • Aygestin (norethindrone) can cause cramps, bloating, trouble sleeping, acne, weight gain, or irregular periods.
  • Tell your doctor about any severe stomach pain or yellowing of your eyes or skin.
  • Follow the dosing schedule exactly to take the estrogen-only and combination estrogen/progestin pills.
  • Shouldn't be used forever. Talk to your doctor regularly to see if you still need treatment.
  • Can cause nausea, dizziness, bloating, and breast tenderness.
  • Tell your doctor about any unusual vaginal bleeding.
  • Get emergency care if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.
Learn more
More about Climara ProSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Climara Pro (estradiol / levonorgestrel patch)?
Worth itNot sureNot worth it
More about AngeliqSide effectsFDA package insert
Have you used Angeliq (drospirenone / estradiol)?
Worth itNot sureNot worth it
More about CombipatchSide effectsReviews & ratingsFDA package insert
Have you used Combipatch (estradiol / norethindrone patch)?
Worth itNot sureNot worth it
More about EstraceSide effectsFDA package insert
Have you used Estrace (Estradiol)?
Worth itNot sureNot worth it
More about AygestinSide effectsReviews & ratingsFDA package insert
Have you used Aygestin (norethindrone)?
Worth itNot sureNot worth it
More about PrefestSide effectsFDA package insert
Have you used Prefest (Estradiol / Norgestimate)?
Worth itNot sureNot worth it