Prescription onlyClass: Infection

Complera Alternatives

(emtricitabine / rilpivirine / tenofovir)

Prescription onlyClass: Infection
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Compare Complera (emtricitabine / rilpivirine / tenofovir) to alternatives

These medications are comparable to Complera (emtricitabine / rilpivirine / tenofovir) or used for similar purposes.

Complera
(emtricitabine / rilpivirine / tenofovir)

Odefsey
(emtricitabine / rilpivirine / tenofovir)

Atripla
(efavirenz / emtricitabine / tenofovir)

Truvada
(emtricitabine / tenofovir)

Stribild
(elvitegravir / cobicistat / emtricitabine / tenofovir)

Edurant
(rilpivirine)

Emtriva
(emtricitabine)

Treats HIV infection Complera (emtricitabine / rilpivirine / tenofovir) is a convenient 3-in-1 medication used to treat HIV infections.Treats HIV infection Odefsey (emtricitabine / rilpivirine / tenofovir) is a convenient 3-in-1 medication used to treat HIV infections. It's similar to Complera, but contains a newer HIV drug which has shown to cause less harmful effects on your kidneys and bones.Treats HIV infection. Atripla (efavirenz / emtricitabine / tenofovir) is a convenient 3-in-1 medication used to treat HIV infections. It is a second-line choice due to its high incidence of undesired side effects.Works with other medicines to treat HIV infection. Truvada (Emtricitabine / Tenofovir) is a popular combination medicine that has two drugs with the same mechanism of action to treat and prevent HIV infection.Coming soon.Works with other medications to treat HIV infection. Edurant (rilpivirine) is a good HIV drug that has to be used in combination with other HIV medications in patients who are new to treatment or are looking for alternatives to a current HIV regimen.Works with other medicines to treat HIV infection. Emtriva (emtricitabine) is a first-line and commonly used drug that is taken in combination with other HIV medications to treat or prevent HIV.
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Reviews & ratings
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Reviews for Complera (emtricitabine / rilpivirine / tenofovir)
Not enough review data. Review it!
of people (All ages) say Complera (emtricitabine / rilpivirine / tenofovir) is worth it
Not enough review data. Review it!
say it works well
Not enough review data. Review it!
say it's a big hassle
Have you used Complera (emtricitabine / rilpivirine / tenofovir)?
Worth itNot sureNot worth it
Reviews for Odefsey (emtricitabine / rilpivirine / tenofovir)
Not enough review data. Review it!
-100% worse vs. Complera (emtricitabine / rilpivirine / tenofovir)
Not enough review data. Review it!
-100% worse vs. Complera (emtricitabine / rilpivirine / tenofovir)
Not enough review data. Review it!
+100% better vs. Complera (emtricitabine / rilpivirine / tenofovir)
