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Dilaudid Alternatives

(Hydromorphone)

  • Pill
  • Extended release
  • Oral solution
  • Suppository
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Compare Dilaudid (Hydromorphone) to alternatives

These medications are comparable to Dilaudid (Hydromorphone) or used for similar purposes.

Dilaudid
(Hydromorphone)

Codeine

Oxycontin
(Oxycodone)

Percocet
(Oxycodone / Acetaminophen)

Treats moderate to severe pain. Dilaudid (Hydromorphone) is a fast-acting, potent medication that treats problems needing strong pain relief.Treats mild to moderate pain. Codeine works well for mild to moderate pain, but it may not be an great option for all people.Treats severe pain. Oxycontin (Oxycodone) provides options for treating both short and long-term moderate to severe pain, but no matter how long you take it, you’ll need to watch out for constipation.Treats moderate to severe pain. Percocet (Oxycodone / Acetaminophen) is the strongest prescription combination pain medicine for as needed pain relief, but make sure you don't take too much acetaminophen (Tylenol) to avoid liver problems or death.
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Reviews & ratings
Button Group. All currently active
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5.65625Dilaudid
Reviews for Dilaudid (Hydromorphone)
75%
of people say Dilaudid (Hydromorphone) is worth it
72%
say it works well
9%
say it's a big hassle

Not enough reviews for this drug. Help someone out, leave a review!

Reviews for Oxycontin (Oxycodone)
66%
9% vs. Dilaudid (Hydromorphone)
50%
22% vs. Dilaudid (Hydromorphone)
19%
10% vs. Dilaudid (Hydromorphone)
Reviews for Percocet (Oxycodone / Acetaminophen)
69%
6% vs. Dilaudid (Hydromorphone)
49%
23% vs. Dilaudid (Hydromorphone)
15%
6% vs. Dilaudid (Hydromorphone)
Side effects
DilaudidcodeineOxycodonePercocet
  • Joint pain 4%
  • Weight decreased 1%
More Dilaudid side effects »

We haven’t found good data for codeine side effects.

FDA side effect reports for codeine »
  • Drowsiness 19%
  • Constipation 16%
  • Nausea 12%
  • Itching 11%
  • Vomiting 5%
  • Dizziness 4%
  • Dry mouth 4%
  • Sweating 3%
More Oxycodone side effects »

The Percocet FDA package insert doesn’t have numbers about how common side effects are.

More about Percocet side effects »
How it works
DilaudidcodeineOxycodonePercocet
Dilaudid (Hydromorphone) is an opioid medicine (similar to morphine) that works in the brain to lower pain perception.Codeine is an opiate agonist. It blocks pain receptors in the brain.Oxycontin (Oxycodone) is an opioid medicine (similar to morphine) that works in the brain to lower pain perception.Percocet (Oxycodone / Acetaminophen) is a combination pain medicine. Oxycodone is an opioid (similar to morphine) that works in the brain to lower pain perception. Acetaminophen is a non-opioid pain reliever and fever reducer.
Type of medication
DilaudidcodeineOxycodonePercocet
Pain reliever
Opioid
Prescription only
Pain reliever
Opioid
Prescription only
Pain reliever
Opioid
Prescription only
Pain reliever
Opioid
Acetaminophen (APAP)
Prescription only
Available as
DilaudidcodeineOxycodonePercocet
  • Pill
  • Extended release
  • Oral solution
  • Suppository
  • Pill
  • Liquid
  • Pill
  • Extended release
  • Oral solution
  • Liquid
  • Pill
  • Oral solution
Used for (click to learn more)
DilaudidcodeineOxycodonePercocet
Risk factors for serious side effects
DilaudidcodeineOxycodonePercocet
  • Current use of medicine that affects liver enzyme CYP 3A4
  • Age 65 or greater
  • Higher dose
  • People with not enough thyroid hormones
  • History of lung problems
  • Children age 18 and younger
  • Long-term use during pregnancy
  • Taking more than the prescribed dose
  • Long-term use
  • History of drug abuse
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Age 65 or greater
  • Age 65 years or older
Detailed Dilaudid (Hydromorphone) risks & warnings »
Coming soon.Coming soon.Coming soon.
Pregnancy category
DilaudidcodeineOxycodonePercocet
CFDA pregnancy category (Weigh risks vs. benefits)

