Prescription onlyLower-cost generic available

Delestrogen Alternatives

(Estradiol Valerate Injection)

  • Injection
  • Hot flashes and night sweats
  • Vaginal dryness and inflammation
  • Low estrogen
  • Primary ovarian failure
  • Advanced prostate cancer
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Compare Delestrogen (Estradiol Valerate Injection) to alternatives

These medications are comparable to Delestrogen (Estradiol Valerate Injection) or used for similar purposes.

Delestrogen
(Estradiol Valerate Injection)

Premarin
(Conjugated Estrogens)

Prempro
(Conjugated Estrogens / Medroxyprogesterone Acetate)

Provera
(Medroxyprogesterone)

Vivelle-Dot
(Estradiol Patch)

Climara
(Estradiol Patch)

Estring
(Estradiol Vaginal Ring)

Activella
(Estradiol / Norethindrone)

Divigel
(Estradiol Gel)

Treats low estrogen and relieves menopause symptoms. The Delestrogen (Estradiol Valerate Injection) is a good once-a-month option for treating menopause symptoms and low estrogen, as long as you're comfortable with needles.Treats low estrogen, relieves menopause symptoms, and lowers your risk of osteoporosis. Premarin (Conjugated Estrogens) relieves menopausal symptoms and prevents bone loss. It's an oral hormone replacement, so it can have a lot of side effects, and it's important to think through the benefits and potential hassles of this drug before using it.Coming soon.Regulates your menstrual cycle and supplements estrogen treatments for menopause. Provera (Medroxyprogesterone) works well to regulate your menstrual cycle and stop irregular bleeding. It also protects the uterus from estrogen's harmful effects.Treats low estrogen, relieves menopause symptoms, and lowers your risk of osteoporosis. The Vivelle-Dot (Estradiol Patch) needs to be replaced twice a week, but it comes in more strengths than other patches. It may have fewer side effects than oral estrogen pills.Treats low estrogen, relieves menopause symptoms, and lowers your risk of osteoporosis. You only have to think about the Climara (Estradiol Patch) once a week, and it may have fewer side effects than oral estrogen pills.Relieves vaginal dryness due to menopause. Estring (Estradiol Vaginal Ring) is a vaginal ring that may be less of a hassle than estrogen pills, gels, patches, or vaginal creams, but comes with the same side effects.Relieves menopause symptoms and lowers your risk of osteoporosis. Activella (Estradiol / Norethindrone) is effective at treating symptoms related to menopause and preventing bone loss. The estrogen/progestin combo is a good options for women with an intact uterus.Relieves hot flashes due to menopause. Divigel (Estradiol Gel) comes in 3 different strengths. It uses lower doses of estrogen than other hormone replacements and is easy to use and apply.
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Reviews & ratings
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3.9714285714285715Delestrogen
Reviews for Delestrogen (Estradiol Valerate Injection)
46%
of people say Delestrogen (Estradiol Valerate Injection) is worth it
26%
say it works well
14%
say it's a big hassle
Reviews for Premarin (Conjugated Estrogens)
50%
+4% vs. Delestrogen (Estradiol Valerate Injection)
43%
+17% vs. Delestrogen (Estradiol Valerate Injection)
11%
+3% vs. Delestrogen (Estradiol Valerate Injection)

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Reviews for Estring (Estradiol Vaginal Ring)
62%
+16% vs. Delestrogen (Estradiol Valerate Injection)
40%
+14% vs. Delestrogen (Estradiol Valerate Injection)
18%
4% vs. Delestrogen (Estradiol Valerate Injection)

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Not enough reviews for this drug. Help someone out, leave a review!

Side effects
DelestrogenPremarinPremproProveraVivelle-DotClimaraEstringEstradiol NorethindroneDivigel

We haven’t found good data for Delestrogen side effects.

FDA side effect reports for Delestrogen »
  • Abdominal pain 5%
  • Back pain 4%
  • Muscle weakness 4%
  • Breast pain 4%
  • Passing gas 4%
  • Thick vaginal discharge 3%
  • Vaginal moniliasis 2%
  • Nervousness 2%
  • Itching 2%
  • Leg cramps 2%
More Premarin side effects »

We haven’t found good data for Prempro side effects.

