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Dilantin Alternatives

(Phenytoin)

  • Extended release
  • Chewable tablet
  • Liquid
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Compare Dilantin (Phenytoin) to alternatives

These medications are comparable to Dilantin (Phenytoin) or used for similar purposes.

Dilantin
(Phenytoin)

Lamictal
(Lamotrigine)

Trileptal
(Oxcarbazepine)

Tegretol
(Carbamazepine)

Qudexy Xr
(Topiramate)

Depacon
(Valproate, Valproic Acid, Or Divalproex)

Keppra
(Levetiracetam)

Prevents seizures. Dilantin (Phenytoin) is effective at preventing seizures, but has many drug interactions and side effects. If your blood tests show that you have the right amount of Dilantin (Phenytoin) levels, you’ll have a lower chance of getting side effects.Prevents seizures and stabilizes mood. Lamictal (Lamotrigine) is most useful for treating severe seizure disorders, and for bipolar disorder with more depression symptoms than manic symptoms. Just be careful to increase your dose slowly to avoid skin rash.Prevents seizures. Trileptal (Oxcarbazepine) is effective at preventing seizures and you don’t need to get regular blood tests to make sure it’s effective, but it has many drug interactions.Prevents seizures, stabilizes mood, and relieves nerve pain. Tegretol (Carbamazepine) is useful for preventing seizures and relieving certain types of nerve pain, but interacts with many drugs.Prevents seizures and migraine headaches. Qudexy Xr (Topiramate) is useful for preventing seizures and migraines, and doesn't require blood tests while you're on it.Prevents seizures and stabilizes mood. Depacon (Valproate, Valproic Acid, Or Divalproex) is good long-term prevention for epilepsy, bipolar disorder, and migraines, but can cause weight gain.Prevents seizures. Keppra (Levetiracetam) is effective for preventing seizures in people with epilepsy. Compared to other anti-seizure medications, it has few drug interactions and you don’t need to get your levels checked.
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Reviews & ratings
Button Group. All currently active
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Not enough reviews for this drug. Help someone out, leave a review!

Reviews for Lamictal (Lamotrigine)
67%
16% vs. Dilantin (Phenytoin)
58%
9% vs. Dilantin (Phenytoin)
19%
19% vs. Dilantin (Phenytoin)

Not enough reviews for this drug. Help someone out, leave a review!

Reviews for Tegretol (Carbamazepine)
58%
25% vs. Dilantin (Phenytoin)
42%
25% vs. Dilantin (Phenytoin)
21%
21% vs. Dilantin (Phenytoin)
Reviews for Qudexy Xr (Topiramate)
54%
29% vs. Dilantin (Phenytoin)
52%
15% vs. Dilantin (Phenytoin)
33%
33% vs. Dilantin (Phenytoin)
Reviews for Depacon (Valproate, Valproic Acid, Or Divalproex)
46%
37% vs. Dilantin (Phenytoin)
39%
28% vs. Dilantin (Phenytoin)
27%
27% vs. Dilantin (Phenytoin)

Not enough reviews for this drug. Help someone out, leave a review!

Side effects
DilantinLamictalTrileptalTegretolTopamaxDepakoteKeppra

We haven’t found good data for Dilantin side effects.

