Prescription onlyLower-cost generic availableClass: Musculoskeletal

ColcrysAlternatives

(colchicine)

Prescription onlyLower-cost generic availableClass: Musculoskeletal
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Compare Colcrys (colchicine) to alternatives

These medications are comparable to Colcrys (colchicine) or used for similar purposes.

Colcrys
(colchicine)

Celebrex
(celecoxib)

Indocin
(indomethacin)

Deltasone
(prednisone)

Zyloprim
(allopurinol)

Prevents and treats gout. Colcrys (colchicine) is a second-choice treatment for gout attacks. Be careful how much you use since it can cause problems with your blood.Relieves pain and inflammation. Celebrex (Celecoxib) works well for treating pain and causes less upset stomach than other NSAIDs.Treats pain and swelling. Indocin (Indomethacin) works well for mild to moderate pain and swelling, but it shouldn't be used long-term since it has some serious side effects.Calms down your immune system. Deltasone (Prednisone) is a common oral corticosteroid that's great for controlling the unwanted symptoms from your immune responses and will make you feel better. There are lots of side effects but most of are tolerable or can be managed.Lowers uric acid levels in blood, and prevents gout flare-ups. Zyloprim (allopurinol) works well to prevent gout attacks and is cheaper than some alternatives, but it takes a few weeks to start working.
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Reviews & ratings
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Have you used Colcrys (colchicine)?
Worth itNot sureNot worth it
Reviews for Celebrex (celecoxib)
57%
-26% worse vs. Colcrys (colchicine)
38%
-45% worse vs. Colcrys (colchicine)
14%
+3% better vs. Colcrys (colchicine)
550 reviews
Have you used Celebrex (celecoxib)?
Worth itNot sureNot worth it

Not enough reviews for this drug. Help someone out, leave a review!

Have you used Indocin (indomethacin)?
Worth itNot sureNot worth it
Reviews for Deltasone (prednisone)
59%
-24% worse vs. Colcrys (colchicine)
45%
-38% worse vs. Colcrys (colchicine)
20%
-3% worse vs. Colcrys (colchicine)
540 reviews
Have you used Deltasone (prednisone)?
Worth itNot sureNot worth it

Not enough reviews for this drug. Help someone out, leave a review!

Have you used Zyloprim (allopurinol)?
Worth itNot sureNot worth it
Side effects
ColcrysCelebrexIndocinPrednisoneAllopurinol
  • Stomach problems 6%
  • Diarrhea 9%
  • Gout 2%
  • Throat pain 3%
More Colcrys side effects »

We haven’t found good data for Celebrex side effects.

FDA side effect reports for Celebrex »
  • Headache 5%
  • Post procedural hemorrhage 5%
  • Itching 3%
  • Diarrhea 1%
  • Rash 2%
More Indocin side effects »

The Prednisone FDA package insert doesn’t have numbers about how common side effects are.

More about Prednisone side effects »

The Allopurinol FDA package insert doesn’t have numbers about how common side effects are.

