Treats low estrogen and relieves menopause symptoms.
Our pharmacists’ bottom line
Combipatch (Estradiol / Norethindrone Patch) is effective at treating menopause symptoms, and it can be a good choice for women who need estrogen/progestin combo medications, but prefer to use a patch every twice a week instead of pills every day.
- Twice-a-week patch. Good for people who don't want to take daily pills.
- Combipatch (Estradiol / Norethindrone Patch) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, vaginal dryness).
- Fewer side effects than pills since patches contain lower amounts of hormones.
- Good for women with an intact uterus. The norethindrone (a progestin) protects against the risk of cancer in the uterus caused by estrogen treatment.
- More potential side effects than single-ingredient medications since it exposes your whole body to two hormones, estrogen and norethindrone (a progestin).
- Increases your risk of developing blood clots and stroke.
- You may get irregular bleeding and spotting that can last a few months to a year.
- Patch can fall off.
- Can be expensive since it's only available as a brand name product.
Save on your next Combipatch (Estradiol / Norethindrone Patch) prescription
Be sure you’re getting the lowest price for your medication, even if you have insurance.
- Prices for (1) 8 patches of 0.05mg/0.14mg package of Combipatch (Estradiol / Norethindrone Patch)
- Kroger Pharmacy
Side effects for Combipatch (Estradiol / Norethindrone Patch)
From clinical trials of Combipatch / Endometrial hyperplasia (0.05/0.14 mg) ( 325)
- Breast painBreast pain34% for Combipatch vs.0% for placebo
- Menstrual crampsMenstrual cramps30% for Combipatch vs.0% for placebo
- HeadacheHeadache25% for Combipatch vs.0% for placebo
- Application site reactionApplication site reaction20% for Combipatch vs.0% for placebo
- PainPain19% for Combipatch vs.0% for placebo
- Inflammation inside the noseInflammation inside the nose19% for Combipatch vs.0% for placebo
- Menstrual disorderMenstrual disorder17% for Combipatch vs.0% for placebo
- Back painBack pain15% for Combipatch vs.0% for placebo
- Flu syndromeFlu syndrome14% for Combipatch vs.0% for placebo
- DiarrheaDiarrhea14% for Combipatch vs.0% for placebo
What to expect when you start Combipatch (Estradiol / Norethindrone Patch)Skip what to expect section. Skip to Risks & Warnings section.
- Remove the patch by tearing the package by hand and not with scissors. Never cut the patch.
- Apply the sticky side of the patch to clean, dry, hairless skin below your waistline on areas as instructed by the manufacturer (never on your breast).
- Replace the patch twice a week (every 3-4 days) on a different area of your skin to lower your risk of skin irritation.
- Fold together the sticky sides of used patches before throwing them away to avoid exposing others to the medicine. Don't flush them down the toilet.
- Shouldn't be used forever. Talk to your doctor regularly to see if you still need treatment.
- Can cause nausea, dizziness, bloating, and breast tenderness.
- Tell your doctor about any unusual vaginal bleeding.
- Get emergency care if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.
Risks and Warnings for Combipatch (Estradiol / Norethindrone Patch)Skip Risks and Warnings section. Skip to Tips section.
- Higher risk if:
- › Using estrogen for more than one year
Vaginal bleeding after menopause can be a warning sign of uterus (endometrial) cancer, so let your doctor know if you notice any unusual bleeding. When estrogen is prescribed to women after menopause who still have a uterus, progestin should be used with it to lower the risk of cancer. Low-dose vaginal estrogen products are often a better choice than oral pills for women 65 years or older who have vaginal symptoms.
This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.