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Clozaril Alternatives

(Clozapine)

  • Pill
  • Dissolving tablet
  • Liquid
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Compare Clozaril (Clozapine) to alternatives

These medications are comparable to Clozaril (Clozapine) or used for similar purposes.

Clozaril
(Clozapine)

Zyprexa
(Olanzapine)

Ativan
(Lorazepam)

Risperdal
(Risperidone)

Haldol
(Haloperidol)

Saphris
(Asenapine)

Abilify
(Aripiprazole)

Seroquel
(Quetiapine)

Chlorpromazine

Helps control your thoughts and actions. Clozaril (Clozapine) treats schizophrenia when other drugs haven't worked, but you'll have to get blood work done regularly and might gain weight.Helps control your thoughts and mood. Zyprexa (Olanzapine) is good for treating psychosis, mania, and agitation. More likely to cause weight gain and sleepiness than other antipsychotics.Helps you relax. Ativan (Lorazepam) is okay for occasional or short-term use (up to 4 weeks) for anxiety and sleep. Less likely to have drug interactions, but more likely to cause withdrawal symptoms compared to similar drugs.Helps control your thoughts and mood. Risperdal (Risperidone) is good for treating psychosis, mania, and irritability. Among newer antipsychotic medicines, more likely to cause side effects, especially weight gain and hormone problems.Helps control your thoughts and calms agitation. Haldol (Haloperidol) is okay for treating psychosis and agitation. It's less likely to cause weight gain than other antipsychotics, but it's more likely to cause other bad side effects.Coming soon.Helps control your thoughts and mood. Abilify (Aripiprazole) is good for treating psychosis and mania, and can help with depression. Less likely to cause side effects than any other antipsychotic, but has a risk of suicidal thoughts for people age 24 and younger.Helps control your thoughts and mood. Seroquel (Quetiapine) is good for treating psychosis and mania. Fewer side effects than most antipsychotics, but might be less effective for people over age 40 with schizophrenia.Coming soon.
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Reviews & ratings
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Reviews for Zyprexa (Olanzapine)
45%
22% vs. Clozaril (Clozapine)
53%
30% vs. Clozaril (Clozapine)
47%
+3% vs. Clozaril (Clozapine)
Reviews for Ativan (Lorazepam)
70%
+3% vs. Clozaril (Clozapine)
50%
33% vs. Clozaril (Clozapine)
15%
+35% vs. Clozaril (Clozapine)
Reviews for Risperdal (Risperidone)
48%
19% vs. Clozaril (Clozapine)
41%
42% vs. Clozaril (Clozapine)
48%
+2% vs. Clozaril (Clozapine)
Reviews for Haldol (Haloperidol)
37%
30% vs. Clozaril (Clozapine)
41%
42% vs. Clozaril (Clozapine)
35%
+15% vs. Clozaril (Clozapine)

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Reviews for Abilify (Aripiprazole)
42%
25% vs. Clozaril (Clozapine)
38%
45% vs. Clozaril (Clozapine)
35%
+15% vs. Clozaril (Clozapine)
Reviews for Seroquel (Quetiapine)
52%
15% vs. Clozaril (Clozapine)
46%
37% vs. Clozaril (Clozapine)
28%
+22% vs. Clozaril (Clozapine)

Not enough reviews for this drug. Help someone out, leave a review!

Side effects
ClozarilZyprexaAtivanRisperdalHaldolSaphrisAbilifySeroquelchlorpromazine

The Clozaril FDA package insert doesn’t have numbers about how common side effects are.

More about Clozaril side effects »
  • Relaxation or sleepiness 39%
  • Increased appetite 25%
  • Weight increase 22%
  • Drowsiness 22%
  • Dry mouth 15%
  • Dizziness 12%
  • Muscle weakness 9%
  • Fatigue 8%
  • Constipation 6%
  • Indigestion 6%
More Zyprexa side effects »

The Ativan FDA package insert doesn’t have numbers about how common side effects are.

More about Ativan side effects »
  • Relaxation or sleepiness 48%
  • Increased appetite 29%
  • Fatigue 22%
  • Parkinsonism 17%
  • Constipation 11%
  • Dizziness 11%
  • Abdominal pain upper 11%
  • Common cold 10%
  • Nausea 9%
  • Indigestion 8%
More Risperdal side effects »

The Haldol FDA package insert doesn’t have numbers about how common side effects are.

