Prescription onlyLower-cost generic availableClass: Women's health

Climara Alternatives

(estradiol patch)

Prescription onlyLower-cost generic availableClass: Women's health
Back to: Full Site Navigation

Compare Climara (estradiol patch) to alternatives

These medications are comparable to Climara (estradiol patch) or used for similar purposes.

Climara
(estradiol patch)

Premarin
(conjugated estrogens)

Prempro
(conjugated estrogens / medroxyprogesterone acetate)

Provera
(medroxyprogesterone)

Estring
(estradiol vaginal ring)

Treats low estrogen, relieves menopause symptoms, and lowers your risk of osteoporosis. Climara (estradiol patch) is a treatment for low estrogen that is used only once weekly, and it may have fewer side effects than oral estrogen pills.Treats low estrogen, relieves menopause symptoms, and lowers your risk of osteoporosis. Premarin (Conjugated Estrogens) relieves menopausal symptoms and prevents bone loss. It's an oral hormone replacement, so it can have a lot of side effects, and it's important to think through the benefits and potential hassles of this drug before using it.Coming soon.Regulates your menstrual cycle and supplements estrogen treatments for menopause. Provera (Medroxyprogesterone) works well to regulate your menstrual cycle and stop irregular bleeding. It also protects the uterus from estrogen's harmful effects.Relieves vaginal dryness due to menopause. Estring (Estradiol Vaginal Ring) is a vaginal ring that may be less of a hassle than estrogen pills, gels, patches, or vaginal creams, but comes with the same side effects.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
Coupons for Climara
Best available price for 4 (4 once-weekly patches of 0.05mg/day) cartons of climara
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Climara (estradiol patch)?
Worth itNot sureNot worth it
Reviews for Premarin
50%
+50% better vs. Climara
43%
+24% better vs. Climara
11%
+11% better vs. Climara
154 reviews
Have you used Premarin (conjugated estrogens)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Prempro (conjugated estrogens / medroxyprogesterone acetate)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Provera (medroxyprogesterone)?
Worth itNot sureNot worth it
Reviews for Estring
63%
+37% better vs. Climara
39%
+28% better vs. Climara
18%
+18% better vs. Climara
Have you used Estring (estradiol vaginal ring)?
Worth itNot sureNot worth it
Side effects
ClimaraPremarinPremproProveraEstring
  • Breast pain 1%
  • Sinus infection 1%
  • Stuffy nose 1%
  • Swelling of arms and legs 7%
  • Stomach pain 3%
  • Pain 1%
More Climara side effects »
  • Excessive vaginal bleeding 13%
  • Abdominal pain 5%
  • Breast pain 3%
  • Passing gas 4%
  • Pain 1%
  • Thick vaginal discharge 3%
  • Endometrial hyperplasia 5%
  • Vaginitis 5%
  • Sleep difficulty 1%
More Premarin side effects »

We haven’t found good data for Prempro side effects.

FDA side effect reports for Prempro »

We haven’t found good data for Provera side effects.

FDA side effect reports for Provera »
  • Headache 13%
  • Thick vaginal discharge 7%
  • Back pain 6%
  • Yeast infection 6%
  • Ear, nose, or throat infection 5%
  • Vaginitis 5%
  • Vaginal discomfort/pain 5%
  • Sinus inflammation 4%
  • Asymptomatic genital bacterial growth 4%
  • Abdominal pain 4%
More Estring side effects »
How it works
ClimaraPremarinPremproProveraEstring
The Climara (estradiol patch) replaces estrogen that your body loses during and after menopause. Higher levels of estrogen help relieve symptoms of menopause and prevent bone loss.Premarin (Conjugated Estrogens) is an oral medication that replaces estrogen hormones during and after menopause. Higher levels of estrogen lower menopause-related hot flashes, flushing, night sweats, vaginal problems, and bone loss.Coming soon.Provera (Medroxyprogesterone) contains medroxyprogesterone, a progesterone hormone that works to balance hormone changes in the body. In premenopausal women, it prevents thickening of the uterus lining and regulates your menstrual cycle. It's also added to hormone therapy to protect the uterus from the harmful effects of estrogen.Estring (Estradiol Vaginal Ring) is a vaginal ring that replaces estrogen hormones in your vagina that your body loses during menopause. Estrogen helps rebuild and maintain vaginal tissue, relieving symptoms of vaginal dryness, soreness, irritation, and painful sex.
Type of medication
ClimaraPremarinPremproProveraEstring
Prescription onlyPrescription onlyPrescription onlyPrescription only
Available as
ClimaraPremarinPremproProveraEstring
  • Patch
  • Pill
  • Pill
  • Pill
  • Vaginal ring
Used for
ClimaraPremarinPremproProveraEstring
  • Hot Flashes And Night Sweats
  • Hot Flashes And Night Sweats
  • Menopause Moderate To Severe Abnormal Vasomotor Function Menopause Moderate To Severe Vaginal Atrophy Moderate To Severe Vulvar Atrophy Postmenopausal Osteoporosis
  • Amenorrhea
  • Vaginal Dryness And Inflammation
Risk factors for serious side effects
ClimaraPremarinPremproProveraEstring
  • Using estrogen for more than one year
  • Personal or family history of breast cancer
  • Personal or family history of blood clots
  • Smoking
Detailed Climara (estradiol patch) risks & warnings »
  • Using estrogen for more than one year
  • Personal or family history of breast cancer
  • Duration of use
  • Personal or family history of blood clots
  • Obesity
Detailed Premarin (conjugated estrogens) risks & warnings »
    Coming soon.
    • Personal or family history of breast cancer
    • Family history of ovarian cancer
    • Personal or family history of blood clots
    • Smoking
    • Obesity
    Detailed Provera (medroxyprogesterone) risks & warnings »
    • Using estrogen for more than one year
    • Personal or family history of breast cancer
    • Duration of use
    • Personal or family history of blood clots
    • Obesity
    Detailed Estring (estradiol vaginal ring) risks & warnings »
    Pregnancy

    Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

    Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

    Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

    Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

    Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

    Pain
    ClimaraPremarinPremproProveraEstring
    No pain related info.
    • Get emergency care if you notice swelling or pain in your lower legs, sudden shortness of breath, or an unexplained severe headache.
    No pain related info.No pain related info.No pain related info.
    Weight
    ClimaraPremarinPremproProveraEstring
    • Can cause nausea, dizziness, bloating, and breast tenderness. Tell your doctor right away if you have unusual vaginal bleeding.
    • Can cause nausea, dizziness, bloating and breast tenderness.
    No weight related info.
    • Provera (Medroxyprogesterone) contains progestin. It could cause a higher risk of ovarian cancer, especially if you have a family history of it. Your doctor can help you weigh the risks versus the benefits of this medication.
    • Can cause headache, weight gain, breast tenderness, or changes in mood.
    No weight related info.
    Upsides and benefits
    ClimaraPremarinPremproProveraEstring
    • Climara (estradiol patch) replaces estrogen to your whole body and relieves many symptoms due to low estrogen, like hot flashes and vaginal dryness.
    • The patch is good for people who don't want to or can't take daily pills.
    • Climara (estradiol patch) is available as a generic product, which lowers the cost.
    • By using a patch instead of a pill, there's a lower risk of side effects such as blood clots and stroke since lower amounts of estrogen are used in patches.
    • Lowers your risk of fractures by keeping your bones healthy.
    • Premarin (Conjugated Estrogens) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, night sweats, vaginal dryness).
    • Lowers your risk of fractures by keeping your bones healthy. Make sure you also take enough calcium and Vitamin D.
    • Improves mood, energy, and mental alertness for some people.
    • Does not expose your partner to estrogen during sexual acitivities like vaginal estrogen creams.
    • Can help relieve symptoms of prostate cancer or advanced breast cancer in some people.
    Coming soon
    • Provera (Medroxyprogesterone) can be used to treat multiple hormone problems in women.
    • After menopause, taking estrogen raises your risk of uterine cancer. However, taking progesterone, like in Provera (Medroxyprogesterone), along with estrogen gives you the positive effects of estrogen, but also prevents it from damaging your uterus.
    • Women taking an estrogen/progestin combination medications have a lower risk of uterine cancer.
    • Estring (Estradiol Vaginal Ring) relieves vaginal dryness and irritation to make sex more enjoyable.
    • Works locally in the vagina and doesn't expose the rest of your body to estrogen like pills do.
    • Good option for people who don't want to take oral pills.
    • Generally works well with fewer side effects.
    • Many women think Estring (Estradiol Vaginal Ring) is easy to insert and comfortable to use.
    • In a 12-week study, Estring (Estradiol Vaginal Ring) worked well to improve vaginal problems, reduced pain during urination, and sudden urges to urinate.
    • Estring (Estradiol Vaginal Ring) slowly releases estrogen over the 90 days the ring is in place, so you only have to remove and insert a new one every three months.
    Downsides and risks
    ClimaraPremarinPremproProveraEstring
    • The patch can fall off, especially if you like to regularly swim, take baths or use saunas or steamrooms.
    • Increases your risk of uterine and breast cancer.
    • If you have your uterus, you have to use the Climara (estradiol patch) with another hormone called progestin to lower your risk of uterine cancer.
    • Can worsen other health conditions, like high cholesterol, asthma, diabetes, fluid retention, underactive thyroid and migraines.
    • If you're only having vaginal dryness or inflammation and not hot flashes, it's better to use creams that you can apply to the affected area instead of Climara (estradiol patch).
    • More potential side effects than estrogen creams since it exposes your whole body to estrogen.
    • Increases your risk of uterine and breast cancer.
    • If you have your uterus, you have to take Premarin (Conjugated Estrogens) with another hormone called progestin to lower your risk of uterine cancer.
    • Increases your risk of developing blood clots and stroke.
    • Can't be used in people with liver problems.
    • Can be expensive since it's only available as a brand name product.
