Depo-Estradiol

(estradiol cypionate injection)

3.2/ 5 average rating with 109 reviewsforDepo-Estradiol
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Treats low estrogen and relieves menopause symptoms.

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Our bottom line

Depo-Estradiol (estradiol cypionate injection) is a good once-a-month option for treating menopause symptoms and low estrogen, as long as you're comfortable with needles.

Quick facts about Depo-Estradiol
  • Drug class: Women's health
  • Rx status: Prescription only
  • Generic status: No lower cost generic available
Prices and discounts
Lowest price for 1 5ml-of-5mg-ml vials
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$103.02

Upsides

  • You only need an injection once a month, which can be less of a hassle than pills, patches, creams, and gels.
  • Your doctor can show you how to inject yourself so you can do it on your own at home.
  • Replenishes estrogen to your whole body and relieves multiple symptoms.
  • Less side effects since lower amounts of estrogen is used compared to the pills.

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What to expect from Depo-Estradiol, on one page

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People’s experience with Depo-Estradiol

109reviews so far. What do you think?

Downsides

  • Requires injection with a needle, which can be difficult for some people.
  • Increases your risk of endometrial and breast cancer.
  • If you have an intact uterus, you have to use Depo-Estradiol (estradiol cypionate injection) with another hormone called progestin to lower your risk of uterine cancer.
  • Can't be used in people with liver problems.
  • Can be expensive since it's only available as a brand name product.

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Sign up and get Pill Talk, the latest in health & medicine news from Iodine

Get our free fact sheet

What to expect from Depo-Estradiol, on one page

Download Fact Sheet
Prices and discounts
Lowest price for 1 5ml-of-5mg-ml vials
Determining your location...
$103.02
How it works

The Depo-Estradiol (estradiol cypionate injection) replaces estrogen hormone, which your body loses during menopause. Increasing estrogen relieves hot flashes, night sweats, and vaginal problems.

Quick facts about Depo-Estradiol
  • Drug class: Women's health
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Used for

Dosage forms

  • Injection
People’s experience with Depo-Estradiol

109reviews so far. What do you think?

What to expect when you take Depo-Estradiol (estradiol cypionate injection) for Menopause symptoms

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Skip side effects section. Skip to risks and warnings section.

Side effect rates for Depo-Estradiol (estradiol cypionate injection)

Risks and Warnings for Depo-Estradiol (estradiol cypionate injection)

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    • Higher risk if:
    • Taking estrogen replacement for more than one year

    Vaginal bleeding after menopause can be a warning sign of uterus (endometrial) cancer, so let your doctor know if you notice any unusual bleeding. Using medicines like Depo-Estradiol (estradiol cypionate injection) for more than a year can increase your risk. Talk to your doctor about other medicines you can take with Depo-Estradiol (estradiol cypionate injection) to protect yourself from cancer if you are worried.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect