Prescription onlyLower-cost generic availableClass: Women's health

Covaryx Alternatives

(Esterified Estrogen / Methyltestosterone)

Prescription onlyLower-cost generic availableClass: Women's health
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Compare Covaryx (Esterified Estrogen / Methyltestosterone) to alternatives

These medications are comparable to Covaryx (Esterified Estrogen / Methyltestosterone) or used for similar purposes.

Covaryx
(Esterified Estrogen / Methyltestosterone)

Angeliq
(Drospirenone / Estradiol)

Climara Pro
(Estradiol / Levonorgestrel Patch)

Combipatch
(Estradiol / Norethindrone Patch)

Activella
(Estradiol / Norethindrone)

Prefest
(Estradiol / Norgestimate)

Relieves hot flashes due to menopause. Covaryx (Esterified Estrogen / Methyltestosterone) is a good option if estrogen alone didn’t help relieve your hot flashes and night sweats, but there are more possible side effects from the androgen medicine, methyltestosterone.Relieves hot flashes and vaginal dryness due to menopause. Angeliq (Drospirenone / Estradiol) helps relieve menopausal symptoms. There can be many side effects, so it's important to think through the benefits and potential hassles of this drug before using it.Relieves hot flashes and lowers your risk of osteoporosis. The Climara Pro (Estradiol / Levonorgestrel Patch) is effective at treating menopause symptoms, and it can be a good choice for women who need estrogen/progestin combo medications, but prefer to use a patch once a week instead of pills every day.Treats low estrogen and relieves menopause symptoms. Combipatch (Estradiol / Norethindrone Patch) is effective at treating menopause symptoms, and it can be a good choice for women who need estrogen/progestin combo medications, but prefer to use a patch every twice a week instead of pills every day.Relieves menopause symptoms and lowers your risk of osteoporosis. Activella (Estradiol / Norethindrone) is effective at treating symptoms related to menopause and preventing bone loss. The estrogen/progestin combo is a good options for women with an intact uterus.Relieves menopause symptoms and lowers your risk of osteoporosis. Prefest (Estradiol / Norgestimate) is effective at treating symptoms related to menopause and bone loss. It has a difficult dosing schedule to follow, but doesn't affect your cholesterol and triglyceride levels as much as other estrogen products.
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Reviews & ratings
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Not enough reviews for this drug. Help someone out, leave a review!

Have you used Covaryx (Esterified Estrogen / Methyltestosterone)?
Worth itNot sureNot worth it

Not enough reviews for this drug. Help someone out, leave a review!

Have you used Angeliq (Drospirenone / Estradiol)?
Worth itNot sureNot worth it

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Have you used Climara Pro (Estradiol / Levonorgestrel Patch)?
Worth itNot sureNot worth it

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Have you used Combipatch (Estradiol / Norethindrone Patch)?
Worth itNot sureNot worth it

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Have you used Activella (Estradiol / Norethindrone)?
Worth itNot sureNot worth it

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Have you used Prefest (Estradiol / Norgestimate)?
Worth itNot sureNot worth it
Side effects
CovaryxAngeliqClimara ProCombipatchEstradiol NorethindronePrefest

We haven’t found good data for Covaryx side effects.

FDA side effect reports for Covaryx »
  • Stomach pain 3%
  • Headache 1%
  • Yeast infections 5%
  • Breast pain 2%
  • Nausea 2%
  • Diarrhea 1%
  • Swelling of arms and legs 1%
  • Vaginal bleeding 14%
More Angeliq side effects »
  • Application site reaction 41%
  • Vaginal bleeding 37%
  • Breast pain 19%
  • Upper respiratory infection 13%
  • Low mood disorder 6%
  • Back pain 6%
  • Flu syndrome 5%
  • Pain 5%
  • Headache 5%
More Climara Pro side effects »
  • Breast pain 18%
  • Menstrual cramps 15%
  • Back pain 6%
  • Nausea 4%
  • Flu syndrome 2%
  • Papanicolaou smear suspicious 3%
  • Muscle weakness 4%
  • Abdominal pain 3%
More Combipatch side effects »
  • Breast pain 24%
  • Ear, nose, or throat infection 18%
  • Headache 16%
  • Sinus inflammation 7%
  • Sleep difficulty 6%
  • Back pain 6%
  • Post-menopausal bleeding 5%
  • Uterine fibroid 5%
  • Infection viral 4%
  • Moniliasis genital 4%
More Estradiol Norethindrone side effects »
  • Headache 23%
  • Upper respiratory-tract infection 21%
  • Breast pain 16%
  • Back pain 12%
  • Abdominal pain 12%
  • Flu-like symptomsa-like symptoms 11%
  • Joint pain 9%
  • Vaginal bleeding (all) 9%
  • Menstrual cramps 8%
  • Sinus inflammation 8%
More Prefest side effects »
How it works
CovaryxAngeliqClimara ProCombipatchEstradiol NorethindronePrefest
Covaryx (Esterified Estrogen / Methyltestosterone) contains two hormones, an estrogen and an androgen, that work together to balance hormone changes in your body and relieve menopause symptoms.Angeliq (Drospirenone / Estradiol) is a combination medicine that works to balance hormone changes in your body during and after menopause. Estradiol (an estrogen) reduces hot flashes and night sweats. Drospirenone (a progestin) protects the uterus from damage.Climara Pro (Estradiol / Levonorgestrel Patch) is an estrogen/progestin combo patch that works to balance hormone changes in your body during and after menopause. Estradiol (an estrogen) reduces hot flashes and night sweats and prevents bone loss, but can also harm cells in the uterus after menopause. Levonorgestrel (a progestin) protects the uterus from damage.Combipatch (Estradiol / Norethindrone Patch) is an estrogen/progestin combination patch that works to balance hormone changes in your body during and after menopause. Estradiol (an estrogen) reduces hot flashes and night sweats and prevents bone loss, but can also harm cells in the uterus after menopause. Norethindrone (a progestin) protects the uterus from damage.Activella (Estradiol / Norethindrone) contains two hormones that work to balance hormone changes in your body during and after menopause. Estradiol (an estrogen) reduces hot flashes and night sweats and prevents bone loss, but can also harm cells in the uterus after menopause. Norethindrone (a progestin) protects the uterus from damage.Prefest (Estradiol / Norgestimate) is a combination oral medicine that works to balance hormone changes in your body during and after menopause. Estradiol (an estrogen) reduces hot flashes and night sweats and prevents bone loss, but can also harm cells in the uterus after menopause. Norgestimate (a progestin) protects the uterus from damage.
Type of medication
CovaryxAngeliqClimara ProCombipatchEstradiol NorethindronePrefest
Prescription only
Prescription only
Prescription only
Prescription only
Prescription only
Prescription only
Available as
CovaryxAngeliqClimara ProCombipatchEstradiol NorethindronePrefest
  • Pill
  • Pill
  • Patch
  • Patch
  • Pill
  • Pill
Used for
CovaryxAngeliqClimara ProCombipatchEstradiol NorethindronePrefest
  • Hot Flashes And Night Sweats
  • Hot Flashes And Night Sweats
  • Hot Flashes And Night Sweats
  • Hot Flashes And Night Sweats
  • Hot Flashes And Night Sweats
Risk factors for serious side effects
CovaryxAngeliqClimara ProCombipatchEstradiol NorethindronePrefest
  • Using estrogen for more than one year
  • Personal or family history of breast cancer
  • Duration of use
  • Personal or family history of blood clots
  • Obesity
  • Systemic lupus erythematosus (SLE)
  • Women of childbearing age
  • High levels of triglycerides
  • History of liver problems
  • High dose androgen therapy
Detailed Covaryx (Esterified Estrogen / Methyltestosterone) risks & warnings »
  • Using estrogen for more than one year
  • Personal or family history of breast cancer
  • Using estrogen for more than one year
  • Personal or family history of blood clots
  • Smoking
  • Obesity
  • Systemic lupus erythematosus (SLE)
  • Smoking
  • Obesity
  • High blood pressure
  • High blood sugar
  • High cholesterol
  • Age 50 or older
  • Age 65 or older
  • Kidney disease
  • Liver disease
  • Addison's disease
  • Medicines that cause high potassium levels
Detailed Angeliq (Drospirenone / Estradiol) risks & warnings »
  • Using estrogen for more than one year
  • Personal or family history of breast cancer
  • Duration of use
  • Personal or family history of blood clots
  • Obesity
  • Systemic lupus erythematosus (SLE)
  • Women of childbearing age
  • High levels of triglycerides
  • Family history of ovarian cancer
Detailed Climara Pro (Estradiol / Levonorgestrel Patch) risks & warnings »
  • Using estrogen for more than one year
  • Personal or family history of breast cancer
  • Duration of use
  • Personal or family history of blood clots
  • Obesity
  • Systemic lupus erythematosus (SLE)
  • Women of childbearing age
  • High levels of triglycerides
  • Family history of ovarian cancer
Detailed Combipatch (Estradiol / Norethindrone Patch) risks & warnings »
  • Using estrogen for more than one year
  • Personal or family history of breast cancer
  • Duration of use
  • Personal or family history of blood clots
  • Obesity
  • Systemic lupus erythematosus (SLE)
  • Women of childbearing age
  • High levels of triglycerides
  • Family history of ovarian cancer
Detailed Activella (Estradiol / Norethindrone) risks & warnings »
  • Using estrogen for more than one year
  • Personal or family history of breast cancer
  • Duration of use
  • Personal or family history of blood clots
  • Obesity
  • Systemic lupus erythematosus (SLE)
  • Women of childbearing age
  • High levels of triglycerides
  • Family history of ovarian cancer
Detailed Prefest (Estradiol / Norgestimate) risks & warnings »
Pregnancy

