Prescription onlyLower-cost generic availableClass: Gastrointestinal

Cytotec Alternatives

(Misoprostol)

Prescription onlyLower-cost generic availableClass: Gastrointestinal
Back to: Full Site Navigation

Compare Cytotec (Misoprostol) to alternatives

These medications are comparable to Cytotec (Misoprostol) or used for similar purposes.

Cytotec
(Misoprostol)

Carafate
(Sucralfate)

Aciphex
(Rabeprazole)

Pepcid
(Famotidine)

Prevacid
(Lansoprazole)

Protonix
(Pantoprazole)

Prilosec
(Omeprazole)

Prevents stomach ulcers and used for women's health. Cytotec (Misoprostol) is an okay medication used to prevent stomach ulcers, but can never be used by women who are pregnant or breastfeeding unless you're trying to induce labor.Coming soon.Treats heartburn and ulcers. Aciphex (Rabeprazole) is an effective medicine to treat heartburn and ulcers, but can be expensive.Relieves heartburn. Pepcid (Famotidine) works well for heartburn but may not last as long or start working as quickly as other antacids.Treats heartburn and stomach ulcers. Prevacid (Lansoprazole) gives you long-lasting heartburn relief and helps heal ulcers.Treats heartburn and stomach ulcers. Protonix (Pantoprazole) gives you long-lasting heartburn relief. Choose the cheapest proton pump inhibitor because they all work equally well for heartburn.Treats heartburn and stomach ulcers. Prilosec (Omeprazole) gives you long-lasting heartburn relief. Choose the cheapest proton pump inhibitor because they all work equally well for heartburn.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
No pricing data for this drug at this filter setting. Try searching onGoodRx
No pricing data for this drug at this filter setting. Try searching onGoodRx
No pricing data for this drug at this filter setting. Try searching onGoodRx
No pricing data for this drug at this filter setting. Try searching onGoodRx
No pricing data for this drug at this filter setting. Try searching onGoodRx
No pricing data for this drug at this filter setting. Try searching onGoodRx
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected

Not enough reviews for this drug. Help someone out, leave a review!

Have you used Cytotec (Misoprostol)?
Worth itNot sureNot worth it

Not enough reviews for this drug. Help someone out, leave a review!

Have you used Carafate (Sucralfate)?
Worth itNot sureNot worth it

Not enough reviews for this drug. Help someone out, leave a review!

Have you used Aciphex (Rabeprazole)?
Worth itNot sureNot worth it
Reviews for Pepcid (Famotidine)
75%
+75% better vs. Cytotec (Misoprostol)
41%
+41% better vs. Cytotec (Misoprostol)
8%
-8% worse vs. Cytotec (Misoprostol)
853 reviews
Have you used Pepcid (Famotidine)?
Worth itNot sureNot worth it

Not enough reviews for this drug. Help someone out, leave a review!

Have you used Prevacid (Lansoprazole)?
Worth itNot sureNot worth it
Reviews for Protonix (Pantoprazole)
68%
+68% better vs. Cytotec (Misoprostol)
51%
+51% better vs. Cytotec (Misoprostol)
13%
-13% worse vs. Cytotec (Misoprostol)
584 reviews
Have you used Protonix (Pantoprazole)?
Worth itNot sureNot worth it
Reviews for Prilosec (Omeprazole)
80%
+80% better vs. Cytotec (Misoprostol)
59%
+59% better vs. Cytotec (Misoprostol)
8%
-8% worse vs. Cytotec (Misoprostol)
1167 reviews
Have you used Prilosec (Omeprazole)?
Worth itNot sureNot worth it
Side effects
CytotecCarafateAciphexPepcidPrevacidPantoprazoleOmeprazole
  • Diarrhea 13%
  • Abdominal pain 7%
  • Nausea 3%
  • Passing gas 3%
  • Headache 2%
  • Indigestion 2%
More Cytotec side effects »

We haven’t found good data for Carafate side effects.