FDA side effect reports for Dilantin »
  • Double vision 41%
  • Dizziness 27%
  • Lack of muscle coordination 18%
  • Blurred vision 15%
  • Nausea 14%
  • Vomiting 14%
  • Headache 10%
  • Inflammation inside the nose 5%
  • Sleep difficulty 4%
  • Incoordination 4%
More Lamictal side effects »
  • Dizziness 16%
  • Diarrhea 5%
  • Nausea 4%
  • Nervousness 3%
  • Headache 3%
  • Coordination abnormal 2%
  • Pain back 2%
  • Sinus inflammation 2%
  • Rash 2%
  • Amnesia 2%
More Trileptal side effects »
  • Dizziness 32%
  • Drowsiness 19%
  • Nausea 19%
  • Vomiting 15%
  • Itching 6%
  • Constipation 5%
  • Dry mouth 5%
  • Muscle weakness 4%
  • Blurred vision 4%
  • Rash 3%
More Tegretol side effects »
  • Tingling sensation 45%
  • Slowed-down thinking and movements 19%
  • Dizziness 17%
  • Drowsiness 17%
  • Fatigue 17%
  • Change in taste 14%
  • Difficulty with concentration/attention 13%
  • Nervousness 12%
  • Difficulty with memory 11%
  • Vision abnormal 11%
More Topamax side effects »
  • Nausea 34%
  • Muscle weakness 20%
  • Vomiting 20%
  • Abdominal pain 17%
  • Dizziness 12%
  • Headache 10%
  • Double vision 7%
  • Involuntary eye movement 7%
  • Lack of muscle coordination 7%
  • Accidental injury 6%
More Depakote side effects »
  • Drowsiness 7%
  • Nasal congestion 7%
  • Muscle weakness 6%
  • Neck pain 6%
  • Decreased appetite 6%
  • Fatigue 6%
  • Infection 5%
  • Aggression 5%
  • Dizziness 5%
  • Headache 4%
More Keppra side effects »
How it works
DilantinLamictalTrileptalTegretolTopamaxDepakoteKeppra
Dilantin (Phenytoin) is an antiepileptic medication. It prevents seizures by stabilizing brain cells and lowering abnormal communication within the brain.Lamictal (Lamotrigine) is an antiepileptic. Researchers don't know exactly how it works, but it seems to calm nerve activity in the brain.Trileptal (Oxcarbazepine) is an antiepileptic medication. It reduces seizures by blocking certain types of nerve activity that regulate how your brain cells communicate with each other.Tegretol (Carbamazepine) is an antiepileptic. Researchers don't know exactly how it works, but it seems to block certain kinds of nerve activity to reduce seizures and pain.Qudexy Xr (Topiramate) is an antiepileptic. Researchers don't know exactly how it works, but it seems to affect multiple parts of the brain to control seizures and migraines.Depacon (Valproate, Valproic Acid, Or Divalproex) is an antiepileptic. Researchers don't know exactly how it works. It seems to increase the amount of GABA, a chemical that calms nerves in the brain.Keppra (Levetiracetam) is an antiepileptic medication. It prevents seizures by helping regulate neurotransmitters in the brain.
Type of medication
DilantinLamictalTrileptalTegretolTopamaxDepakoteKeppra
Anticonvulsant
Hydantoin
Prescription only
AnticonvulsantPrescription only
AnticonvulsantPrescription only
AnticonvulsantPrescription only
AnticonvulsantPrescription only
AnticonvulsantPrescription only
AnticonvulsantPrescription only
Available as
DilantinLamictalTrileptalTegretolTopamaxDepakoteKeppra
  • Extended release
  • Chewable tablet
  • Liquid
  • Pill
  • Extended release
  • Chewable tablet
  • Dissolving tablet
  • Pill
  • Liquid
  • Pill
  • Extended release
  • Chewable tablet
  • Oral suspension
  • Pill
  • Extended release capsule
  • Pill
  • Extended release
  • Extended release capsule
  • Sprinkle
  • Liquid
  • Pill
  • Extended release
  • Liquid
Used for (click to learn more)
DilantinLamictalTrileptalTegretolTopamaxDepakoteKeppra
How well it works for depression
The free Iodine Start program helps people track how well they are improving, and find the right antidepressant faster.
The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Dilantin (Phenytoin)The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Lamictal (Lamotrigine)The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Trileptal (Oxcarbazepine)The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Tegretol (Carbamazepine)The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Qudexy Xr (Topiramate)The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Depacon (Valproate, Valproic Acid, Or Divalproex)The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Keppra (Levetiracetam)
Risk factors for serious side effects
DilantinLamictalTrileptalTegretolTopamaxDepakoteKeppra
  • People of Asian ancestry
  • Starting Dilantin (Phenytoin) within the first two months
  • Infusing Dilantin (Phenytoin) too fast
    • History of depression
    • History of osteoporosis
    • History of fractures
    • Stopping Dilantin (Phenytoin) suddenly
    Detailed Dilantin (Phenytoin) risks & warnings »
    Coming soon.Coming soon.Coming soon.Coming soon.Coming soon.Coming soon.
    Pregnancy category
    DilantinLamictalTrileptalTegretolTopamaxDepakoteKeppra
    DFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    CFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    CFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    DFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    DFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    DFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    CFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    Alcohol
    No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.
    Food
    No specific food-related info.
