Prescription onlyLower-cost generic availableClass: Mental health



Prescription onlyLower-cost generic availableClass: Mental health
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Improves mood and relieves certain kinds of pain.

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Our bottom line

Cymbalta (Duloxetine) is good for treating depression and anxiety, and may help with chronic pain. More likely than other antidepressants to cause problems if you drink or have high blood pressure.

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What is GoodRx?


  • Effective at relieving depression and anxiety symptoms.
  • Lowers relapse rates for depression.
  • Can relieve some types of chronic pain. Might be particularly good at pain relief for people who are also depressed.
  • Six out of ten people who use an antidepressant for the first time find that it works for them.
People say this drug is:
496 reviews


  • Not a good option if you're a heavy drinker, or if you have liver or kidney problems.
  • Not the best option for people with high blood pressure.
  • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
  • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
How it works

Cymbalta (Duloxetine) is a serotonin and norepinephrine reuptake inhibitor (SNRI) antidepressant. It increases serotonin and norepinephrine activity in the brain, which regulates mood.

What to expect when you take Cymbalta (duloxetine) for Depression

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Side effect rates for Cymbalta (duloxetine)

13755 From clinical trials of Cymbalta / All
  • Nausea
  • Headache
  • Dry mouth
  • Somnolencee
  • Fatigue
  • Sleep difficulty
  • Constipation
  • Dizziness
  • Diarrhea
  • Decreased appetite

Risks and Warnings for Cymbalta (duloxetine)

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    • Higher risk if:
    • Age 24 years or younger

    Cymbalta (Duloxetine) may increase the risk of suicidal thoughts or behavior. Watch for worsening depression or any unusual changes in mood or behavior, especially during the first few months of treatment or when the dose changes. Report anything concerning to a doctor immediately. Cymbalta (Duloxetine) is not approved for use in children younger than age 18.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Cymbalta (duloxetine)

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  • The cost remains prohibitive even though it's offered under a generic name now
  • Take with food to avoid upset stomach.
  • A little hassle cause medication should be taken with food like a meal.
  • Take with meal
  • I started taking it with breakfast in the morning, however, one year in I started experiencing severe nausea​ to the point of throwing up in a Chick-fil-A.I talked to my doctor and decided to take it before bed. This has helped and I haven't been sick yet.
Kidneys and liver
  • Not a good option if you're a heavy drinker, or if you have liver or kidney problems.
  • Full effects in 8 to 12 weeks for mood, 2 weeks for pain.
  • I took a low dose and it still worked. Now I take 30MG every other day and still get anxiety relief and pain relief.
  • Caused me extreme scratching where I had my worse nerve pain.
  • it made my chest hurt and was giving me chest pains, felt like little jolts in my chest. felt pain when I took a deep breath
  • prevents orgasm
  • It will make you very sleepy for the first week or two but it helped my anxiety the first week and by week three my depression was more manageable! I take it with Wellbutrin to combat the sleepiness side effect.
  • Took it in the morning and would feel drowsy during the day. So tried taking it at night, but it leads to restless sleep although you might fall asleep more quickly. Just have to weigh the pros and cons according to your preference - either way it leaves you somewhat tired, which is still better than being anxious! First few weeks on the medication can be hard and make you want to stop it, but if you persevere it is totally worth it.
  • Is a good antidepressant but does cause some weight gain (15 pounds); however, I'd rather be a little over weight and happy than having horrible anxiety every day.