Prescription onlyLower-cost generic available

Diflucan Alternatives

(Fluconazole)

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Compare Diflucan (Fluconazole) to alternatives

These medications are comparable to Diflucan (Fluconazole) or used for similar purposes.

Diflucan
(Fluconazole)

Sporanox
(Itraconazole)

Lamisil
(Terbinafine)

Nizoral
(Ketoconazole)

Kills yeast and fungus. Diflucan (Fluconazole) is a quick, cheap, and convenient way to get rid of a yeast infection. (It's used for other kinds of fungal infections, too.) You have to avoid alcohol, though.Coming soon.Treats fungal infections. Lamisil (Terbinafine) has the highest cure rate of all antifungal medications, but you need to take it for a few weeks or months to see if it'll work for you.Treats fungal infections. Nizoral (Ketoconazole) is a medication used on your skin to treat fungal infections; however, it takes several weeks for full recovery, and the directions are specific to each type of medication.
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Reviews & ratings
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5.392857142857143Diflucan
Reviews for Diflucan (Fluconazole)
75%
of people say Diflucan (Fluconazole) is worth it
61%
say it works well
21%
say it's a big hassle

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Side effects
DiflucanItraconazoleTerbinafineKetoconazole

The Diflucan FDA package insert doesn’t have numbers about how common side effects are.

More about Diflucan side effects »

We haven’t found good data for Itraconazole side effects.

FDA side effect reports for Itraconazole »
  • Rash 4%
  • Headache 3%
  • Diarrhea 3%
  • Taste disturbance 2%
  • Liver enzyme abnormalities 2%
  • Indigestion 1%
  • Itching 1%
More Terbinafine side effects »
  • Any side effect 3%
  • Application site reaction 1%
More Ketoconazole side effects »
How it works
DiflucanItraconazoleTerbinafineKetoconazole
Diflucan (Fluconazole) is an oral antifungal medicine. It prevents yeast and fungi from reproducing and making their protective outer cell wall.Coming soon.Lamisil (Terbinafine) is an antifungal medication that prevents the fungi from creating the protective layers it needs to survive. It treats scalp, toenail, and fingernail infections.Nizoral (Ketoconazole) is an antifungal medicine. It prevents yeast and fungi from reproducing and making their protective outer cell wall.
Type of medication
DiflucanItraconazoleTerbinafineKetoconazole
AntifungalPrescription only
Coming soon.
AntifungalPrescription only
AntifungalPrescription or OTC
Available as
DiflucanItraconazoleTerbinafineKetoconazole
  • Pill
  • Liquid
  • Pill
  • Liquid
  • Pill
  • Granule
  • Cream, gel, or ointment
  • Topical spray
  • Pill
  • Cream, gel, or ointment
  • Foam
  • Shampoo
Used for (click to learn more)
DiflucanItraconazoleTerbinafineKetoconazole
  • Aspergillosis
Risk factors for serious side effects
DiflucanItraconazoleTerbinafineKetoconazole
      Detailed Diflucan (Fluconazole) risks & warnings »
      Coming soon.Coming soon.Coming soon.
      Pregnancy category
      DiflucanItraconazoleTerbinafineKetoconazole
      DFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      CFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      BFDA pregnancy category (Probably safe)