FDA side effect reports for Carafate »
  • Headache 10%
  • Diarrhea 5%
  • Nausea 5%
  • Abdominal pain 5%
  • Vomiting 4%
  • Sore throat 1%
  • Passing gas 2%
  • Pain 2%
More Aciphex side effects »
  • Headache 5%
  • Diarrhea 2%
More Pepcid side effects »
  • Diarrhea 2%
  • Abdominal pain 1%
More Prevacid side effects »

We haven’t found good data for Pantoprazole side effects.

FDA side effect reports for Pantoprazole »
  • Upper respiratory infection 75%
  • Fever 33%
  • Headache 7%
  • Abdominal pain 5%
  • Nausea 4%
  • Diarrhea 4%
  • Accidental injuries 4%
  • Passing gas 3%
  • Vomiting 3%
More Omeprazole side effects »
How it works
CytotecCarafateAciphexPepcidPrevacidPantoprazoleOmeprazole
Cytotec (Misoprostol) is a prostaglandin medication that protects the stomach from irritation and ulcers. It lowers the amount of acid your stomach produces and protects the lining from drugs that can irritate it. Cytotec (Misoprostol) also causes uterine contractions and cervical ripening in women to induce labor.Coming soon.Aciphex (Rabeprazole) is a proton pump inhibitor (PPI). It lowers the amount of acid in your stomach, treats heartburn, and heals ulcers.Pepcid (Famotidine) is a type of antacid called an H2 blocker. It blocks the chemical histamine, which lowers acid production in your stomach. This treats heartburn and helps ulcers heal.Prevacid (Lansoprazole) is a proton pump inhibitor (PPI). It lowers the amount of acid in your stomach, treats heartburn, and heals ulcers.Protonix (Pantoprazole) is a proton pump inhibitor (PPI). It lowers the amount of acid in your stomach, treats heartburn, and heals ulcers.Prilosec (Omeprazole) is a proton pump inhibitor (PPI). It lowers the amount of acid in your stomach, treats heartburn, and heals ulcers.
Type of medication
CytotecCarafateAciphexPepcidPrevacidPantoprazoleOmeprazole
Prescription only
Prescription only
Prescription or OTC
Prescription or OTC
Prescription only
Prescription or OTC
Available as
CytotecCarafateAciphexPepcidPrevacidPantoprazoleOmeprazole
  • Pill
  • Pill
  • Liquid
  • Extended release
  • Pill
  • Chewable tablet
  • Liquid
  • Extended release
  • Dissolving tablet extended release
  • Extended release
  • Extended release
Used for
CytotecCarafateAciphexPepcidPrevacidPantoprazoleOmeprazole
  • Ulcer Prevention From Taking NSAI Ds
  • Duodenal Ulcer Disease
Risk factors for serious side effects
CytotecCarafateAciphexPepcidPrevacidPantoprazoleOmeprazole
  • Pregnancy
  • Breastfeeding
  • Women of childbearing age
    Detailed Cytotec (Misoprostol) risks & warnings »
    Coming soon.
      • Helicobacter pylori infection
      • Autoimmune disease
      • Being hospitalized
      • Antibiotic use
      • Osteoporosis
      • Age 50 or older
      • Using high medication doses
      • Long-term therapy (1 year or more)
      • Smoking
      • Use of other medications that weaken bones
        Detailed Aciphex (Rabeprazole) risks & warnings »
          • Current kidney disease
            Detailed Pepcid (Famotidine) risks & warnings »
              • Helicobacter pylori infection
              • Autoimmune disease
              • Being hospitalized
              • Antibiotic use
              • Osteoporosis
              • Age 50 or older
              • Using high medication doses
              • Long-term therapy (1 year or more)
              • Smoking
              • Use of other medications that weaken bones
                Detailed Prevacid (Lansoprazole) risks & warnings »
                  • Helicobacter pylori infection
                  • Autoimmune disease
                  • Osteoporosis
                  • Age 50 or older
                  • Using high medication doses
                  • Long-term therapy (1 year or more)
                  • Smoking
                  • Use of other medications that weaken bones
                      Detailed Protonix (Pantoprazole) risks & warnings »
                        • Helicobacter pylori infection
                        • Autoimmune disease
                        • Being hospitalized
                        • Antibiotic use
                        • Osteoporosis
                        • Age 50 or older
                        • Using high medication doses
                        • Long-term therapy (1 year or more)
                        • Smoking
                        • Use of other medications that weaken bones
                          Detailed Prilosec (Omeprazole) risks & warnings »
                          Pregnancy