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Sex
CovaryxAngeliqClimara ProCombipatchEstradiol NorethindronePrefest
  • The small amout of androgen hormone may be good for your bones and libido. Androgens work in the bones, skin, and hair. They also help estrogen lower the effects of menopause.
No sex related info.No sex related info.No sex related info.No sex related info.No sex related info.
Weight
CovaryxAngeliqClimara ProCombipatchEstradiol NorethindronePrefest
  • Can cause nausea, dizziness, bloating, and breast tenderness.
No weight related info.
  • Can cause nausea, dizziness, bloating, and breast tenderness.
  • Climara Pro (Estradiol / Levonorgestrel Patch) is a mixture of estrogen and progestin. It could cause a higher risk of ovarian cancer, especially if you have a family history of it. Your doctor can help you weigh the risks versus the benefits of this medication.
  • Can cause nausea, dizziness, bloating, and breast tenderness.
  • Combipatch (Estradiol / Norethindrone Patch) is a mixture of estrogen and progestin. It could cause a higher risk of ovarian cancer, especially if you have a family history of it. Your doctor can help you weigh the risks versus the benefits of this medication.
  • Can cause nausea, dizziness, bloating, and breast tenderness.
  • Activella (Estradiol / Norethindrone) is a mixture of estrogen and progestin. It could cause a higher risk of ovarian cancer, especially if you have a family history of it. Your doctor can help you weigh the risks versus the benefits of this medication.
  • Can cause nausea, dizziness, bloating, and breast tenderness.
  • Prefest (Estradiol / Norgestimate) is a mixture of estrogen and progestin. It could cause a higher risk of ovarian cancer, especially if you have a family history of it. Your doctor can help you weigh the risks versus the benefits of this medication.
Upsides and benefits
CovaryxAngeliqClimara ProCombipatchEstradiol NorethindronePrefest
  • Covaryx (Esterified Estrogen / Methyltestosterone) relieves menopause symptoms that don't respond to estrogen therapy alone.
  • The small amout of androgen hormone may be good for your bones and libido. Androgens work in the bones, skin, and hair. They also help estrogen lower the effects of menopause.
  • For some women, a low-dose estrogen-androgen medicine like Covaryx (Esterified Estrogen / Methyltestosterone) relieved hot flashes and night sweats similar to high dose estrogen-only therapy.
  • Covaryx (Esterified Estrogen / Methyltestosterone) is available in 2 strengths, a half-strength and full-strength. Your doctor will start you at the lowest dose on a cyclic schedule (3 weeks on and 1 week off).
  • Angeliq (Drospirenone / Estradiol) replaces estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, night sweats, vaginal dryness).
  • Useful for women who experience moderate to severe symptoms of menopause.
  • Improves mood, energy, and mental alertness for some people.
  • Good for women with an intact uterus. The drospirenone (a progestin) protects against the risk of cancer in the uterus from estrogen treatment.
  • Once-a-week patch. Good for people who don't want to take daily pills.
  • The Climara Pro (Estradiol / Levonorgestrel Patch) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, vaginal dryness).
  • Fewer side effects than pills since patches contain lower amounts of hormones.
  • Good for women with an intact uterus. The levonorgestrel (a progestin) protects against the risk of cancer in the uterus caused by estrogen treatment.
  • Twice-a-week patch. Good for people who don't want to take daily pills.
  • Combipatch (Estradiol / Norethindrone Patch) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, vaginal dryness).
  • Fewer side effects than pills since patches contain lower amounts of hormones.
  • Good for women with an intact uterus. The norethindrone (a progestin) protects against the risk of cancer in the uterus caused by estrogen treatment.
  • Activella (Estradiol / Norethindrone) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, night sweats, vaginal dryness).