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      See the FDA package insert
      CFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      Alcohol
      • You have to avoid alcohol while on this medication.
      • Don't drink alcohol when you take this medication.
      No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.
      Food
      No specific food-related info.No specific food-related info.
      • If you're taking the oral granules, mix them in a spoonful of mashed potatoes or pudding, and then swallow it whole without chewing. Don't use fruit-based soft foods.
      No specific food-related info.
      Kidneys and liver
      No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.
      Sex
      • You have to avoid having sex for at least a week after you take Fluconazole.
      • Can interact with birth control pills, so you'll need to use condoms or other barriers if you do have sex.
      • If you're taking this for a vaginal yeast infection, you only have to take it once. Don't have sex for at least 7 days.
      No specific sex-related info.No specific sex-related info.No specific sex-related info.
      Sleep
      No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.
      Weight
      No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.
      Upsides and benefits
      DiflucanItraconazoleTerbinafineKetoconazole
      • Available in generic.
      • For women with yeast infections, you only have to take one pill one time.
      Coming soon.
      • Recommended as a first-choice treatment for fungal infections. It has a high cure rate and very few side effects.
      • Available as a generic medication, so it's cheap.
      • It's the only antifungal medication that is available in different oral forms and can be used by children.
      • Recommended as a first choice medication to treat skin infections caused by fungi, including cradle cap, seborrheic dermatitis, and tinea versicolor.
      • Nizoral (Ketoconazole) isn't taken orally, so it doesn't cause liver issues.
      • Can be used with other medications to help control redness and swelling.
      • The 1% shampoo is available over-the-counter in the drugstore.
      Downsides and risks
      DiflucanItraconazoleTerbinafineKetoconazole
      • You have to avoid alcohol while on this medication.
      • You have to avoid having sex for at least a week after you take Fluconazole.
      • Can interact with birth control pills, so you'll need to use condoms or other barriers if you do have sex.
      Coming soon.
      • It can take weeks to months to see any changes in the infection.
      • While Lamisil (Terbinafine) has the highest cure rate of all antifungal medications, there's still a chance it may not work.
      • Can cause headache, nausea, vomiting, and diarrhea.
      • The foams (Extina and Ketodan) and gel (Xolegel) are only available as brand name and can be more expensive.
      • The 2.5% shampoo and creams are available only by prescription, but are generic.
      • The shampoo has to be left on for at least 5-10 minutes after lathering before you rinse it off.
      • It can take a few weeks for the infection to clear and a few months before the skin returns to its normal color.
      • The fungal infections can be confused for other skin infections, so if Nizoral (Ketoconazole) doesn't work, it could be caused by another skin problem.
      Tips from our pharmacists for people taking the medication
      DiflucanItraconazoleTerbinafineKetoconazole
      • If you're taking this for a vaginal yeast infection, you only have to take it once. Don't have sex for at least 7 days.
      • For other fungal infections, take it exactly how your doctor tells you to.
      • Don't drink alcohol when you take this medication.
      • If you're on birth control pills, Fluconazole can make them less effective. Consider using another method (condoms, diaphragms) along with the pills.
      • Can cause nausea, vomiting, diarrhea and headache.
      Coming soon.
      • It can take a few months for improvements to be seen, especially for finger and toenail infections.
      • You can be more likely to get a sunburn, so put on sunblock when you go outside.
      • If you're taking the oral granules, mix them in a spoonful of mashed potatoes or pudding, and then swallow it whole without chewing. Don't use fruit-based soft foods.
      • Your doctor will have you get regular blood work done to make sure Lamisil (Terbinafine) isn't causing side effects.
      • If you forget your daily dose, take it as soon as you remember, unless it's less than 4 hours to your next dose, then skip it. Don't take two doses at once.
      • The shampoo is meant to be used once every 3 to 4 days, while the cream, gel and foam are meant to be used one to three times a day.
      • It can take at least 2 to 6 weeks for the infection to completely clear, and it can take 3 to 6 months before the skin returns to its original color for some infections.
      • Make sure Nizoral (Ketoconazole) doesn't get into the eyes.
      • If you're using the foam, spray the foam into the cap, not your hands since it can melt before you put it on, and apply onto the skin, not the hair.
      • Can cause redness, swelling, and an irritated or burning sensation to the area where you put Nizoral (Ketoconazole) on.
      Learn more
      More about DiflucanSide effectsReviews & ratingsAlternativesFDA package insert
      More about ItraconazoleSide effectsFDA package insert
      More about TerbinafineSide effectsReviews & ratingsFDA package insert
      More about KetoconazoleSide effectsReviews & ratingsFDA package insert