FDA side effect reports for Prempro »

We haven’t found good data for Provera side effects.

FDA side effect reports for Provera »
  • Headache 26%
  • Low mood disorder 7%
  • Weight increased 7%
  • Vaginal bleeding between periods 6%
  • Sinus headache 6%
  • Common cold 5%
  • Ear, nose, or throat infection 5%
  • Back pain 5%
  • Neck pain 5%
  • Constipation 4%
More Vivelle-Dot side effects »
  • Breast pain 25%
  • Ear, nose, or throat infection 9%
  • Abdominal pain 8%
  • Headache 8%
  • Swelling due to excess fluid 7%
  • Thick vaginal discharge 6%
  • Passing gas 6%
  • Inflammation inside the nose 5%
  • Sore throat 4%
  • Pain 4%
More Climara side effects »

The Estring FDA package insert doesn’t have numbers about how common side effects are.

More about Estring side effects »
  • Excessive vaginal bleeding 14%
  • Injury accidental 13%
  • Endometrial thickening 6%
  • Back pain 6%
  • Sinus inflammation 5%
  • Common cold 3%
  • Headache 3%
  • Weight increase 3%
  • "stomach flu" 2%
  • Other events 2%
More Estradiol Norethindrone side effects »
  • Metrorrhagia 8%
  • Breast tenderness 7%
  • Ear, nose, or throat infection 4%
  • Vaginal mycosis 3%
  • Common cold 2%
More Divigel side effects »
How it works
DelestrogenPremarinPremproProveraVivelle-DotClimaraEstringEstradiol NorethindroneDivigel
The Delestrogen (Estradiol Valerate Injection) replaces an estrogen hormone, estradiol, that your body loses during menopause. Higher levels of estradiol lower menopause-related hot flashes, night sweats, and vaginal problems.Premarin (Conjugated Estrogens) is an oral medication that replaces estrogen hormones during and after menopause. Higher levels of estrogen lower menopause-related hot flashes, flushing, night sweats, vaginal problems, and bone loss.Coming soon.Provera (Medroxyprogesterone) contains medroxyprogesterone, a progesterone hormone that works to balance hormone changes in the body. In premenopausal women, it prevents thickening of the uterus lining and regulates your menstrual cycle. It's also added to hormone therapy to protect the uterus from the harmful effects of estrogen.The Vivelle-Dot (Estradiol Patch) replaces an estrogen hormone, estradiol, that your body loses during and after menopause. Higher levels of estradiol relieve symptoms of low estrogen and menopause and prevent bone loss.The Climara (Estradiol Patch) replaces an estrogen hormone, estradiol, that your body loses during and after menopause. Higher levels of estradiol relieve symptoms of low estrogen and menopause and prevent bone loss.Estring (Estradiol Vaginal Ring) is a vaginal ring that replaces estrogen hormones in your vagina that your body loses during menopause. Estrogen helps rebuild and maintain vaginal tissue, relieving symptoms of vaginal dryness, soreness, irritation, and painful sex.Activella (Estradiol / Norethindrone) contains two hormones that work to balance hormone changes in your body during and after menopause. Estradiol (an estrogen) reduces hot flashes and night sweats and prevents bone loss, but can also harm cells in the uterus after menopause. Norethindrone (a progestin) protects the uterus from damage.Divigel (Estradiol Gel) replaces estrogen hormones in your vagina that your body loses during menopause. Estrogen helps relieve symptoms of menopause, such as hot flashes, night sweats, and vaginal problems.
Type of medication
DelestrogenPremarinPremproProveraVivelle-DotClimaraEstringEstradiol NorethindroneDivigel
Hormone replacement
Estrogen derivative
Prescription only
Hormone replacement
Estrogen derivative
Prescription only
Coming soon.
Hormone replacement
Progestin
Prescription only
Hormone replacement
Estrogen derivative
Prescription only
Hormone replacement
Estrogen derivative
Prescription only
Hormone replacement
Estrogen derivative
Prescription only
Hormone replacement
Estrogen
Progestin
Prescription only
Hormone replacement
Estrogen derivative
Prescription only
Available as
DelestrogenPremarinPremproProveraVivelle-DotClimaraEstringEstradiol NorethindroneDivigel
  • Injection
  • Pill
  • Pill
  • Pill
  • Patch
  • Patch
  • Vaginal ring
  • Pill
  • Cream, gel, or ointment
Used for (click to learn more)
DelestrogenPremarinPremproProveraVivelle-DotClimaraEstringEstradiol NorethindroneDivigel
  • Hot flashes and night sweats
  • Hot flashes and night sweats
  • Menopause - Moderate to severe abnormal vasomotor function Menopause - Moderate to severe vaginal atrophy - Moderate to severe vulvar atrophy Postmenopausal osteoporosis
  • Amenorrhea
  • Hot flashes and night sweats
  • Hot flashes and night sweats
  • Vaginal dryness and inflammation
  • Hot flashes and night sweats
  • Hot flashes and night sweats
Risk factors for serious side effects
DelestrogenPremarinPremproProveraVivelle-DotClimaraEstringEstradiol NorethindroneDivigel
  • Using estrogen for more than one year
  • Personal or family history of breast cancer
  • Duration of use
  • Personal or family history of blood clots
  • Obesity
  • Systemic lupus erythematosus (SLE)
  • Smoking
  • Obesity
  • High blood pressure
  • High blood sugar
  • High cholesterol
  • Age 50 or older
  • Women of childbearing age
  • High levels of triglycerides
Detailed Delestrogen (Estradiol Valerate Injection) risks & warnings »
Coming soon.Coming soon.Coming soon.Coming soon.Coming soon.Coming soon.Coming soon.Coming soon.
Pregnancy category
DelestrogenPremarinPremproProveraVivelle-DotClimaraEstringEstradiol NorethindroneDivigel
XFDA pregnancy category (Unsafe)