                          Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

                          Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

                          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                          Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

                          Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

                          Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

                          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                          Interactions
                          CytotecCarafateAciphexPepcidPrevacidPantoprazoleOmeprazole
                          No interactions related info.No interactions related info.
                          • Many drugs can interact with Aciphex (Rabeprazole), so talk to your doctor or pharmacist before starting any new medicines.
                          • Few drug interactions.
                          • Can interact with other drugs, so be sure your doctor knows all the medicine you're taking before starting Prevacid (Lansoprazole).
                          • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Prevacid (Lansoprazole).
                          • Less risk of drug interactions with Pantoprazole than with other proton pump inhibitors.
                          • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Pantoprazole.
                          • Can interact with other drugs so be sure your doctor knows all the medicine you're taking before starting Omeprazole.
                          • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Omeprazole.
                          Food
                          CytotecCarafateAciphexPepcidPrevacidPantoprazoleOmeprazole
                          • Needs to be taken with a meal, with the last dose of the day being taken at bedtime.
                          • Take it with food to avoid getting diarrhea.
                          No food related info.
                          • Take Aciphex (Rabeprazole) with or without food. It can work better for some people if it's taken 30 minutes before a meal.
                          No food related info.
                          • Take Prevacid (Lansoprazole) about 1 hour before a meal.
                          • Take with or without food.
                          • Take 1 hour before a meal.
                          Kidneys and liver
                          CytotecCarafateAciphexPepcidPrevacidPantoprazoleOmeprazole
                          No kidneys and liver related info.No kidneys and liver related info.No kidneys and liver related info.
                          • Can cause more serious side effects for people with kidney disease. Ask your doctor to give you a lower dose or choose a different option.
                          • Because Pepcid (Famotidine) is processed by the kidney it can cause some worrisome side effects for people with kidney problems. These include confusion, delirium, and a dangerous irregular heartbeat known as QT prolongation. If you have kidney problems, you may need a different dose to prevent this increased risk for side effects.
                          No kidneys and liver related info.No kidneys and liver related info.No kidneys and liver related info.
                          Pain
                          CytotecCarafateAciphexPepcidPrevacidPantoprazoleOmeprazole
                          • Doesn't treat stomach pain or discomfort caused by NSAIDs.
                          No pain related info.
                          • Call your doctor if you have watery stools, stomach pain, or a fever because it could be a sign of a serious infection.
                          No pain related info.No pain related info.No pain related info.No pain related info.
                          Upsides and benefits
                          CytotecCarafateAciphexPepcidPrevacidPantoprazoleOmeprazole
                          • Starts working in 30 minutes and lasts for at least 3 hours.
                          • Cytotec (Misoprostol) can be used while you are also taking nonsteroidal anti-inflammatory drugs (NSAIDs) and aspirin.
                          • It does a good job of lowering your chance of developing stomach ulcers caused by NSAIDs.
                          • Helps induce labor in women.
                          Coming soon
                          • Relieves heartburn symptoms and heals ulcers better than other stomach medicines, such as Pepcid, Tagamet, and Zantac.
                          • Lasts longer than other similar stomach medicines. Most people take it once a day.
                          • Your body won't develop a tolerance to Aciphex (Rabeprazole), so it'll work the same way as long as you need to keep taking it.
                          • Once heartburn symptoms are treated, a low dose of Aciphex (Rabeprazole) can be taken daily.
                          • Most people can take Famotidine without any noticeable day-to-day side effects.
                          • Famotidine lasts longer than many other antacids like Maalox and Tums, and you only need to take it once or twice a day.
