Prescription onlyClass: Women's health

Depo-Estradiol

(estradiol cypionate injection)

Prescription onlyClass: Women's health
Back to: Full Site NavigationSkip to: side effects sectionSkip to: What to expect sectionSkip to: Risks and warnings sectionSkip to: Common concerns from users and pharmacists
4.28Depo-Estradiol

Treats low estrogen and relieves menopause symptoms.

Skip Upsides & Downsides section. Skip to side effects section.

Our bottom line

Depo-Estradiol (estradiol cypionate injection) is a good once-a-month option for treating menopause symptoms and low estrogen, as long as you're comfortable with needles.

Prices and discounts
Lowest price for 28 28 tablets of 0.5mg/0.1mg packages
Determining your location...
$39.12

Upsides

  • You only need an injection once a month, which can be less of a hassle than pills, patches, creams, and gels.
  • Your doctor can show you how to inject yourself so you can do it on your own at home.
  • Replenishes estrogen to your whole body and relieves multiple symptoms.
  • Less side effects since lower amounts of estrogen is used compared to the pills.
People’s experience with Depo-Estradiol

109reviews so far. What do you think?

Worth itNot sureNot worth it

Downsides

  • Requires injection with a needle, which can be difficult for some people.
  • Increases your risk of endometrial and breast cancer.
  • If you have an intact uterus, you have to use Depo-Estradiol (estradiol cypionate injection) with another hormone called progestin to lower your risk of uterine cancer.
  • Can't be used in people with liver problems.
  • Can be expensive since it's only available as a brand name product.
Prices and discounts
Lowest price for 28 28 tablets of 0.5mg/0.1mg packages
Determining your location...
$39.12
How it works

The Depo-Estradiol (estradiol cypionate injection) replaces estrogen hormone, which your body loses during menopause. Increasing estrogen relieves hot flashes, night sweats, and vaginal problems.

People’s experience with Depo-Estradiol

109reviews so far. What do you think?

Worth itNot sureNot worth it
Used for
Dosage forms
  • Injection

What to expect when you take Depo-Estradiol (estradiol cypionate injection) for Menopause symptoms

Skip what to expect section. Skip to Risks & Warnings section.
Skip side effects section. Skip to What to Expect and Pharmacists Tips section.

Side effect rates for Depo-Estradiol (estradiol cypionate injection)

Risks and Warnings for Depo-Estradiol (estradiol cypionate injection)

Skip risks section. Skip to common concerns section.
    • Higher risk if:
    • Taking estrogen replacement for more than one year

    Vaginal bleeding after menopause can be a warning sign of uterus (endometrial) cancer, so let your doctor know if you notice any unusual bleeding. Using medicines like Depo-Estradiol (estradiol cypionate injection) for more than a year can increase your risk. Talk to your doctor about other medicines you can take with Depo-Estradiol (estradiol cypionate injection) to protect yourself from cancer if you are worried.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect