Prescription onlyLower-cost generic availableClass: Neuro/psych

Comtan 

(entacapone)

Prescription onlyLower-cost generic availableClass: Neuro/psych
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Treats Parkinson's disease.

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Our bottom line

Comtan (entacapone) enhances the effect of carbidopa/levodopa. It's usually added on when carbidopa/levodopa starts to lose its effect on Parkinson's disease.

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Upsides

  • Allows you to get more out of carbidopa/levodopa, especially in later stages of Parkinson's disease.
  • Comtan (entacapone) is available in a single pill combination with carbidopa/levodopa.

Downsides

  • Must be taken with other medicines for Parkinson's disease
  • Can make you lightheaded especially if you suddenly stand up from sitting or lying down.
  • Can make you very sleepy
  • May require frequent adjustments before finding the dose that works best for you
How it works

Comtan (entacapone) is a COMT inhibitor. It prevents levodopa from breaking down before it enters the brain.

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Side effect rates for Comtan (entacapone)

1003 From clinical trials of entacapone / Parkinson's disease
  • Difficulty controlling movements
  • Nausea
  • Muscle spasm
  • Changes in urine color
  • Diarrhea
  • Muscle rigidity
  • Dizziness
  • Abdominal pain
  • Fatigue
  • Constipation

Risks and Warnings for Comtan (entacapone)

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    • Higher risk if:
    • Taking other medicines for Parkinson's

    Comtan (entacapone) can make you very sleepy. Don't drive or do anything that requires your full concentration until you know how Comtan (entacapone) affects you. This is more likely if you're also taking other medicines for Parkinson's. Talk to your doctor if this bothers you.

Common concerns from people taking Comtan (entacapone)

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Sleep
  • Comtan (entacapone) can make you very sleepy. Don't drive or do anything that requires your full concentration until you know how Comtan (entacapone) affects you. This is more likely if you're also taking other medicines for Parkinson's. Talk to your doctor if this bothers you.
  • Can make you very sleepy. Don't drive or do anything requiring concentration until you know how it affects you.
  • Can make you very sleepy