Have you used Odefsey (emtricitabine / rilpivirine / tenofovir)?
Worth itNot sureNot worth it
Reviews for Atripla (efavirenz / emtricitabine / tenofovir)
Not enough review data. Review it!
Same vs. Complera (emtricitabine / rilpivirine / tenofovir)
Not enough review data. Review it!
Same vs. Complera (emtricitabine / rilpivirine / tenofovir)
Not enough review data. Review it!
+100% better vs. Complera (emtricitabine / rilpivirine / tenofovir)
Have you used Atripla (efavirenz / emtricitabine / tenofovir)?
Worth itNot sureNot worth it
Reviews for Truvada (emtricitabine / tenofovir)
100%
Same vs. Complera (emtricitabine / rilpivirine / tenofovir)
94%
-6% worse vs. Complera (emtricitabine / rilpivirine / tenofovir)
0%
+100% better vs. Complera (emtricitabine / rilpivirine / tenofovir)
Have you used Truvada (emtricitabine / tenofovir)?
Worth itNot sureNot worth it
Reviews for Stribild (elvitegravir / cobicistat / emtricitabine / tenofovir)
Not enough review data. Review it!
Same vs. Complera (emtricitabine / rilpivirine / tenofovir)
Not enough review data. Review it!
Same vs. Complera (emtricitabine / rilpivirine / tenofovir)
Not enough review data. Review it!
+80% better vs. Complera (emtricitabine / rilpivirine / tenofovir)
Have you used Stribild (elvitegravir / cobicistat / emtricitabine / tenofovir)?
Worth itNot sureNot worth it
Reviews for Edurant (rilpivirine)
Not enough review data. Review it!
-100% worse vs. Complera (emtricitabine / rilpivirine / tenofovir)
Not enough review data. Review it!
Same vs. Complera (emtricitabine / rilpivirine / tenofovir)
Not enough review data. Review it!
+100% better vs. Complera (emtricitabine / rilpivirine / tenofovir)
Have you used Edurant (rilpivirine)?
Worth itNot sureNot worth it
Reviews for Emtriva (emtricitabine)
Not enough review data. Review it!
-100% worse vs. Complera (emtricitabine / rilpivirine / tenofovir)
Not enough review data. Review it!
-100% worse vs. Complera (emtricitabine / rilpivirine / tenofovir)
Not enough review data. Review it!
+100% better vs. Complera (emtricitabine / rilpivirine / tenofovir)
Have you used Emtriva (emtricitabine)?
Worth itNot sureNot worth it
Side effects
CompleraOdefseyAtriplaTruvadaStribildEdurantEmtriva
  • Headache 2%
  • Depressive disorders 2%
  • Sleep difficulty 2%
More Complera side effects »
  • Headache 19%
  • Low mood disorder 19%
  • Drowsiness 14%
  • Nausea 11%
  • Dizziness 8%
  • Abdominal pain 8%
  • Vomiting 6%
  • Rash 6%
More Odefsey side effects »
  • Diarrhea 9%
  • Low mood disorder 9%
  • Fatigue 9%
  • Nausea 9%
  • Sinus inflammation 8%
  • Ear, nose, or throat infection 8%
  • Dizziness 8%
  • Rash event 7%
  • Headache 6%
  • Anxiety 5%
More Atripla side effects »
  • > 5% bone mineral density loss 7%
  • Headache 1%
  • Syphilis 1%
  • Secondary syphilis 2%
  • Abdominal pain 2%
More Truvada side effects »

