Prescription onlyNo lower cost generic available


(Estradiol / Norethindrone Patch)

Prescription onlyNo lower cost generic available
  • Patch
  • Hot flashes and night sweats
  • Vaginal dryness and inflammation
  • Low estrogen
  • Primary ovarian failure
Back to: Full Site NavigationSkip to: side effects sectionSkip to: What to expect sectionSkip to: Risks and warnings sectionSkip to: Common concerns from users and pharmacists

Treats low estrogen and relieves menopause symptoms.

Skip Upsides & Downsides section. Skip to side effects section.

Our bottom line

Combipatch (Estradiol / Norethindrone Patch) is effective at treating menopause symptoms, and it can be a good choice for women who need estrogen/progestin combo medications, but prefer to use a patch every twice a week instead of pills every day.

Price and discounts
  • (1) 8 patches of 0.05mg/0.14mg package
  • Cost for (1) 8 patches of 0.05mg/0.14mg package of Combipatch (Estradiol / Norethindrone Patch) at pharmacies


  • Twice-a-week patch. Good for people who don't want to take daily pills.
  • Combipatch (Estradiol / Norethindrone Patch) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, vaginal dryness).
  • Fewer side effects than pills since patches contain lower amounts of hormones.
  • Good for women with an intact uterus. The norethindrone (a progestin) protects against the risk of cancer in the uterus caused by estrogen treatment.


  • More potential side effects than single-ingredient medications since it exposes your whole body to two hormones, estrogen and norethindrone (a progestin).
  • Increases your risk of developing blood clots and stroke.
  • You may get irregular bleeding and spotting that can last a few months to a year.
  • Patch can fall off.
  • Can be expensive since it's only available as a brand name product.
Skip side effects section. Skip to What to Expect and Pharmacists Tips section.

Side effect rates for Combipatch (Estradiol / Norethindrone Patch)

325 From clinical trials of Combipatch / Endometrial hyperplasia (0.05/0.14 mg)
  • Breast pain
  • Menstrual cramps
  • Headache
  • Application site reaction
  • Inflammation inside the nose
  • Pain
  • Menstrual disorder
  • Back pain
  • Flu syndrome
  • Diarrhea

Risks and Warnings for Combipatch (Estradiol / Norethindrone Patch)

Skip risks section. Skip to common concerns section.
    • Higher risk if:
    • Using estrogen for more than one year

    Vaginal bleeding after menopause can be a warning sign of uterus (endometrial) cancer, so let your doctor know if you notice any unusual bleeding. When estrogen is prescribed to women after menopause who still have a uterus, progestin should be used with it to lower the risk of cancer. Low-dose vaginal estrogen products are often a better choice than oral pills for women 65 years or older who have vaginal symptoms.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Combipatch (Estradiol / Norethindrone Patch)

Final section. Do you want to return to drug navigation?
  • Can cause nausea, dizziness, bloating, and breast tenderness.
  • Combipatch (Estradiol / Norethindrone Patch) is a mixture of estrogen and progestin. It could cause a higher risk of ovarian cancer, especially if you have a family history of it. Your doctor can help you weigh the risks versus the benefits of this medication.