Prescription onlyNo lower cost generic available


(Estradiol Cypionate Injection)

  • Injection
  • Hot flashes and night sweats
  • Low estrogen
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Treats low estrogen and relieves menopause symptoms.

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Prescription onlyNo lower cost generic available

Our pharmacists’ bottom line

The Depo-Estradiol (Estradiol Cypionate Injection) is a good once-a-month option for treating menopause symptoms and low estrogen, as long as you're comfortable with needles.

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  • You only need an injection once a month, which can be less of a hassle than pills, patches, creams, and gels.
  • Your doctor can show you how to inject yourself so you can do it on your own at home.
  • The Depo-Estradiol (Estradiol Cypionate Injection) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, vaginal dryness, low energy, irritability).
  • Fewer side effects than oral hormone replacements since lower amounts of estrogen are used.
  • Lowers your risk of fractures by keeping your bones healthy. Make sure you also get enough calcium and Vitamin D.
  • Requires injection with a needle, which can be difficult for some people.
  • Increases your risk of endometrial and breast cancer.
  • If you have your uterus, you have to use the Depo-Estradiol (Estradiol Cypionate Injection) with another hormone called progestin to lower your risk of uterine cancer.
  • Increases your risk of developing blood clots and stroke.
  • Can't be used in people with liver problems.
  • Can be expensive since it's only available as a brand name product.
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Side effects for Depo-Estradiol (Estradiol Cypionate Injection)

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These are side effects of Depo-Estradiol (Estradiol Cypionate Injection) reported to the FDA by people taking it, and by doctors and pharmacists.

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What to expect when you take Depo-Estradiol (Estradiol Cypionate Injection)

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Tips from our pharmacists
  • The Depo-Estradiol (Estradiol Cypionate Injection) is an injection that you use once a month in one of your muscles.
  • Use a new needle and syringe each time you give yourself an injection, and throw away the used syringes and needles in a protective (sharps) container. Don’t throw them in the trash.
  • Store the Depo-Estradiol (Estradiol Cypionate Injection) at room temperature, away from heat and direct light, and don’t let it get cold.
  • If you’re using the Depo-Estradiol (Estradiol Cypionate Injection) only for vaginal symptoms, there are other medicines that can work better with fewer side effects (like a vaginal cream).

Risks and Warnings for Depo-Estradiol (Estradiol Cypionate Injection)

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    • Higher risk if:
    • Using estrogen for more than one year

    Vaginal bleeding after menopause can be a warning sign of uterus (endometrial) cancer, so let your doctor know if you notice any unusual bleeding. When estrogen is prescribed to women after menopause who still have a uterus, progestin should be used with it to lower the risk of cancer. Low-dose vaginal estrogen products are often a better choice than oral pills for women 65 years or older who have vaginal symptoms.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Depo-Estradiol (Estradiol Cypionate Injection)

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The FDA category for this medication is X. It is advised that you: Unsafe