Prescription onlyLower-cost generic available

Delestrogen

(Estradiol Valerate Injection)

  • Injection
  • Hot flashes and night sweats
  • Vaginal dryness and inflammation
  • Low estrogen
  • Primary ovarian failure
  • Advanced prostate cancer
Back to: Full Site NavigationSkip to: side effects sectionSkip to: What to expect sectionSkip to: Risks and warnings sectionSkip to: Tips from users and pharmacists

Treats low estrogen and relieves menopause symptoms.

Skip Upsides & Downsides section. Skip to side effects section.
Prescription onlyLower-cost generic available

Our pharmacists’ bottom line

The Delestrogen (Estradiol Valerate Injection) is a good once-a-month option for treating menopause symptoms and low estrogen, as long as you're comfortable with needles.

Worth it?Is it worth it?
Works well?Does it work?
Hassle?Is it a hassle?
  • You only need an injection once a month, which can be less of a hassle than pills, patches, creams, and gels.
  • The Delestrogen (Estradiol Valerate Injection) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, vaginal dryness, low energy, irritability).
  • Good for people who don't want to take daily pills.
  • Less side effects since lower amounts of estrogen is used compared to the oral pills.
  • Lowers your risk of fractures by keeping your bones healthy. Make sure you also get enough calcium and Vitamin D.
  • Can help relieve symptoms of prostate cancer or advanced breast cancer in some people.
  • Requires injection with a needle, which can be difficult for some people.
  • Increases your risk of endometrial and breast cancer.
  • If you have your uterus, you have to use the Delestrogen (Estradiol Valerate Injection) with another hormone called progestin to lower your risk of uterine cancer.
  • Increases your risk of developing blood clots and stroke.
  • Can worsen your other health conditions, like high cholesterol, asthma, diabetes, fluid retention, and migraines.
  • Can't be used in people with liver problems.
No pricing data for this drug at this filter setting. Try searching onGoodRx
Skip side effects sections. Skip to What to Expect and Pharmacists Tips section.

Side effects for Delestrogen (Estradiol Valerate Injection)

Button Group. All currently active
Button Group. All currently active

These are side effects of Delestrogen (Estradiol Valerate Injection) reported to the FDA by people taking it, and by doctors and pharmacists.

0 reports

What to expect when you take Delestrogen (Estradiol Valerate Injection)

Skip what to expect section. Skip to Risks & Warnings section.
Tips from our pharmacists
  • The Delestrogen (Estradiol Valerate Injection) is an injection that you use once a month in one of your muscles.
  • Use a new needle and syringe each time you give yourself an injection, and throw away the used syringes and needles in a protective (sharps) container. Don’t throw them in the trash.
  • Store the Delestrogen (Estradiol Valerate Injection) at room temperature, away from heat and direct light, and don’t let it get cold.
  • If you’re using the Delestrogen (Estradiol Valerate Injection) only for vaginal symptoms, there are other medicines that can work better with fewer side effects (like a vaginal cream).

Risks and Warnings for Delestrogen (Estradiol Valerate Injection)

Skip Risks and Warnings section. Skip to Tips section.
    • Higher risk if:
    • Using estrogen for more than one year

    Vaginal bleeding after menopause can be a warning sign of uterus (endometrial) cancer, so let your doctor know if you notice any unusual bleeding. When estrogen is prescribed to women after menopause who still have a uterus, progestin should be used with it to lower the risk of cancer. Low-dose vaginal estrogen products are often a better choice than oral pills for women 65 years or older who have vaginal symptoms.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Delestrogen (Estradiol Valerate Injection)

Final section. Do you want to return to drug navigation?
The FDA category for this medication is X. It is advised that you: Unsafe
Pregnancy