Prescription onlyLower-cost generic availableClass: Mental health

Clozaril Alternatives

(clozapine)

Prescription onlyLower-cost generic availableClass: Mental health
Back to: Full Site Navigation

Compare Clozaril (clozapine) to alternatives

These medications are comparable to Clozaril (clozapine) or used for similar purposes.

Clozaril
(clozapine)

Zyprexa
(olanzapine)

Ativan
(lorazepam)

Risperdal
(risperidone)

Haldol
(haloperidol)

Saphris
(asenapine)

Abilify
(aripiprazole)

Seroquel
(quetiapine)

Thorazine
(chlorpromazine)

Helps control your thoughts and actions. Clozaril (Clozapine) treats schizophrenia when other drugs haven't worked, but you'll have to get blood work done regularly and might gain weight.Helps control your thoughts and mood. Zyprexa (Olanzapine) is good for treating psychosis, mania, and agitation. More likely to cause weight gain and sleepiness than other antipsychotics.Helps you relax. Ativan (Lorazepam) is okay for occasional or short-term use (up to 4 weeks) for anxiety and sleep. Less likely to have drug interactions, but more likely to cause withdrawal symptoms compared to similar drugs.Helps control your thoughts and mood. Risperdal (Risperidone) is good for treating psychosis, mania, and irritability. Among newer antipsychotic medicines, more likely to cause side effects, especially weight gain and hormone problems.Helps control your thoughts and calms agitation. Haldol (Haloperidol) is okay for treating psychosis and agitation. It's less likely to cause weight gain than other antipsychotics, but it's more likely to cause other bad side effects.Treats bipolar disorder and schizophrenia. While Saphris (asenapine) has fewer side effects compared with other medicines that treat bipolar disorder and schizophrenia, it can be more expensive.Helps control your thoughts and mood. Abilify (Aripiprazole) is good for treating psychosis and mania, and can help with depression. Less likely to cause side effects than any other antipsychotic, but has a risk of suicidal thoughts for people age 24 and younger.Helps control your thoughts and mood. Seroquel (Quetiapine) is good for treating psychosis and mania. Fewer side effects than most antipsychotics, but might be less effective for people over age 40 with schizophrenia.Stabilizes your mood. Thorazine (chlorpromazine) has more side effects than other medicines like it. It is most useful during psychotic episodes because it slows you down quickly.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
Coupons for Clozaril
Prices and coupon for 90 (100mg) tablets of clozapine
No pricing data for this drug at this filter setting. Try searching onGoodRx
No pricing data for this drug at this filter setting. Try searching onGoodRx
No pricing data for this drug at this filter setting. Try searching onGoodRx
No pricing data for this drug at this filter setting. Try searching onGoodRx
No pricing data for this drug at this filter setting. Try searching onGoodRx
No pricing data for this drug at this filter setting. Try searching onGoodRx
No pricing data for this drug at this filter setting. Try searching onGoodRx
No pricing data for this drug at this filter setting. Try searching onGoodRx
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
