Prescription onlyLower-cost generic available

Cytotec Alternatives

(Misoprostol)

  • Pill
  • Ulcer prevention from taking NSAIDs
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Compare Cytotec (Misoprostol) to alternatives

These medications are comparable to Cytotec (Misoprostol) or used for similar purposes.

Cytotec
(Misoprostol)

Carafate
(Sucralfate)

Aciphex
(Rabeprazole)

Pepcid
(Famotidine)

Prevacid
(Lansoprazole)

Protonix
(Pantoprazole)

Prilosec
(Omeprazole)

Prevents stomach ulcers and used for women's health. Cytotec (Misoprostol) is an okay medication used to prevent stomach ulcers, but can never be used by women who are pregnant or breastfeeding unless you're trying to induce labor.Coming soon.Treats heartburn and ulcers. Aciphex (Rabeprazole) is an effective medicine to treat heartburn and ulcers, but can be expensive.Relieves heartburn. Pepcid (Famotidine) works well for heartburn but may not last as long or start working as quickly as other antacids.Treats heartburn and stomach ulcers. Prevacid (Lansoprazole) gives you long-lasting heartburn relief and helps heal ulcers.Treats heartburn and stomach ulcers. Protonix (Pantoprazole) gives you long-lasting heartburn relief. Choose the cheapest proton pump inhibitor because they all work equally well for heartburn.Treats heartburn and stomach ulcers. Prilosec (Omeprazole) gives you long-lasting heartburn relief. Choose the cheapest proton pump inhibitor because they all work equally well for heartburn.
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Reviews & ratings
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Reviews for Pepcid (Famotidine)
75%
+75% vs. Cytotec (Misoprostol)
41%
+41% vs. Cytotec (Misoprostol)
8%
8% vs. Cytotec (Misoprostol)

Not enough reviews for this drug. Help someone out, leave a review!

Reviews for Protonix (Pantoprazole)
69%
+69% vs. Cytotec (Misoprostol)
51%
+51% vs. Cytotec (Misoprostol)
13%
13% vs. Cytotec (Misoprostol)
Reviews for Prilosec (Omeprazole)
80%
+80% vs. Cytotec (Misoprostol)
59%
+59% vs. Cytotec (Misoprostol)
7%
7% vs. Cytotec (Misoprostol)
Side effects
CytotecCarafateAciphexPepcidPrevacidPantoprazoleOmeprazole

The Cytotec FDA package insert doesn’t have numbers about how common side effects are.

More about Cytotec side effects »

We haven’t found good data for Carafate side effects.

FDA side effect reports for Carafate »
  • Passing gas 2%
  • Pain 2%
  • Constipaton 1%
  • Infection 1%
  • Sore throat 1%
More Aciphex side effects »

The Pepcid FDA package insert doesn’t have numbers about how common side effects are.

More about Pepcid side effects »
  • Diarrhea 2%
  • Abdominal pain 1%
More Prevacid side effects »

We haven’t found good data for Pantoprazole side effects.

FDA side effect reports for Pantoprazole »

The Omeprazole FDA package insert doesn’t have numbers about how common side effects are.

More about Omeprazole side effects »
How it works
CytotecCarafateAciphexPepcidPrevacidPantoprazoleOmeprazole
Cytotec (Misoprostol) is a prostaglandin medication that protects the stomach from irritation and ulcers. It lowers the amount of acid your stomach produces and protects the lining from drugs that can irritate it. Cytotec (Misoprostol) also causes uterine contractions and cervical ripening in women to induce labor.Coming soon.Aciphex (Rabeprazole) is a proton pump inhibitor (PPI). It lowers the amount of acid in your stomach, treats heartburn, and heals ulcers.Pepcid (Famotidine) is a type of antacid called an H2 blocker. It blocks the chemical histamine, which lowers acid production in your stomach. This treats heartburn and helps ulcers heal.Prevacid (Lansoprazole) is a proton pump inhibitor (PPI). It lowers the amount of acid in your stomach, treats heartburn, and heals ulcers.Protonix (Pantoprazole) is a proton pump inhibitor (PPI). It lowers the amount of acid in your stomach, treats heartburn, and heals ulcers.Prilosec (Omeprazole) is a proton pump inhibitor (PPI). It lowers the amount of acid in your stomach, treats heartburn, and heals ulcers.
Type of medication
CytotecCarafateAciphexPepcidPrevacidPantoprazoleOmeprazole
ProstaglandinPrescription only
Coming soon.
Acid reducer
Proton pump inhibitor
Prescription only
Acid reducer
Histamine blocker
Prescription or OTC
Acid reducer
Proton pump inhibitor
Prescription or OTC
Acid reducer
Proton pump inhibitor
Prescription only
Acid reducer
Proton pump inhibitor
Prescription or OTC
Available as
CytotecCarafateAciphexPepcidPrevacidPantoprazoleOmeprazole
  • Pill
  • Pill
  • Liquid
  • Extended release
  • Pill
  • Chewable tablet
  • Liquid
  • Extended release
  • Dissolving tablet extended release
  • Extended release
  • Extended release
Used for (click to learn more)
CytotecCarafateAciphexPepcidPrevacidPantoprazoleOmeprazole
  • Ulcer prevention from taking NSAIDs
  • Duodenal ulcer disease
Risk factors for serious side effects
CytotecCarafateAciphexPepcidPrevacidPantoprazoleOmeprazole
  • Pregnancy
  • Breastfeeding
  • Women of childbearing age
    Detailed Cytotec (Misoprostol) risks & warnings »
    Coming soon.Coming soon.Coming soon.Coming soon.Coming soon.Coming soon.
    Pregnancy category
    CytotecCarafateAciphexPepcidPrevacidPantoprazoleOmeprazole
    XFDA pregnancy category (Unsafe)

    Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

    See the FDA package insert
    BFDA pregnancy category (Probably safe)

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    See the FDA package insert
    CFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    BFDA pregnancy category (Probably safe)

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    See the FDA package insert
    BFDA pregnancy category (Probably safe)

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    See the FDA package insert
    BFDA pregnancy category (Probably safe)

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    See the FDA package insert
    CFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    Alcohol
    No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.
    Food
    • Needs to be taken with a meal, with the last dose of the day being taken at bedtime.
    • Take it with food to avoid getting diarrhea.
    • The usual dose is 200 mcg four times a day with food, but if it makes you feel sick, you can probably take 100 mcg instead.
    • Cytotec (Misoprostol) can cause diarrhea, stomach cramping, or nausea in some people. In most cases these problems happen during the first few weeks of treatment and stop after a week. You can lower your risk of diarrhea by taking Cytotec (Misoprostol) with food.
    No specific food-related info.
    • Take Aciphex (Rabeprazole) with or without food. It can work better for some people if it's taken 30 minutes before a meal.
    No specific food-related info.
    • Take Prevacid (Lansoprazole) about 1 hour before a meal.
    • Take with or without food.
    • Take the oral suspension 30 minutes before a meal mixed only with applesauce or apple juice. Follow instructions carefully.
    • Take 1 hour before a meal.
    Kidneys and liver
    No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.
    • Can cause more serious side effects for people with kidney disease. Ask your doctor to give you a lower dose or choose a different option.
    No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.
    Sex
    No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.
    Sleep
    No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.
    Weight
    No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.
    Upsides and benefits
    CytotecCarafateAciphexPepcidPrevacidPantoprazoleOmeprazole
    • Starts working in 30 minutes and lasts for at least 3 hours.
    • Cytotec (Misoprostol) can be used while you are also taking nonsteroidal anti-inflammatory drugs (NSAIDs) and aspirin.
    • It does a good job of lowering your chance of developing stomach ulcers caused by NSAIDs.
    • Helps induce labor in women.
    Coming soon.
    • Relieves heartburn symptoms and heals ulcers better than other stomach medicines, such as Pepcid, Tagamet, and Zantac.
    • Lasts longer than other similar stomach medicines. Most people take it once a day.
    • Your body won't develop a tolerance to Aciphex (Rabeprazole), so it'll work the same way as long as you need to keep taking it.
    • Once heartburn symptoms are treated, a low dose of Aciphex (Rabeprazole) can be taken daily.
    • Most people can take Famotidine without any noticeable day-to-day side effects.
    • Famotidine lasts longer than many other antacids like Maalox and Tums, and you only need to take it once or twice a day.
    • Few drug interactions.
    • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
    • Available as both a generic and over-the-counter option, so it's pretty affordable.
    • Most people can take Prevacid (Lansoprazole) without any noticeable day-to-day side effects.
    • Prevacid (Lansoprazole) lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once or twice a day.
    • Sometimes if one PPI doesn't work, another medication in the same class will work for you.
    • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
    • Available as both a generic and over-the-counter option, so it's pretty affordable.
    • Most people can take Pantoprazole without any noticeable day-to-day side effects.
    • Pantoprazole lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once or twice a day.
    • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
    • In studies it was better than a placebo (sugar pill) and as good as other proton pump inhibitors at treating heartburn.
    • Available as both a generic and over-the-counter option, so it's pretty affordable.
    • Most people can take Omeprazole without any noticeable day-to-day side effects.
    • Omeprazole lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once or twice a day.
    • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
    • In studies it was better than a placebo (sugar pill) and as good as other proton pump inhibitors at treating heartburn.
    • Available as both a generic and over-the-counter option, so it's pretty affordable.
    Downsides and risks
    CytotecCarafateAciphexPepcidPrevacidPantoprazoleOmeprazole
    • Can't be used by women who are pregnant or breastfeeding, unless your doctor is trying to induce labor. It can terminate the pregnancy altogether.
    • Doesn't lower the risk of intestinal ulcers (only works for stomach ulcers).
    • Should be taken the entire time you're using NSAIDs if you're at risk for getting an ulcer.
    • Doesn't treat stomach pain or discomfort caused by NSAIDs.
    • Needs to be taken with a meal, with the last dose of the day being taken at bedtime.
    Coming soon.
