Prescription onlyLower-cost generic available



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Helps you feel less queasy.

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Prescription onlyLower-cost generic available

Our bottom line

Compro (Prochlorperazine) can be used to treat severe nausea and vomiting and can be taken orally or rectally, but get ready for a nap.


  • Available in generic, so it's cheap.
  • Can be taken by mouth, as a shot, or rectally.
  • Can take anywhere from 10 minutes (by shot) to 60 minutes (rectally) to start working.


  • Can make you really drowsy. Drinking alcohol with it can make the drowsiness even worse.
  • Can't be used by people over 65 because they can be more affected by the side effects.
  • It can make you more likely to get heatstroke.

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What to expect when you take Compro (Prochlorperazine)

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Tips from our pharmacists
  • Compro comes in different forms. Be clear on which one you were prescribed - swallow tablets orally, unwrap and insert suppositories rectally.
  • You'll likely feel very sleepy, sluggish, or less alert after taking Compro. Avoid driving or other tasks that require your focused attention; be safe.
  • Don't drink alcohol to avoid intense side effects.
  • Taking certain medications for pain, allergies, or mood conditions can worsen the side effects of Compro.
  • Avoid using if you experience seizures (epilepsy).
  • Don't use if you're 65 or older because you're at higher risk for serious side effects.
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Side effects for Compro (Prochlorperazine)

Manufacturers don’t say how common these side effects are

  • Abnormally large breasts in males
  • Agranulocytosis
  • Amenorrhoea
  • Aplastic anaemia
  • Asphyxia
  • Asthma
  • Bleeding under the skin
  • Blood disorder
  • Body shaking
  • Body temperature increased
  • Breast feeding
  • Cholestasis
  • Cogwheel rigidity
  • Colon atonic
  • Coloring of the skin
  • Constipation
  • Constricted pupil
  • Corneal deposits
  • Cough
  • Dangerously high body temperature
  • Death
  • Deep skin swelling
  • Dependence physiological
  • Dermatitis contact
  • Dermatitis exfoliative
  • Difficulty swallowing
  • Dilated pupil
  • Dizziness
  • Drooling
  • Drowsiness
  • Dry mouth
  • Edema cerebral
  • Electroencephalogram abnormal
  • Eosinophilia
  • Excessive bruising or bleeding
  • Extrapyramidal symptoms
  • Eye deviation
  • Eye retina disorder
  • Feeling jittery
  • Flu
  • Gait shuffling
  • Grand mal convulsion
  • Headache
  • Hepatocellular injury
  • High blood sugar
  • Hives
  • Hyperactive muscle reflexes
  • Hypersensitivity
  • Ileus paralytic
  • Impotence
  • Increased appetite
  • Infection
  • Itching
  • Jaundice cholestatic
  • Keratopathy
  • Laryngeal oedema
  • Leaking fluid from nipples
  • Leg or ankle swelling
  • Life-threatening fever and muscle rigidity
  • Lockjaw
  • Low blood cell count
  • Low blood pressure
  • Low blood sugar
  • Low red blood cell count
  • Low red blood cells
  • Low white blood cells
  • Lupus, autoimmune disorder
  • Lupus, autoimmune disorder
  • Malignant syndrome nos
  • Menstruation irregular
  • Mitral valve incompetence
  • Motor restlessness
  • Movements involuntary
  • Muscle rigidity
  • Muscle spasms
  • Muscle twitching
  • Nasal congestion
  • Obstipation
  • Opisthotonus
  • Orofacial dyskinesia
  • Paralyzed intestines
  • Persistent and painful erection
  • Petit mal epilepsy
  • Phaeochromocytoma
  • Pigmentation skin
  • Pregnancy test false positive
  • Pregnancy test positive
  • Protrusion tongue
  • Pseudoparkinsonism
  • Rash
  • Redness
  • Relaxation or sleepiness
  • Restlessness
  • Retinitis pigmentosa
  • Scaly, itchy rash
  • Sensitivity to light
  • Serious allergic reaction
  • Shortness of breath
  • Skin disorder
  • Sleep difficulty
  • Stopped heart and circulation
  • Stupor
  • Sudden death
  • Sugar in urine
  • Swelling due to excess fluid
  • Tenderness
  • Throat sore
  • Throat tightness
  • Torticollis
  • Tremor
  • Tremulousness
  • Urinary retention
  • Vision blurred
  • Weight increased
  • Yellow skin or eyes

Risks and Warnings for Compro (Prochlorperazine)

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    • Higher risk if:
    • Over age 65
    • Dementia
    • Taking antipsychotics

    It is not recommended for people with dementia over age 65 who are taking antipsychotic medications to take Compro (Prochlorperazine), as there is an increased risk of death. Your doctor will discuss alternatives.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Compro (Prochlorperazine)

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The FDA category for this medication is N. It is advised that you: Unknown
  • Upsides and downsides from our pharmacists
  • Can make you really drowsy. Drinking alcohol with it can make the drowsiness even worse.
  • Tips from our pharmacists
  • Don't drink alcohol to avoid intense side effects.
  • Upsides and downsides from our pharmacists
  • Can make you really drowsy. Drinking alcohol with it can make the drowsiness even worse.