Prescription onlyLower-cost generic availableClass: Mental health



Prescription onlyLower-cost generic availableClass: Mental health
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Improves mood and relieves certain kinds of pain.

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Our bottom line

Cymbalta (Duloxetine) is good for treating depression and anxiety, and may help with chronic pain. More likely than other antidepressants to cause problems if you drink or have high blood pressure.

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  • Effective at relieving depression and anxiety symptoms.
  • Lowers relapse rates for depression.
  • Can relieve some types of chronic pain. Might be particularly good at pain relief for people who are also depressed.
  • Six out of ten people who use an antidepressant for the first time find that it works for them.
People’s experience with Cymbalta

496reviews so far. What do you think?

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  • Not a good option if you're a heavy drinker, or if you have liver or kidney problems.
  • Not the best option for people with high blood pressure.
  • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
  • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
Prices and discounts
Lowest price for 30 60mg capsules
Determining your location...
  • Price before coupon
  • Lowest price with coupon
    93% savings
How it works

Cymbalta (Duloxetine) is a serotonin and norepinephrine reuptake inhibitor (SNRI) antidepressant. It increases serotonin and norepinephrine activity in the brain, which regulates mood.

People’s experience with Cymbalta

496reviews so far. What do you think?

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Used for
Dosage forms
  • Extended release

What to expect when you take Cymbalta (duloxetine) for Depression

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Side effect rates for Cymbalta (duloxetine)

13755 From clinical trials of Cymbalta / All
  • Nausea
  • Headache
  • Dry mouth
  • Somnolencee
  • Fatigue
  • Insomnia
  • Constipation
  • Dizziness
  • Diarrhea
  • Decreased appetite

Risks and Warnings for Cymbalta (duloxetine)

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    • Higher risk if:
    • Age 24 years or younger

    Cymbalta (Duloxetine) may increase the risk of suicidal thoughts or behavior. Watch for worsening depression or any unusual changes in mood or behavior, especially during the first few months of treatment or when the dose changes. Report anything concerning to a doctor immediately. Cymbalta (Duloxetine) is not approved for use in children younger than age 18.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Cymbalta (duloxetine)

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  • My doctor's didn't tell me you should try to limit alcohol when taking this because cymbalta can be hard on your liver. Luckily I read it online. It's just good to be cautious, you've only got one liver.
  • Take with food to avoid upset stomach.
  • Take with meal
  • I started taking it with breakfast in the morning, however, one year in I started experiencing severe nausea​ to the point of throwing up in a Chick-fil-A.I talked to my doctor and decided to take it before bed. This has helped and I haven't been sick yet.
  • Take with food in morning. Caused a bit of nausea at first but this dissipated within the first two weeks.
Kidneys and liver
  • Not a good option if you're a heavy drinker, or if you have liver or kidney problems.
  • Full effects in 8 to 12 weeks for mood, 2 weeks for pain.
  • I wish I knew it would have as beneficial an effect on my chronic pain as it did on my chronic depression; I would have stopped my pain medication earlier and relied on the Cymbalta, also would have continued taking the Cymbalta, which I did not do.
  • I took a low dose and it still worked. Now I take 30MG every other day and still get anxiety relief and pain relief.
  • it made my chest hurt and was giving me chest pains, felt like little jolts in my chest. felt pain when I took a deep breath
  • prevents orgasm
  • Adjustment period took 2-3 months (nausea, inability to orgasm, increased anxiety). But since it stabilized it's done wonders. Recommended if you're looking for a long-term medication.
  • It will make you very sleepy for the first week or two but it helped my anxiety the first week and by week three my depression was more manageable! I take it with Wellbutrin to combat the sleepiness side effect.
  • Took it in the morning and would feel drowsy during the day. So tried taking it at night, but it leads to restless sleep although you might fall asleep more quickly. Just have to weigh the pros and cons according to your preference - either way it leaves you somewhat tired, which is still better than being anxious! First few weeks on the medication can be hard and make you want to stop it, but if you persevere it is totally worth it.
  • I take it for chronic pain and lack of sleep. I have stopped and started Cymbalta during this past year with no issues.2 friends are also taking this & reported they no longer felt like themselves. I did not have any problem. It gave me some pain relief and I do sleep better. My side effects are occasional brain fog, lack of appetite, drowsiness. I will start taking it an hour or so before bed to eliminate the brain fog during my working hours.
  • Is a good antidepressant but does cause some weight gain (15 pounds); however, I'd rather be a little over weight and happy than having horrible anxiety every day.
  • Doesn't seem to make you put on weight too badly, really helps with blocking random illogical suicidal thoughts, helps depression, but barely helped my anxiety, at times anxiety felt worse, occasionally caused aggressiveness. Chronic night sweats which. Similar to the effects of menopause. Changing dosages or being on too higher dosages disables your sex drive almost completely hard to maintain erection, difficult to reach orgasm for a few months. Brain fog and memory jaded.
  • As soon as I commenced taking this, the weight dropped off without dieting or exercise. This was absolutely wonderful. I have since gained 4kg during the past two years and that would be because I needed to increase dosage to 90mg which would now be increasing my appetite. I need to keep weight in check but is not difficult. The previous medication acted like an appetite stimulant which was the last thing I needed in my life.