Prescription onlyNo lower cost generic available


(Estradiol / Norethindrone Patch)

  • Patch
  • Hot flashes and night sweats
  • Vaginal dryness and inflammation
  • Low estrogen
  • Primary ovarian failure
Back to: Full Site NavigationSkip to: side effects sectionSkip to: What to expect sectionSkip to: Risks and warnings sectionSkip to: Tips from users and pharmacists

Treats low estrogen and relieves menopause symptoms.

Skip Upsides & Downsides section. Skip to side effects section.
Prescription onlyNo lower cost generic available

Our pharmacists’ bottom line

Combipatch (Estradiol / Norethindrone Patch) is effective at treating menopause symptoms, and it can be a good choice for women who need estrogen/progestin combo medications, but prefer to use a patch every twice a week instead of pills every day.

  • Twice-a-week patch. Good for people who don't want to take daily pills.
  • Combipatch (Estradiol / Norethindrone Patch) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, vaginal dryness).
  • Fewer side effects than pills since patches contain lower amounts of hormones.
  • Good for women with an intact uterus. The norethindrone (a progestin) protects against the risk of cancer in the uterus caused by estrogen treatment.
  • More potential side effects than single-ingredient medications since it exposes your whole body to two hormones, estrogen and norethindrone (a progestin).
  • Increases your risk of developing blood clots and stroke.
  • You may get irregular bleeding and spotting that can last a few months to a year.
  • Patch can fall off.
  • Can be expensive since it's only available as a brand name product.

Save on your next Combipatch (Estradiol / Norethindrone Patch) prescription

Be sure you’re getting the lowest price for your medication, even if you have insurance.

Skip side effects sections. Skip to What to Expect and Pharmacists Tips section.

Side effects for Combipatch (Estradiol / Norethindrone Patch)

From clinical trials of Combipatch / Endometrial hyperplasia (0.05/0.14 mg) ( 325)

  • Breast painBreast pain34% for Combipatch vs.0% for placebo
  • Menstrual crampsMenstrual cramps30% for Combipatch vs.0% for placebo
  • HeadacheHeadache25% for Combipatch vs.0% for placebo
  • Application site reactionApplication site reaction20% for Combipatch vs.0% for placebo
  • PainPain19% for Combipatch vs.0% for placebo
  • Inflammation inside the noseInflammation inside the nose19% for Combipatch vs.0% for placebo
  • Menstrual disorderMenstrual disorder17% for Combipatch vs.0% for placebo
  • Back painBack pain15% for Combipatch vs.0% for placebo
  • Flu syndromeFlu syndrome14% for Combipatch vs.0% for placebo
  • DiarrheaDiarrhea14% for Combipatch vs.0% for placebo

What to expect when you start Combipatch (Estradiol / Norethindrone Patch)

Skip what to expect section. Skip to Risks & Warnings section.
Tips from our pharmacists
  • Remove the patch by tearing the package by hand and not with scissors. Never cut the patch.
  • Apply the sticky side of the patch to clean, dry, hairless skin below your waistline on areas as instructed by the manufacturer (never on your breast).
  • Replace the patch twice a week (every 3-4 days) on a different area of your skin to lower your risk of skin irritation.
  • Fold together the sticky sides of used patches before throwing them away to avoid exposing others to the medicine. Don't flush them down the toilet.
  • Shouldn't be used forever. Talk to your doctor regularly to see if you still need treatment.
  • Can cause nausea, dizziness, bloating, and breast tenderness.
  • Tell your doctor about any unusual vaginal bleeding.
  • Get emergency care if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.

Risks and Warnings for Combipatch (Estradiol / Norethindrone Patch)

Skip Risks and Warnings section. Skip to Tips section.
    • Higher risk if:
    • Using estrogen for more than one year

    Vaginal bleeding after menopause can be a warning sign of uterus (endometrial) cancer, so let your doctor know if you notice any unusual bleeding. When estrogen is prescribed to women after menopause who still have a uterus, progestin should be used with it to lower the risk of cancer. Low-dose vaginal estrogen products are often a better choice than oral pills for women 65 years or older who have vaginal symptoms.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Combipatch (Estradiol / Norethindrone Patch)

Final section. Do you want to return to drug navigation?
The FDA category for this medication is X. It is advised that you: Unsafe