Reviews for Clozaril (clozapine)
Not enough review data. Review it!
of people (All ages) say Clozaril (clozapine) is worth it
Not enough review data. Review it!
say it works well
Not enough review data. Review it!
say it's a big hassle
Have you used Clozaril (clozapine)?
Worth itNot sureNot worth it
Reviews for Zyprexa (olanzapine)
41%
-16% worse vs. Clozaril (clozapine)
51%
-20% worse vs. Clozaril (clozapine)
51%
+6% better vs. Clozaril (clozapine)
Have you used Zyprexa (olanzapine)?
Worth itNot sureNot worth it
Reviews for Ativan (lorazepam)
71%
+14% better vs. Clozaril (clozapine)
51%
-20% worse vs. Clozaril (clozapine)
15%
+42% better vs. Clozaril (clozapine)
642 reviews
Have you used Ativan (lorazepam)?
Worth itNot sureNot worth it
Reviews for Risperdal (risperidone)
42%
-15% worse vs. Clozaril (clozapine)
47%
-24% worse vs. Clozaril (clozapine)
49%
+8% better vs. Clozaril (clozapine)
Have you used Risperdal (risperidone)?
Worth itNot sureNot worth it
Reviews for Haldol (haloperidol)
38%
-19% worse vs. Clozaril (clozapine)
42%
-29% worse vs. Clozaril (clozapine)
34%
+23% better vs. Clozaril (clozapine)
Have you used Haldol (haloperidol)?
Worth itNot sureNot worth it
Reviews for Saphris (asenapine)
Not enough review data. Review it!
-7% worse vs. Clozaril (clozapine)
Not enough review data. Review it!
-33% worse vs. Clozaril (clozapine)
Not enough review data. Review it!
+44% better vs. Clozaril (clozapine)
Have you used Saphris (asenapine)?
Worth itNot sureNot worth it
Reviews for Abilify (aripiprazole)
44%
-13% worse vs. Clozaril (clozapine)
40%
-31% worse vs. Clozaril (clozapine)
34%
+23% better vs. Clozaril (clozapine)
252 reviews
Have you used Abilify (aripiprazole)?
Worth itNot sureNot worth it
Reviews for Seroquel (quetiapine)
56%
-1% worse vs. Clozaril (clozapine)
50%
-21% worse vs. Clozaril (clozapine)
27%
+30% better vs. Clozaril (clozapine)
250 reviews
Have you used Seroquel (quetiapine)?
Worth itNot sureNot worth it
Reviews for Thorazine (chlorpromazine)
Not enough review data. Review it!
-57% worse vs. Clozaril (clozapine)
Not enough review data. Review it!
-71% worse vs. Clozaril (clozapine)
Not enough review data. Review it!
+57% better vs. Clozaril (clozapine)
Have you used Thorazine (chlorpromazine)?
Worth itNot sureNot worth it
Side effects
ClozarilZyprexaAtivanRisperdalHaldolSaphrisAbilifySeroquelchlorpromazine
  • Drowsiness/sedation 39%
  • Salivation 31%
  • Abnormally fast heart beat 25%
  • Dizziness/vertigo 19%
  • Constipation 14%
  • Low blood pressure 9%
  • Headache 7%
  • Dry mouth 6%
  • Sweating 6%
  • Fainting 6%
More Clozaril side effects »
  • Dizziness 7%
  • Constipation 6%
  • Personality disorder 4%
  • Weight gain 5%
  • Positional low blood pressure 3%
  • Restlessness 4%
  • Drowsiness 22%
  • Dry mouth 15%
  • Muscle weakness 9%
  • Indigestion 6%
More Zyprexa side effects »
  • Relaxation or sleepiness 16%
  • Dizziness 7%
  • Weakness 4%
  • Unsteadiness 3%
More Ativan side effects »
  • Parkinsonism 16%
  • Relaxation or sleepiness 7%
  • Restlessness 6%
  • Tremor 3%
  • Dizziness 1%
  • Nausea 3%
  • Muscle twitching 4%
  • Diarrhea 1%
  • Excessive saliva 2%
  • Vision blurred 1%
More Risperdal side effects »