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

See the FDA package insert
XFDA pregnancy category (Unsafe)

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

See the FDA package insert
XFDA pregnancy category (Unsafe)

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

See the FDA package insert
XFDA pregnancy category (Unsafe)

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

See the FDA package insert
XFDA pregnancy category (Unsafe)

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

See the FDA package insert
XFDA pregnancy category (Unsafe)

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

See the FDA package insert
XFDA pregnancy category (Unsafe)

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

See the FDA package insert
XFDA pregnancy category (Unsafe)

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

See the FDA package insert
XFDA pregnancy category (Unsafe)

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

See the FDA package insert
Alcohol
No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.
  • The gel is alcohol-based and flammable, so you shouldn't smoke while applying it.
Food
No specific food-related info.No specific food-related info.No specific food-related info.No specific food-related info.No specific food-related info.No specific food-related info.No specific food-related info.No specific food-related info.No specific food-related info.
Kidneys and liver
No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.
Sex
No specific sex-related info.
  • Does not expose your partner to estrogen during sexual acitivities like vaginal estrogen creams.
No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.
  • Estring (Estradiol Vaginal Ring) relieves vaginal dryness and irritation to make sex more enjoyable.
  • You don’t have to remove Estring (Estradiol Vaginal Ring) to treat a vaginal infection or have sex.
No specific sex-related info.No specific sex-related info.
Sleep
No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.
Weight
No specific weight-related info.No specific weight-related info.No specific weight-related info.
  • Can cause headache, weight gain, breast tenderness, or changes in mood.
No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.
Upsides and benefits
DelestrogenPremarinPremproProveraVivelle-DotClimaraEstringEstradiol NorethindroneDivigel
  • You only need an injection once a month, which can be less of a hassle than pills, patches, creams, and gels.
  • The Delestrogen (Estradiol Valerate Injection) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, vaginal dryness, low energy, irritability).
  • Less side effects since lower amounts of estrogen is used compared to the oral pills.
  • Good for people who don't want to take daily pills.
  • Lowers your risk of fractures by keeping your bones healthy. Make sure you also get enough calcium and Vitamin D.
  • Can help relieve symptoms of prostate cancer or advanced breast cancer in some people.
  • Premarin (Conjugated Estrogens) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, night sweats, vaginal dryness).
  • Lowers your risk of fractures by keeping your bones healthy. Make sure you also take enough calcium and Vitamin D.
  • Does not expose your partner to estrogen during sexual acitivities like vaginal estrogen creams.
  • Improves mood, energy, and mental alertness for some people.
  • Can help relieve symptoms of prostate cancer or advanced breast cancer in some people.
Coming soon.
  • Provera (Medroxyprogesterone) can be used to treat multiple hormone problems in women.
  • After menopause, taking estrogen raises your risk of uterine cancer. However, taking progesterone, like in Provera (Medroxyprogesterone), along with estrogen gives you the positive effects of estrogen, but also prevents it from damaging your uterus.
  • Women taking an estrogen/progestin combination medications have a lower risk of uterine cancer.
  • Comes in 4 different strengths.
  • The Vivelle-Dot (Estradiol Patch) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen, like hot flashes and vaginal dryness.