    • Take with food to avoid upset stomach.
    • Trileptal (Oxcarbazepine) can be taken with or without food.
    No specific food-related info.No specific food-related info.
    • Take with food to avoid upset stomach.
    No specific food-related info.
    Kidneys and liver
    • If you have kidney problems, your dose and kidney function will have to be checked regularly to make sure Dilantin (Phenytoin) levels don’t get too high.
    No specific kidneys and liver-related info.
    • If you have kidney problems, your dose may need to be adjusted. Your doctor will check your kidney function regularly.
    No specific kidneys and liver-related info.
    • A few people will get kidney stones.
    No specific kidneys and liver-related info.
    • If you have kidney problems, your dose may need to be adjusted. Your doctor will check your kidney function regularly.
    Sex
    No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.
    Sleep
    No specific sleep-related info.No specific sleep-related info.
    • Can cause difficulty concentrating, tiredness or drowsiness, and problems with coordination.
    • You can experience dizziness, drowsiness, double vision, stomach upset, and trouble with coordination while on this.
    No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.
    • You can experience drowsiness, weakness, dizziness, or respiratory infections while on this.
    Weight
    No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.
    • Can cause sleepiness, speech problems, tingling sensations, and weight loss.
    • Can cause upset stomach, hair loss, weight gain, sleepiness, and tremor.
    • May cause hair loss and weight gain.
    No specific weight-related info.
    Upsides and benefits
    DilantinLamictalTrileptalTegretolTopamaxDepakoteKeppra
    • Dilantin (Phenytoin) is effective at preventing seizures, and treating seizures in an emergency.
    • Available in an oral suspension and chewable tablets if you have trouble swallowing capsules.
    • Available as a generic.
    • Effective at lowering the frequency of seizures in people with epilepsy or Lennox-Gestaut syndrome. Typically used together with other medications for severe seizure disorders.
    • Works best for partial, tonic-clonic, and absence seizures.
    • A first-line treatment for bipolar disorder. Effective long-term treatment for stabilizing mood. Prevents both depressive and manic episodes, but the effect is greater for preventing depression.
    • Doesn't require routine blood tests.
    • Trileptal (Oxcarbazepine) is effective at lowering the frequency of seizures, especially for people with partial seizures.
    • If you have trouble swallowing tablets, Trileptal (Oxcarbazepine) is also available as an oral solution.
    • Available in a generic form.
    • You won’t need to get regular blood tests to check the drug levels in your body.
    • Lowers the frequency of seizures, especially for people with tonic-clonic and partial seizures.
    • First-line option for trigeminal neuralgia (nerve pain involving the face, head, and neck), and can relieve other types of nerve pain.
    • May be helpful in stabilizing mood for people with bipolar disorder.
    • Used on its own or with other antiepileptic medicines to lower the frequency of seizures, especially for people with tonic-clonic or partial seizures, or Lennox-Gestaut syndrome.
    • Doesn't need routine blood tests.
    • Helpful in preventing frequent migraine headaches.
    • Lowers the frequency of seizures, especially for people with absence, tonic-clonic, and complex partial seizures.
    • One of the first-line options to stabilize mood for people with bipolar disorder.
    • Helpful in preventing frequent migraine headaches.
    • Lowers the frequency of seizures, including partial-onset, generalized tonic-clonic, and myoclonic seizures.
    • Unlike many other medications for epilepsy, this has very few drug interactions, so your other medicines shouldn't be affected.
    • If you have trouble swallowing tablets, Keppra (Levetiracetam) is also available as an oral solution.
    • You won’t need to get regular blood tests to check the drug levels in your body.
    Downsides and risks
    DilantinLamictalTrileptalTegretolTopamaxDepakoteKeppra
    • Need to get blood tests regularly to make sure Dilantin (Phenytoin) has safe and effective levels in your body.
    • Can cause changes in your appearance, such as unwanted hair growth, enlargement of the gums, and coarsening of your facial features.
    • If you have kidney problems, your dose and kidney function will have to be checked regularly to make sure Dilantin (Phenytoin) levels don’t get too high.
    • Can make many other medicines less effective, including birth control.
    • Can cause double vision, dizziness, sleepiness, and headache.
    • Has the risk of a rare but life-threatening rash.
    • Can make hormonal birth control less effective.
    • Might be less effective than other medicines for treating manic episodes (acute mania) in people with bipolar disorder.
    • It’s important to take your dose on time so that Trileptal (Oxcarbazepine) has steady levels in your body.
    • Can cause difficulty concentrating, tiredness or drowsiness, and problems with coordination.
    • Being pregnant lowers the levels of Trileptal (Oxcarbazepine), so the medicine might not be as effective at preventing seizures.
