Prescription onlyLower-cost generic availableClass: Mental health

Elavil Alternatives

(amitriptyline)

Prescription onlyLower-cost generic availableClass: Mental health
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Compare Elavil (amitriptyline) to alternatives

These medications are comparable to Elavil (amitriptyline) or used for similar purposes.

Elavil
(amitriptyline)

Cymbalta
(duloxetine)

Norpramin
(desipramine)

Celexa
(citalopram)

Neurontin
(gabapentin)

Zoloft
(sertraline)

Remeron
(mirtazapine)

Pamelor
(nortriptyline)

Oleptro
(trazodone)

Paxil
(paroxetine)

Tofranil
(imipramine hydrochloride)

Effexor
(venlafaxine)

Improves mood and relieves certain kinds of pain. Elavil (Amitriptyline) is an older antidepressant that's sometimes used to treat pain and sleep problems, but it can have more side effects than similar medications.Improves mood and relieves certain kinds of pain. Cymbalta (Duloxetine) is good for treating depression and anxiety, and may help with chronic pain. More likely than other antidepressants to cause problems if you drink or have high blood pressure.Stabilizes your mood. Norpramin (desipramine) is not a first choice for treating depression because of its effects on the heart, but it can be good if other medicines haven't worked.Improves mood and helps you relax. Celexa (Citalopram) is good for treating depression and anxiety. Might be less likely to cause side effects than some antidepressants, but not the best choice for people with heart or liver problems.Treats tingling and burning nerve pain. Neurontin (Gabapentin) is an old seizure disorder medicine that's now used to treat nerve-related pain caused by different conditions.Improves mood and helps you relax. Zoloft (Sertraline) is good for treating depression and anxiety. It's more likely to cause insomnia and diarrhea than other antidepressants.Improves mood. Remeron (mirtazapine) improves your mood and helps you sleep better, but can cause more weight gain than any other antidepressant.Improves your mood. Pamelor (Nortriptyline) is a good option for treating depression, especially for people who also have problems with persistent nerve pain.Improves mood and helps you sleep. Oleptro (Trazodone) works well as a sleep aid, but has more side effects when used at higher doses for treating depression.Improves mood and helps you relax. Paxil (Paroxetine) is good for treating depression and anxiety but it causes more weight gain, sleepiness, and withdrawal symptoms than other antidepressants.Improves your mood and stops bedwetting in children. Tofranil (imipramine hydrochloride) is one of the first choice medicines used to treat depression, but it can cause weight gain and sleepiness.Improves mood and helps you relax. Effexor (Venlafaxine) is good for treating depression and anxiety. It may work when other antidepressants haven't, but it's more likely to cause side effects and withdrawal symptoms than other antidepressants.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.48Elavil
Reviews for Elavil
53%
of people (All ages) say Elavil is worth it
36%
say it works well
25%
say it's a big hassle
134 reviews
Have you used Elavil (amitriptyline)?
Worth itNot sureNot worth it
Reviews for Cymbalta
58%
-5% worse vs. Elavil
49%
-13% worse vs. Elavil
24%
-1% worse vs. Elavil
496 reviews
Have you used Cymbalta (duloxetine)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Norpramin (desipramine)?
Worth itNot sureNot worth it
Reviews for Celexa
61%
-8% worse vs. Elavil
51%
-15% worse vs. Elavil
16%
-9% worse vs. Elavil
520 reviews
Have you used Celexa (citalopram)?
Worth itNot sureNot worth it
Reviews for Neurontin
57%
-4% worse vs. Elavil
40%
-4% worse vs. Elavil
19%
-6% worse vs. Elavil
620 reviews
Have you used Neurontin (gabapentin)?
Worth itNot sureNot worth it
Reviews for Zoloft
59%
-6% worse vs. Elavil
41%
-5% worse vs. Elavil
15%
-10% worse vs. Elavil
1472 reviews
Have you used Zoloft (sertraline)?
Worth itNot sureNot worth it
Reviews for Remeron
45%
+8% better vs. Elavil
39%
-3% worse vs. Elavil
26%
+1% better vs. Elavil
152 reviews
Have you used Remeron (mirtazapine)?
Worth itNot sureNot worth it
Reviews for Pamelor
79%
-26% worse vs. Elavil
79%
-43% worse vs. Elavil
21%
-4% worse vs. Elavil
Have you used Pamelor (nortriptyline)?
Worth itNot sureNot worth it
Reviews for Oleptro
73%
-20% worse vs. Elavil
49%
-13% worse vs. Elavil
24%
-1% worse vs. Elavil
Have you used Oleptro (trazodone)?
Worth itNot sureNot worth it
Reviews for Paxil
52%
+1% better vs. Elavil
39%
-3% worse vs. Elavil
24%
-1% worse vs. Elavil
694 reviews
Have you used Paxil (paroxetine)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Tofranil (imipramine hydrochloride)?
Worth itNot sureNot worth it
Reviews for Effexor
62%
-9% worse vs. Elavil
51%
-15% worse vs. Elavil
23%
-2% worse vs. Elavil
577 reviews
Have you used Effexor (venlafaxine)?
Worth itNot sureNot worth it
Side effects
ElavilCymbaltadesipramineCelexaNeurontinZoloftRemeronPamelorOleptroPaxilTofranilEffexor

