Combipatch
Alternatives

(estradiol / norethindrone patch)

Combipatch (estradiol / norethindrone patch)

Prescription only

Angeliq (drospirenone / estradiol)

Prescription only
1 of 4 alternatives
Treats low estrogen and relieves menopause symptoms.

Combipatch (estradiol / norethindrone patch) is a twice weekly patch that effectively treats menopause and causes less blood clots or stroke than combination pills.

Relieves hot flashes and vaginal dryness due to menopause.

Angeliq (drospirenone / estradiol) helps relieve menopausal symptoms. There can be many side effects, so it's important to think through the benefits and potential hassles of this drug before using it.

Upsides
  • Twice weekly patch. Good for people who don't want to take daily pills.
  • Replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, vaginal dryness).
  • Less likely to cause blood clots or stroke than pills since patches contain a lower amount of hormones.
  • Good for women with an intact uterus.
  • You can bathe, shower, and swim while wearing the patch, as long as you don't rub the patch.
  • Angeliq (drospirenone / estradiol) replaces estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, night sweats, vaginal dryness).
  • Useful for women who experience moderate to severe symptoms of menopause.
  • Improves mood, energy, and mental alertness for some people.
  • Good for women with an intact uterus. The drospirenone (a progestin) protects against the risk of cancer in the uterus from estrogen treatment.
Downsides
  • More potential side effects than single ingredient medications since it exposes your whole body to two hormones.
  • You may get irregular bleeding and spotting that can last a few months to a year.
  • The patch can't be exposed to direct sunlight for long periods of time.
  • Can be expensive since it's only available as a brand name product.
  • There are more possible side effects since it exposes your whole body to two hormones.
  • Angeliq (drospirenone / estradiol) can't be used by women who have had their uterus removed.
  • You may get irregular bleeding and spotting that can last a few months to a year.
  • Compared to other estrogen-progestin combination medicines, you might be more likely to have blood clots with Angeliq (drospirenone / estradiol).
  • Angeliq (drospirenone / estradiol) might increase your potassium, which can be dangerous if you're taking other medicines that do the same.
Used for
  • Hot flashes
  • Vaginal dryness and inflammation
  • Low estrogen
  • Primary ovarian failure
Dosage forms
  • Patch
  • Pill
Price
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$168.57
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Lowest price near you
$171.4
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Side effects
10possible side effects
  • Breast pain
    34%
  • Menstrual cramps
    30%
  • Headache
    25%
  • Skin irritation
    20%
  • Pain
    19%
  • Stuffy nose
    19%
  • Menstrual problems
    17%
  • Back pain
    15%
  • Flu like symptoms
    14%
  • Diarrhea
    14%
See more detailed side effects
7possible side effects
  • Stomach pain
    6%
  • Headache
    6%
  • Yeast infections
    6%
  • Breast pain
    3%
  • Nausea
    3%
  • Diarrhea
    2%
  • Swelling of arms and legs
    2%
See more detailed side effects
Risks and warnings
  • Endometrial cancer

    Using estrogen for more than one year

  • Breast cancer

    Personal or family history of breast cancer

    ...and 1 more risk factors

  • Increased risk of blood clots and stroke

    Personal or family history of blood clots

    ...and 3 more risk factors

  • Dementia

    Aged 65 or older

  • Pancreas swelling (pancreatitis)

    High levels of triglycerides

See more detailed risks and warnings
  • Endometrial cancer

    Using estrogen for more than one year

  • Breast cancer

    Personal or family history of breast cancer

    ...and 1 more risk factors

  • Increased risk of blood clots and stroke

    Personal or family history of blood clots

    ...and 3 more risk factors

  • Increased risk of heart disease

    Smoking

    ...and 5 more risk factors

  • Dementia

    Age 65 or older

  • Increased potassium

    Kidney disease

    ...and 3 more risk factors

See more detailed risks and warnings