Prescription onlyLower-cost generic available


(Testosterone Cypionate Injection)

  • Injection
  • Low testosterone
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Treats low testosterone.

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Prescription onlyLower-cost generic available

Our bottom line

This testosterone injection only has to be given once or twice a month and you can do it at home, but someone has to help you inject.


  • A first-choice treatment for low testosterone in men and delayed puberty in boys.
  • Available in generic.
  • Only has to be given once every 2 to 4 weeks.
  • The shot can be done at home.
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  • Only available as a shot.
  • Has to be given by someone else since it has to be injected into your buttocks.
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What to expect when you take Depo-Testosterone (Testosterone Cypionate Injection)

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Tips from our pharmacists
  • Your doctor will show you how to inject this correctly.
  • Can cause nausea, vomiting and headache.
  • Can cause increased acne and changes in sex drive.
  • Keep this medication locked up and away from children since it's a controlled substance.
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Side effects for Depo-Testosterone (Testosterone Cypionate Injection)

Manufacturers don’t say how common these side effects are

  • Abnormally large breasts in males
  • Acne
  • Alterations in liver function tests
  • Anxiety
  • Cholestatic jaundice
  • Excessive frequency and duration of penile erections
  • Excessive hair growth
  • Generalized paresthesia
  • Headache
  • Hepatocellular neoplasms and peliosis hepatis
  • Hypersensitivity
  • Increased or decreased libido
  • Low mood disorder
  • Male pattern of baldness
  • Nausea
  • Oligospermia
  • Pain at injection site
  • Retention of sodium, chloride, water, potassium, calcium, inorganic phosphates.
  • Scaly skin rash

Risks and Warnings for Depo-Testosterone (Testosterone Cypionate Injection)

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    • Higher risk if:
    • Male

    Taking Depo-Testosterone (Testosterone Cypionate Injection) can cause swelling and breast tissue changes if you're a man. Talk to your doctor if this is a problem.

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Depo-Testosterone (Testosterone Cypionate Injection)

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The FDA category for this medication is X. It is advised that you: Unsafe
Kidneys and liver
  • Risks from our pharmacists
  • There have been reports of people on Depo-Testosterone (Testosterone Cypionate Injection) who have developed high levels of calcium in the blood, which can be bad for the kidneys. This can happen if you are unable to move around or have cancer. If you notice a metallic taste in your mouth, muscle or joint pain or a bad headache, talk to your doctor, since they may have to stop the medication.
  • Tips from our pharmacists
  • Can cause increased acne and changes in sex drive.
  • Risks from our pharmacists
  • If you're a man taking Depo-Testosterone (Testosterone Cypionate Injection), you can see changes in your sex drive, including overstimulation and prolonged frequent erections. Talk to your doctor if this happens, since they might have to change the dose.
  • Risks from our pharmacists
  • If you're taking Depo-Testosterone (Testosterone Cypionate Injection), and you notice swelling in your legs, or a sudden increase in your weight, talk to your doctor. This can be a serious side effect involving your heart.