The Haldol FDA package insert doesn’t have numbers about how common side effects are.

More about Haldol side effects »
  • Trouble sleeping 2%
  • Sleepiness 6%
  • Difficulty controlling movements 3%
  • Restlessness 3%
  • Numbness in the mouth 4%
  • Dizziness 1%
  • Weight gain 2%
More Saphris side effects »
  • Headache 4%
  • Agitation 2%
  • Sleep difficulty 5%
  • Anxiety 4%
  • Nausea 4%
  • Restlessness 9%
  • Constipation 4%
  • Vomiting 5%
  • Dizziness 3%
  • Indigestion 2%
More Abilify side effects »
  • Drowsiness 42%
  • Dizziness 15%
  • Nausea 6%
  • Fatigue 5%
  • Increased appetite 8%
  • Abnormally fast heart beat 8%
  • Vomiting 4%
  • Dry mouth 7%
  • Nasal congestion 4%
  • Weight increased 6%
More Seroquel side effects »

The chlorpromazine FDA package insert doesn’t have numbers about how common side effects are.

More about chlorpromazine side effects »
How it works
ClozarilZyprexaAtivanRisperdalHaldolSaphrisAbilifySeroquelchlorpromazine
Clozaril (Clozapine) is an atypical antipsychotic. Researchers don't know exactly how it works. It seems to change dopamine and serotonin activity in your brain, which affects thoughts and mood.Zyprexa (Olanzapine) is an atypical antipsychotic. Researchers don't know exactly how it works. It seems to change dopamine and serotonin activity in your brain, which affects thoughts and mood.Ativan (Lorazepam) is a fast-acting benzodiazepine. It affects neurotransmitters in the brain and calms the nervous system. This reduces anxiety and can cause sleepiness.Risperdal (Risperidone) is an atypical antipsychotic. Researchers don't know exactly how it works. It seems to change dopamine and serotonin activity in your brain, which affects thoughts and mood.Haldol (Haloperidol) is a traditional antipsychotic. Researchers don't know exactly how it works, but it seems to change dopamine activity in your brain, which affects thoughts and mood.While it's not clear how Saphris (asenapine) helps to treat bipolar disorder or schizophrenia, it changes the amount of dopamine and serotonin in the brain, two chemicals that are known to regulate mood.Abilify (Aripiprazole) is an atypical antipsychotic. Researchers don't know exactly how it works. It seems to change dopamine and serotonin activity in your brain, which affects thoughts and mood.Seroquel (Quetiapine) is an atypical antipsychotic. Researchers don't know exactly how it works. It seems to change dopamine and serotonin activity in your brain, which affects thoughts and mood.Thorazine (chlorpromazine) is a derivative of phenothiazine, which regulates dopamine levels in your brain to improve your mood.
Type of medication
ClozarilZyprexaAtivanRisperdalHaldolSaphrisAbilifySeroquelchlorpromazine
Prescription only
Prescription only
Prescription only
Prescription only
Prescription only
Prescription only
Prescription only
Prescription only
Prescription only
Available as
ClozarilZyprexaAtivanRisperdalHaldolSaphrisAbilifySeroquelchlorpromazine
  • Pill
  • Dissolving tablet
  • Liquid
  • Pill
  • Dissolving tablet
  • Injection
  • Pill
  • Liquid
  • Pill
  • Dissolving tablet
  • Liquid
  • Injection
  • Pill
  • Liquid
  • Injection
  • Dissolving pill
  • Pill
  • Dissolving tablet
  • Liquid
  • Injection
  • Pill
  • Extended release
  • Pill
  • Injection
Used for
ClozarilZyprexaAtivanRisperdalHaldolSaphrisAbilifySeroquelchlorpromazine
Risk factors for serious side effects
ClozarilZyprexaAtivanRisperdalHaldolSaphrisAbilifySeroquelchlorpromazine
  • Dehydration
  • Taking blood pressure medications
  • Seizure disorder
  • Alcohol abuse
  • History of heart problems
Detailed Clozaril (clozapine) risks & warnings »
  • Elderly patients with dementia
  • History of heart problems
  • Drug interactions
  • People with diabetes
  • People with high cholesterol
Detailed Zyprexa (olanzapine) risks & warnings »
  • Taking more than the prescribed dose
  • Taking longer than 4 weeks
  • History of drug abuse
  • Long-term use
  • Alcohol
Detailed Ativan (lorazepam) risks & warnings »
  • Elderly patients with dementia
  • History of heart problems
  • Drug interactions
  • People with diabetes
  • People with high cholesterol
Detailed Risperdal (risperidone) risks & warnings »
  • Elderly patients with dementia
  • History of heart problems
  • Drug interactions
  • People with diabetes
  • People with high cholesterol
Detailed Haldol (haloperidol) risks & warnings »
  • People age 65 or older with dementia and psychosis
  • Taking antipsychotic medications
  • High blood pressure
  • History of heart disease
Detailed Saphris (asenapine) risks & warnings »
  • Elderly patients with dementia
  • Age 24 years or younger
  • History of heart problems