    Coming soon
    • You can't take Provera (Medroxyprogesterone) if you've had a hysterectomy (your uterus removed). You also can't take it if you're pregnant or breastfeeding, have unusual vaginal bleeding, or have a history of blood clots, certain kinds of cancer, stroke, heart attack, liver problems, or bleeding problems.
    • Estring (Estradiol Vaginal Ring) may not be the best estrogen product if you have a narrow vagina or frequent vaginal infections.
    • The ring can fall out without you noticing it.
    • Increases your risk of endometrial (uterine cancer).
    • If you have your uterus, you might need to use Estring (Estradiol Vaginal Ring) with another hormone called progestin to lower your risk of uterine cancer.
    • Can be expensive since it's only available as a brand name product.
    Tips from our pharmacists for people taking the medication
    ClimaraPremarinPremproProveraEstring
    • Remove the patch by tearing the package by hand and not with scissors. Never cut the patch.
    • Apply the sticky side of the patch to clean, dry, hairless skin on your lower belly or the upper areas of your buttocks as directed by the manufacturer. Don't put it on your waistline or on your breasts. Press the patch firmly in place for at least 10 seconds, especially around the edges.
    • Replace the patch every 7 days on a different area of your skin to prevent skin irritation.
    • Fold together the sticky sides of used patches before throwing them away to avoid exposing others to the medicine. Don't flush them down the toilet.
    • Should not be used forever. Talk to your doctor regularly to see if you still need treatment.
    • Can cause nausea, dizziness, bloating, and breast tenderness. Tell your doctor right away if you have unusual vaginal bleeding.
    • Take Premarin (Conjugated Estrogens) at the same time each day. If you miss a dose, take it as soon as possible, but if it’s almost time for your next dose, take only that dose.
    • Use the lowest dose possible of Premarin (Conjugated Estrogens) and take it only as long as needed. Talk to your doctor regularly to see if you still need treatment. If you’re taking Premarin (Conjugated Estrogens) only for vaginal symptoms or to prevent bone loss, there are other medicines that can work better with fewer side effects (like a vaginal cream for menopause symptoms, or non-estrogen medicine for bone loss).
    • Can cause nausea, dizziness, bloating and breast tenderness.
    • Get emergency care if you notice swelling or pain in your lower legs, sudden shortness of breath, or an unexplained severe headache.
    • Tell your doctor about any unusual vaginal bleeding.
    Coming soon
    • The dose of Provera (Medroxyprogesterone) will be different depending on what you’re using it for, so take it exactly the way your doctor tells you.
    • Talk to your doctor every few months about using the lowest possible dose of Provera (Medroxyprogesterone). Since there can be a lot of long-term side effects, take it only as long as you need it.
    • Can cause headache, weight gain, breast tenderness, or changes in mood.
    • If you're taking Provera (Medroxyprogesterone) to regulate your period, you'll get withdrawal bleeding 3 to 7 days after stopping Provera (Medroxyprogesterone).
    • Insert the ring as deeply as possible into your vagina. You shouldn't feel the ring once it's inserted.
    • The ring is good for 90 days in your vagina. If it falls out before the 90 days are up, just clean it with warm water and reinsert.
    • You don’t have to remove Estring (Estradiol Vaginal Ring) to treat a vaginal infection or have sex.
    • It can take up to 2 to 3 weeks to feel the full benefits.
    • Most people don't have many side effects, but temporary nausea, dizziness, bloating, and breast tenderness are possible.
    • Tell your doctor about any unusual vaginal bleeding.
    Learn more
    More about ClimaraSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Climara (estradiol patch)?
    Worth itNot sureNot worth it
    More about PremarinSide effectsReviews & ratingsFDA package insert
    Have you used Premarin (conjugated estrogens)?
    Worth itNot sureNot worth it
    More about PremproSide effectsReviews & ratingsFDA package insert
    Have you used Prempro (conjugated estrogens / medroxyprogesterone acetate)?
    Worth itNot sureNot worth it
    More about ProveraSide effectsReviews & ratingsFDA package insert
    Have you used Provera (medroxyprogesterone)?
    Worth itNot sureNot worth it
    More about EstringSide effectsReviews & ratingsFDA package insert
    Have you used Estring (estradiol vaginal ring)?
    Worth itNot sureNot worth it