Prescription onlyClass: Women's health


(estradiol gel)

Prescription onlyClass: Women's health
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Relieves hot flashes due to menopause.

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Our bottom line

Divigel (Estradiol Gel) comes in 3 different strengths. It uses lower doses of estrogen than other hormone replacements and is easy to use and apply.

Prices and discounts
Lowest price for 30 30 packets of 1mg gel cartons
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  • Divigel (Estradiol Gel) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, vaginal dryness).
  • Good for people who don't want to take daily pills.
  • The pre-measured packets are easy to use and can be taken anywhere.
  • Fewer side effects than pills since there are lower amounts of estrogen in topical gels.
  • In studies, when people used low doses of Divigel (Estradiol Gel), their symptoms started to improve in 5 weeks and they felt continued improvement over 8 to 12 weeks. People using the highest doses of Divigel (Estradiol Gel) felt better in just 2 weeks.
  • Divigel (Estradiol Gel) is available in 3 strengths.
  • Very few women (less than 1%) had skin irritation from the medicine.
  • Can lower your risk of fractures by keeping your bones healthy. Make sure you also get enough calcium and Vitamin D.
  • Improves mood, energy, and mental alertness for some people.
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  • Increases your risk of endometrial and breast cancer.
  • If you have your uterus, you have to use Divigel (Estradiol Gel) with another hormone called progestin to lower your risk of uterine cancer.
  • Increases your risk of developing blood clots and stroke.
  • Can't be used in people with liver problems.
  • It's possible to expose other people to the estrogen before it's absorbed by your skin.
  • Can be expensive since it's only available as a brand name product.
Prices and discounts
Lowest price for 30 30 packets of 1mg gel cartons
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How it works

Divigel (Estradiol Gel) replaces estrogen hormones in your vagina that your body loses during menopause. Estrogen helps relieve symptoms of menopause, such as hot flashes, night sweats, and vaginal problems.

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Used for
  • Hot flashes and night sweats
Dosage forms
  • Cream, gel, or ointment
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Side effect rates for Divigel (estradiol gel)

248 From clinical trials of Divigel / Postmenopausal estrogen replacement (0.5 g/day)
  • Breast Tenderness
  • Metrorrhagia
  • Nasopharyngitis
  • Upper Respiratory Tract Infection
  • Vaginal mycosis

Risks and Warnings for Divigel (estradiol gel)

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    • Higher risk if:
    • Using estrogen for more than one year

    Vaginal bleeding after menopause can be a warning sign of uterus (endometrial) cancer, so let your doctor know if you notice any unusual bleeding. When estrogen is prescribed to women after menopause who still have a uterus, progestin should be used with it to lower the risk of cancer. Low-dose vaginal estrogen products are often a better choice than oral pills for women 65 years or older who have vaginal symptoms.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Divigel (estradiol gel)

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  • The gel is alcohol-based and flammable, so you shouldn't smoke while applying it.
  • Can cause nausea, dizziness, bloating, and breast tenderness.