Prescription onlyNo lower cost generic available

Zorvolex

(Diclofenac)

  • Pill
  • Osteoarthritis pain
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Treats arthritis pain and swelling.

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Prescription onlyNo lower cost generic available

Our pharmacists’ bottom line

Zorvolex (Diclofenac) is an okay medication used to treat pain and swelling caused by arthritis. However, because of the risk of heart attack, you should limit the amount you take.

  • Clinical studies show that Zorvolex (Diclofenac) is better at relieving arthritis pain than acetaminophen (Tylenol).
  • Can be used as needed to treat pain and swelling.
  • Available as a generic.
  • You should avoid alcohol while on Zorvolex (Diclofenac) since it can increase your risk of stomach issues.
  • If you're taking it on a regular basis, you'll need to get labs done to make sure your liver and kidneys aren't being affected.
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Side effects for Zorvolex (Diclofenac)

From clinical trials of Diclofenac / Osteoarthritis pain (35 mg) ( 704)

  • HeadacheHeadache8% for Diclofenac vs.0% for placebo
  • Ear, nose, or throat infectionEar, nose, or throat infection8% for Diclofenac vs.0% for placebo
  • NauseaNausea7% for Diclofenac vs.2% for placebo
  • Urinary tract infectionUrinary tract infection7% for Diclofenac vs.0% for placebo
  • DiarrheaDiarrhea6% for Diclofenac vs.3% for placebo
  • NauseaNausea6% for Diclofenac vs.0% for placebo
  • Common coldCommon cold6% for Diclofenac vs.0% for placebo
  • DiarrheaDiarrhea6% for Diclofenac vs.0% for placebo
  • ArthritisArthritis5% for Diclofenac vs.0% for placebo
  • Sinus inflammationSinus inflammation5% for Diclofenac vs.0% for placebo

What to expect when you take Zorvolex (Diclofenac)

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Tips from our pharmacists
  • Take it with food to avoid getting diarrhea.
  • Don't drink alcohol while using Zorvolex (Diclofenac).
  • Don't take other anti-inflammatory medications (NSAIDs) without talking to your doctor or pharmacist.
  • Can cause swelling in your legs, abdominal pain, constipation, diarrhea, and an upset stomach.
  • Don't take antacids with magnesium since they can interact with Zorvolex (Diclofenac).
  • Take Zorvolex (Diclofenac) at the smallest dose possible for the shortest amount of time to prevent an increased risk of heart attack.

Risks and Warnings for Zorvolex (Diclofenac)

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    • Higher risk if:
    • History of heart problems
    • High blood pressure
    • High cholesterol
    • Diabetes
    • Being overweight or obese
    • Smoking

    Zorvolex (Diclofenac) can increase your chance of having blood clots, heart attack, or stroke. Take the lowest dose for the shortest time possible to lower your risk. Never take Zorvolex (Diclofenac) during the first two weeks after having heart surgery.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Zorvolex (Diclofenac)

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The FDA category for this medication is D. It is advised that you: Weigh risks vs. benefits
Pregnancy
Alcohol
  • Upsides and downsides from our pharmacists
  • You should avoid alcohol while on Zorvolex (Diclofenac) since it can increase your risk of stomach issues.
  • Tips from our pharmacists
  • Don't drink alcohol while using Zorvolex (Diclofenac).
Food
  • Tips from our pharmacists
  • Take it with food to avoid getting diarrhea.
Kidneys & liver
  • Upsides and downsides from our pharmacists
  • If you're taking it on a regular basis, you'll need to get labs done to make sure your liver and kidneys aren't being affected.
  • Risks from our pharmacists
  • Zorvolex (Diclofenac), and similar medications in the NSAID family, can lower kidney function or cause permanent kidney damage. Taking the lowest dose for the shortest amount of time necessary can lower your risk of kidney problems. It's important to get lab tests to check your kidney function periodically if you use Zorvolex (Diclofenac) for long periods of time.
  • If prescribed to take 1 pill twice a day, try 1 a day. I took 2 a day for years and I can no longer take it because it effects the kidney function. Had I known 1 a day would work I could probably still be taking them safely.
    Age: 62
    Gender: Man
    Taken for: Osteoarthritis pain