  • Drug interactions
  • People with diabetes
Detailed Abilify (aripiprazole) risks & warnings »
  • Elderly patients with dementia
  • History of heart problems
  • Drug interactions
  • People with diabetes
  • People with high cholesterol
Detailed Seroquel (quetiapine) risks & warnings »
  • People over 65 with dementia and psychosis
  • Taking antipsychotic medications
  • Asthma
  • COPD
  • Acute respiratory infections
Detailed Thorazine (chlorpromazine) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Interactions
ClozarilZyprexaAtivanRisperdalHaldolSaphrisAbilifySeroquelchlorpromazine
No interactions related info.No interactions related info.
  • Less likely to have drug interactions compared to other benzodiazepines, so it might be a better option if you're taking multiple medications.
No interactions related info.No interactions related info.No interactions related info.No interactions related info.No interactions related info.No interactions related info.
Alcohol
ClozarilZyprexaAtivanRisperdalHaldolSaphrisAbilifySeroquelchlorpromazine
  • You need to limit the amount of alcohol you drink while on Clozaril (Clozapine).
  • Can cause dizziness or drowsiness. Avoid alcohol and be careful when changing positions or doing anything that requires your full attention until you know how it affects you.
No alcohol related info.
  • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
  • Not safe to use with alcohol.
No alcohol related info.No alcohol related info.No alcohol related info.No alcohol related info.No alcohol related info.
  • Don't combine with alcohol or narcotics because it can cause you to stop breathing.
Food
ClozarilZyprexaAtivanRisperdalHaldolSaphrisAbilifySeroquelchlorpromazine
No food related info.
  • Zyprexa (Olanzapine) can increase your blood sugar and cholesterol. Zyprexa (Olanzapine) is more likely to raise your blood sugar and cholesterol compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
  • Zyprexa (Olanzapine) can cause you to gain weight. Zyprexa (Olanzapine) is more likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
No food related info.
  • Risperdal (Risperidone) can increase your blood sugar and cholesterol. Exercise and eat healthy food to lower your risk.
  • Risperdal (Risperidone) can cause you to gain weight. Exercise and eat healthy food to lower your risk.
  • Haldol (Haloperidol) can increase your blood sugar and cholesterol. However, Haldol (Haloperidol) is less likely to raise your blood sugar and cholesterol compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
  • Haldol (Haloperidol) can cause you to gain weight. However, Haldol (Haloperidol) is less likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
No food related info.No food related info.
  • Seroquel (Quetiapine) can increase your blood sugar and cholesterol. Seroquel (Quetiapine) is more likely to raise your blood sugar and cholesterol compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
  • Seroquel (Quetiapine) can cause you to gain weight. Seroquel (Quetiapine) is moderately likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
No food related info.
Sleep
ClozarilZyprexaAtivanRisperdalHaldolSaphrisAbilifySeroquelchlorpromazine
  • Can cause dizziness or drowsiness. Avoid alcohol and be careful when changing positions or doing anything that requires your full attention until you know how it affects you.
  • Might make you more sleepy than some antipsychotics.
  • Can cause dizziness and drowsiness.
  • Can cause memory problems, drowsiness, dizziness, and confusion.
  • Can cause temporary dizziness and drowsiness.
  • Can cause dizziness and drowsiness.
  • It can cause dizziness, drowsiness, and can lower your blood pressure.
No sleep related info.No sleep related info.
  • Can cause dizziness, drowsiness, and low blood pressure.
  • Can make you very sleepy so don't drive or do anything that requires concentration until you know how it affects you.
Weight
ClozarilZyprexaAtivanRisperdalHaldolSaphrisAbilifySeroquelchlorpromazine
  • Can affect your weight, cholesterol, and blood sugar control.
  • People on Clozaril (Clozapine) have reported weight gain. This is common. If this bothers you, talk to your doctor about what you can do to stop this from happening.
  • More likely to cause weight gain and problems with cholesterol or blood sugar compared to other antipsychotics.
  • May cause weight gain and worsen cholesterol or blood sugar.
  • Zyprexa (Olanzapine) can cause you to gain weight. Zyprexa (Olanzapine) is more likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
No weight related info.
  • Moderate risk of weight gain and problems with cholesterol or blood sugar compared to other antipsychotics.
