Prescription onlyLower-cost generic availableClass: Neurology

Depacon Alternatives

(valproate, valproic acid, or divalproex)

Prescription onlyLower-cost generic availableClass: Neurology
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Compare Depacon (valproate, valproic acid, or divalproex) to alternatives

These medications are comparable to Depacon (valproate, valproic acid, or divalproex) or used for similar purposes.

Depacon
(valproate, valproic acid, or divalproex)

Lamictal
(lamotrigine)

Tegretol
(carbamazepine)

Qudexy Xr
(topiramate)

Inderal
(propranolol)

Prevents seizures and stabilizes mood. Depacon (Valproate, Valproic Acid, Or Divalproex) is good long-term prevention for epilepsy, bipolar disorder, and migraines, but can cause weight gain.Prevents seizures and stabilizes mood. Lamictal (Lamotrigine) is most useful for treating severe seizure disorders, and for bipolar disorder with more depression symptoms than manic symptoms. Just be careful to increase your dose slowly to avoid skin rash.Prevents seizures, stabilizes mood, and relieves nerve pain. Tegretol (Carbamazepine) is useful for preventing seizures and relieving certain types of nerve pain, but interacts with many drugs.Prevents seizures and migraine headaches. Qudexy Xr (Topiramate) is useful for preventing seizures and migraines, and doesn't require blood tests while you're on it.Lowers blood pressure and controls heart rate. Inderal (Propranolol) is good for treating many heart problems and other problems in the body, but it has more side effects than other beta blockers. You can't miss doses.
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Best available price for 60 (500mg) tablets of depakote
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.44Depakote
Reviews for Depakote
46%
of people (All ages) say Depakote is worth it
40%
say it works well
27%
say it's a big hassle
Have you used Depacon (valproate, valproic acid, or divalproex)?
Worth itNot sureNot worth it
Reviews for Lamictal
66%
-20% worse vs. Depakote
58%
-18% worse vs. Depakote
18%
-9% worse vs. Depakote
184 reviews
Have you used Lamictal (lamotrigine)?
Worth itNot sureNot worth it
Reviews for Tegretol
56%
-10% worse vs. Depakote
43%
-3% worse vs. Depakote
23%
-4% worse vs. Depakote
Have you used Tegretol (carbamazepine)?
Worth itNot sureNot worth it
Reviews for Topamax
52%
-6% worse vs. Depakote
50%
-10% worse vs. Depakote
36%
+9% better vs. Depakote
Have you used Qudexy Xr (topiramate)?
Worth itNot sureNot worth it
Reviews for Propranolol
66%
-20% worse vs. Depakote
62%
-22% worse vs. Depakote
15%
-12% worse vs. Depakote
Have you used Inderal (propranolol)?
Worth itNot sureNot worth it
Side effects
DepakoteLamictalTegretolTopamaxPropranolol
  • Nausea 7%
  • Drowsiness 7%
  • Dizziness 8%
  • Vomiting 9%
  • Accidental injury 6%
  • Muscle weakness 3%
  • Abdominal pain 1%
  • Indigestion 1%
  • Any side effect 4%
  • Rash 3%
More Depakote side effects »
  • Dizziness 25%
  • Headache 9%
  • Double vision 21%
  • Lack of muscle coordination 16%
  • Nausea 9%
  • Blurred vision 11%
  • Inflammation inside the nose 5%
  • Drowsiness 7%
  • Sore throat 1%
  • Rash 5%