We haven’t found good data for Stribild side effects.

FDA side effect reports for Stribild »
  • Depressive disorders 5%
  • Headache 3%
  • Sleep difficulty 3%
  • Rash 3%
  • Abdominal pain 2%
  • Fatigue 2%
  • Abnormal dreams 2%
More Edurant side effects »
  • Diarrhea 23%
  • Nasal stuffiness/runniness (rhinitis) 18%
  • Nausea 18%
  • Rash 17%
  • Physical weakness and/or lack of energy 16%
  • Increased cough 14%
  • Headache 13%
  • Vomiting 9%
  • Abdominal pain 8%
  • Sleep difficulty 7%
More Emtriva side effects »
How it works
CompleraOdefseyAtriplaTruvadaStribildEdurantEmtriva
Complera (emtricitabine / rilpivirine / tenofovir) is a combination pill that contains three antiretroviral (ARV) drugs. It treats HIV infections by preventing the virus from attacking your immune cells and multiplying.Odefsey (emtricitabine / rilpivirine / tenofovir) is a combination pill that contains three antiretroviral (ARV) drugs. It treats HIV infections by preventing the virus from attacking your immune cells and multiplying.Atripla (efavirenz / emtricitabine / tenofovir) is a combination pill that contains three antiretroviral (ARV) drugs. It treats HIV infections by preventing the virus from attacking your immune cells and multiplying.Truvada (Emtricitabine / Tenofovir) is a combination medication that stops the replication of the human immunodeficiency virus (HIV) within important cells of the body. Emtricitabine and tenofovir both prevent the virus from taking over normal functions of the cell for its own purposes.Coming soon.Edurant (rilpivirine) is a Non-nucleoside reverse transcriptase inhibitor (NNRTI). It treats HIV by stopping the virus from replicating within cells in your immune system.Emtriva (emtricitabine) is a Nucleoside reverse transcriptase inhibitor (NRTI). It treats HIV by stopping the virus from replicating within cells in your immune system.
Type of medication
CompleraOdefseyAtriplaTruvadaStribildEdurantEmtriva
Prescription only
Prescription only
Prescription only
Prescription only
Prescription only
Prescription only
Prescription only
Available as
CompleraOdefseyAtriplaTruvadaStribildEdurantEmtriva
  • Pill
  • Pill
  • Pill
  • Pill
  • Pill
  • Pill
  • Pill
  • Liquid
Used for
CompleraOdefseyAtriplaTruvadaStribildEdurantEmtriva
  • HIV Infection
Risk factors for serious side effects
CompleraOdefseyAtriplaTruvadaStribildEdurantEmtriva
  • Liver disease
  • Women
  • Obesity
  • Hepatitis B Virus infection
  • History of mental health problems
Detailed Complera (emtricitabine / rilpivirine / tenofovir) risks & warnings »
  • Liver disease
  • Women
  • Obesity
  • Hepatitis B Virus infection
  • History of mental health problems
Detailed Odefsey (emtricitabine / rilpivirine / tenofovir) risks & warnings »
  • Liver disease
  • Women
  • Obesity
  • Hepatitis B Virus infection
  • History of mental health problems
Detailed Atripla (efavirenz / emtricitabine / tenofovir) risks & warnings »
  • Infection with chronic hepatitis B and stopping Truvada (Emtricitabine / Tenofovir)
  • Taking high dose anti-inflammatory drugs (NSAIDs)
  • Undiscovered HIV infection
Detailed Truvada (emtricitabine / tenofovir) risks & warnings »
    Coming soon.
    • History of mental health problems
    • Exposure to other infections
    • Start of a new HIV medication
    • Change in HIV therapy
    • Prior severe allergic reaction to Edurant (rilpivirine)
    Detailed Edurant (rilpivirine) risks & warnings »
    • Liver disease
    • Women
    • Obesity
    • Hepatitis B Virus infection
    • HIV
    Detailed Emtriva (emtricitabine) risks & warnings »
    Pregnancy