  • May cause weight gain and worsen cholesterol or blood sugar.
  • Risperdal (Risperidone) can cause you to gain weight. Exercise and eat healthy food to lower your risk.
  • Less likely to cause weight gain and problems with cholesterol and blood sugar than most other antipsychotics.
  • Haldol (Haloperidol) can cause you to gain weight. However, Haldol (Haloperidol) is less likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
  • People on medicines like Saphris (asenapine) have had weight gain and higher blood sugar to the point of having diabetes. Your doctor will work with you to stop that from happening.
  • Least likely antipsychotic to cause weight gain.
  • Abilify (Aripiprazole) can cause you to gain weight. Abilify (Aripiprazole) is the least likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
  • Sometimes causes weight gain, sleepiness, and low blood pressure.
  • May cause weight gain and worsen cholesterol or blood sugar.
  • Seroquel (Quetiapine) can cause you to gain weight. Seroquel (Quetiapine) is moderately likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
No weight related info.
Upsides and benefits
ClozarilZyprexaAtivanRisperdalHaldolSaphrisAbilifySeroquelchlorpromazine
  • Clinical studies show that Clozaril (Clozapine) is effective in treating schizophrenia when other medications have failed.
  • Has the lowest risk of causing movement problems when compared to other antipsychotic medicines.
  • Clozaril (Clozapine) is available as a normal tablet and as a mint-flavored tablet that dissolves on the tongue without water.
  • Available as a generic, which is cheaper.
  • Effective at relieving psychotic symptoms, manic episodes, and agitation in people with schizophrenia and bipolar disorder.
  • Lowers relapse rates for schizophrenia and bipolar disorder.
  • Antipsychotic medicines are all about equally effective.
  • Less likely to cause heart problems than some antipsychotics.
  • Effective at relieving short-term anxiety and sleeplessness.
  • Can be used together with antidepressants to manage anxiety disorders. Especially helpful for anxiety symptoms while you wait for an antidepressant to kick in (it can take several weeks).
  • Less likely to have drug interactions compared to other benzodiazepines, so it might be a better option if you're taking multiple medications.
  • Effective at relieving psychotic symptoms, manic episodes, irritability, and aggressive behavior.
  • Lowers relapse rates in people with schizophrenia and people with irritability associated with autism.
  • Antipsychotic medicines are all about equally effective.
  • Less likely to cause heart problems than some antipsychotics.
  • Effective at relieving psychotic symptoms and agitation.
  • Works just as well as other antipsychotic medicines.
  • Less likely to cause weight gain and problems with cholesterol and blood sugar than most other antipsychotics.
  • Saphris (asenapine) can be used to treat bipolar disorder in children age 10 or older, and schizophrenia in children age 12 or older.
  • You don't need water to take Saphris (asenapine); the pill dissolves in your mouth right away.
  • Compared to other medicines, the side effects of Saphris (asenapine) are milder.
  • Effective at relieving psychotic symptoms and manic episodes. All antipsychotic medicines are about equally effective.
  • More energizing than other antipsychotics.
  • Fewer side effects than any other antipsychotics.
  • Least likely antipsychotic to cause weight gain.
  • Less likely to cause heart problems compared to some antipsychotics.
  • Studies show that it can also be helpful for depression, especially in women, if your symptoms don't go away with an antidepressant alone.
  • Available as a generic, which is cheaper.
  • Effective at relieving psychotic symptoms and manic episodes.
  • Antipsychotic medicines are all about equally effective.
  • Fewer side effects than most antipsychotic medicines.
  • Less likely to cause heart problems compared to some antipsychotics.
  • Compared to other antipsychotics, the least likely to cause Extrapyramidal Symptoms (EPS): Movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
  • Acts fast to slow you down during a psychotic episode.
  • Can also be used for nausea or migraines.
  • Safe for use in children as young as 6 months.
  • Comes in a sugar-coated pill for easy administration.
Downsides and risks
ClozarilZyprexaAtivanRisperdalHaldolSaphrisAbilifySeroquelchlorpromazine
  • You need to get blood work done every time you can get a prescription filled for Clozaril (Clozapine).
  • You can only get Clozaril (Clozapine) at certain pharmacies that are registered to provide it.
