Over-the-counterLower-cost generic availableClass: Respiratory

Dayquil Cold And Flu Alternatives

(acetaminophen / phenylephrine / dextromethorphan)

Over-the-counterLower-cost generic availableClass: Respiratory
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Compare Dayquil Cold And Flu (acetaminophen / phenylephrine / dextromethorphan) to alternatives

These medications are comparable to Dayquil Cold And Flu (acetaminophen / phenylephrine / dextromethorphan) or used for similar purposes.

Dayquil Cold And Flu
(acetaminophen / phenylephrine / dextromethorphan)

Tylenol Cold And Flu Severe
(acetaminophen / phenylephrine / dextromethorphan / guaifenesin)

Alka-Seltzer Plus Day Cold And Flu
(acetaminophen / dextromethorphan / phenylephrine)

Relieves cold and flu symptoms. Dayquil Cold And Flu (Acetaminophen / Phenylephrine / Dextromethorphan) is a useful combination medicine that relieves cold and flu symptoms, but make sure you really need all of its ingredients.Relieves cold and flu symptoms. Tylenol Cold And Flu Severe (Acetaminophen / Phenylephrine / Dextromethorphan / Guaifenesin) is an okay combination medicine that relieves cold and flu symptoms, so make sure you really need all of its ingredients.Relieves cold and flu symptoms. Alka-Seltzer Plus Day Cold And Flu (Acetaminophen / Dextromethorphan / Phenylephrine) is good for multiple cold symptoms, but it's more medicine than you need if you only have one symptom.
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Reviews & ratings
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5.09Dayquil Cold And Flu
Reviews for Dayquil Cold And Flu (acetaminophen / phenylephrine / dextromethorphan)
81%
of people (All ages) say Dayquil Cold And Flu (acetaminophen / phenylephrine / dextromethorphan) is worth it
38%
say it works well
5%
say it's a big hassle
1034 reviews
Have you used Dayquil Cold And Flu (acetaminophen / phenylephrine / dextromethorphan)?
Worth itNot sureNot worth it
Reviews for Tylenol Cold And Flu Severe (acetaminophen / phenylephrine / dextromethorphan / guaifenesin)
Not enough review data. Review it!
-48% worse vs. Dayquil Cold And Flu (acetaminophen / phenylephrine / dextromethorphan)
Not enough review data. Review it!
-5% worse vs. Dayquil Cold And Flu (acetaminophen / phenylephrine / dextromethorphan)
Not enough review data. Review it!
+5% better vs. Dayquil Cold And Flu (acetaminophen / phenylephrine / dextromethorphan)
Have you used Tylenol Cold And Flu Severe (acetaminophen / phenylephrine / dextromethorphan / guaifenesin)?
Worth itNot sureNot worth it
Reviews for Alka-Seltzer Plus Day Cold And Flu (acetaminophen / dextromethorphan / phenylephrine)
Not enough review data. Review it!
-31% worse vs. Dayquil Cold And Flu (acetaminophen / phenylephrine / dextromethorphan)
Not enough review data. Review it!
+12% better vs. Dayquil Cold And Flu (acetaminophen / phenylephrine / dextromethorphan)
Not enough review data. Review it!
-20% worse vs. Dayquil Cold And Flu (acetaminophen / phenylephrine / dextromethorphan)
Have you used Alka-Seltzer Plus Day Cold And Flu (acetaminophen / dextromethorphan / phenylephrine)?
Worth itNot sureNot worth it
Side effects
Dayquil Cold And FluTylenol Cold And Flu SevereAlka-Seltzer Plus Day Cold And Flu

We haven’t found good data for Dayquil Cold And Flu side effects.

FDA side effect reports for Dayquil Cold And Flu »

We haven’t found good data for Tylenol Cold And Flu Severe side effects.

FDA side effect reports for Tylenol Cold And Flu Severe »

We haven’t found good data for Alka-Seltzer Plus Day Cold And Flu side effects.

FDA side effect reports for Alka-Seltzer Plus Day Cold And Flu »
How it works
Dayquil Cold And FluTylenol Cold And Flu SevereAlka-Seltzer Plus Day Cold And Flu
Dayquil Cold And Flu (Acetaminophen / Phenylephrine / Dextromethorphan) is a combination medicine that treats cold and flu symptoms. Acetaminophen relieves pain and reduces fever. Dextromethorphan is a cough suppressant. Phenylephrine is a decongestant that clears your sinuses.Tylenol Cold And Flu Severe (Acetaminophen / Phenylephrine / Dextromethorphan / Guaifenesin) is a combination medicine that treats cold and flu symptoms. Acetaminophen relieves pain and reduces fever. Dextromethorphan is a cough suppressant. Phenylephrine is a decongestant that clears your sinuses. Guaifenesin is an expectorant that breaks up and thins out mucus.Alka-Seltzer Plus Day Cold And Flu (Acetaminophen / Dextromethorphan / Phenylephrine) is a combination medicine that treats cold and flu symptoms. Acetaminophen relieves pain and reduces fever. Dextromethorphan is a cough suppressant. Phenylephrine is a decongestant that clears your sinuses.
Type of medication
Dayquil Cold And FluTylenol Cold And Flu SevereAlka-Seltzer Plus Day Cold And Flu
Over-the-counter
Over-the-counter
Over-the-counter
Available as
Dayquil Cold And FluTylenol Cold And Flu SevereAlka-Seltzer Plus Day Cold And Flu
  • Pill
  • Liquid
  • Pill
  • Liquid
  • Pill
Used for
Dayquil Cold And FluTylenol Cold And Flu SevereAlka-Seltzer Plus Day Cold And Flu
Risk factors for serious side effects
Dayquil Cold And FluTylenol Cold And Flu SevereAlka-Seltzer Plus Day Cold And Flu
  • Drinking more than 2 alcoholic beverages a day
  • Taking with other Tylenol-containing medicines
  • History of liver disease
  • History of high blood pressure
  • Taking MAO inhibitors
Detailed Dayquil Cold And Flu (acetaminophen / phenylephrine / dextromethorphan) risks & warnings »
  • Drinking more than 2 alcoholic beverages a day
  • Taking with other Tylenol-containing medicines
  • History of liver disease
  • History of high blood pressure
  • Taking MAO inhibitors
Detailed Tylenol Cold And Flu Severe (acetaminophen / phenylephrine / dextromethorphan / guaifenesin) risks & warnings »
  • Drinking more than 2 alcoholic beverages a day
  • Taking with other Tylenol-containing medicines
  • History of liver disease
  • History of high blood pressure
  • Taking MAO inhibitors
Detailed Alka-Seltzer Plus Day Cold And Flu (acetaminophen / dextromethorphan / phenylephrine) risks & warnings »
Pregnancy