More about Haldol side effects »

We haven’t found good data for Saphris side effects.

FDA side effect reports for Saphris »
  • Drowsiness 20%
  • Extrapyramidal disorder 17%
  • Relaxation or sleepiness 17%
  • Fatigue 15%
  • Restlessness 9%
  • Fever 8%
  • Vomiting 7%
  • Decreased appetite 5%
  • Excessive saliva 5%
  • Sleep difficulty 5%
More Abilify side effects »
  • Drowsiness 42%
  • Dry mouth 31%
  • Dizziness 17%
  • Fatigue 10%
  • Increased appetite 9%
  • Headache 7%
  • Nausea 6%
  • Constipation 6%
  • Muscle weakness 6%
  • Positional low blood pressure 5%
More Seroquel side effects »

We haven’t found good data for chlorpromazine side effects.

FDA side effect reports for chlorpromazine »
How it works
ClozarilZyprexaAtivanRisperdalHaldolSaphrisAbilifySeroquelchlorpromazine
Clozaril (Clozapine) is an atypical antipsychotic. Researchers don't know exactly how it works. It seems to change dopamine and serotonin activity in your brain, which affects thoughts and mood.Zyprexa (Olanzapine) is an atypical antipsychotic. Researchers don't know exactly how it works. It seems to change dopamine and serotonin activity in your brain, which affects thoughts and mood.Ativan (Lorazepam) is a fast-acting benzodiazepine. It affects neurotransmitters in the brain and calms the nervous system. This reduces anxiety and can cause sleepiness.Risperdal (Risperidone) is an atypical antipsychotic. Researchers don't know exactly how it works. It seems to change dopamine and serotonin activity in your brain, which affects thoughts and mood.Haldol (Haloperidol) is a traditional antipsychotic. Researchers don't know exactly how it works, but it seems to change dopamine activity in your brain, which affects thoughts and mood.Coming soon.Abilify (Aripiprazole) is an atypical antipsychotic. Researchers don't know exactly how it works. It seems to change dopamine and serotonin activity in your brain, which affects thoughts and mood.Seroquel (Quetiapine) is an atypical antipsychotic. Researchers don't know exactly how it works. It seems to change dopamine and serotonin activity in your brain, which affects thoughts and mood.Coming soon.
Type of medication
ClozarilZyprexaAtivanRisperdalHaldolSaphrisAbilifySeroquelchlorpromazine
Antipsychotic
2nd generation
Prescription only
Antipsychotic
Atypical
Prescription only
Anti-anxiety
Benzodiazepine
Prescription only
Antipsychotic
Atypical
Prescription only
Antipsychotic
Typical
Prescription only
Coming soon.
Antipsychotic
Atypical
Prescription only
Antipsychotic
Atypical
Prescription only
Coming soon.
Available as
ClozarilZyprexaAtivanRisperdalHaldolSaphrisAbilifySeroquelchlorpromazine
  • Pill
  • Dissolving tablet
  • Liquid
  • Pill
  • Dissolving tablet
  • Injection
  • Pill
  • Liquid
  • Pill
  • Dissolving tablet
  • Liquid
  • Injection
  • Pill
  • Liquid
  • Injection
  • Pill
  • Pill
  • Dissolving tablet
  • Liquid
  • Injection
  • Pill
  • Extended release
  • Pill
Used for (click to learn more)
ClozarilZyprexaAtivanRisperdalHaldolSaphrisAbilifySeroquelchlorpromazine
  • Bipolar I disorder
  • Acute intermittent porphyria Apprehension
How well it works for depression
The free Iodine Start program helps people track how well they are improving, and find the right antidepressant faster.
The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Clozaril (Clozapine)The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Zyprexa (Olanzapine)The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Ativan (Lorazepam)The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Risperdal (Risperidone)The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Haldol (Haloperidol)The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Saphris (Asenapine)The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Abilify (Aripiprazole)The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Seroquel (Quetiapine)The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Chlorpromazine
Risk factors for serious side effects
ClozarilZyprexaAtivanRisperdalHaldolSaphrisAbilifySeroquelchlorpromazine
    • Dehydration
    • Taking blood pressure medications
    • Seizure disorder
    • Alcohol abuse
    • History of heart problems
    • Over 65 and having dementia
      • Diabetes
            • Stopping Clozaril (Clozapine) suddenly
            Detailed Clozaril (Clozapine) risks & warnings »
            Coming soon.Coming soon.Coming soon.Coming soon.Coming soon.Coming soon.Coming soon.Coming soon.
            Pregnancy category
            ClozarilZyprexaAtivanRisperdalHaldolSaphrisAbilifySeroquelchlorpromazine
            BFDA pregnancy category (Probably safe)

            Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

            See the FDA package insert
            CFDA pregnancy category (Weigh risks vs. benefits)

            Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

            See the FDA package insert
            DFDA pregnancy category (Weigh risks vs. benefits)

            Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

            See the FDA package insert
            CFDA pregnancy category (Weigh risks vs. benefits)

            Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

            See the FDA package insert
            CFDA pregnancy category (Weigh risks vs. benefits)

            Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

            See the FDA package insert
            CFDA pregnancy category (Weigh risks vs. benefits)

            Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

            See the FDA package insert
            CFDA pregnancy category (Weigh risks vs. benefits)

            Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

            See the FDA package insert
            CFDA pregnancy category (Weigh risks vs. benefits)

            Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

            See the FDA package insert
            NFDA pregnancy category (Unknown)

            The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

            See the FDA package insert
            Alcohol
            • You need to limit the amount of alcohol you drink while on Clozaril (Clozapine).
            • Can cause dizziness or drowsiness. Avoid alcohol and be careful when changing positions or doing anything that requires your full attention until you know how it affects you.
            • People on Clozaril (Clozapine) have reported having seizures. The risk gets higher with increasing dose or if you have conditions that make you more likely to have seizures, like alcohol abuse. If you're on medications because you've had seizures in the past, talk to your doctor to see if the medications need to be adjusted.
            No specific alcohol-related info.
            • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
            • Not safe to use with alcohol.
            No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.
            Food
            No specific food-related info.No specific food-related info.No specific food-related info.No specific food-related info.No specific food-related info.No specific food-related info.No specific food-related info.No specific food-related info.No specific food-related info.
            Kidneys and liver
            No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.
            Sex
            No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.
            Sleep
            • Can cause dizziness or drowsiness. Avoid alcohol and be careful when changing positions or doing anything that requires your full attention until you know how it affects you.
            • Can cause dizziness and drowsiness.
            • Can cause memory problems, drowsiness, dizziness, and confusion.
            • Can cause temporary dizziness and drowsiness.
            • Can cause dizziness and drowsiness.
            • It can cause dizziness, drowsiness, and can lower your blood pressure.
            No specific sleep-related info.
            • Makes you energized. Take in the morning to avoid difficulty sleeping.
            • Can cause dizziness, drowsiness, and low blood pressure.
            No specific sleep-related info.
            Weight
            • Can affect your weight, cholesterol, and blood sugar control.
            • People on Clozaril (Clozapine) have reported weight gain. This is common. If this bothers you, talk to your doctor about what you can do to stop this from happening.
            • More likely to cause weight gain and problems with cholesterol or blood sugar compared to other antipsychotics.
            • May cause weight gain and worsen cholesterol or blood sugar.
            No specific weight-related info.
            • Moderate risk of weight gain and problems with cholesterol or blood sugar compared to other antipsychotics.
            • May cause weight gain and worsen cholesterol or blood sugar.
            • Less likely to cause weight gain and problems with cholesterol and blood sugar than most other antipsychotics.
            No specific weight-related info.
            • Least likely antipsychotic to cause weight gain.
            • Sometimes causes weight gain, sleepiness, and low blood pressure.
            • May cause weight gain and worsen cholesterol or blood sugar.
            No specific weight-related info.
            Upsides and benefits
            ClozarilZyprexaAtivanRisperdalHaldolSaphrisAbilifySeroquelchlorpromazine
            • Clinical studies show that Clozaril (Clozapine) is effective in treating schizophrenia when other medications have failed.
            • Has the lowest risk of causing movement problems when compared to other antipsychotic medicines.
            • Clozaril (Clozapine) is available as a normal tablet and as a mint-flavored tablet that dissolves on the tongue without water.
            • Available as a generic, which is cheaper.
            • Effective at relieving psychotic symptoms, manic episodes, and agitation in people with schizophrenia and bipolar disorder.
