Cymbalta

(duloxetine)

3.6/ 5 average rating with 496 reviewsforCymbalta
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Improves mood and relieves certain types of pain.

Skip Upsides & Downsides section. Skip to side effects section.

Our bottom line

Cymbalta (duloxetine) is good for treating depression, anxiety, and some forms of chronic pain, but it is more likely than other antidepressants to cause problems if you drink alcohol or have high blood pressure.

Quick facts about Cymbalta
  • Drug class: Mental health
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (duloxetine)
Prices and discounts
Lowest price for 30 60mg capsules
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$16.25
  • Price before coupon
    $181.65
  • Lowest price with coupon
    $16.25
    91% savings

Upsides

  • Cymbalta (duloxetine) may help relieve nerve pain from diabetes and other forms of chronic pain.
  • Cymbalta (duloxetine) has several uses, which may be good for people with multiple conditions.
  • Available as a generic, which is cheaper.

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What to expect from Cymbalta, on one page

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People’s experience with Cymbalta

496reviews so far. What do you think?

Downsides

  • Cymbalta (duloxetine) may not be a good option if you're a heavy drinker, or have liver or kidney problems.
  • Cymbalta (duloxetine) can increase high blood pressure.
  • Like most antidepressants, Cymbalta (duloxetine) can cause higher risk of suicidal thoughts and behavior for people aged 24 and younger.

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Sign up and get Pill Talk, the latest in health & medicine news from Iodine

Get our free fact sheet

What to expect from Cymbalta, on one page

Download Fact Sheet
Prices and discounts
Lowest price for 30 60mg capsules
Determining your location...
$16.25
  • Price before coupon
    $181.65
  • Lowest price with coupon
    $16.25
    91% savings
How it works

Cymbalta (duloxetine) is a serotonin and norepinephrine reuptake inhibitor (SNRI). It increases serotonin and norepinephrine activity in the brain, which regulate mood.

Quick facts about Cymbalta
  • Drug class: Mental health
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (duloxetine)

Dosage forms

  • Pill
  • Extended release
People’s experience with Cymbalta

496reviews so far. What do you think?

What to expect when you take Cymbalta (duloxetine) for Anxiety

Skip what to expect section. Skip to side effects section.
Skip side effects section. Skip to risks and warnings section.

Side effect rates for Cymbalta (duloxetine)

From 13755 clinical trials of Cymbalta when taken for any indication
  • Nausea
  • Headache
  • Dry mouth
  • Drowsiness
  • Fatigue
  • Difficulty sleeping
  • Constipation
  • Dizziness
  • Diarrhea
  • Decreased appetite

Risks and Warnings for Cymbalta (duloxetine)

Skip risks section. Skip to common concerns section.
    • Higher risk if:
    • Age 24 years or younger

    Cymbalta (duloxetine) may increase the risk of suicidal thoughts or behavior. Look out for worsening depression or any unusual changes in mood or behavior, especially during the first few months of treatment or when the dose changes. Let your doctor know immediately if you notice any of these things. Cymbalta (duloxetine) is not approved for use in children younger than age 18.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Cymbalta (duloxetine)

