Duetact

(pioglitazone / glimepiride)

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Lowers blood sugar.

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Duetact (pioglitazone / glimepiride) combines 2 different anti-diabetic medicines into one to help improve blood sugar control, but it is associated with serious complications such as heart failure.

Quick facts about Duetact
  • Drug class: Endocrine
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (pioglitazone / glimepiride)
Prices and discounts
Lowest price for 30 30mg-2mg tablets
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$125.15

Upsides

  • Taken only once a day.
  • Effectively lowers A1c levels and greatly improves blood sugar control as a combination medicine compared to taking the 2 individual medicines alone.
  • Duetact (pioglitazone / glimepiride) is a good add-on treatment option for people who are unable to fully control their blood sugar levels through diet and exercise alone.
  • Duetact (pioglitazone / glimepiride) is an oral medicine so it might be a good alternative for those who don't like injections.

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What to expect from Duetact, on one page

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Downsides

  • Duetact (pioglitazone / glimepiride) might cause weight gain.
  • Might not be a good treatment option for people with heart failure or liver problems.
  • Might cause bone fractures, especially for women.
  • Relatively expensive as a combination medicine compared to the 2 individual medicines alone.
  • Not recommended for people age 65 or older and those with kidney problems because they are more likely to experience side effects such as low blood sugar.

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Sign up and get Pill Talk, the latest in health & medicine news from Iodine

Get our free fact sheet

What to expect from Duetact, on one page

Download Fact Sheet
Prices and discounts
Lowest price for 30 30mg-2mg tablets
Determining your location...
$125.15
How it works

Duetact (pioglitazone / glimepiride) contains 2 prescription medicines called pioglitazone and glimepiride that both help lower blood sugar through the actions of insulin. Glimepiride stimulates your body to release more of its own insulin, while pioglitazone helps your body use the insulin more effectively.

Quick facts about Duetact
  • Drug class: Endocrine
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (pioglitazone / glimepiride)

Dosage forms

  • Pill
Tried Duetact? Write a review!

What to expect when you take Duetact (pioglitazone / glimepiride) for Type 2 diabetes

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Side effect rates for Duetact (pioglitazone / glimepiride)

Risks and Warnings for Duetact (pioglitazone / glimepiride)

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    • Higher risk if:
    • Those with a history of heart failure

    Duetact (pioglitazone / glimepiride) can cause fluid buildup that can lead to or worsen congestive heart failure, especially for those just starting to take the medicine or increasing their dose. Speak to your doctor right away if you experience sudden weight gain, swelling, or trouble breathing. This medicine is not recommended for those who has a history of heart failure.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Duetact (pioglitazone / glimepiride)

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Alcohol
  • Avoid drinking alcohol while taking this medicine.
Kidneys and liver
  • Not recommended for people age 65 or older and those with kidney problems because they are more likely to experience side effects such as low blood sugar.
Weight
  • Duetact (pioglitazone / glimepiride) might cause weight gain.