    • Taking Aciphex (Rabeprazole) in high doses or for longer than 1 year can increase the risk for bone fractures, especially if you already have osteoporosis (weak bones).
    • Many drugs can interact with Aciphex (Rabeprazole), so talk to your doctor or pharmacist before starting any new medicines.
    • There's no generic version available, so it can be expensive.
    • Other antacids like Maalox, Tums, or Rolaids often start to work more quickly than Famotidine.
    • Medication like omeprazole (proton pump inhibitors) works better at healing and preventing stomach ulcers than medication like Famotidine (H2 blockers).
    • Can cause more serious side effects for people with kidney disease. Ask your doctor to give you a lower dose or choose a different option.
    • Depending on the condition you are treating, it can take one to two weeks to get the full effect.
    • If you are taking Prevacid (Lansoprazole) for a long time you should take a calcium supplement to prevent fragile bones.
    • Can interact with other drugs, so be sure your doctor knows all the medicine you're taking before starting Prevacid (Lansoprazole).
    • Doesn't start working as fast as some other antacids like Tums, Rolaids, or Maalox.
    • Can cause low levels of magnesium in the blood. You might need to take a magnesium supplement if you use Pantoprazole long-term.
    • Can be expensive. Other alternatives are usually cheaper than Pantoprazole.
    • Less risk of drug interactions with Pantoprazole than with other proton pump inhibitors.
    • Doesn't start working as fast as some other antacids like Tums, Rolaids, or Maalox.
    • Like with other proton pump inhibitors, long-term use can cause weak or broken bones.
    • Can cause low levels of magnesium in the blood. You might need to take a magnesium supplement if you use Omeprazole long-term.
    • Although the generic is affordable, other medications might still be cheaper than Omeprazole.
    • Can interact with other drugs so be sure your doctor knows all the medicine you're taking before starting Omeprazole.
    • Doesn't start working as fast as some other antacids like Tums, Rolaids, or Maalox.
    • Like with other proton pump inhibitors, long-term use can cause weak or broken bones.
    Tips from our pharmacists for people taking the medication
    CytotecCarafateAciphexPepcidPrevacidPantoprazoleOmeprazole
    • Take it with food to avoid getting diarrhea.
    • Don't take it with antacids that have magnesium since Cytotec (Misoprostol) won't work as well.
    • Don't give Cytotec (Misoprostol) to anyone that it isn't prescribed for, especially women who are pregnant or are trying to become pregnant.
    • The usual dose is 200 mcg four times a day with food, but if it makes you feel sick, you can probably take 100 mcg instead.
    Coming soon.
    • Can take a few days to start working.
    • Take Aciphex (Rabeprazole) with or without food. It can work better for some people if it's taken 30 minutes before a meal.
    • Call your doctor if you have watery stools, stomach pain, or a fever because it could be a sign of a serious infection.
    • Aciphex (Rabeprazole) can lower the amount of magnesium in your body. Initial and follow-up blood tests may be needed before starting Aciphex (Rabeprazole).
    • Short-term treatment of ulcers and acid reflux.
    • Take Prevacid (Lansoprazole) about 1 hour before a meal.
    • Don't chew or crush capsules, but swallow them whole.
    • If you have trouble swallowing, there's a tablet available that dissolves in your mouth.
    • Give Prevacid (Lansoprazole) a chance to work. You'll see some benefits right away, but the full effects can take a week or so to kick in.
    • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Prevacid (Lansoprazole).
    • Take with or without food.
    • Swallow tablets whole; don't split, crush, or chew.
    • Take the oral suspension 30 minutes before a meal mixed only with applesauce or apple juice. Follow instructions carefully.
    • When using Pantoprazole long-term, take a calcium citrate with vitamin D supplement daily to prevent bone loss. Be sure it's calcium citrate because it works the best when using a proton pump inhibitor.
    • Get a blood test for your magnesium level once a year; you may need a magnesium supplement while using Pantoprazole.
    • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Pantoprazole.
    • Take 1 hour before a meal.
    • Don't chew or crush capsules; swallow them whole.
    • If you have trouble swallowing you can carefully open the capsules and sprinkle the inside pellets onto applesauce. Swallow the applesauce without chewing or crushing the pellets.
    • When using Omeprazole long-term, take a calcium citrate with vitamin D supplement daily to prevent bone loss. Be sure it's calcium citrate because it works the best when using a proton pump inhibitor.
    • Get a blood test for your magnesium level once a year; you may need a magnesium supplement while using Omeprazole.
    • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Omeprazole.
    Learn more
    More about CytotecSide effectsAlternativesFDA package insert
    More about CarafateSide effectsReviews & ratingsFDA package insert
    More about AciphexSide effectsReviews & ratingsFDA package insert
    More about PepcidSide effectsReviews & ratingsFDA package insert
    More about PrevacidSide effectsReviews & ratingsFDA package insert
    More about PantoprazoleSide effectsReviews & ratingsFDA package insert
    More about OmeprazoleSide effectsReviews & ratingsFDA package insert