Prescription onlyLower-cost generic available



Prescription onlyLower-cost generic available
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Improves mood and relieves certain kinds of pain.

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Our bottom line

Cymbalta (Duloxetine) is good for treating depression and anxiety, and may help with chronic pain. More likely than other antidepressants to cause problems if you drink or have high blood pressure.

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  • Effective at relieving depression and anxiety symptoms.
  • Lowers relapse rates for depression.
  • Can relieve some types of chronic pain. Might be particularly good at pain relief for people who are also depressed.
  • Six out of ten people who use an antidepressant for the first time find that it works for them.
People say this drug is:
411 reviews


  • Not a good option if you're a heavy drinker, or if you have liver or kidney problems.
  • Not the best option for people with high blood pressure.
  • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
  • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.

What to expect when you take Cymbalta (Duloxetine) for Depression

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Side effect rates for Cymbalta (Duloxetine)

13755 From clinical trials of Cymbalta / Any condition
  • Nausea
  • Headache
  • Dry mouth
  • Somnolencee
  • Fatigue
  • Sleep difficulty
  • Constipation
  • Dizziness
  • Diarrhea
  • Decreased appetite

Risks and Warnings for Cymbalta (Duloxetine)

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    • Higher risk if:
    • Age 24 years or younger

    Cymbalta (Duloxetine) may increase the risk of suicidal thoughts or behavior. Watch for worsening depression or any unusual changes in mood or behavior, especially during the first few months of treatment or when the dose changes. Report anything concerning to a doctor immediately. Cymbalta (Duloxetine) is not approved for use in children younger than age 18.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Cymbalta (Duloxetine)

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  • Take with food to avoid upset stomach.
  • Take with food in morning. Caused a bit of nausea at first but this dissipated within the first two weeks.
  • I started taking it with breakfast in the morning, however, one year in I started experiencing severe nausea​ to the point of throwing up in a Chick-fil-A.I talked to my doctor and decided to take it before bed. This has helped and I haven't been sick yet.
  • Take with meal
Kidneys and liver
  • Not a good option if you're a heavy drinker, or if you have liver or kidney problems.
  • it helped with my pain and depression but hurt my kidneys and i stayed short of breath
  • Full effects in 8 to 12 weeks for mood, 2 weeks for pain.
  • worst side effect was extreme fatigue that never went away. Nerve 7 muscle Pain was actually made worse In the first week after starting i experienced 1 day of pain reduction and a really good mood. That disappeared and for the 3 months i took it i had no benefits.
  • Works great! Took Sciatica daily pain away pretty much. No sex drive!
  • unbearable extreme fatigue, muscle weakness, malaise, leghargy, worse mood, nausea, dizziness, brain fog, muscle pain No mood lift, felt worse than before.
  • prevents orgasm
  • I take it at night to avoid drowsiness and it helps with pain during sleep.
  • Took it in the morning and would feel drowsy during the day. So tried taking it at night, but it leads to restless sleep although you might fall asleep more quickly. Just have to weigh the pros and cons according to your preference - either way it leaves you somewhat tired, which is still better than being anxious! First few weeks on the medication can be hard and make you want to stop it, but if you persevere it is totally worth it.
  • It will make you very sleepy for the first week or two but it helped my anxiety the first week and by week three my depression was more manageable! I take it with Wellbutrin to combat the sleepiness side effect.
  • Is a good antidepressant but does cause some weight gain (15 pounds); however, I'd rather be a little over weight and happy than having horrible anxiety every day.
  • Does it cause a lot of perspiration and weight gain--sertraline did