                          • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
                          • Available as both a generic and over-the-counter option, so it's pretty affordable.
                          • Few drug interactions.
                          • Most people can take Prevacid (Lansoprazole) without any noticeable day-to-day side effects.
                          • Prevacid (Lansoprazole) lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once or twice a day.
                          • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
                          • Available as both a generic and over-the-counter option, so it's pretty affordable.
                          • Sometimes if one PPI doesn't work, another medication in the same class will work for you.
                          • Most people can take Pantoprazole without any noticeable day-to-day side effects.
                          • Pantoprazole lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once or twice a day.
                          • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
                          • In studies it was better than a placebo (sugar pill) and as good as other proton pump inhibitors at treating heartburn.
                          • Available as both a generic and over-the-counter option, so it's pretty affordable.
                          • Most people can take Omeprazole without any noticeable day-to-day side effects.
                          • Omeprazole lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once or twice a day.
                          • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
                          • In studies it was better than a placebo (sugar pill) and as good as other proton pump inhibitors at treating heartburn.
                          • Available as both a generic and over-the-counter option, so it's pretty affordable.
                          Downsides and risks
                          CytotecCarafateAciphexPepcidPrevacidPantoprazoleOmeprazole
                          • Can't be used by women who are pregnant or breastfeeding, unless your doctor is trying to induce labor. It can terminate the pregnancy altogether.
                          • Doesn't lower the risk of intestinal ulcers (only works for stomach ulcers).
                          • Should be taken the entire time you're using NSAIDs if you're at risk for getting an ulcer.
                          • Doesn't treat stomach pain or discomfort caused by NSAIDs.
                          • Needs to be taken with a meal, with the last dose of the day being taken at bedtime.
                          Coming soon
                          • Taking Aciphex (Rabeprazole) in high doses or for longer than 1 year can increase the risk for bone fractures, especially if you already have osteoporosis (weak bones).
                          • Many drugs can interact with Aciphex (Rabeprazole), so talk to your doctor or pharmacist before starting any new medicines.
                          • There's no generic version available, so it can be expensive.
                          • Other antacids like Maalox, Tums, or Rolaids often start to work more quickly than Famotidine.
                          • Medication like omeprazole (proton pump inhibitors) works better at healing and preventing stomach ulcers than medication like Famotidine (H2 blockers).
                          • Can cause more serious side effects for people with kidney disease. Ask your doctor to give you a lower dose or choose a different option.
                          • Doesn't start working as fast as some other antacids like Tums, Rolaids, or Maalox.
                          • Depending on the condition you are treating, it can take one to two weeks to get the full effect.
                          • If you are taking Prevacid (Lansoprazole) for a long time you should take a calcium supplement to prevent fragile bones.
                          • Can interact with other drugs, so be sure your doctor knows all the medicine you're taking before starting Prevacid (Lansoprazole).
                          • Doesn't start working as fast as some other antacids like Tums, Rolaids, or Maalox.
                          • Like with other proton pump inhibitors, long-term use can cause weak or broken bones.
                          • Can cause low levels of magnesium in the blood. You might need to take a magnesium supplement if you use Pantoprazole long-term.
                          • Can be expensive. Other alternatives are usually cheaper than Pantoprazole.
                          • Less risk of drug interactions with Pantoprazole than with other proton pump inhibitors.
                          • Doesn't start working as fast as some other antacids like Tums, Rolaids, or Maalox.
                          • Like with other proton pump inhibitors, long-term use can cause weak or broken bones.
                          • Can cause low levels of magnesium in the blood. You might need to take a magnesium supplement if you use Omeprazole long-term.