  • The patch is good for people who don't want to take daily pills.
  • Can be worn while swimming, bathing, and showering.
  • By using a patch instead of a pill, there's a lower risk of side effects such as blood clots and stroke since lower amounts of estrogen are used in patches.
  • Lowers your risk of fractures by keeping your bones healthy. Make sure you also get enough calcium and Vitamin D.
  • Improves mood, energy, and mental alertness for some people.
  • The Climara (Estradiol Patch) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen, like hot flashes and vaginal dryness.
  • The patch is good for people who don't want to take daily pills.
  • Can be worn while swimming, bathing, and showering.
  • By using a patch instead of a pill, there's a lower risk of side effects such as blood clots and stroke since lower amounts of estrogen are used in patches.
  • Lowers your risk of fractures by keeping your bones healthy. Make sure you also get enough calcium and Vitamin D.
  • Improves mood, energy, and mental alertness for some people.
  • Estring (Estradiol Vaginal Ring) relieves vaginal dryness and irritation to make sex more enjoyable.
  • Works locally in the vagina and doesn't expose the rest of your body to estrogen like pills do.
  • Good option for people who don't want to take oral pills.
  • Generally works well with fewer side effects.
  • Many women think Estring (Estradiol Vaginal Ring) is easy to insert and comfortable to use.
  • In a 12-week study, Estring (Estradiol Vaginal Ring) worked well to improve vaginal problems, reduced pain during urination, and sudden urges to urinate.
  • Estring (Estradiol Vaginal Ring) slowly releases estrogen over the 90 days the ring is in place, so you only have to remove and insert a new one every three months.
  • Activella (Estradiol / Norethindrone) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, night sweats, vaginal dryness).
  • Good choice for women with intact uterus. The norethindrone (a progestin) protects against the risk of cancer in the uterus from estrogen treatment.
  • Mimvey brand is less expensive than other estrogen/progestin combination medicines.
  • Lowers your risk of fractures by keeping your bones healthy. Make sure you also get enough calcium and Vitamin D.
  • Improves mood, energy, and mental alertness for some people.
  • Divigel (Estradiol Gel) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, vaginal dryness).
  • The pre-measured packets are easy to use and can be taken anywhere.
  • Fewer side effects than pills since there are lower amounts of estrogen in topical gels.
  • In studies, when people used low doses of Divigel (Estradiol Gel), their symptoms started to improve in 5 weeks and they felt continued improvement over 8 to 12 weeks. People using the highest doses of Divigel (Estradiol Gel) felt better in just 2 weeks.
  • Divigel (Estradiol Gel) is available in 3 strengths.
  • Very few women (less than 1%) had skin irritation from the medicine.
  • Can lower your risk of fractures by keeping your bones healthy. Make sure you also get enough calcium and Vitamin D.
  • Good for people who don't want to take daily pills.
  • Improves mood, energy, and mental alertness for some people.
Downsides and risks
DelestrogenPremarinPremproProveraVivelle-DotClimaraEstringEstradiol NorethindroneDivigel
  • Requires injection with a needle, which can be difficult for some people.
  • If you have your uterus, you have to use the Delestrogen (Estradiol Valerate Injection) with another hormone called progestin to lower your risk of uterine cancer.
  • Can worsen your other health conditions, like high cholesterol, asthma, diabetes, fluid retention, and migraines.
  • Increases your risk of endometrial and breast cancer.
  • Can't be used in people with liver problems.
  • More potential side effects than estrogen creams since it exposes your whole body to estrogen.
  • If you have your uterus, you have to take Premarin (Conjugated Estrogens) with another hormone called progestin to lower your risk of uterine cancer.
