Prescription onlyNo lower cost generic available



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Treats heartburn and ulcers.

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Prescription onlyNo lower cost generic available

Our bottom line

Dexilant (Dexlansoprazole) is an effective medicine to treat heartburn and ulcers, but can be expensive.


  • Relieves heartburn symptoms and heals ulcers better than other stomach medicines, such as Pepcid, Tagamet, and Zantac.
  • Lasts longer than other similar stomach medicines. Most people take it once a day.
  • Your body won't develop a tolerance to Dexilant (Dexlansoprazole), so it'll work the same way as long as you need to keep taking it.
  • Once heartburn symptoms are treated, a low dose of Dexilant (Dexlansoprazole) can be taken daily.
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  • Taking Dexilant (Dexlansoprazole) in high doses or for longer than 1 year can increase the risk for bone fractures, especially if you already have osteoporosis (weak bones).
  • Many drugs can interact with Dexilant (Dexlansoprazole), so talk to your doctor or pharmacist before starting any new medicines.
  • There's no generic version available, so it can be expensive.

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What to expect when you take Dexilant (Dexlansoprazole)

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Tips from our pharmacists
  • Can take a few days to start working.
  • Take Dexilant (Dexlansoprazole) with or without food. It can work better for some people if it's taken 30 minutes before a meal.
  • Call your doctor if you have watery stools, stomach pain, or a fever because it could be a sign of a serious infection.
  • Dexilant (Dexlansoprazole) can lower the amount of magnesium in your body. Initial and follow-up blood tests may be needed before starting Dexilant (Dexlansoprazole).
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Side effects for Dexilant (Dexlansoprazole)

From clinical trials of Dexilant / Acid reflux  ( 3517)

  • DiarrheaDiarrhea5% for Dexilant vs.3% for placebo
  • Abdominal painAbdominal pain4% for Dexilant vs.4% for placebo
  • NauseaNausea3% for Dexilant vs.3% for placebo
  • Ear, nose, or throat infectionEar, nose, or throat infection2% for Dexilant vs.1% for placebo
  • VomitingVomiting2% for Dexilant vs.1% for placebo
  • Passing gasPassing gas2% for Dexilant vs.1% for placebo
  • DiarrheaDiarrhea1% for Dexilant vs.0% for placebo

Risks and Warnings for Dexilant (Dexlansoprazole)

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  • Heartburn and feelings of upset stomach can be warning signs of a more serious stomach problem or cancer. If you need to take Dexilant (Dexlansoprazole) for 2 weeks or more go see a doctor. It's safest to get checked out to make sure you do not have a serious stomach condition.

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Dexilant (Dexlansoprazole)

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The FDA category for this medication is B. It is advised that you: Probably safe
  • Take before acidic dinner/alcohol. Do not take with other meds in morning. Cancels out antidepressants.
  • Tips from our pharmacists
  • Take Dexilant (Dexlansoprazole) with or without food. It can work better for some people if it's taken 30 minutes before a meal.
  • You can't take iron supplements with it so make sure you're getting enough with the food you eat.