  • Good choice for women with intact uterus. The norethindrone (a progestin) protects against the risk of cancer in the uterus from estrogen treatment.
  • Lowers your risk of fractures by keeping your bones healthy. Make sure you also get enough calcium and Vitamin D.
  • Improves mood, energy, and mental alertness for some people.
  • Mimvey brand is less expensive than other estrogen/progestin combination medicines.
  • Prefest (Estradiol / Norgestimate) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, night sweats, vaginal dryness).
  • Lowers your risk of fractures by keeping your bones healthy. Make sure you also get enough calcium and Vitamin D.
  • Improves mood, energy, and mental alertness for some people.
  • Good for women with an intact uterus. The norgestimate (a progestin) protects against the risk of cancer in the uterus caused by estrogen treatment.
  • Doesn't affect your cholesterol levels as much as other estrogen treatments.
Downsides and risks
CovaryxAngeliqClimara ProCombipatchEstradiol NorethindronePrefest
  • Increases your risk of endometrial and breast cancer.
  • Increases your risk of developing blood clots and stroke.
  • Can worsen your other health conditions, like high cholesterol, asthma, diabetes, fluid retention, and migraines.
  • Can't be used in people with liver problems.
  • There are some possible added side effects from the androgen medicine, such as fluid accumulation, worsening liver function tests, or heart problems, that you don't get when taking estrogen alone.
  • There are more possible side effects since it exposes your whole body to two hormones.
  • Angeliq (Drospirenone / Estradiol) can't be used by women who have had their uterus removed.
  • You may get irregular bleeding and spotting that can last a few months to a year.
  • Compared to other estrogen-progestin combination medicines, you might be more likely to have blood clots with Angeliq (Drospirenone / Estradiol).
  • Angeliq (Drospirenone / Estradiol) might increase your potassium, which can be dangerous if you're taking other medicines that do the same.
  • More potential side effects than single-ingredient medications since it exposes your whole body to two hormones, estrogen and levonorgestrel (a progestin).
  • Increases your risk of developing blood clots and stroke.
  • You may get irregular bleeding and spotting that can last a few months to a year.
  • Patch can fall off.
  • Can be expensive since it's only available as a brand name product.
  • More potential side effects than single-ingredient medications since it exposes your whole body to two hormones, estrogen and norethindrone (a progestin).
  • Increases your risk of developing blood clots and stroke.
  • You may get irregular bleeding and spotting that can last a few months to a year.
  • Patch can fall off.
  • Can be expensive since it's only available as a brand name product.
  • More potential side effects since it exposes your whole body to two hormones, estrogen and norethindrone (a progestin).
  • Increases your risk of developing blood clots and stroke.
  • You may get irregular bleeding and spotting that can last a few months to a year.
  • More potential side effects since it exposes your whole body to two hormones, estrogen and norgestimate (a progestin).
  • Dosing schedule can be hard to follow with the 2 different kind of pills (estrogen-only and estrogen/progestin pills).
  • Increases your risk of developing blood clots and stroke.
  • You may get irregular bleeding and spotting that can last a few months to a year.
Tips from our pharmacists for people taking the medication
CovaryxAngeliqClimara ProCombipatchEstradiol NorethindronePrefest
  • Take Covaryx (Esterified Estrogen / Methyltestosterone) at the same time every day with food.
  • Talk to your doctor regularly (every 3 to 6 months) about using the lowest dose possible and taking it only as long as needed.
  • Don’t eat grapefruit or drink grapefruit juice while taking this medicine.