  • Increases your risk of uterine and breast cancer.
  • Can't be used in people with liver problems.
  • Can be expensive since it's only available as a brand name product.
Coming soon.
  • You can't take Provera (Medroxyprogesterone) if you've had a hysterectomy (your uterus removed). You also can't take it if you're pregnant or breastfeeding, have unusual vaginal bleeding, or have a history of blood clots, certain kinds of cancer, stroke, heart attack, liver problems, or bleeding problems.
  • You need to replace the Vivelle-Dot (Estradiol Patch) twice a week, compared to other patches that are once a week.
  • If you have your uterus, you have to use the Vivelle-Dot (Estradiol Patch) with another hormone called progestin to lower your risk of uterine cancer.
  • Patch can fall off.
  • Increases your risk of uterine and breast cancer.
  • Can worsen other health conditions, like high cholesterol, asthma, diabetes, fluid retention, and migraines.
  • Can't be used in people with liver problems.
  • If you have your uterus, you have to use the Climara (Estradiol Patch) with another hormone called progestin to lower your risk of uterine cancer.
  • Patch can fall off.
  • Increases your risk of uterine and breast cancer.
  • Can worsen other health conditions, like high cholesterol, asthma, diabetes, fluid retention, and migraines.
  • Can't be used in people with liver problems.
  • Estring (Estradiol Vaginal Ring) may not be the best estrogen product if you have a narrow vagina or frequent vaginal infections.
  • The ring can fall out without you noticing it.
  • Increases your risk of endometrial (uterine cancer).
  • If you have your uterus, you might need to use Estring (Estradiol Vaginal Ring) with another hormone called progestin to lower your risk of uterine cancer.
  • Can be expensive since it's only available as a brand name product.
  • More potential side effects since it exposes your whole body to two hormones, estrogen and norethindrone (a progestin).
  • You may get irregular bleeding and spotting that can last a few months to a year.
  • If you have your uterus, you have to use Divigel (Estradiol Gel) with another hormone called progestin to lower your risk of uterine cancer.
  • It's possible to expose other people to the estrogen before it's absorbed by your skin.
  • Increases your risk of endometrial and breast cancer.
  • Can't be used in people with liver problems.
  • Can be expensive since it's only available as a brand name product.
Tips from our pharmacists for people taking the medication
DelestrogenPremarinPremproProveraVivelle-DotClimaraEstringEstradiol NorethindroneDivigel
  • The Delestrogen (Estradiol Valerate Injection) is an injection that you use once a month in one of your muscles.
  • Use a new needle and syringe each time you give yourself an injection, and throw away the used syringes and needles in a protective (sharps) container. Don’t throw them in the trash.
  • Store the Delestrogen (Estradiol Valerate Injection) at room temperature, away from heat and direct light, and don’t let it get cold.
  • If you’re using the Delestrogen (Estradiol Valerate Injection) only for vaginal symptoms, there are other medicines that can work better with fewer side effects (like a vaginal cream).
  • Take Premarin (Conjugated Estrogens) at the same time each day. If you miss a dose, take it as soon as possible, but if it’s almost time for your next dose, take only that dose.
  • Use the lowest dose possible of Premarin (Conjugated Estrogens) and take it only as long as needed. Talk to your doctor regularly to see if you still need treatment. If you’re taking Premarin (Conjugated Estrogens) only for vaginal symptoms or to prevent bone loss, there are other medicines that can work better with fewer side effects (like a vaginal cream for menopause symptoms, or non-estrogen medicine for bone loss).
  • Can cause nausea, dizziness, bloating and breast tenderness.
  • Get emergency care if you notice swelling or pain in your lower legs, sudden shortness of breath, or an unexplained severe headache.
Coming soon.