  • If you don't get Clozaril (Clozapine) within 7 days of it being ready at the pharmacy, then you have to get blood work done again and get a new prescription from your doctor.
  • You need to limit the amount of alcohol you drink while on Clozaril (Clozapine).
  • More likely to cause weight gain and problems with cholesterol or blood sugar compared to other antipsychotics.
  • Might make you more sleepy than some antipsychotics.
  • Mild risk of Extrapyramidal Symptoms (EPS): Movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
  • You might need routine blood tests to check how the medicine is affecting your body.
  • All antipsychotics come with side effects that make them difficult to take. You might need to try a few different medicines until you find one that works for you and that you can tolerate.
  • Can cause memory problems, drowsiness, dizziness, and confusion.
  • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
  • Compared to other benzodiazepines, more likely to cause withdrawal if you take it for a long time and then stop suddenly.
  • Most people find that it gets less effective over time.
  • Mild to moderate risk of Extrapyramidal Symptoms (EPS): Movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
  • Moderate risk of weight gain and problems with cholesterol or blood sugar compared to other antipsychotics.
  • Compared to other antipsychotics, higher risk of hormone problems that cause nipples to leak and male breasts to grow abnormally large.
  • You might need routine blood tests to check how the medicine is affecting your body.
  • All antipsychotics come with side effects that make them difficult to take. You might need to try a few different medicines until you find one that works for you and that you can tolerate.
  • It's an older medicine and has a lot more side effects than newer antipsychotics.
  • Compared to other antipsychotics, it causes more hormone problems that can cause nipples to leak fluid, and sudden, dangerous abnormal heart rhythms.
  • Has a higher risk of extrapyramidal symptoms (EPS): movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements. One of these symptoms (called tardive dyskinesia) is permanent and more likely if you take this medicine for many years.
  • You might need routine blood tests to check how the medicine is affecting your body.
  • All antipsychotics have side effects that make them difficult to take. You might need to try a few different medicines until you find one that works best for you.
  • Saphris (asenapine) is only available as a brand name.
  • Compared to other medicines, Saphris (asenapine) can cause changes in your hormones and make you sleepy.
  • You have to take Saphris (asenapine) twice a day, which can be hard to remember.
  • Mild risk of Extrapyramidal Symptoms (EPS): Movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
  • Can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
  • You might need routine blood tests to check how the medicine is affecting your body.
  • All antipsychotics come with side effects that make them difficult to take. You might need to try a few different medicines until you find one that works for you and that you can tolerate.
  • In studies, less effective for people over age 40 for schizophrenia.
  • Sometimes causes weight gain, sleepiness, and low blood pressure.
  • You might need routine blood tests to check how the medicine is affecting your body.
  • All antipsychotics come with side effects that make them difficult to take. You might need to try a few different medicines until you find one that works for you and that you can tolerate.
  • Has more side effects than other medicines like it.
  • Can affect how your other medicines work.
  • Makes you more sensitive to the sun.
  • Can make you dizzy or lightheaded, especially when injected.
  • Cannot be stopped right away.
Tips from our pharmacists for people taking the medication
ClozarilZyprexaAtivanRisperdalHaldolSaphrisAbilifySeroquelchlorpromazine
  • Take Clozaril (Clozapine) exactly as prescribed and don't stop taking it without talking to your doctor.
  • Can cause dizziness or drowsiness. Avoid alcohol and be careful when changing positions or doing anything that requires your full attention until you know how it affects you.
  • Blood tests are needed before you start this medicine and before every refill. You need to pick up the medicine within 7 days of your blood tests.
  • Can affect your weight, cholesterol, and blood sugar control.
  • Takes 4 to 6 weeks to see full effects on thoughts and mood.
  • Can cause dizziness and drowsiness.
  • For the first week, avoid activities that require you to be alert.
