Prescription onlyLower-cost generic available

Depacon

(Valproate, Valproic Acid, Or Divalproex)

  • Pill
  • Extended release
  • Extended release capsule
  • Sprinkle
  • Liquid
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Prevents seizures and stabilizes mood.

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Prescription onlyLower-cost generic available

Our pharmacists’ bottom line

Depacon (Valproate, Valproic Acid, Or Divalproex) is good long-term prevention for epilepsy, bipolar disorder, and migraines, but can cause weight gain.

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  • Lowers the frequency of seizures, especially for people with absence, tonic-clonic, and complex partial seizures.
  • One of the first-line options to stabilize mood for people with bipolar disorder.
  • Helpful in preventing frequent migraine headaches.
  • Can cause upset stomach, hair loss, weight gain, sleepiness, and tremor.
  • Can cause liver damage, so it's probably not safe if you already have liver problems.
  • Not safe to use if you're pregnant.
  • Requires routine blood tests to see how the medicine is affecting your body.

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Side effects for Depacon (Valproate, Valproic Acid, Or Divalproex)

From clinical trials of Depakote / Adjunctive therapy for epilepsy, complex partial seizures ( 147)

  • NauseaNausea48% for Depakote vs.14% for placebo
  • HeadacheHeadache31% for Depakote vs.21% for placebo
  • Muscle weaknessMuscle weakness27% for Depakote vs.7% for placebo
  • VomitingVomiting27% for Depakote vs.7% for placebo
  • DrowsinessDrowsiness27% for Depakote vs.11% for placebo
  • DizzinessDizziness25% for Depakote vs.13% for placebo
  • TremorTremor25% for Depakote vs.6% for placebo
  • Abdominal painAbdominal pain23% for Depakote vs.6% for placebo
  • Double visionDouble vision16% for Depakote vs.9% for placebo
  • DiarrheaDiarrhea13% for Depakote vs.6% for placebo

What to expect when you take Depacon (Valproate, Valproic Acid, Or Divalproex) for Seizures

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Tips from our pharmacists
  • For the first week, avoid activities that require you to be alert.
  • Don't use if pregnant.
  • Requires routine blood tests.
  • Take with food to avoid upset stomach.
  • May cause hair loss and weight gain.
  • Different versions of Depakote have different dosing. Be careful.
  • Report confusion, persistent abdominal pain, yellowing of eyes/skin, or easy bruising to your doctor.
  • Takes 3 to 4 weeks to feel full effects on mood.

Risks and Warnings for Depacon (Valproate, Valproic Acid, Or Divalproex)

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  • Depacon (Valproate, Valproic Acid, Or Divalproex) can cause birth defects. If you're considering having a baby, talk to your doctor about alternative medications.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Depacon (Valproate, Valproic Acid, Or Divalproex)

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The FDA category for this medication is D. It is advised that you: Weigh risks vs. benefits
Pregnancy
Food
  • Tips from our pharmacists
  • Take with food to avoid upset stomach.
Weight gain or loss
  • Upsides and downsides from our pharmacists
  • Can cause upset stomach, hair loss, weight gain, sleepiness, and tremor.
  • Tips from our pharmacists
  • May cause hair loss and weight gain.
  • Noticeable weight gain around my gut. Had to start dieting and running on tread mill to combat the weight gain. Did not eliminate migraines, but made them less frequent and less intense. Now I can usually knock them out with a sumatriptan.
    Anonymous
    Taken for: Migraine prevention
    Duration taken: A year or so
  • The side effects can be extreme: hand tremors, weight gain, memory issues, and others.
    Age: 35
    Gender: Man
    Taken for: Seizures
    Duration taken: Two years or more
  • Be aware that if you are getting better, you'll need to lower your dose, and do it as soon as you can. I've been feeling better, but I started to get more sleepy and I could not wake up in the mornings because I couldn't listen to my alarms. Other than that, and the weight gain, it's amazing.
    Age: 21
    Gender: Woman
    Taken for: Bipolar I disorder (manic)