More about Allopurinol side effects »
How it works
ColcrysCelebrexIndocinPrednisoneAllopurinol
Colcrys (colchicine) stops the redness and swelling in gout attacks by blocking the cells that cause inflammation from going to the affected joints.Celebrex (Celecoxib) is a non-steroidal anti-inflammatory drug (NSAID). It blocks the inflammation process in your body, which relieves swelling and pain.Indocin (Indomethacin) is a non-steroidal anti-inflammatory drug (NSAID). It blocks the inflammation process in your body, which relieves swelling and pain.Deltasone (Prednisone) is a corticosteroid that's similar to what your body naturally makes. It reduces swelling and other immune responses that can cause you pain, discomfort, or harm.Zyloprim (allopurinol) is a xanthine oxidase inhibitor. It lowers uric acid levels in your blood, which can stop gout attacks and kidney stones.
Type of medication
ColcrysCelebrexIndocinPrednisoneAllopurinol
Prescription only
Prescription only
Prescription only
Prescription only
Prescription only
Available as
ColcrysCelebrexIndocinPrednisoneAllopurinol
  • Pill
  • Pill
  • Pill
  • Extended release
  • Liquid
  • Suppository
  • Pill
  • Extended release
  • Liquid
  • Pill
  • Injection
Used for
ColcrysCelebrexIndocinPrednisoneAllopurinol
Risk factors for serious side effects
ColcrysCelebrexIndocinPrednisoneAllopurinol
      • Grapefruit
      • Grapefruit juice
      • Protease inhibitors
      • Antifungal antibiotics
      • Calcium channel blockers
      • Cyclosporine
      • Anti-cholesterol medicines
      • Digoxin
      • Kidney problems
      • Elderly
      • Use of statins or cholesterol medications
      • Use of cyclosporine
      Detailed Colcrys (colchicine) risks & warnings »
      • Long-term use
      • History of heart disease
      • History of heart bypass surgery (coronary artery bypass graft/CABG)
      • Age 65 or older
      • History of GI bleed or peptic ulcer disease
      • History of high blood pressure
      • Taking water pills (diuretics)
      • History of heart failure
        • History of asthma
        • Kidney Disease
        • Heart Failure
        • Liver Disease
        • Also taking diuretics
        • Also taking ACE inhibitors
        • Also taking Angiotensin Receptor Blockers (ARBs)
        • Age 65 or older
        • Late pregnancy (more than 30 weeks)
        Detailed Celebrex (celecoxib) risks & warnings »
        • History of cardiovascular disease
        • High blood pressure
        • Smoking
        • History of stomach bleeding or ulcers
        • Age 65 years or older
        • Women of childbearing age
        • Asthma
        • Rhinitis
        • Nasal Polyps
        • Aspirin Allergy
        • NSAID Allergy
        • Current kidney problems
        • Current liver problems
        • Current kidney problems
        • Medicine that increase potassium
        • Use of salt substitute
        • Blood-thinning medicines
        • Low blood platelet count
        Detailed Indocin (indomethacin) risks & warnings »
        • Lowering dose or stopping too quickly especially after long-term treatment
        • Stress such as trauma, surgery or infection
        • Long-term treatment
        • Not vaccinated against viral diseases
        • Contact with people who have viral illness
        • History of bacterial or viral conditions
        • Duration of treatment
          • History of psychiatric conditions
          • Dose of Deltasone (Prednisone)
          • Duration of treatment
          • Women of childbearing age
          • History of stomach bleeding
          • Active or history of stomach or duodenal ulcers
          • Ulcerative colitis
          • Taking Deltasone (Prednisone) with other medicine that can cause stomach problems
          Detailed Deltasone (prednisone) risks & warnings »
            • History of kidney stones
                • Taking other medications that also cause sleepiness
                • Recreational drug use
                • Excessive alcohol use
                • Elderly
                Detailed Zyloprim (allopurinol) risks & warnings »
                Pregnancy

                Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                Price
                ColcrysCelebrexIndocinPrednisoneAllopurinol
                No price related info.No price related info.No price related info.
                • Short-term use in controlling immune responses that are causing you discomfort, and works quickly to relieve symptoms like swelling, rash, asthma attacks, gout attacks.
                No price related info.
                Interactions
                ColcrysCelebrexIndocinPrednisoneAllopurinol
                • Many foods and medicines can interact with Colcrys (colchicine), which can be dangerous. If you have liver or kidney problems, these interactions can be worse. Talk to your doctor and pharmacist to see what dose of Colcrys (colchicine) you should take based on your diet and other medicines.
                No interactions related info.No interactions related info.No interactions related info.No interactions related info.
                Food
                ColcrysCelebrexIndocinPrednisoneAllopurinol
                • Take Colcrys (colchicine) with or without food.
                • Many foods and medicines can interact with Colcrys (colchicine), which can be dangerous. If you have liver or kidney problems, these interactions can be worse. Talk to your doctor and pharmacist to see what dose of Colcrys (colchicine) you should take based on your diet and other medicines.
                • Take it with a meal or a snack to prevent an upset stomach.
                • Take with food or milk to help prevent upset stomach.
                • Take with food to decrease stomach upset.
                • Take with food or milk to prevent an upset stomach.
                Kidneys and liver
                ColcrysCelebrexIndocinPrednisoneAllopurinol
                • Doses needs to be changed if you have kidney or liver problems.
                • Many foods and medicines can interact with Colcrys (colchicine), which can be dangerous. If you have liver or kidney problems, these interactions can be worse. Talk to your doctor and pharmacist to see what dose of Colcrys (colchicine) you should take based on your diet and other medicines.
                • Can also affect your kidneys or cause permanent kidney damage if taken for a long time.
                • Can hurt your kidneys, so don't use it if you have a history of kidney problems.
                • Celebrex (Celecoxib), and similar medications in the NSAID family, can cause lower kidney function or cause permanent kidney damage. You're at higher risk for this if you've a history of kidney disease, heart failure, and liver disease. Taking Diuretic, ACE inhibitor, or Angiotensin Receptor Blocker (ARB) medications also increases your risk. If you are 65 or older you're also at a higher risk for these types of kidney problems.
                • Not a good choice if you have kidney, liver, or stomach problems.
                • Indocin (Indomethacin) is processed by the kidney and liver. If you have kidney or liver problems, talk to your doctor because you may need a different dose. (No dose adjustments are specified on the manufacturer's label.)
                • Adrenal suppression leading to adrenal crisis can occur if you lower your dose or stop taking Deltasone (Prednisone) too quickly. Symptoms include joint or muscle pain, extreme low energy and depression. Changes in your Deltasone (Prednisone) dose need to be done slowly over time. Talk to your doctor before you make any changes or stop the medication.
                • Kidney stones can form while taking Zyloprim (allopurinol), so you need to drink a lot of fluids to help prevent this.
                Pain
                ColcrysCelebrexIndocinPrednisoneAllopurinol
                No pain related info.
                • Relieves pain and inflammation for many types of arthritis, including osteoarthritis, rheumatoid arthritis, and juvenile rheumatoid arthritis.
                • Good for treating muscle aches and pains, as well as menstrual cramps.
                • Can hurt your kidneys, so don't use it if you have a history of kidney problems.
                • In studies, Indocin (Indomethacin) was more effective than Tylenol for treating osteoarthritis pain.
                No pain related info.No pain related info.
                Sleep
                ColcrysCelebrexIndocinPrednisoneAllopurinol
                No sleep related info.No sleep related info.No sleep related info.No sleep related info.
                • Taking Zyloprim (allopurinol) can make you feel sleepy or dizzy, especially if you're taking other medicines that can also make you feel sleepy, or if you're taking recreational drugs or drinking too much alcohol. Avoid driving or doing other tasks that require concentration until you know how this medication affects you. Get up very slowly from a seated or lying down position.
                Upsides and benefits
                ColcrysCelebrexIndocinPrednisoneAllopurinol
                • Colcrys (colchicine) treats and stops sudden gout attacks.
                • It can be used to prevent gout when people are first starting on allopurinol.
                • Colcrys (colchicine) also treats Familial Mediterranean fever.
                • Relieves pain and inflammation for many types of arthritis, including osteoarthritis, rheumatoid arthritis, and juvenile rheumatoid arthritis.
                • Good for treating muscle aches and pains, as well as menstrual cramps.
                • Causes fewer stomach problems than other NSAIDs like Ibuprofen or Naproxen.
                • Lasts longer than Ibuprofen.
                • Effective option to relieve mild to moderate pain and swelling.
                • Treats inflammation problems, such as rheumatoid arthritis, osteoarthritis, and acute gout attacks.
                • In studies, Indocin (Indomethacin) was more effective than Tylenol for treating osteoarthritis pain.
                • It works as well as Celebrex for treating an acute gout attacks.
                • Available in capsules, long-acting capsules, suppositories, and as a suspension. All forms, except the suspension, are available as generic medications.
                • Steroid magic, can help you feel better, have more energy and get more appetite.
                • Useful for many conditions.
                • Short-term use in controlling immune responses that are causing you discomfort, and works quickly to relieve symptoms like swelling, rash, asthma attacks, gout attacks.
                • Long-term use in suppressing the immune system from causing your body harm, like many autoimmune related conditions.
                • Zyloprim (allopurinol) works well to lower uric acid in the body.
                • It is available as a generic medication.
                Downsides and risks
                ColcrysCelebrexIndocinPrednisoneAllopurinol