  • May cause weight gain and worsen cholesterol or blood sugar.
  • Report any unusual thoughts, inability to control muscle movements, or fever and excess sweating to your doctor.
  • Elderly people with dementia shouldn't take it.
  • Good for short-term relief of anxiety symptoms.
  • Starts working in 45 minutes when swallowed.
  • Starts working in 10 to 20 minutes when dissolved under your tongue.
  • Can cause temporary dizziness and drowsiness.
  • Addictive. Long-term use can cause dependence or abuse.
  • Not safe to use with alcohol.
  • Takes 4 to 6 weeks to see full effects on thoughts and mood.
  • Can cause dizziness and drowsiness.
  • For the first week, avoid activities that require you to be alert.
  • May cause weight gain and worsen cholesterol or blood sugar.
  • Report any unusual thoughts, inability to control muscle movements, or fever and excess sweating to your doctor.
  • Elderly people with dementia shouldn't take it.
  • It'll take 4 to 6 weeks to see the medication's full effects on your thoughts.
  • It can cause dizziness, drowsiness, and can lower your blood pressure.
  • For the first week, avoid activities like driving that require you to be alert.
  • Immediately tell your doctor if you can't control your muscle movements or if you have a fever or excess sweating.
  • Don't use in elderly people who have dementia.
  • The oral liquid concentrate can be mixed with water or juice before taking it.
  • To take Saphris (asenapine), place the pill under your tongue and let it dissolve completely. Don't chew or swallow the pill, and don't eat or drink for 10 minutes after you take it.
  • You might feel numbness or tingling in your mouth or throat after you take Saphris (asenapine). This usually goes away after an hour.
  • Don't drive or do anything requiring concentration until you know how Saphris (asenapine) affects you.
  • Don't stop taking Saphris (asenapine) suddenly without talking to your doctor first because it can be very dangerous.
  • If you miss a dose of Saphris (asenapine), take it as soon as you remember, unless it’s time for your next dose; don't take 2 doses at the same time.
  • Keep Saphris (asenapine) in your pantry away from heat, moisture, and light. Don't store it in your bathroom's medicine cabinet.
  • Takes 4 to 6 weeks to see full effects on thoughts and mood.
  • Makes you energized. Take in the morning to avoid difficulty sleeping.
  • For the first week, avoid activities that require you to be alert.
  • May worsen cholesterol or blood sugar.
  • Report any unusual thoughts, inability to control muscle movements, or fever and excess sweating to your doctor.
  • Elderly people with dementia shouldn't take it.
  • Takes 4 to 6 weeks to see full effects on thoughts and mood.
  • Can cause dizziness, drowsiness, and low blood pressure.
  • For the first week, avoid activities that require you to be alert.
  • May cause weight gain and worsen cholesterol or blood sugar.
  • Report any unusual thoughts, inability to control muscle movements, or fever and excess sweating to your doctor.
  • Elderly people with dementia shouldn't take it.
  • Can make you very sleepy so don't drive or do anything that requires concentration until you know how it affects you.
  • Can cause involuntary muscle movements just like other medicines for your mood.
  • Can dry you out and make you more sensitive to the sun.
  • Don't combine with alcohol or narcotics because it can cause you to stop breathing.
  • Cannot be stopped suddenly.
Learn more
More about ClozarilSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Clozaril (clozapine)?
Worth itNot sureNot worth it
More about ZyprexaSide effectsReviews & ratingsFDA package insert
Have you used Zyprexa (olanzapine)?
Worth itNot sureNot worth it
More about AtivanSide effectsReviews & ratingsFDA package insert
Have you used Ativan (lorazepam)?
Worth itNot sureNot worth it
More about RisperdalSide effectsReviews & ratingsFDA package insert
Have you used Risperdal (risperidone)?
Worth itNot sureNot worth it
More about HaldolSide effectsReviews & ratingsFDA package insert
Have you used Haldol (haloperidol)?
Worth itNot sureNot worth it
More about SaphrisSide effectsReviews & ratingsFDA package insert
Have you used Saphris (asenapine)?
Worth itNot sureNot worth it
More about AbilifySide effectsReviews & ratingsFDA package insert
Have you used Abilify (aripiprazole)?
Worth itNot sureNot worth it
More about SeroquelSide effectsReviews & ratingsFDA package insert
Have you used Seroquel (quetiapine)?
Worth itNot sureNot worth it
More about chlorpromazineSide effectsFDA package insert
Have you used Thorazine (chlorpromazine)?
Worth itNot sureNot worth it