    • Interacts with many other medicines and supplements.
    • If you have kidney problems, your dose may need to be adjusted. Your doctor will check your kidney function regularly.
    • Higher risk of skin reactions compared to other antiepileptic medicines, ranging from mild to life-threatening rash.
    • Can cause blurry vision, dizziness, and upset stomach.
    • Interacts with many other medicines and supplements.
    • Not safe to use if you're pregnant.
    • Requires routine blood tests to see how the medicine is affecting your body.
    • Can cause sleepiness, speech problems, tingling sensations, and weight loss.
    • A few people will get kidney stones.
    • Not safe to use if you're pregnant.
    • Can cause upset stomach, hair loss, weight gain, sleepiness, and tremor.
    • Can cause liver damage, so it's probably not safe if you already have liver problems.
    • Not safe to use if you're pregnant.
    • Requires routine blood tests to see how the medicine is affecting your body.
    • It’s important to take your dose on time so that Keppra (Levetiracetam) has consistent levels in your body.
    • May not be the best drug to take if you have a history of psychiatric issues, such as depression or bipolar disorder.
    • Keppra (Levetiracetam) is only FDA-approved to be taken with other medicines to treat epilepsy.
    • If you have kidney problems, your dose may need to be adjusted. Your doctor will check your kidney function regularly.
    Tips from our pharmacists for people taking the medication
    DilantinLamictalTrileptalTegretolTopamaxDepakoteKeppra
    • Can cause loss of coordination, confusion, uncontrollable eye movements, and unwanted hair growth while on this.
    • If you’re taking supplements, let your doctor know. You’ll likely have to space out the supplements and Dilantin (Phenytoin) so they don’t interact.
    • Makes many drugs less effective, so make sure your doctor has a complete list of what you’re taking.
    • If you need to stop taking Dilantin (Phenytoin), do so over at least one week to prevent withdrawal seizures.
    • If you start having skin rashes or thoughts of suicide, tell your doctor immediately.
    • Follow dose adjustments set by your doctor to minimize skin rash.
    • Report rash, blurry vision, fever, persistent headache, or neck stiffness to your doctor.
    • Makes hormonal birth control less effective.
    • Takes 4 to 6 weeks to feel full effects on mood.
    • Take with food to avoid upset stomach.
    • You can experience dizziness, drowsiness, double vision, stomach upset, and trouble with coordination while on this.
    • If you need to stop taking Trileptal (Oxcarbazepine), do so over at least one week to prevent withdrawal seizures.
    • Trileptal (Oxcarbazepine) makes birth control and many other medicines less effective.
    • Trileptal (Oxcarbazepine) can be taken with or without food.
    • If you're taking the oral suspension, use the measuring device given with the medicine. Don’t use your household tablespoons to measure.
    • If you start having skin rashes or thoughts of suicide, tell your doctor immediately.
    • Report skin rashes or blistering immediately.
    • Takes up to 5 weeks to feel full effects on mood.
    • For the first week, avoid activities that require you to be alert.
    • Don't use if pregnant.
    • Requires routine blood tests.
    • Report confusion, persistent abdominal pain, yellowing of eyes/skin, or easy bruising to your doctor.
    • Can cause tingling skin sensations and reduced appetite.
    • Report any confusion, decreased sweating, fever, or changes in behavior or vision.
    • For the first week, avoid activities that require you to be alert.
    • Don't use if pregnant.
    • Takes 3 to 4 weeks to feel full effects on mood.
    • May cause hair loss and weight gain.
    • Different versions of Depakote have different dosing. Be careful.
    • For the first week, avoid activities that require you to be alert.
    • Don't use if pregnant.
    • Requires routine blood tests.
    • Take with food to avoid upset stomach.
    • Report confusion, persistent abdominal pain, yellowing of eyes/skin, or easy bruising to your doctor.
    • Takes 3 to 4 weeks to feel full effects on mood.
    • You can experience drowsiness, weakness, dizziness, or respiratory infections while on this.
    • If you start having skin rashes or changes in your mood, tell your doctor immediately.
    • If you need to stop taking Keppra (Levetiracetam), do so over at least one week to prevent withdrawal seizures.
    • If you are taking the oral solution, use the measuring device given with the medicine. Don’t use your household tablespoons to measure.
    • Don’t crush or cut this medicine before taking it, or else you’ll have dangerously high levels of this drug in your body.
    Learn more
    More about DilantinSide effectsReviews & ratingsAlternativesFDA package insert
    More about LamictalSide effectsReviews & ratingsFDA package insert
    More about TrileptalSide effectsReviews & ratingsFDA package insert
    More about TegretolSide effectsReviews & ratingsFDA package insert
    More about TopamaxSide effectsReviews & ratingsFDA package insert
    More about DepakoteSide effectsReviews & ratingsFDA package insert
    More about KeppraSide effectsReviews & ratingsFDA package insert