Prescription onlyLower-cost generic availableClass: Women's health


(estradiol valerate injection)

Prescription onlyLower-cost generic availableClass: Women's health
Back to: Full Site NavigationSkip to: side effects sectionSkip to: What to expect sectionSkip to: Risks and warnings sectionSkip to: Common concerns from users and pharmacists

Treats low estrogen and relieves menopause symptoms.

Skip Upsides & Downsides section. Skip to side effects section.

Our bottom line

The Delestrogen (Estradiol Valerate Injection) is a good once-a-month option for treating menopause symptoms and low estrogen, as long as you're comfortable with needles.

No pricing data for this drug at this filter setting. Try searching onGoodRx


  • You only need an injection once a month, which can be less of a hassle than pills, patches, creams, and gels.
  • The Delestrogen (Estradiol Valerate Injection) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, vaginal dryness, low energy, irritability).
  • Good for people who don't want to take daily pills.
  • Less side effects since lower amounts of estrogen is used compared to the oral pills.
  • Lowers your risk of fractures by keeping your bones healthy. Make sure you also get enough calcium and Vitamin D.
  • Can help relieve symptoms of prostate cancer or advanced breast cancer in some people.
People say this drug is:
35 reviews


  • Requires injection with a needle, which can be difficult for some people.
  • Increases your risk of endometrial and breast cancer.
  • If you have your uterus, you have to use the Delestrogen (Estradiol Valerate Injection) with another hormone called progestin to lower your risk of uterine cancer.
  • Increases your risk of developing blood clots and stroke.
  • Can worsen your other health conditions, like high cholesterol, asthma, diabetes, fluid retention, and migraines.
  • Can't be used in people with liver problems.
How it works

The Delestrogen (Estradiol Valerate Injection) replaces an estrogen hormone, estradiol, that your body loses during menopause. Higher levels of estradiol lower menopause-related hot flashes, night sweats, and vaginal problems.

Skip side effects section. Skip to What to Expect and Pharmacists Tips section.

Side effect rates for Delestrogen (estradiol valerate injection)

0 reports
These are side effects of Delestrogen (estradiol valerate injection) reported to the FDA by people taking it, and by doctors and pharmacists.
Filter group. All currently selected
Filter group. All currently selected

Risks and Warnings for Delestrogen (estradiol valerate injection)

Skip risks section. Skip to common concerns section.
    • Higher risk if:
    • Using estrogen for more than one year

    Vaginal bleeding after menopause can be a warning sign of uterus (endometrial) cancer, so let your doctor know if you notice any unusual bleeding. When estrogen is prescribed to women after menopause who still have a uterus, progestin should be used with it to lower the risk of cancer. Low-dose vaginal estrogen products are often a better choice than oral pills for women 65 years or older who have vaginal symptoms.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Delestrogen (estradiol valerate injection)

Final section. Do you want to return to drug navigation?