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    Food
    CompleraOdefseyAtriplaTruvadaStribildEdurantEmtriva
    No food related info.
    • Take each dose with a light meal.
    No food related info.No food related info.No food related info.
    • Take each dose with a meal.
    • Taken with or without food once a day.
    • Emtriva (emtricitabine) should be taken at the same time everyday, with or without food.
    Kidneys and liver
    CompleraOdefseyAtriplaTruvadaStribildEdurantEmtriva
    • Not recommended for patients with kidney damage.
    • Complera (emtricitabine / rilpivirine / tenofovir) is not yet approved for treating Hepatitis B. If you have hepatitis B and HIV, don't stop taking Complera (emtricitabine / rilpivirine / tenofovir) without talking to your doctor since your hepatitis can get worse. Your doctor will check your liver regularly.
    • People on Complera (emtricitabine / rilpivirine / tenofovir) have reported kidney damage, which can be made worse if you take high doses of anti-inflammatory drugs called NSAIDs (Motrin/Advil, Aleve, Mobic, Voltaren, etc.). Call your doctor if you develop bone pain, pain in your arms or legs, or pain or weakness in your muscles. Your doctor will do blood tests to check your kidneys regularly while you're taking Complera (emtricitabine / rilpivirine / tenofovir).
    No kidneys and liver related info.
    • Might be inconvenient if used in patients with poorly functioning kidneys because there is no way to adjust the dose of the individual drug components.
    • One of the medications in Atripla (efavirenz / emtricitabine / tenofovir) can cause kidney damage. This can be made worse if you take high doses of anti-inflammatory drugs called NSAIDs (Motrin/Advil, Aleve, Mobic, Voltaren, etc.). Call your doctor if you develop bone pain, pain in your arms or legs, or pain or weakness in your muscles.
    • Can cause unusual dreams, or kidney or liver damage.
    • Truvada (Emtricitabine / Tenofovir) is removed from the body by the kidneys, so the dose of Truvada (Emtricitabine / Tenofovir) needs to be lowered if you have any kidney problems.
    • Before starting Truvada (Emtricitabine / Tenofovir), your doctor will test you for hepatitis B to make sure you're not infected. People who've stopped Truvada (Emtricitabine / Tenofovir) and had chronic hepatitis B have suffered from liver damage and failure.
    • People on Truvada (Emtricitabine / Tenofovir) have reported kidney damage, which can be made worse if you take high doses of anti-inflammatory drugs called NSAIDs (Motrin/Advil, Aleve, Mobic, Voltaren, etc.). Call your doctor if you develop bone pain, pain in your arms or legs, or pain or weakness in your muscles.
    No kidneys and liver related info.
    • Can be used in patients with mild or moderate kidney damage.
    • Patients with kidney damage will need to be closely monitored by their doctors in order to provide an appropriate dose.
    • The dose of Emtriva (emtricitabine) should be adjusted if you have poor kidney health. Your doctor will provide lab tests to ensure you are taking the appropriate dose. Be sure to attend your scheduled doctor and lab appointments in order to make sure that Emtriva (emtricitabine) is working well and safely for you.
    Upsides and benefits
    CompleraOdefseyAtriplaTruvadaStribildEdurantEmtriva
    • Complera (emtricitabine / rilpivirine / tenofovir) combines three medications into one tablet, so it's easy to take.
    • Complera (emtricitabine / rilpivirine / tenofovir) might be an option for HIV treatment if other HIV drug combinations haven't worked for you.
    • There are drug assistance programs available either through the government (AIDS Drug Assistance Program aka. ADAP) or through the drug manufacturer which can help with drug costs and co-pays.
    • Odefsey (emtricitabine / rilpivirine / tenofovir) combines three medications into one tablet, so it's easy to take.
    • Odefsey (emtricitabine / rilpivirine / tenofovir) is currently the smallest combination HIV tablet available.
    • Odefsey (emtricitabine / rilpivirine / tenofovir) works similar to Complera, but is less likely to cause harmful side effects on your kidneys and bones.
    • Odefsey (emtricitabine / rilpivirine / tenofovir) might be an option for HIV treatment if other HIV drug combinations haven't worked for you.
    • Atripla (efavirenz / emtricitabine / tenofovir) combines three medications into one tablet, so it's easy to take.
    • Atripla (efavirenz / emtricitabine / tenofovir) might be an option for HIV treatment if other HIV drug combinations haven't worked for you.
