Prescription onlyNo lower cost generic available


(Estradiol / Norethindrone Patch)

  • Patch
  • Hot flashes and night sweats
  • Vaginal dryness and inflammation
  • Low estrogen
  • Primary ovarian failure
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Treats low estrogen and relieves menopause symptoms.

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Prescription onlyNo lower cost generic available

Our pharmacists’ bottom line

Combipatch (Estradiol / Norethindrone Patch) is effective at treating menopause symptoms, and it can be a good choice for women who need estrogen/progestin combo medications, but prefer to use a patch every twice a week instead of pills every day.

  • Twice-a-week patch. Good for people who don't want to take daily pills.
  • Combipatch (Estradiol / Norethindrone Patch) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, vaginal dryness).
  • Fewer side effects than pills since patches contain lower amounts of hormones.
  • Good for women with an intact uterus. The norethindrone (a progestin) protects against the risk of cancer in the uterus caused by estrogen treatment.
  • More potential side effects than single-ingredient medications since it exposes your whole body to two hormones, estrogen and norethindrone (a progestin).
  • Increases your risk of developing blood clots and stroke.
  • You may get irregular bleeding and spotting that can last a few months to a year.
  • Patch can fall off.
  • Can be expensive since it's only available as a brand name product.

Save on your next Combipatch (Estradiol / Norethindrone Patch) prescription

Be sure you’re getting the lowest price for your medication, even if you have insurance.

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Side effects for Combipatch (Estradiol / Norethindrone Patch)

From clinical trials of Combipatch / Endometrial hyperplasia (0.05/0.14 mg) ( 325)

  • Breast painBreast pain34% for Combipatch vs.0% for placebo
  • Menstrual crampsMenstrual cramps30% for Combipatch vs.0% for placebo
  • HeadacheHeadache25% for Combipatch vs.0% for placebo
  • Application site reactionApplication site reaction20% for Combipatch vs.0% for placebo
  • PainPain19% for Combipatch vs.0% for placebo
  • Inflammation inside the noseInflammation inside the nose19% for Combipatch vs.0% for placebo
  • Menstrual disorderMenstrual disorder17% for Combipatch vs.0% for placebo
  • Back painBack pain15% for Combipatch vs.0% for placebo
  • Flu syndromeFlu syndrome14% for Combipatch vs.0% for placebo
  • DiarrheaDiarrhea14% for Combipatch vs.0% for placebo

What to expect when you take Combipatch (Estradiol / Norethindrone Patch)

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Tips from our pharmacists
  • Remove the patch by tearing the package by hand and not with scissors. Never cut the patch.
  • Apply the sticky side of the patch to clean, dry, hairless skin below your waistline on areas as instructed by the manufacturer (never on your breast).
  • Replace the patch twice a week (every 3-4 days) on a different area of your skin to lower your risk of skin irritation.
  • Fold together the sticky sides of used patches before throwing them away to avoid exposing others to the medicine. Don't flush them down the toilet.
  • Shouldn't be used forever. Talk to your doctor regularly to see if you still need treatment.
  • Can cause nausea, dizziness, bloating, and breast tenderness.
  • Tell your doctor about any unusual vaginal bleeding.
  • Get emergency care if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.

Risks and Warnings for Combipatch (Estradiol / Norethindrone Patch)

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    • Higher risk if:
    • Using estrogen for more than one year

    Vaginal bleeding after menopause can be a warning sign of uterus (endometrial) cancer, so let your doctor know if you notice any unusual bleeding. When estrogen is prescribed to women after menopause who still have a uterus, progestin should be used with it to lower the risk of cancer. Low-dose vaginal estrogen products are often a better choice than oral pills for women 65 years or older who have vaginal symptoms.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Combipatch (Estradiol / Norethindrone Patch)

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The FDA category for this medication is X. It is advised that you: Unsafe
  • Great patch vbeen taking it 10 yrs. you. Sleep all night. No mood swings and no hot flashes Worth the $
    Age: 65
    Gender: Woman
    Taken for: Hot flashes and night sweats