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Kidneys and liver
Dayquil Cold And FluTylenol Cold And Flu SevereAlka-Seltzer Plus Day Cold And Flu
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
  • To avoid hurting your liver, you need to keep track of the total amount of acetaminophen (APAP) you are taking since it is a very common ingredient in pain and cold/flu combination medicines.
Pain
Dayquil Cold And FluTylenol Cold And Flu SevereAlka-Seltzer Plus Day Cold And Flu
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than to other pain medications like aspirin or ibuprofen.
  • To avoid hurting your liver, you need to keep track of the total amount of acetaminophen (APAP) you are taking since it is a very common ingredient in pain and cold/flu combination medicines.
Upsides and benefits
Dayquil Cold And FluTylenol Cold And Flu SevereAlka-Seltzer Plus Day Cold And Flu
  • Dayquil Cold And Flu (Acetaminophen / Phenylephrine / Dextromethorphan) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, a cough, fever, and pain.
  • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
  • Tylenol Cold And Flu Severe (Acetaminophen / Phenylephrine / Dextromethorphan / Guaifenesin) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, a cough, fever, and pain.
  • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
  • Alka-Seltzer Plus Day Cold And Flu (Acetaminophen / Dextromethorphan / Phenylephrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, a cough, fever, and pain.
  • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than to other pain medications like aspirin or ibuprofen.
Downsides and risks
Dayquil Cold And FluTylenol Cold And Flu SevereAlka-Seltzer Plus Day Cold And Flu
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • Phenylephrine doesn't last as long as other oral decongestants like pseudoephedrine.
  • You shouldn't use it if you have high blood pressure.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • Phenylephrine doesn't last as long as other oral decongestants like pseudoephedrine.
  • You shouldn't use it if you have high blood pressure.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
  • Two of the medications in this product could potentially work against each other. Guaifenesin makes mucus easier to cough up, while dextromethorphan stops you from coughing.
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine.
  • You shouldn't use it if you have high blood pressure.
  • To avoid hurting your liver, you need to keep track of the total amount of acetaminophen (APAP) you are taking since it is a very common ingredient in pain and cold/flu combination medicines.
Tips from our pharmacists for people taking the medication
Dayquil Cold And FluTylenol Cold And Flu SevereAlka-Seltzer Plus Day Cold And Flu
  • Phenylephrine, the decongestant, can make you restless, so don't take it too close to bedtime.
  • If you get the liquid form, use the dosing cup to measure the exact amount of medicine you need.
  • Follow age-specific dosing instructions on how much to take.
  • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
  • Let your doctor know if your symptoms don't improve in a few days, or if you have a really bad sore throat with a fever, headache, nausea, or vomiting.
  • Phenylephrine, the decongestant, can make you restless, so don't take it too close to bedtime.
  • Don't crush, chew, or dissolve the caplets.
  • Follow age-specific dosing instructions on how much to take.
  • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
  • Let your doctor know if your symptoms don't improve in a few days, or if you have a really bad sore throat with a fever, headache, nausea, or vomiting.
  • Alka-Seltzer Plus Day Cold And Flu (Acetaminophen / Dextromethorphan / Phenylephrine) starts working in about 30 minutes.
  • Phenylephrine (the decongestant ingredient) can make you restless, so don't take it too close to bedtime.
  • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
  • Let your doctor know if your symptoms don't improve in a few days, or if you have a really bad sore throat with a fever, headache, nausea, or vomiting.
Learn more
More about Dayquil Cold And FluSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Dayquil Cold And Flu (acetaminophen / phenylephrine / dextromethorphan)?
Worth itNot sureNot worth it
More about Tylenol Cold And Flu SevereSide effectsReviews & ratingsFDA package insert
Have you used Tylenol Cold And Flu Severe (acetaminophen / phenylephrine / dextromethorphan / guaifenesin)?
Worth itNot sureNot worth it
More about Alka-Seltzer Plus Day Cold And FluSide effectsReviews & ratingsFDA package insert
Have you used Alka-Seltzer Plus Day Cold And Flu (acetaminophen / dextromethorphan / phenylephrine)?
Worth itNot sureNot worth it