More Lamictal side effects »
  • Dizziness 32%
  • Drowsiness 19%
  • Nausea 18%
  • Vomiting 15%
  • Lack of muscle coordination 15%
  • Constipation 5%
  • Itching 6%
  • Dry mouth 5%
  • Muscle weakness 4%
  • Rash 3%
More Tegretol side effects »
  • Ear, nose, or throat infection 16%
  • Diarrhea 8%
  • Weight decrease 7%
  • Difficulty with concentration/attention 7%
  • Inflammation inside the nose 5%
  • Tingling sensation 3%
  • Infection 3%
  • Infection viral 3%
  • Rash 3%
  • Fatigue 17%
More Topamax side effects »
  • Dizziness 5%
  • Fatigue 2%
  • Constipation 3%
More Propranolol side effects »
How it works
DepakoteLamictalTegretolTopamaxPropranolol
Depacon (Valproate, Valproic Acid, Or Divalproex) is an antiepileptic. Researchers don't know exactly how it works. It seems to increase the amount of GABA, a chemical that calms nerves in the brain.Lamictal (Lamotrigine) is an antiepileptic. Researchers don't know exactly how it works, but it seems to calm nerve activity in the brain.Tegretol (Carbamazepine) is an antiepileptic. Researchers don't know exactly how it works, but it seems to block certain kinds of nerve activity to reduce seizures and pain.Qudexy Xr (Topiramate) is an antiepileptic. Researchers don't know exactly how it works, but it seems to affect multiple parts of the brain to control seizures and migraines.Inderal (Propranolol) is an alpha and beta blocker. It lowers blood pressure by slowing heart rate, relaxing blood vessels, and lowering the body's fight-or-flight response.
Type of medication
DepakoteLamictalTegretolTopamaxPropranolol
Prescription onlyPrescription onlyPrescription onlyPrescription onlyPrescription only
Available as
DepakoteLamictalTegretolTopamaxPropranolol
  • Pill
  • Extended release
  • Extended release capsule
  • Sprinkle
  • Liquid
  • Pill
  • Extended release
  • Chewable tablet
  • Dissolving tablet
  • Pill
  • Extended release
  • Chewable tablet
  • Oral suspension
  • Pill
  • Extended release capsule
  • Pill
  • Extended release
  • Liquid
Used for
DepakoteLamictalTegretolTopamaxPropranolol
Risk factors for serious side effects
DepakoteLamictalTegretolTopamaxPropranolol
  • Children under age 2
  • History of metabolic disorders
  • History of depression
  • People also taking Topamax
Detailed Depacon (valproate, valproic acid, or divalproex) risks & warnings »
  • History of depression
  • People also taking Depakote
  • Taking more than the prescribed dose
  • Increasing the dose too quickly
  • Taking birth control pills
Detailed Lamictal (lamotrigine) risks & warnings »
  • People also taking Depakote
  • Asian ancestry
  • History of depression
  • European, Chinese, or Japanese ancestry
  • Age 65 years or older
Detailed Tegretol (carbamazepine) risks & warnings »
  • History of depression
  • Children
  • History of metabolic disorders
  • People also taking Depakote
  • Low-carb diet
Detailed Qudexy Xr (topiramate) risks & warnings »
  • Suddenly stopping Inderal (Propranolol)
  • Major surgery requiring anesthesia
  • Diabetes
  • Concurrent use of non-dihydropyridine calcium channel blockers, digoxin or clonidine
Detailed Inderal (propranolol) risks & warnings »
Pregnancy