            • Lowers relapse rates for schizophrenia and bipolar disorder.
            • Antipsychotic medicines are all about equally effective.
            • Less likely to cause heart problems than some antipsychotics.
            • Effective at relieving short-term anxiety and sleeplessness.
            • Can be used together with antidepressants to manage anxiety disorders. Especially helpful for anxiety symptoms while you wait for an antidepressant to kick in (it can take several weeks).
            • Less likely to have drug interactions compared to other benzodiazepines, so it might be a better option if you're taking multiple medications.
            • Effective at relieving psychotic symptoms, manic episodes, irritability, and aggressive behavior.
            • Lowers relapse rates in people with schizophrenia and people with irritability associated with autism.
            • Antipsychotic medicines are all about equally effective.
            • Less likely to cause heart problems than some antipsychotics.
            • Effective at relieving psychotic symptoms and agitation.
            • Works just as well as other antipsychotic medicines.
            • Less likely to cause weight gain and problems with cholesterol and blood sugar than most other antipsychotics.
            Coming soon.
            • Effective at relieving psychotic symptoms and manic episodes. All antipsychotic medicines are about equally effective.
            • More energizing than other antipsychotics.
            • Fewer side effects than any other antipsychotics.
            • Least likely antipsychotic to cause weight gain.
            • Studies show that it can also be helpful for depression, especially in women, if your symptoms don't go away with an antidepressant alone.
            • Less likely to cause heart problems compared to some antipsychotics.
            • Available as a generic, which is cheaper.
            • Effective at relieving psychotic symptoms and manic episodes.
            • Fewer side effects than most antipsychotic medicines.
            • Compared to other antipsychotics, the least likely to cause Extrapyramidal Symptoms (EPS): Movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
            • Antipsychotic medicines are all about equally effective.
            • Less likely to cause heart problems compared to some antipsychotics.
            Coming soon.
            Downsides and risks
            ClozarilZyprexaAtivanRisperdalHaldolSaphrisAbilifySeroquelchlorpromazine
            • You need to get blood work done every time you can get a prescription filled for Clozaril (Clozapine).
            • You can only get Clozaril (Clozapine) at certain pharmacies that are registered to provide it.
            • If you don't get Clozaril (Clozapine) within 7 days of it being ready at the pharmacy, then you have to get blood work done again and get a new prescription from your doctor.
            • You need to limit the amount of alcohol you drink while on Clozaril (Clozapine).
            • More likely to cause weight gain and problems with cholesterol or blood sugar compared to other antipsychotics.
            • Might make you more sleepy than some antipsychotics.
            • Mild risk of Extrapyramidal Symptoms (EPS): Movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
            • You might need routine blood tests to check how the medicine is affecting your body.
            • All antipsychotics come with side effects that make them difficult to take. You might need to try a few different medicines until you find one that works for you and that you can tolerate.
            • Can cause memory problems, drowsiness, dizziness, and confusion.
            • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
            • Compared to other benzodiazepines, more likely to cause withdrawal if you take it for a long time and then stop suddenly.
            • Most people find that it gets less effective over time.
            • Mild to moderate risk of Extrapyramidal Symptoms (EPS): Movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
            • Moderate risk of weight gain and problems with cholesterol or blood sugar compared to other antipsychotics.
            • Compared to other antipsychotics, higher risk of hormone problems that cause nipples to leak and male breasts to grow abnormally large.
            • You might need routine blood tests to check how the medicine is affecting your body.
            • All antipsychotics come with side effects that make them difficult to take. You might need to try a few different medicines until you find one that works for you and that you can tolerate.
            • It's an older medicine and has a lot more side effects than newer antipsychotics.
            • Compared to other antipsychotics, it causes more hormone problems that can cause nipples to leak fluid, and sudden, dangerous abnormal heart rhythms.
            • Has a higher risk of extrapyramidal symptoms (EPS): movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements. One of these symptoms (called tardive dyskinesia) is permanent and more likely if you take this medicine for many years.
            • All antipsychotics have side effects that make them difficult to take. You might need to try a few different medicines until you find one that works best for you.