The Elavil FDA package insert doesn’t have numbers about how common side effects are.

More about Elavil side effects »
  • Nausea 15%
  • Headache 2%
  • Dry mouth 8%
  • Somnolencee 7%
  • Fatigue 4%
  • Sleep difficulty 4%
  • Constipation 5%
  • Dizziness 4%
  • Diarrhea 3%
  • Decreased appetite 5%
More Cymbalta side effects »

The desipramine FDA package insert doesn’t have numbers about how common side effects are.

More about desipramine side effects »
  • Nausea 7%
  • Dry mouth 6%
  • Drowsiness 8%
  • Sleep difficulty 1%
  • Sweating increased 2%
  • Diarrhea 3%
  • Tremor 2%
  • Ejaculation disorder 5%
  • Inflammation inside the nose 1%
  • Indigestion 1%
More Celexa side effects »
  • Dizziness 21%
  • Drowsiness 16%
  • Leg or ankle swelling 6%
  • Muscle weakness 1%
  • Diarrhea 2%
  • Infection 2%
  • Dry mouth 3%
  • Constipation 2%
  • Accidental injury 2%
  • Vomiting 2%
More Neurontin side effects »
  • Nausea 14%
  • Diarrhea/loose stools 9%
  • Sleep difficulty 7%
  • Mouth dry 7%
  • Drowsiness 7%
  • Dizziness 5%
  • Tremor 8%
  • Fatigue 3%
  • Sweating increased 5%
  • Constipation 2%
More Zoloft side effects »
  • Sleepiness 36%
  • Dry mouth 10%
  • Increased appetite 15%
  • Constipation 6%
  • Weight gain 10%
  • Lack of energy 3%
  • Dizziness 4%
  • Flu syndrome 2%
  • Abnormal dreams 3%
  • Abnormal thinking 2%
More Remeron side effects »

We haven’t found good data for Pamelor side effects.

FDA side effect reports for Pamelor »
  • Somnolence/sedation 27%
  • Drowsiness 21%
  • Dry mouth 14%
  • Headache 6%
  • Dizziness/lightheadedness 13%
  • Dizziness 13%
  • Nausea 8%
  • Fatigue 7%
More Oleptro side effects »
  • Nausea 17%
  • Drowsiness 14%
  • Dry mouth 6%
  • Headache 1%
  • Muscle weakness 9%
  • Constipation 5%
  • Sleep difficulty 7%
  • Ejaculatory disturbance‡§ 13%
  • Dizziness 7%
  • Diarrhea 4%
More Paxil side effects »

The Tofranil FDA package insert doesn’t have numbers about how common side effects are.