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Interactions
DepakoteLamictalTegretolTopamaxPropranolol
No interactions related info.No interactions related info.
  • Interacts with many other medicines and supplements.
No interactions related info.No interactions related info.
Food
DepakoteLamictalTegretolTopamaxPropranolol
  • Take with food to avoid upset stomach.
  • Take with food to avoid upset stomach.
No food related info.No food related info.No food related info.
Kidneys and liver
DepakoteLamictalTegretolTopamaxPropranolol
  • Can cause liver damage, so it's probably not safe if you already have liver problems.
No kidneys and liver related info.No kidneys and liver related info.
  • Qudexy Xr (Topiramate) may increase your risk for kidney stones. Stay well-hydrated to lower your risk.
  • A few people will get kidney stones.
No kidneys and liver related info.
Weight
DepakoteLamictalTegretolTopamaxPropranolol
  • May cause hair loss and weight gain.
  • Can cause upset stomach, hair loss, weight gain, sleepiness, and tremor.
No weight related info.No weight related info.
  • Can cause sleepiness, speech problems, tingling sensations, and weight loss.
No weight related info.
Upsides and benefits
DepakoteLamictalTegretolTopamaxPropranolol
  • Lowers the frequency of seizures, especially for people with absence, tonic-clonic, and complex partial seizures.
  • One of the first-line options to stabilize mood for people with bipolar disorder.
  • Helpful in preventing frequent migraine headaches.
  • Effective at lowering the frequency of seizures in people with epilepsy or Lennox-Gestaut syndrome. Typically used together with other medications for severe seizure disorders.
  • Works best for partial, tonic-clonic, and absence seizures.
  • A first-line treatment for bipolar disorder. Effective long-term treatment for stabilizing mood. Prevents both depressive and manic episodes, but the effect is greater for preventing depression.
  • Doesn't require routine blood tests.
  • Lowers the frequency of seizures, especially for people with tonic-clonic and partial seizures.
  • First-line option for trigeminal neuralgia (nerve pain involving the face, head, and neck), and can relieve other types of nerve pain.
  • May be helpful in stabilizing mood for people with bipolar disorder.
  • Used on its own or with other antiepileptic medicines to lower the frequency of seizures, especially for people with tonic-clonic or partial seizures, or Lennox-Gestaut syndrome.
  • Helpful in preventing frequent migraine headaches.
  • Doesn't need routine blood tests.
  • A first-choice treatment to prevent chest pain (angina).
  • A first-choice treatment for heart failure, heart attack, heart valve disorders, and abnormal heart rhythm.
  • Also treats and prevents many non-heart problems, such as tremors, anxiety, migraines, and liver disease symptoms.
Downsides and risks
DepakoteLamictalTegretolTopamaxPropranolol
  • Can cause upset stomach, hair loss, weight gain, sleepiness, and tremor.
  • Can cause liver damage, so it's probably not safe if you already have liver problems.
  • Not safe to use if you're pregnant.
  • Requires routine blood tests to see how the medicine is affecting your body.
  • Can cause double vision, dizziness, sleepiness, and headache.
  • Has the risk of a rare but life-threatening rash.
  • Can make hormonal birth control less effective.
  • Might be less effective than other medicines for treating manic episodes (acute mania) in people with bipolar disorder.
  • Interacts with many other medicines and supplements.
  • Higher risk of skin reactions compared to other antiepileptic medicines, ranging from mild to life-threatening rash.
  • Can cause blurry vision, dizziness, and upset stomach.
  • Not safe to use if you're pregnant.
  • Requires routine blood tests to see how the medicine is affecting your body.
  • Can cause sleepiness, speech problems, tingling sensations, and weight loss.
  • A few people will get kidney stones.
  • Not safe to use if you're pregnant.
  • Taking a beta blocker might make you feel more tired or out of breath during exercise or normal daily routines. This gets better for most people, but for some might not go away.
  • Has more side effects than some beta blockers because it crosses into the brain and central nervous system.
  • Not a first-choice treatment for high blood pressure according to the latest guidelines, except if you have heart failure or heart disease. As a second choice, your doctor might add it to medicines you're already taking if your blood pressure is still too high.
  • Can hide symptoms of low blood sugar if you're diabetic.
  • You can't miss doses. Stopping Propranolol suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
Tips from our pharmacists for people taking the medication
DepakoteLamictalTegretolTopamaxPropranolol
  • For the first week, avoid activities that require you to be alert.
  • Don't use if pregnant.
  • Requires routine blood tests.
  • Take with food to avoid upset stomach.
  • May cause hair loss and weight gain.
  • Different versions of Depakote have different dosing. Be careful.
  • Report confusion, persistent abdominal pain, yellowing of eyes/skin, or easy bruising to your doctor.
  • Takes 3 to 4 weeks to feel full effects on mood.
  • Follow dose adjustments set by your doctor to minimize skin rash.
  • Take with food to avoid upset stomach.
  • Report rash, blurry vision, fever, persistent headache, or neck stiffness to your doctor.
  • Makes hormonal birth control less effective.
  • Takes 4 to 6 weeks to feel full effects on mood.
  • For the first week, avoid activities that require you to be alert.
  • Report skin rashes or blistering immediately.
  • Don't use if pregnant.
  • Requires routine blood tests.
  • Report confusion, persistent abdominal pain, yellowing of eyes/skin, or easy bruising to your doctor.
  • Takes up to 5 weeks to feel full effects on mood.
  • For the first week, avoid activities that require you to be alert.
  • Don't use if pregnant.
  • Can cause tingling skin sensations and reduced appetite.
  • Report any confusion, decreased sweating, fever, or changes in behavior or vision.
  • Takes 3 to 4 weeks to feel full effects on mood.
  • Can cause dizziness in the first few days.
  • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
  • Can cause insomnia and fatigue.
  • Can hide symptoms of low blood sugar. Be careful if you're diabetic.
  • Don't stop taking this medicine suddenly.
Learn more
More about DepakoteSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Depacon (valproate, valproic acid, or divalproex)?
Worth itNot sureNot worth it
More about LamictalSide effectsReviews & ratingsFDA package insert
Have you used Lamictal (lamotrigine)?
Worth itNot sureNot worth it
More about TegretolSide effectsReviews & ratingsFDA package insert
Have you used Tegretol (carbamazepine)?
Worth itNot sureNot worth it
More about TopamaxSide effectsReviews & ratingsFDA package insert
Have you used Qudexy Xr (topiramate)?
Worth itNot sureNot worth it
More about PropranololSide effectsReviews & ratingsFDA package insert
Have you used Inderal (propranolol)?
Worth itNot sureNot worth it