Prescription onlyLower-cost generic availableClass: Neuro/psych



Prescription onlyLower-cost generic availableClass: Neuro/psych
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Treats migraine headaches.

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Our bottom line

Migranal (dihydroergotamine) is not as good as other medicines to treat migraines because of side effects, but it can be an alternative if these haven't worked.

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  • If your migraines usually last more than 2 days, or if you have more frequent migraines,Migranal (dihydroergotamine) can work better than other medicines.
  • Migranal (dihydroergotamine) is available as a nasal spray or an injection, which is good if you're not able to swallow pills when you have migraines.


  • Migranal (dihydroergotamine) can't prevent migraines from happening; it can only treat them.
  • Taking too much of Migranal (dihydroergotamine) over a period of time can be poisonous. Talk to your doctor if your headaches aren't getting better.
  • Migranal (dihydroergotamine) can only be used for migraines and cluster headaches. It won't work for tension headaches.
  • Not recommended for children.
How it works

Migranal (dihydroergotamine) is a medicine to treat migraines. Migraines are caused by opening of blood vessels in the brain. Migranal (dihydroergotamine) relieves the headache by tightening the blood vessels.

What to expect when you take Migranal (dihydroergotamine) for Migraine headache

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Side effect rates for Migranal (dihydroergotamine)

1228 From clinical trials of dihydroergotamine / Migraine
  • Stuffy nose
  • Nausea
  • Changes in taste
  • Nasal irritation
  • Vomiting
  • Dizziness
  • Sore throat
  • Sleepiness
  • Diarrhea
  • Tingling or prickling sensation

Risks and Warnings for Migranal (dihydroergotamine)

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    • Higher risk if:
    • Macrolide antibiotics
    • Protease inhibitors

    Talk to your doctor or pharmacist right away if you're taking Migranal (dihydroergotamine) and you have to take macrolide antibiotics or medicines for HIV called protease inhibitors. Migranal (dihydroergotamine) can last a lot longer in the body if you take those medicines. You're at higher risk for stroke and less blood supply to your arms or legs if you take those medicines and Migranal (dihydroergotamine).

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Migranal (dihydroergotamine)

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