Treats low estrogen and relieves menopause symptoms.
Our pharmacists’ bottom line
The Depo-Estradiol (Estradiol Cypionate Injection) is a good once-a-month option for treating menopause symptoms and low estrogen, as long as you're comfortable with needles.
- You only need an injection once a month, which can be less of a hassle than pills, patches, creams, and gels.
- Your doctor can show you how to inject yourself so you can do it on your own at home.
- The Depo-Estradiol (Estradiol Cypionate Injection) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, vaginal dryness, low energy, irritability).
- Fewer side effects than oral hormone replacements since lower amounts of estrogen are used.
- Lowers your risk of fractures by keeping your bones healthy. Make sure you also get enough calcium and Vitamin D.
- Requires injection with a needle, which can be difficult for some people.
- Increases your risk of endometrial and breast cancer.
- If you have your uterus, you have to use the Depo-Estradiol (Estradiol Cypionate Injection) with another hormone called progestin to lower your risk of uterine cancer.
- Increases your risk of developing blood clots and stroke.
- Can't be used in people with liver problems.
- Can be expensive since it's only available as a brand name product.
Side effects for Depo-Estradiol (Estradiol Cypionate Injection)
These are side effects of Depo-Estradiol (Estradiol Cypionate Injection) reported to the FDA by people taking it, and by doctors and pharmacists.
What to expect when you take Depo-Estradiol (Estradiol Cypionate Injection)Skip what to expect section. Skip to Risks & Warnings section.
- The Depo-Estradiol (Estradiol Cypionate Injection) is an injection that you use once a month in one of your muscles.
- Use a new needle and syringe each time you give yourself an injection, and throw away the used syringes and needles in a protective (sharps) container. Don’t throw them in the trash.
- Store the Depo-Estradiol (Estradiol Cypionate Injection) at room temperature, away from heat and direct light, and don’t let it get cold.
- If you’re using the Depo-Estradiol (Estradiol Cypionate Injection) only for vaginal symptoms, there are other medicines that can work better with fewer side effects (like a vaginal cream).
Risks and Warnings for Depo-Estradiol (Estradiol Cypionate Injection)Skip Risks and Warnings section. Skip to Tips section.
- Higher risk if:
- › Using estrogen for more than one year
Vaginal bleeding after menopause can be a warning sign of uterus (endometrial) cancer, so let your doctor know if you notice any unusual bleeding. When estrogen is prescribed to women after menopause who still have a uterus, progestin should be used with it to lower the risk of cancer. Low-dose vaginal estrogen products are often a better choice than oral pills for women 65 years or older who have vaginal symptoms.
This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.