                          • Although the generic is affordable, other medications might still be cheaper than Omeprazole.
                          • Can interact with other drugs so be sure your doctor knows all the medicine you're taking before starting Omeprazole.
                          Tips from our pharmacists for people taking the medication
                          CytotecCarafateAciphexPepcidPrevacidPantoprazoleOmeprazole
                          • Take it with food to avoid getting diarrhea.
                          • Don't take it with antacids that have magnesium since Cytotec (Misoprostol) won't work as well.
                          • Don't give Cytotec (Misoprostol) to anyone that it isn't prescribed for, especially women who are pregnant or are trying to become pregnant.
                          • The usual dose is 200 mcg four times a day with food, but if it makes you feel sick, you can probably take 100 mcg instead.
                          Coming soon
                          • Can take a few days to start working.
                          • Take Aciphex (Rabeprazole) with or without food. It can work better for some people if it's taken 30 minutes before a meal.
                          • Call your doctor if you have watery stools, stomach pain, or a fever because it could be a sign of a serious infection.
                          • Aciphex (Rabeprazole) can lower the amount of magnesium in your body. Initial and follow-up blood tests may be needed before starting Aciphex (Rabeprazole).
                          • Short-term treatment of ulcers and acid reflux.
                          • Take Prevacid (Lansoprazole) about 1 hour before a meal.
                          • Don't chew or crush capsules, but swallow them whole.
                          • If you have trouble swallowing, there's a tablet available that dissolves in your mouth.
                          • Give Prevacid (Lansoprazole) a chance to work. You'll see some benefits right away, but the full effects can take a week or so to kick in.
                          • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Prevacid (Lansoprazole).
                          • Take with or without food.
                          • Swallow tablets whole; don't split, crush, or chew.
                          • Take the oral suspension 30 minutes before a meal mixed only with applesauce or apple juice. Follow instructions carefully.
                          • When using Pantoprazole long-term, take a calcium citrate with vitamin D supplement daily to prevent bone loss. Be sure it's calcium citrate because it works the best when using a proton pump inhibitor.
                          • Get a blood test for your magnesium level once a year; you may need a magnesium supplement while using Pantoprazole.
                          • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Pantoprazole.
                          • Take 1 hour before a meal.
                          • Don't chew or crush capsules; swallow them whole.
                          • If you have trouble swallowing you can carefully open the capsules and sprinkle the inside pellets onto applesauce. Swallow the applesauce without chewing or crushing the pellets.
                          • When using Omeprazole long-term, take a calcium citrate with vitamin D supplement daily to prevent bone loss. Be sure it's calcium citrate because it works the best when using a proton pump inhibitor.
                          • Get a blood test for your magnesium level once a year; you may need a magnesium supplement while using Omeprazole.
                          • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Omeprazole.
                          Learn more
                          More about CytotecSide effectsAlternativesFDA package insert
                          Have you used Cytotec (Misoprostol)?
                          Worth itNot sureNot worth it
                          More about CarafateSide effectsReviews & ratingsFDA package insert
                          Have you used Carafate (Sucralfate)?
                          Worth itNot sureNot worth it
                          More about AciphexSide effectsReviews & ratingsFDA package insert
                          Have you used Aciphex (Rabeprazole)?
                          Worth itNot sureNot worth it
                          More about PepcidSide effectsReviews & ratingsFDA package insert
                          Have you used Pepcid (Famotidine)?
                          Worth itNot sureNot worth it
                          More about PrevacidSide effectsReviews & ratingsFDA package insert
                          Have you used Prevacid (Lansoprazole)?
                          Worth itNot sureNot worth it
                          More about PantoprazoleSide effectsReviews & ratingsFDA package insert
                          Have you used Protonix (Pantoprazole)?
                          Worth itNot sureNot worth it
                          More about OmeprazoleSide effectsReviews & ratingsFDA package insert
                          Have you used Prilosec (Omeprazole)?
                          Worth itNot sureNot worth it