Creon

(pancrelipase)

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Helps breaks down food.

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Our bottom line

Creon (pancrelipase) works well breaking down food when your pancreas isn't working well, but you'll need to work with your doctor to find a dose that works best for you.

Quick facts about Creon
  • Drug class: Endocrine
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Upsides

  • The sprinkle capsule can be swallowed whole or can be opened up and mixed with applesauce if you have a hard time swallowing pills.
  • It's safe to use for children and infants.
  • Studies show that Creon (pancrelipase) works well to lower stool frequency and improve stomach pain, gassiness, and stool consistency.
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Downsides

  • You need to take Creon (pancrelipase) with every meal and snack.
  • It may affect your blood sugar levels so you'll have to check your sugar levels more often if you're diabetic.
  • Sometimes you'll need to take another medication with Creon (pancrelipase) for it to work well.
  • It can be expensive and there is no generic version.
How it works

Creon (pancrelipase) replaces three important enzymes that are normally made in the pancreas to break down food.

Quick facts about Creon
  • Drug class: Endocrine
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Used for

  • Pancreatic insufficiency

Dosage forms

  • Pill
  • Delayed-release
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What to expect when you take Creon (pancrelipase) for Pancreatic insufficiency

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Side effect rates for Creon (pancrelipase)

From 96 clinical trials of Creon when taken for pancreatic insufficiency
  • High blood sugar
  • Vomiting
  • Dizziness
  • Cough
  • Low blood sugar
  • Abdominal pain
  • Abnormal feces
  • Gassy
  • Frequent bowel movements
  • Common cold

Risks and Warnings for Creon (pancrelipase)

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    • Higher risk if:
    • High dose
    • Long-term use

    Creon (pancrelipase) can sometimes cause serious scarring of the colon, especially when used in high doses or for a long time. You should take Creon (pancrelipase) only as directed, and not more than or longer than your doctor recommends.

Common concerns from people taking Creon (pancrelipase)

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Food
  • Creon (pancrelipase) should be taken with every meal and snack.
  • You need to take Creon (pancrelipase) with every meal and snack.