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Price
  • Abrupt discontinuation of Cymbalta (duloxetine) may cause withdrawal symptoms. If you want stop to taking Cymbalta (duloxetine), talk to your doctor.
Alcohol
  • Avoid use of alcohol.
  • Reviewed Cymbaltaon 8/11/2017My doctor's didn't tell me you should try to limit alcohol when taking this because cymbalta can be hard on your liver. Luckily I read it online. It's just good to be cautious, you've only got one liver.
    32
    Woman
    A few months
    Anxiety
Food
  • Take with or without food, Swallow the capsule whole; do not crush or chew.
  • Reviewed Cymbaltaon 7/24/2016Take with meal
    30
    Woman
    Depression
  • Reviewed Cymbaltaon 11/17/2016I started taking it with breakfast in the morning, however, one year in I started experiencing severe nausea​ to the point of throwing up in a Chick-fil-A.I talked to my doctor and decided to take it before bed. This has helped and I haven't been sick yet.
    18
    Woman
    Chronic muscle and joint pain
  • Reviewed Cymbaltaon 1/9/2017Take with food in morning. Caused a bit of nausea at first but this dissipated within the first two weeks.
    45
    Man
    Depression
Pain
  • Reviewed Cymbaltaon 4/22/2017I have been taking this drug for a week and the side effects are unbearable. Ironically it is increasing my pain and exacerbating my sciatica. The joint pain, muscle stiffness, and fatigue are unreal. I am primarily taking this for depression and anxiety but also with the thought that it would decrease my back pain.
    35
    Woman
    A couple weeks
    Depression
  • Reviewed Cymbaltaon 9/6/2015I took a low dose and it still worked. Now I take 30MG every other day and still get anxiety relief and pain relief.
    63
    Woman
    Two years or more
    Anxiety
  • Reviewed Cymbaltaon 1/15/2016it made my chest hurt and was giving me chest pains, felt like little jolts in my chest. felt pain when I took a deep breath
    55
    Woman
    Less than a week
Sex
  • Reviewed Cymbaltaon 8/3/2015prevents orgasm
    48
    Woman
    Two years or more
  • Reviewed Cymbaltaon 6/6/2017Adjustment period took 2-3 months (nausea, inability to orgasm, increased anxiety). But since it stabilized it's done wonders. Recommended if you're looking for a long-term medication.
    25
    Woman
    Two years or more
    Anxiety
Sleep
  • Reviewed Cymbaltaon 9/23/2016It will make you very sleepy for the first week or two but it helped my anxiety the first week and by week three my depression was more manageable! I take it with Wellbutrin to combat the sleepiness side effect.
    27
    Woman
    Depression
  • Reviewed Cymbaltaon 12/15/2016Took it in the morning and would feel drowsy during the day. So tried taking it at night, but it leads to restless sleep although you might fall asleep more quickly. Just have to weigh the pros and cons according to your preference - either way it leaves you somewhat tired, which is still better than being anxious! First few weeks on the medication can be hard and make you want to stop it, but if you persevere it is totally worth it.
    23
    Man
    Anxiety
  • Reviewed Cymbaltaon 4/3/2017I take it for chronic pain and lack of sleep. I have stopped and started Cymbalta during this past year with no issues.2 friends are also taking this & reported they no longer felt like themselves. I did not have any problem. It gave me some pain relief and I do sleep better. My side effects are occasional brain fog, lack of appetite, drowsiness. I will start taking it an hour or so before bed to eliminate the brain fog during my working hours.
    56
    Woman
    A year or so
    Chronic muscle and joint pain
Weight
  • Reviewed CymbaltaIs a good antidepressant but does cause some weight gain (15 pounds); however, I'd rather be a little over weight and happy than having horrible anxiety every day.
    37
    Woman
    Two years or more
    Anxiety
  • Reviewed Cymbaltaon 7/12/2017Doesn't seem to make you put on weight too badly, really helps with blocking random illogical suicidal thoughts, helps depression, but barely helped my anxiety, at times anxiety felt worse, occasionally caused aggressiveness. Chronic night sweats which. Similar to the effects of menopause. Changing dosages or being on too higher dosages disables your sex drive almost completely hard to maintain erection, difficult to reach orgasm for a few months. Brain fog and memory jaded.
    25
    Man
    Two years or more
    Anxiety
  • Reviewed Cymbaltaon 7/30/2017As soon as I commenced taking this, the weight dropped off without dieting or exercise. This was absolutely wonderful. I have since gained 4kg during the past two years and that would be because I needed to increase dosage to 90mg which would now be increasing my appetite. I need to keep weight in check but is not difficult. The previous medication acted like an appetite stimulant which was the last thing I needed in my life.
    68
    Woman
    Two years or more
    Depression