                • Colcrys (colchicine) doesn't work as well as nonsteroidal anti-inflammatory drugs (NSAIDs) or corticosteroids to treat gout attacks.
                • Taking Colcrys (colchicine) for too long can cause problems with your blood.
                • Doses needs to be changed if you have kidney or liver problems.
                • While Colcrys (colchicine) stops the redness and swelling of gout attacks, it doesn't stop the pain.
                • If you're taking Colcrys (colchicine) to stop gout flare-ups, you can only use it for 3 to 6 months after your levels have stabilized.
                • The capsules (Mitigare) are only approved for prevention, but not treatment of gout.
                • The longer you take Celebrex (Celecoxib), the more likely you are to have stomach problems, including inflammation, ulcers, and bleeding. Can also happen if you take Celebrex (Celecoxib) on an empty stomach.
                • Like all NSAIDs, it can raise your risk of blood clots, heart attack, or a stroke.
                • Can also affect your kidneys or cause permanent kidney damage if taken for a long time.
                • Indocin (Indomethacin) can cause serious heart and stomach problems. The risk goes up the longer you take it, but problems can happen at any time. Don't take Indocin (Indomethacin) any longer than your doctor recommends.
                • Indocin (Indomethacin) raises your risk of bleeding, especially when taken with other blood-thinning medicines.
                • There are similar medicines that you don't have to take as often and can work just as well.
                • Not a good choice if you have kidney, liver, or stomach problems.
                • Lots of side effects, especially with long term use.
                • Short-term use can cause mood changes, trouble sleeping and increase in blood pressure, blood sugar, and possible water retention.
                • Long-term use can cause problems with skin, bone, eye health and put you at a higher risk for infections.
                • People with certain conditions will have to pay extra attention to their symptoms or may have to adjust the dose of other medicines when taking Prednisone.
                • When using corticosteroids for more than 1 week, you will need to work with a doctor to get off the medicine slowly.
                • Only available as an oral medicine so the rest of your body will be exposed to the medicine.
                • Zyloprim (allopurinol) can raise the number of gout attacks in the first few weeks.
                • It can take 2 to 6 weeks to feel the full effects of Zyloprim (allopurinol).
                • Kidney stones can form while taking Zyloprim (allopurinol), so you need to drink a lot of fluids to help prevent this.
                Tips from our pharmacists for people taking the medication
                ColcrysCelebrexIndocinPrednisoneAllopurinol
                • Take Colcrys (colchicine) with or without food.
                • At the first sign of a gout attack, take 2 tablets. Don't take more than 3 tablets a day in order to avoid serious side effects.
                • Wait at least 3 days before using Colcrys (colchicine) again, or at least 12 hours if you had been using Colcrys (colchicine) prophylactically.
                • Almost all people experience some nausea, vomiting, or diarrhea after taking Colcrys (colchicine).
                • Let your doctor know of any serious nausea, vomiting, diarrhea, or if you have tingling in your fingers or toes.
                • Avoid grapefruit and grapefruit juice while taking Colcrys (colchicine).
                • Starts working in 1 to 3 hours.
                • Take it with a meal or a snack to prevent an upset stomach.
                • Can make you bruise or bleed more easily and it can also cause stomach ulcers.
                • Don't take it with other blood thinners, like aspirin, unless your doctor tells you it's safe.
                • Can hurt your kidneys, so don't use it if you have a history of kidney problems.
                • Takes about 30 minutes to start working and can last about 4 to 6 hours.
                • Can cause stomach ulcers or bleeding. Don't take it with other blood-thinning medicines without talking to your doctor first.
                • Can cause headaches. If the headaches continue even after you take a lower dose, talk to your doctor about stopping Indocin (Indomethacin).
                • The long-acting capsules must be swallowed whole. Don't crush them.
                • Take with food or milk to help prevent upset stomach.
                • The dose and duration on how long you need the medicine depends on your condition and response.
                • Take it exactly as your doctor prescribed.
                • Take with food to decrease stomach upset.
                • Can cause trouble sleeping. Take in the morning or 2-3 hours before bed if more than one dose is needed.
                • Can cause changes in mood, blood pressure, blood sugar, and water retention.
                • You should check your blood pressure and blood sugar when taking this medicine if you already have high blood pressure or diabetes.
                • A taper is is often needed to stop the medicine, especially if you've been on it for more than 1 week.
                • Drink plenty of water while taking Zyloprim (allopurinol).
                • Take with food or milk to prevent an upset stomach.
                • It takes at least 2 to 6 weeks to experience the full benefit of this medicine.
                • Your doctor can run blood tests to make sure the medication is working as it should.
                • During the first few weeks of starting this, you may need to be on a second anti-gout medicine to prevent flare-ups because Zyloprim (allopurinol) can cause gout attacks when you first start it.
                • If you're taking this because you have cancer, your doctor might have to change the doses of some of your chemotherapy drugs.
                Learn more
                More about ColcrysSide effectsReviews & ratingsAlternativesFDA package insert
                Have you used Colcrys (colchicine)?
                Worth itNot sureNot worth it
                More about CelebrexSide effectsReviews & ratingsFDA package insert
                Have you used Celebrex (celecoxib)?
                Worth itNot sureNot worth it
                More about IndocinSide effectsReviews & ratingsFDA package insert
                Have you used Indocin (indomethacin)?
                Worth itNot sureNot worth it
                More about PrednisoneSide effectsReviews & ratingsFDA package insert
                Have you used Deltasone (prednisone)?
                Worth itNot sureNot worth it
                More about AllopurinolSide effectsReviews & ratingsFDA package insert
                Have you used Zyloprim (allopurinol)?
                Worth itNot sureNot worth it