            • You might need routine blood tests to check how the medicine is affecting your body.
            Coming soon.
            • Can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
            • Mild risk of Extrapyramidal Symptoms (EPS): Movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
            • You might need routine blood tests to check how the medicine is affecting your body.
            • All antipsychotics come with side effects that make them difficult to take. You might need to try a few different medicines until you find one that works for you and that you can tolerate.
            • In studies, less effective for people over age 40 for schizophrenia.
            • Sometimes causes weight gain, sleepiness, and low blood pressure.
            • You might need routine blood tests to check how the medicine is affecting your body.
            • All antipsychotics come with side effects that make them difficult to take. You might need to try a few different medicines until you find one that works for you and that you can tolerate.
            Coming soon.
            Tips from our pharmacists for people taking the medication
            ClozarilZyprexaAtivanRisperdalHaldolSaphrisAbilifySeroquelchlorpromazine
            • Take Clozaril (Clozapine) exactly as prescribed and don't stop taking it without talking to your doctor.
            • Can cause dizziness or drowsiness. Avoid alcohol and be careful when changing positions or doing anything that requires your full attention until you know how it affects you.
            • Blood tests are needed before you start this medicine and before every refill. You need to pick up the medicine within 7 days of your blood tests.
            • Can affect your weight, cholesterol, and blood sugar control.
            • Takes 4 to 6 weeks to see full effects on thoughts and mood.
            • Can cause dizziness and drowsiness.
            • For the first week, avoid activities that require you to be alert.
            • May cause weight gain and worsen cholesterol or blood sugar.
            • Report any unusual thoughts, inability to control muscle movements, or fever and excess sweating to your doctor.
            • Elderly people with dementia shouldn't take it.
            • Good for short-term relief of anxiety symptoms.
            • Starts working in 45 minutes when swallowed.
            • Starts working in 10 to 20 minutes when dissolved under your tongue.
            • Can cause temporary dizziness and drowsiness.
            • Addictive. Long-term use can cause dependence or abuse.
            • Not safe to use with alcohol.
            • Takes 4 to 6 weeks to see full effects on thoughts and mood.
            • Can cause dizziness and drowsiness.
            • For the first week, avoid activities that require you to be alert.
            • May cause weight gain and worsen cholesterol or blood sugar.
            • Report any unusual thoughts, inability to control muscle movements, or fever and excess sweating to your doctor.
            • Elderly people with dementia shouldn't take it.
            • It'll take 4 to 6 weeks to see the medication's full effects on your thoughts.
            • It can cause dizziness, drowsiness, and can lower your blood pressure.
            • For the first week, avoid activities like driving that require you to be alert.
            • Immediately tell your doctor if you can't control your muscle movements or if you have a fever or excess sweating.
            • Don't use in elderly people who have dementia.
            • The oral liquid concentrate can be mixed with water or juice before taking it.
            Coming soon.
            • Makes you energized. Take in the morning to avoid difficulty sleeping.
            • May worsen cholesterol or blood sugar.
            • Takes 4 to 6 weeks to see full effects on thoughts and mood.
            • For the first week, avoid activities that require you to be alert.
            • Report any unusual thoughts, inability to control muscle movements, or fever and excess sweating to your doctor.
            • Elderly people with dementia shouldn't take it.
            • Can cause dizziness, drowsiness, and low blood pressure.
            • Takes 4 to 6 weeks to see full effects on thoughts and mood.
            • For the first week, avoid activities that require you to be alert.
            • May cause weight gain and worsen cholesterol or blood sugar.
            • Report any unusual thoughts, inability to control muscle movements, or fever and excess sweating to your doctor.
            • Elderly people with dementia shouldn't take it.
            Coming soon.
            Learn more
            More about ClozarilSide effectsReviews & ratingsAlternativesFDA package insert
            More about ZyprexaSide effectsReviews & ratingsFDA package insert
            More about AtivanSide effectsReviews & ratingsFDA package insert
            More about RisperdalSide effectsReviews & ratingsFDA package insert
            More about HaldolSide effectsReviews & ratingsFDA package insert
            More about SaphrisSide effectsReviews & ratingsFDA package insert
            More about AbilifySide effectsReviews & ratingsFDA package insert
            More about SeroquelSide effectsReviews & ratingsFDA package insert
            More about chlorpromazineSide effectsFDA package insert