Prescription onlyLower-cost generic availableClass: Infection

Diflucan Alternatives

(fluconazole)

Prescription onlyLower-cost generic availableClass: Infection
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Compare Diflucan (fluconazole) to alternatives

These medications are comparable to Diflucan (fluconazole) or used for similar purposes.

Diflucan
(fluconazole)

Sporanox
(itraconazole)

Lamisil
(terbinafine)

Nizoral
(ketoconazole)

Kills yeast and fungus. Diflucan (Fluconazole) is a quick, cheap, and convenient way to get rid of a yeast infection. (It's used for other kinds of fungal infections, too.) You have to avoid alcohol, though.Treats fungal infections. Sporanox (itraconazole) is effective oral medication that treats many different kinds of fungal infections. However, it has the potential to interact with a lot of other medications and has a few serious but rare side effects.Treats fungal infections. Lamisil (Terbinafine) has the highest cure rate of all antifungal medications, but you need to take it for a few weeks or months to see if it'll work for you.Treats fungal infections. Nizoral (Ketoconazole) is a medication used on your skin to treat fungal infections; however, it takes several weeks for full recovery, and the directions are specific to each type of medication.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.33Diflucan
Reviews for Diflucan
73%
of people (All ages) say Diflucan is worth it
60%
say it works well
20%
say it's a big hassle
Have you used Diflucan (fluconazole)?
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Have you used Sporanox (itraconazole)?
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Have you used Lamisil (terbinafine)?
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Have you used Nizoral (ketoconazole)?
Worth itNot sureNot worth it
Side effects
DiflucanItraconazoleTerbinafineKetoconazole
  • Any side effect 26%
  • Headache 13%
  • Nausea 7%
  • Abdominal pain 6%
  • Diarrhea 3%
  • Skin rash 2%
  • Vomiting 2%
More Diflucan side effects »
  • Nausea 11%
  • Rash 9%
  • Vomiting 5%
  • Swelling due to fluid retention 4%
  • Headache 4%
  • Itching 3%
  • Fever 3%
  • Diarrhea 3%
  • High blood pressure 3%
  • Tiredness 3%
More Itraconazole side effects »
  • Headache 3%
  • Diarrhea 3%
  • Rash 4%
  • Dyspepsia 1%
  • Pruritus 1%
  • Liver Enzyme Abnormalities 2%
  • Taste Disturbance 2%
More Terbinafine side effects »
  • Application site reaction 1%
  • Any side effect 3%
More Ketoconazole side effects »
How it works
DiflucanItraconazoleTerbinafineKetoconazole
Diflucan (Fluconazole) is an oral antifungal medicine. It prevents yeast and fungi from reproducing and making their protective outer cell wall.Sporanox (itraconazole) kills fungus by preventing it from making its protective cell wall.Lamisil (Terbinafine) is an antifungal medication that prevents the fungi from creating the protective layers it needs to survive. It treats scalp, toenail, and fingernail infections.Nizoral (Ketoconazole) is an antifungal medicine. It prevents yeast and fungi from reproducing and making their protective outer cell wall.
Type of medication
DiflucanItraconazoleTerbinafineKetoconazole
Prescription onlyPrescription onlyPrescription onlyPrescription or OTC
Available as
DiflucanItraconazoleTerbinafineKetoconazole
  • Pill
  • Liquid
  • Pill
  • Liquid
  • Pill
  • Granule
  • Cream, gel, or ointment
  • Topical spray
  • Pill
  • Cream, gel, or ointment
  • Foam
  • Shampoo
Used for
DiflucanItraconazoleTerbinafineKetoconazole
Risk factors for serious side effects
DiflucanItraconazoleTerbinafineKetoconazole
    Detailed Diflucan (fluconazole) risks & warnings »
    • History of congestive heart failure
    • Taking other medications that can produce an irregular heartbeat
    Detailed Sporanox (itraconazole) risks & warnings »
    • Past history of liver disease
    • Taking Lamisil (Terbinafine) by mouth
    Detailed Lamisil (terbinafine) risks & warnings »
    • Asthma
    Detailed Nizoral (ketoconazole) risks & warnings »
    Pregnancy

    Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Interactions
    DiflucanItraconazoleTerbinafineKetoconazole
    • Can interact with birth control pills, so you'll need to use condoms or other barriers if you do have sex.
    • Sporanox (itraconazole) has many drug interactions and can't be used together with a lot of other medications. Let your doctor or pharmacist know about all of your medications before starting Sporanox (itraconazole).
    • Sporanox (itraconazole) has a lot of drug interactions. Let your doctor or pharmacist know about all of the medications you're taking.
    No interactions related info.No interactions related info.
    Alcohol
    DiflucanItraconazoleTerbinafineKetoconazole
    • Don't drink alcohol when you take this medication.
    • You have to avoid alcohol while on this medication.
    No alcohol related info.No alcohol related info.No alcohol related info.
    Kidneys and liver
    DiflucanItraconazoleTerbinafineKetoconazole
    No kidneys and liver related info.
    • Sporanox (itraconazole) can be used by people who have kidney problems.
    • There have been reports of liver damage in people taking Lamisil (Terbinafine). Your doctor will do some blood tests to make sure you don't have liver damage before taking this medication. Call your doctor immediately if you have pain in your abdomen, yellowing of the skin or whites of the eyes, have dark urine, or light colored stool. All of these can be signs of changes to your liver.
    No kidneys and liver related info.
    Upsides and benefits
    DiflucanItraconazoleTerbinafineKetoconazole
    • Available in generic.
    • For women with yeast infections, you only have to take one pill one time.
    • Sporanox (itraconazole) is effective in treating infections caused by many different types of fungi.
    • Available as a generic in the capsule form.
    • Sporanox (itraconazole) can be used by people who have kidney problems.
    • Recommended as a first-choice treatment for fungal infections. It has a high cure rate and very few side effects.
    • Available as a generic medication, so it's cheap.
    • It's the only antifungal medication that is available in different oral forms and can be used by children.
    • Recommended as a first choice medication to treat skin infections caused by fungi, including cradle cap, seborrheic dermatitis, and tinea versicolor.
    • Nizoral (Ketoconazole) isn't taken orally, so it doesn't cause liver issues.
    • Can be used with other medications to help control redness and swelling.
    • The 1% shampoo is available over-the-counter in the drugstore.
    Downsides and risks
    DiflucanItraconazoleTerbinafineKetoconazole
    • You have to avoid alcohol while on this medication.
    • You have to avoid having sex for at least a week after you take Fluconazole.
    • Can interact with birth control pills, so you'll need to use condoms or other barriers if you do have sex.
    • The liquid solution is especially likely to cause stomach upset like nausea and diarrhea.
    • Sporanox (itraconazole) is not a good choice for simple fungal infections (like nail infections) in people who have congestive heart failure because it can cause high blood pressure and swelling of the limbs.
    • Sporanox (itraconazole) isn't absorbed in the same way by everyone. You'll likely need to get lab tests done to check on its levels in the blood.
    • Sporanox (itraconazole) can cause serious side effects like allergic reactions, liver toxicity, nerve pain, or hearing loss.
    • Sporanox (itraconazole) has a lot of drug interactions. Let your doctor or pharmacist know about all of the medications you're taking.
    • It can take weeks to months to see any changes in the infection.
    • While Lamisil (Terbinafine) has the highest cure rate of all antifungal medications, there's still a chance it may not work.
    • Can cause headache, nausea, vomiting, and diarrhea.
    • The foams (Extina and Ketodan) and gel (Xolegel) are only available as brand name and can be more expensive.
    • The 2.5% shampoo and creams are available only by prescription, but are generic.
    • The shampoo has to be left on for at least 5-10 minutes after lathering before you rinse it off.
    • It can take a few weeks for the infection to clear and a few months before the skin returns to its normal color.
    • The fungal infections can be confused for other skin infections, so if Nizoral (Ketoconazole) doesn't work, it could be caused by another skin problem.
    Tips from our pharmacists for people taking the medication
    DiflucanItraconazoleTerbinafineKetoconazole
    • If you're taking this for a vaginal yeast infection, you only have to take it once. Don't have sex for at least 7 days.
    • For other fungal infections, take it exactly how your doctor tells you to.
    • Don't drink alcohol when you take this medication.
    • If you're on birth control pills, Fluconazole can make them less effective. Consider using another method (condoms, diaphragms) along with the pills.
    • Can cause nausea, vomiting, diarrhea and headache.
    • If you are taking the pill form, take it after the same meal at the same time each day. If taking the liquid form, take it on an empty stomach with an an accurate measuring device.
    • If you're taking Sporanox (itraconazole) for an infection in the mouth or esophagus, swish the liquid solution in your mouth before swallowing.
    • To make sure that the medicine is effective, be sure to take the full course of this medication, even if you are feeling better.
    • Sporanox (itraconazole) should not be taken with any heartburn medications - especially proton pump inhibitors like Nexium or Prilosec.
    • Be sure to use a reliable form of birth control while taking Sporanox (itraconazole).
    • It can take a few months for improvements to be seen, especially for finger and toenail infections.
    • You can be more likely to get a sunburn, so put on sunblock when you go outside.
    • If you're taking the oral granules, mix them in a spoonful of mashed potatoes or pudding, and then swallow it whole without chewing. Don't use fruit-based soft foods.
    • Your doctor will have you get regular blood work done to make sure Lamisil (Terbinafine) isn't causing side effects.
    • If you forget your daily dose, take it as soon as you remember, unless it's less than 4 hours to your next dose, then skip it. Don't take two doses at once.
    • The shampoo is meant to be used once every 3 to 4 days, while the cream, gel and foam are meant to be used one to three times a day.
    • It can take at least 2 to 6 weeks for the infection to completely clear, and it can take 3 to 6 months before the skin returns to its original color for some infections.
    • Make sure Nizoral (Ketoconazole) doesn't get into the eyes.
    • If you're using the foam, spray the foam into the cap, not your hands since it can melt before you put it on, and apply onto the skin, not the hair.
    • Can cause redness, swelling, and an irritated or burning sensation to the area where you put Nizoral (Ketoconazole) on.
    Learn more
    More about DiflucanSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Diflucan (fluconazole)?
    Worth itNot sureNot worth it
    More about ItraconazoleSide effectsFDA package insert
    Have you used Sporanox (itraconazole)?
    Worth itNot sureNot worth it
    More about TerbinafineSide effectsReviews & ratingsFDA package insert
    Have you used Lamisil (terbinafine)?
    Worth itNot sureNot worth it
    More about KetoconazoleSide effectsReviews & ratingsFDA package insert
    Have you used Nizoral (ketoconazole)?
    Worth itNot sureNot worth it