Prescription onlyNo lower cost generic available

Divigel

(Estradiol Gel)

  • Cream, gel, or ointment
  • Hot flashes and night sweats
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Relieves hot flashes due to menopause.

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Prescription onlyNo lower cost generic available

Our pharmacists’ bottom line

Divigel (Estradiol Gel) comes in 3 different strengths. It uses lower doses of estrogen than other hormone replacements and is easy to use and apply.

  • Divigel (Estradiol Gel) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, vaginal dryness).
  • Good for people who don't want to take daily pills.
  • The pre-measured packets are easy to use and can be taken anywhere.
  • Fewer side effects than pills since there are lower amounts of estrogen in topical gels.
  • In studies, when people used low doses of Divigel (Estradiol Gel), their symptoms started to improve in 5 weeks and they felt continued improvement over 8 to 12 weeks. People using the highest doses of Divigel (Estradiol Gel) felt better in just 2 weeks.
  • Divigel (Estradiol Gel) is available in 3 strengths.
  • Very few women (less than 1%) had skin irritation from the medicine.
  • Can lower your risk of fractures by keeping your bones healthy. Make sure you also get enough calcium and Vitamin D.
  • Improves mood, energy, and mental alertness for some people.
  • Increases your risk of endometrial and breast cancer.
  • If you have your uterus, you have to use Divigel (Estradiol Gel) with another hormone called progestin to lower your risk of uterine cancer.
  • Increases your risk of developing blood clots and stroke.
  • Can't be used in people with liver problems.
  • It's possible to expose other people to the estrogen before it's absorbed by your skin.
  • Can be expensive since it's only available as a brand name product.

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Side effects for Divigel (Estradiol Gel)

From clinical trials of Divigel / Postmenopausal estrogen replacement (0.5 g/day) ( 248)

  • Breast tendernessBreast tenderness6% for Divigel vs.2% for placebo
  • MetrorrhagiaMetrorrhagia6% for Divigel vs.2% for placebo
  • Common coldCommon cold4% for Divigel vs.4% for placebo
  • Ear, nose, or throat infectionEar, nose, or throat infection2% for Divigel vs.2% for placebo
  • Vaginal mycosisVaginal mycosis2% for Divigel vs.3% for placebo

What to expect when you take Divigel (Estradiol Gel)

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Tips from our pharmacists
  • Apply all of the gel in the packet to dry, clean, unbroken skin on the right or left upper thigh, alternating each day.
  • Don't put it on your face, breasts, vagina, or irritated skin.
  • Don't rub it in. Let the gel dry before dressing, and don't wash the application site for at least an hour.
  • Wash your hands well after applying the gel.
  • The gel is alcohol-based and flammable, so you shouldn't smoke while applying it.
  • Can cause nausea, dizziness, bloating, and breast tenderness.
  • Tell your doctor about any unusual vaginal bleeding.
  • Get emergency care if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.

Risks and Warnings for Divigel (Estradiol Gel)

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    • Higher risk if:
    • Using estrogen for more than one year

    Vaginal bleeding after menopause can be a warning sign of uterus (endometrial) cancer, so let your doctor know if you notice any unusual bleeding. When estrogen is prescribed to women after menopause who still have a uterus, progestin should be used with it to lower the risk of cancer. Low-dose vaginal estrogen products are often a better choice than oral pills for women 65 years or older who have vaginal symptoms.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Divigel (Estradiol Gel)

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The FDA category for this medication is X. It is advised that you: Unsafe
Pregnancy
Alcohol
  • Tips from our pharmacists
  • The gel is alcohol-based and flammable, so you shouldn't smoke while applying it.
Sleep
  • my gyno didn't think it would help my insomnia since it was not related to night sweats or hot flashes. it worked wonders! I can sleep again & all my symptoms related to insomnia (depression, tiredness, anxiety) disappeared.
    Age: 50
    Gender: Woman
    Taken for: Insomnia
    Duration taken: A year or so