    • There are drug assistance programs available either through the government (AIDS Drug Assistance Program aka. ADAP) or through the drug manufacturer which can help with drug costs and co-pays.
    • First-line treatment for preventing HIV infection in combination with other HIV medications.
    • Only has to be taken once a day.
    • Truvada (Emtricitabine / Tenofovir) prevents and treats HIV infection.
    • Used for preventing HIV infection in case you've been accidentally exposed or if you're in danger of being exposed.
    Coming soon
    • Generally well tolerated.
    • Taken only once daily.
    • Edurant (rilpivirine) is available in other combination tablets.
    • Can be used in patients with mild or moderate kidney damage.
    • Emtriva (emtricitabine) is a first-line drug option used in combination with other HIV medications to treat HIV.
    • Taken with or without food once a day.
    • Emtriva (emtricitabine) is available in many combination tablets if you are looking to lower the number of pills you need to take daily for HIV treatment.
    • Emtriva (emtricitabine) is available as a capsule as well as liquid form.
    Downsides and risks
    CompleraOdefseyAtriplaTruvadaStribildEdurantEmtriva
    • Must be taken with a light meal which includes fat.
    • Cannot be taken with proton pump inhibitors (PPI) like Prilosec or Prevacid. If you need to take an acid reducer, try an antacid like calcium carbonate either 2 hours before or 4 hours after Complera (emtricitabine / rilpivirine / tenofovir). Drugs like Pepcid or Zantac (H2RAs) may also be an option, but these should be taken 12 hours before or 4 hours after Complera (emtricitabine / rilpivirine / tenofovir).
    • Not recommended for patients who have a significantly high level of viral cells or have a very low level of immune cells.
    • Not recommended for patients with kidney damage.
    • Can weaken your bones.
    • Odefsey (emtricitabine / rilpivirine / tenofovir) has to be taken with a light meal.
    • Cannot be taken with proton pump inhibitors (PPI) like Prilosec or Prevacid. If you need an acid reducer, try taking an antacid like calcium carbonate either 2 hours before or 4 hours after Odefsey (emtricitabine / rilpivirine / tenofovir). Drugs like Pepcid or Zantac (H2RAs) may also be an option, but these should be taken 12 hours before or 4 hours after Odefsey (emtricitabine / rilpivirine / tenofovir).
    • Not recommended for patients who have a significantly high level of viral cells or have a very low level of immune cells.
    • Can cause abnormal heart rhythm.
    • Atripla (efavirenz / emtricitabine / tenofovir) can increase your risk of depression, and should be used with caution you have a history of seizures or osteoporosis.
    • Women should avoid becoming pregnant while taking Atripla (efavirenz / emtricitabine / tenofovir) and for 12 weeks after stopping Atripla (efavirenz / emtricitabine / tenofovir).
    • Might be inconvenient if used in patients with poorly functioning kidneys because there is no way to adjust the dose of the individual drug components.
    • Has to be taken at the same time every day or your body can become resistant to the medication.
    • Can't be taken on its own to treat HIV.
    • Can cause unusual dreams, or kidney or liver damage.
    • Can't be taken with any drugs containing lamivudine since both are so similar to each other.
    • Truvada (Emtricitabine / Tenofovir) is removed from the body by the kidneys, so the dose of Truvada (Emtricitabine / Tenofovir) needs to be lowered if you have any kidney problems.
    Coming soon
    • Must be taken in combination with other HIV drugs to treat HIV. Cannot be taken alone as treatment.
    • Must be taken with a meal.
    • Cannot be taken with proton pump inhibitors (PPI) like Prilosec or Prevacid. If you need to take an acid reducer, try an antacid like calcium carbonate either 2 hours before or 4 hours after Edurant (rilpivirine). Drugs like Pepcid or Zantac (H2RAs) may also be an option, but these should be taken 12 hours before or 4 hours after Edurant (rilpivirine).
    • Not recommended for patients who have a significantly high level of viral cells or have a very low level of immune cells.
    • Not recommended for children under 12 years old.
    • Patients with kidney damage will need to be closely monitored by their doctors in order to provide an appropriate dose.
    • Cannot be used by itself to treat or prevent HIV infection.
    Tips from our pharmacists for people taking the medication