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

See the FDA package insert
CFDA pregnancy category (Weigh risks vs. benefits)

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

See the FDA package insert
BFDA pregnancy category (Probably safe)

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

See the FDA package insert
CFDA pregnancy category (Weigh risks vs. benefits)

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

See the FDA package insert
Alcohol
  • Never use alcohol when taking Dilaudid (Hydromorphone).
  • Can cause constipation, breathing problems, nausea, drowsiness, and dizziness. Don't drink alcohol with Codeine.
  • Dizziness and drowsiness is common. While taking this, it’s best to avoid alcohol.
  • Avoid alcohol.
Food
No specific food-related info.
  • Take with food or milk to help prevent upset stomach.
  • Take it with food to lower the chance of an upset stomach.
  • Take it with food to lower the chance of an upset stomach.
Kidneys and liver
No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.
Sex
No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.
Sleep
  • Dizziness and drowsiness are common when taking Dilaudid (Hydromorphone), but your body may adjust over time.
  • Dilaudid (Hydromorphone) will cause drowsiness, so be really careful if you're taking other meds that also cause drowsiness, such as antidepressives, antianxiety meds, or muscle relaxants.
  • Can cause constipation, breathing problems, nausea, drowsiness, and dizziness. Don't drink alcohol with Codeine.
  • It can cause drowsiness or sleepiness.
  • Dizziness and drowsiness is common. While taking this, it’s best to avoid alcohol.
  • Can make you dizzy or drowsy.
  • Dizziness and drowsiness is common, but your body may adjust.
  • Can make you dizzy or drowsy.
Weight
No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.
Upsides and benefits
DilaudidcodeineOxycodonePercocet
  • Works well to relieve moderate to severe pain.
  • Dilaudid (Hydromorphone) is stronger than morphine and works quicker than other pain medications.
  • It doesn't cause as many side effects, like nausea and rashes, as morphine does.
  • It's available as fast-acting tablets, extended-release tablets, and as a liquid.
  • Effective option for relieving mild to moderate pain that wasn't controlled by non-opioid medications.
  • Available as a generic in both tablets and oral solution.
  • Can be used for the short-term relief of a dry cough.
  • Oxycontin (Oxycodone) immediate-release (short acting) works best for “as needed” or “break-through” pain.
  • Long-acting tablets are good for chronic pain that requires around-the-clock relief.
  • Can have fewer side effects than other opioid pain relievers.
  • Generally considered to be stronger than morphine.
  • Combination pain medicine with an opioid component (oxycodone) and non-opioid component (acetaminophen or Tylenol) that takes advantage of different modes of pain relieve in a single pill.
  • Provides quick relief for moderate to severe pain to improve quality of life.
  • Generally considered stronger than Norco or other combination pain medicine for treating pain.
  • Good for as-needed, short-term use, but may be helpful to manage more long-term pain problems if used at the appropriate doses and intervals.
  • Lower rates of misuse compared to pure opioid medicines.
  • Can help you fall asleep easier.
Downsides and risks
DilaudidcodeineOxycodonePercocet
  • People with breathing problems like asthma and COPD need to be monitored very closely if taking Dilaudid (Hydromorphone).
  • Dilaudid (Hydromorphone) isn't usually used for elderly or frail patients.
  • Dizziness and drowsiness are common when taking Dilaudid (Hydromorphone), but your body may adjust over time.
  • Everyone tends to get constipation while on this, so you'll need to stay hydrated and may need to take a stool softener medication.
  • Must be weaned slowly off the medicine after using it longer than 2 weeks.
  • Long-term use will likely cause physical dependence.
  • Codeine is changed to an active form in the body by a liver enzyme. About 10% of people don't have this enzyme and don't get enough pain relief.
  • There are many drug interactions with Codeine, such as antidepressants. Talk to your doctor or pharmacist before starting any new medicine or making any changes.
  • Other pain medications are more potent than Codeine.
  • It's possible to build a tolerance and become dependent on Codeine.