  • The dose of Provera (Medroxyprogesterone) will be different depending on what you’re using it for, so take it exactly the way your doctor tells you.
  • Talk to your doctor every few months about using the lowest possible dose of Provera (Medroxyprogesterone). Since there can be a lot of long-term side effects, take it only as long as you need it.
  • Can cause headache, weight gain, breast tenderness, or changes in mood.
  • If you're taking Provera (Medroxyprogesterone) to regulate your period, you'll get withdrawal bleeding 3 to 7 days after stopping Provera (Medroxyprogesterone).
  • Replace the patch twice a week (every 3-4 days) on a different area of your skin to lower your risk of skin irritation.
  • Remove the patch by tearing the package by hand and not with scissors. Never cut the patch.
  • Apply the sticky side of the patch to clean, dry, hairless skin below your waistline on areas as instructed by the manufacturer (never on your breast).
  • Fold together the sticky sides of used patches before throwing them away to avoid exposing others to the medicine. Don't flush them down the toilet.
  • Shouldn't be used forever. Talk to your doctor regularly to see if you still need treatment.
  • Can cause nausea, dizziness, bloating, and breast tenderness.
  • Get emergency care if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.
  • Replace the patch every 7 days on a different area of your skin to lower your risk of skin irritation.
  • Remove the patch by tearing the package by hand and not with scissors. Never cut the patch.
  • Apply the sticky side of the patch to clean, dry, hairless skin below your waistline on areas as instructed by the manufacturer (never on your breast).
  • Fold together the sticky sides of used patches before throwing them away to avoid exposing others to the medicine. Don't flush them down the toilet.
  • Shouldn't be used forever. Talk to your doctor regularly to see if you still need treatment.
  • Can cause nausea, dizziness, bloating, and breast tenderness.
  • Get emergency care if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.
  • Insert the ring as deeply as possible into your vagina. You shouldn't feel the ring once it's inserted.
  • The ring is good for 90 days in your vagina. If it falls out before the 90 days are up, just clean it with warm water and reinsert.
  • You don’t have to remove Estring (Estradiol Vaginal Ring) to treat a vaginal infection or have sex.
  • It can take up to 2 to 3 weeks to feel the full benefits.
  • Most people don't have many side effects, but temporary nausea, dizziness, bloating, and breast tenderness are possible.
  • Shouldn't be used forever. Talk to your doctor regularly to see if you still need treatment.
  • Can cause nausea, dizziness, bloating, and breast tenderness.
  • Get emergency care if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.
  • Apply all of the gel in the packet to dry, clean, unbroken skin on the right or left upper thigh, alternating each day.
  • Don't put it on your face, breasts, vagina, or irritated skin.
  • Don't rub it in. Let the gel dry before dressing, and don't wash the application site for at least an hour.
  • Wash your hands well after applying the gel.
  • The gel is alcohol-based and flammable, so you shouldn't smoke while applying it.
  • Can cause nausea, dizziness, bloating, and breast tenderness.
  • Get emergency care if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.
Learn more
More about DelestrogenSide effectsReviews & ratingsAlternativesFDA package insert
More about PremarinSide effectsReviews & ratingsFDA package insert
More about PremproSide effectsReviews & ratingsFDA package insert
More about ProveraSide effectsReviews & ratingsFDA package insert
More about Vivelle-DotSide effectsReviews & ratingsFDA package insert
More about ClimaraSide effectsReviews & ratingsFDA package insert
More about EstringSide effectsReviews & ratingsFDA package insert
More about Estradiol NorethindroneSide effectsReviews & ratingsFDA package insert
More about DivigelSide effectsReviews & ratingsFDA package insert