  • Can cause nausea, dizziness, bloating, and breast tenderness.
  • Tell your doctor about any unusual vaginal bleeding.
  • Get emergency care if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.
  • You can get some bleeding if you miss several doses in a row.
  • If you miss a pill and it's been more than 24 hours since you were supposed to take it, skip it and continue your normal dose. Don't ever take a double dose.
  • You and your doctor should regularly talk about how long to use Angeliq (Drospirenone / Estradiol). The longer you are on it, the more likely you are to have problems from it.
  • Can cause nausea, dizziness, and breast tenderness.
  • Tell your doctor about any unusual vaginal bleeding.
  • Tell your doctor or go to an emergency room if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.
  • Remove the patch by tearing the package by hand and not with scissors. Never cut the patch.
  • Apply the sticky side of the patch to clean, dry, hairless skin below your waistline on areas as instructed by the manufacturer (never on your breast).
  • Replace the patch weekly on a different area of your skin to lower your risk of skin irritation.
  • Fold together the sticky sides of used patches before throwing them away to avoid exposing others to the medicine. Don't flush them down the toilet.
  • Shouldn't be used forever. Talk to your doctor regularly to see if you still need treatment.
  • Can cause nausea, dizziness, bloating, and breast tenderness.
  • Tell your doctor about any unusual vaginal bleeding.
  • Get emergency care if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.
  • Remove the patch by tearing the package by hand and not with scissors. Never cut the patch.
  • Apply the sticky side of the patch to clean, dry, hairless skin below your waistline on areas as instructed by the manufacturer (never on your breast).
  • Replace the patch twice a week (every 3-4 days) on a different area of your skin to lower your risk of skin irritation.
  • Fold together the sticky sides of used patches before throwing them away to avoid exposing others to the medicine. Don't flush them down the toilet.
  • Shouldn't be used forever. Talk to your doctor regularly to see if you still need treatment.
  • Can cause nausea, dizziness, bloating, and breast tenderness.
  • Tell your doctor about any unusual vaginal bleeding.
  • Get emergency care if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.
  • Shouldn't be used forever. Talk to your doctor regularly to see if you still need treatment.
  • Can cause nausea, dizziness, bloating, and breast tenderness.
  • Tell your doctor about any unusual vaginal bleeding.
  • Get emergency care if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.
  • Follow the dosing schedule exactly to take the estrogen-only and combination estrogen/progestin pills.
  • Shouldn't be used forever. Talk to your doctor regularly to see if you still need treatment.
  • Can cause nausea, dizziness, bloating, and breast tenderness.
  • Tell your doctor about any unusual vaginal bleeding.
  • Get emergency care if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.
Learn more
More about CovaryxSide effectsAlternativesFDA package insert
Have you used Covaryx (Esterified Estrogen / Methyltestosterone)?
Worth itNot sureNot worth it
More about AngeliqSide effectsFDA package insert
Have you used Angeliq (Drospirenone / Estradiol)?
Worth itNot sureNot worth it
More about Climara ProSide effectsReviews & ratingsFDA package insert
Have you used Climara Pro (Estradiol / Levonorgestrel Patch)?
Worth itNot sureNot worth it
More about CombipatchSide effectsReviews & ratingsFDA package insert
Have you used Combipatch (Estradiol / Norethindrone Patch)?
Worth itNot sureNot worth it
More about Estradiol NorethindroneSide effectsReviews & ratingsFDA package insert
Have you used Activella (Estradiol / Norethindrone)?
Worth itNot sureNot worth it
More about PrefestSide effectsFDA package insert
Have you used Prefest (Estradiol / Norgestimate)?
Worth itNot sureNot worth it