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(Esterified Estrogen / Methyltestosterone)

Prescription onlyLower-cost generic available
  • Pill
  • Hot flashes and night sweats
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Relieves hot flashes due to menopause.

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Our bottom line

Covaryx (Esterified Estrogen / Methyltestosterone) is a good option if estrogen alone didn’t help relieve your hot flashes and night sweats, but there are more possible side effects from the androgen medicine, methyltestosterone.

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  • Covaryx (Esterified Estrogen / Methyltestosterone) relieves menopause symptoms that don't respond to estrogen therapy alone.
  • The small amout of androgen hormone may be good for your bones and libido. Androgens work in the bones, skin, and hair. They also help estrogen lower the effects of menopause.
  • For some women, a low-dose estrogen-androgen medicine like Covaryx (Esterified Estrogen / Methyltestosterone) relieved hot flashes and night sweats similar to high dose estrogen-only therapy.
  • Covaryx (Esterified Estrogen / Methyltestosterone) is available in 2 strengths, a half-strength and full-strength. Your doctor will start you at the lowest dose on a cyclic schedule (3 weeks on and 1 week off).


  • Increases your risk of endometrial and breast cancer.
  • Increases your risk of developing blood clots and stroke.
  • Can worsen your other health conditions, like high cholesterol, asthma, diabetes, fluid retention, and migraines.
  • Can't be used in people with liver problems.
  • There are some possible added side effects from the androgen medicine, such as fluid accumulation, worsening liver function tests, or heart problems, that you don't get when taking estrogen alone.
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Side effect rates for Covaryx (Esterified Estrogen / Methyltestosterone)

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These are side effects of Covaryx (Esterified Estrogen / Methyltestosterone) reported to the FDA by people taking it, and by doctors and pharmacists.
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Risks and Warnings for Covaryx (Esterified Estrogen / Methyltestosterone)

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    • Higher risk if:
    • Using estrogen for more than one year

    Vaginal bleeding after menopause can be a warning sign of uterus (endometrial) cancer, so let your doctor know if you notice any unusual bleeding. When estrogen is prescribed to women after menopause who still have a uterus, progestin should be used with it to lower the risk of cancer. Low-dose vaginal estrogen products are often a better choice than oral pills for women 65 years or older who have vaginal symptoms.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Covaryx (Esterified Estrogen / Methyltestosterone)

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  • The small amout of androgen hormone may be good for your bones and libido. Androgens work in the bones, skin, and hair. They also help estrogen lower the effects of menopause.
  • Can cause nausea, dizziness, bloating, and breast tenderness.