  • Can cause constipation, so you'll need to drink plenty of water or take a stool softener while on it.
  • Dizziness and drowsiness is common. While taking this, it’s best to avoid alcohol.
  • You’ll need to take the immediate-release for a few weeks before you can be switched to the long-acting formulation. It’s not safe to start taking the long-acting one if you've never taken an opioid pain medicine before.
  • Everyone will get constipation, so it’s best to stay hydrated and take a stool softener while on Oxycontin (Oxycodone).
  • Need be weaned slowly off the medicine after using it longer than two weeks.
  • Long-term use will likely cause physical dependence.
  • Dizziness and drowsiness is common, but your body may adjust.
  • Everyone will get constipation - always stay hydrated and take stool softener or stimulant on days you're taking Percocet if you need.
  • All opioid containing medicines have the risk of physical dependence and possibility of withdrawal when used long-term.
  • The non-opioid part of Percocet, acetaminophen (Tylenol), has a high risk of liver failure and death if you take more than the maximum daily dose. Be very careful.
  • Relies on the users to be aware of how much acetaminophen (Tylenol) they are using since it is a very common ingredient in many prescription and non-prescription pain medicines.
  • Avoid alcohol.
Tips from our pharmacists for people taking the medication
DilaudidcodeineOxycodonePercocet
  • Dilaudid (Hydromorphone) is usually taken for a short time. If you take it longer than 2 weeks, you'll need to lower your dose slowly to get off it since stopping suddenly can cause withdrawal symptoms.
  • Usually works within 30 minutes.
  • Dilaudid (Hydromorphone) will cause drowsiness, so be really careful if you're taking other meds that also cause drowsiness, such as antidepressives, antianxiety meds, or muscle relaxants.
  • Never use alcohol when taking Dilaudid (Hydromorphone).
  • It's very important to keep Dilaudid (Hydromorphone) away from children, since it can stop them from breathing.
  • Takes about 30 to 60 minutes to start working and can last about 4 to 6 hours.
  • Can cause constipation, breathing problems, nausea, drowsiness, and dizziness. Don't drink alcohol with Codeine.
  • Take with food or milk to help prevent upset stomach.
  • It can cause drowsiness or sleepiness.
  • Codeine is activated in the body by enzymes in the liver. If you're taking other medications or have liver abnormalities, Codeine can be activated too fast and cause increased side effects.
  • Opioid pain medicine that provides longer pain relief—up to 12 hours.
  • Works best when taken regularly instead of as-needed.
  • Especially useful for people with chronic pain problems.
  • May not be the best choice for people who have never taken an opioid pain medicine because it lasts so long.
  • Swallow it whole. Don't crush, chew, or split the medicine.
  • Avoid activities that need you to be fully alert until you know how it affects you.
  • Constipation is common and may not go away while you're taking this medicine. Drinking lots of water and taking laxatives can help.
  • Talk to your doctor if it doesn't help enough for your pain, or if the side effects are really bad.
  • Can make you dizzy or drowsy.
  • Take it with food to lower the chance of an upset stomach.
  • This is a combination pain medication. It contains both an opioid medicine, and acetaminophen (Tylenol).
  • Starts working in 30 minutes.
  • Works best if you take it as soon as you start feeling pain.
  • Pain relief lasts 4-6 hours.
  • Avoid activities need you to be fully alert until you know how it affects you.
  • Constipation is common and may not go away while you're taking this medicine. Drinking lots of water and using laxatives can help.
  • Don't take more than instructed to prevent liver damage.
  • Use it for the shortest time possible, and at the lowest dose possible, to lower your chance of becoming addicted.
  • Talk to your doctor if it doesn't work well enough to relieve your pain, or if the side effects are really bad.
  • Can make you dizzy or drowsy.
  • Take it with food to lower the chance of an upset stomach.
Learn more
More about DilaudidSide effectsReviews & ratingsAlternativesFDA package insert
More about codeineSide effectsReviews & ratingsFDA package insert
More about OxycodoneSide effectsReviews & ratingsFDA package insert
More about PercocetSide effectsReviews & ratingsFDA package insert