    CompleraOdefseyAtriplaTruvadaStribildEdurantEmtriva
    • Complera (emtricitabine / rilpivirine / tenofovir) should be taken at the same time everyday.
    • For missed doses, take one if you remember within 12 hours of your regularly scheduled time. Don't take two doses at the same time.
    • Take Complera (emtricitabine / rilpivirine / tenofovir) with at least a light meal with 12 grams of fat. Some examples that the makers of Complera (emtricitabine / rilpivirine / tenofovir) list are toast with peanut butter & fruit, roast beef sandwich, or a grilled chicken caesar salad.
    • Immediately report any signs of liver problems (jaundice, dark urine, yellowing of eyes, etc.) or sensitivity reactions (rash, fever, fatigue, difficulty breathing, etc.) to your doctor.
    • Odefsey (emtricitabine / rilpivirine / tenofovir) should be taken at the same time everyday.
    • Take each dose with a light meal.
    • Talk to your doctor immediately if you notice yellowing of eyes or skin, dark urine, rash, fever, fatigue, or have difficulty breathing, as these may be signs of liver problems or sensitivity reactions.
    • Side effects such as dizziness, insomnia, and/or abnormal dreams are common within the first few weeks of starting Atripla (efavirenz / emtricitabine / tenofovir). Talk to your doctor if these side effects last longer or are preventing you from taking your medication regularly.
    • Should be taken on an empty stomach at bedtime to reduce side effects.
    • Women taking Atripla (efavirenz / emtricitabine / tenofovir) should be on effective form(s) of contraception, as Atripla (efavirenz / emtricitabine / tenofovir) can cause birth defects.
    • Keep your regularly scheduled doctor's and lab appointments. These help ensure your medication is working well and safely.
    • Since Truvada (Emtricitabine / Tenofovir) is only taken once a day, try taking it at the same time as your other HIV medications.
    • If being used for kids, the dose of Truvada (Emtricitabine / Tenofovir) will continue to change as they grow, so keep in touch with their doctor.
    • Keep an eye out for any new symptoms or side effects you may start to feel while taking Truvada (Emtricitabine / Tenofovir) and report them to your doctor.
    • Practice safe sex while taking Truvada (Emtricitabine / Tenofovir) since the medication will not stop you from passing HIV to other people.
    Coming soon
    • Edurant (rilpivirine) should be taken at the same time everyday.
    • For missed doses, take one if you remember within 12 hours of your regularly scheduled time. Don't take two doses at the same time.
    • Take each dose with a meal.
    • Immediately report any signs of liver problems (jaundice, dark urine, yellowing of eyes, etc.) or sensitivity reactions (rash, fever, fatigue, difficulty breathing, etc.) to your doctor.
    • Emtriva (emtricitabine) should be taken at the same time everyday, with or without food.
    • For missed doses, take one if you remember within 12 hours of your regularly scheduled time. Don't take extra medicine or double up if you've missed a previous dose.
    • Keep your regularly scheduled doctor's and lab appointments. These help ensure your medication is working well and safely.
    • Immediately report any signs of liver problems (jaundice, dark urine, yellowing of eyes, etc.) or sensitivity reactions (rash, fever, fatigue, difficulty breathing, etc.) to your prescriber.
    Learn more
    More about CompleraSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Complera (emtricitabine / rilpivirine / tenofovir)?
    Worth itNot sureNot worth it
    More about OdefseySide effectsFDA package insert
    Have you used Odefsey (emtricitabine / rilpivirine / tenofovir)?
    Worth itNot sureNot worth it
    More about AtriplaSide effectsReviews & ratingsFDA package insert
    Have you used Atripla (efavirenz / emtricitabine / tenofovir)?
    Worth itNot sureNot worth it
    More about TruvadaSide effectsReviews & ratingsFDA package insert
    Have you used Truvada (emtricitabine / tenofovir)?
    Worth itNot sureNot worth it
    More about StribildSide effectsReviews & ratingsFDA package insert
    Have you used Stribild (elvitegravir / cobicistat / emtricitabine / tenofovir)?
    Worth itNot sureNot worth it
    More about EdurantSide effectsReviews & ratingsFDA package insert
    Have you used Edurant (rilpivirine)?
    Worth itNot sureNot worth it
    More about EmtrivaSide effectsFDA package insert
    Have you used Emtriva (emtricitabine)?
    Worth itNot sureNot worth it