More about Tofranil side effects »
  • Nausea 26%
  • Headache 1%
  • Drowsiness 14%
  • Dry mouth 11%
  • Dizziness 11%
  • Sleep difficulty 8%
  • Abnormal ejaculation 16%
  • Constipation 8%
  • Nervousness 17%
  • Muscle weakness 14%
More Effexor side effects »
How it works
ElavilCymbaltadesipramineCelexaNeurontinZoloftRemeronPamelorOleptroPaxilTofranilEffexor
Elavil (Amitriptyline) is a tricyclic antidepressant (TCA). Researchers don't know exactly how it works. It may change serotonin and norepinephrine activity in the brain, which regulates mood and pain perception. It also has sedative effects.Cymbalta (Duloxetine) is a serotonin and norepinephrine reuptake inhibitor (SNRI) antidepressant. It increases serotonin and norepinephrine activity in the brain, which regulates mood.Norpramin (desipramine) is a tricyclic antidepressant. It increases the amount of norepinephrine and serotonin in the brain, two chemicals that regulate mood.Celexa (Citalopram) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.Neurontin (Gabapentin) is an antiepileptic and nerve pain reliever. Researchers don't know exactly how it works, but it has a similar structure to GABA, a neurotransmitter that calms nerves in the brain and spinal cord.Zoloft (Sertraline) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases the activity of serotonin in the brain, which regulates mood.Remeron (mirtazapine) is an atypical antidepressant. It stimulates your body to make certain chemicals in the brain, such as serotonin and norepinephrine, which regulate mood.Pamelor (Nortriptyline) is a tricyclic antidepressant (TCA). It helps improve your mood by altering the levels of serotonin, norepinephrine, and other similar chemicals in your brain.Oleptro (Trazodone) is a serotonin reuptake inhibitor (SRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.Paxil (Paroxetine) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.Tofranil (imipramine hydrochloride) is a tricyclic antidepressant. It raises the amount of serotonin and norepinephrine in the brain, 2 chemicals that are known to regulate mood. It's not known exactly how Tofranil (imipramine hydrochloride) treats bedwetting.Effexor (Venlafaxine) is a serotonin and norepinephrine reuptake inhibitor (SNRI) antidepressant. It increases serotonin and norepinephrine activity in the brain, which regulate mood.
Type of medication
ElavilCymbaltadesipramineCelexaNeurontinZoloftRemeronPamelorOleptroPaxilTofranilEffexor
Prescription onlyPrescription onlyPrescription onlyPrescription onlyPrescription onlyPrescription onlyPrescription onlyPrescription onlyPrescription onlyPrescription onlyPrescription onlyPrescription only
Available as
ElavilCymbaltadesipramineCelexaNeurontinZoloftRemeronPamelorOleptroPaxilTofranilEffexor
  • Pill
  • Extended release
  • Pill
  • Pill
  • Oral solution
  • Pill
  • Oral solution
  • Pill
  • Liquid
  • Pill
  • Dissolving tablet
  • Pill
  • Liquid
  • Pill
  • Extended release
  • Pill
  • Extended release tablet
  • Liquid
  • Pill
  • Pill
  • Extended release
Used for
ElavilCymbaltadesipramineCelexaNeurontinZoloftRemeronPamelorOleptroPaxilTofranilEffexor
Risk factors for serious side effects
ElavilCymbaltadesipramineCelexaNeurontinZoloftRemeronPamelorOleptroPaxilTofranilEffexor
  • Age 24 years or younger
  • History of bipolar disorder
  • At risk for bipolar disorder
  • History of cardiovascular disease
  • Age 65 years or older
Detailed Elavil (amitriptyline) risks & warnings »
  • Age 24 years or younger
  • Using other medications that affect serotonin
  • Stopping Cymbalta (Duloxetine) suddenly
  • History of high blood pressure
  • Taking other blood-thinning drugs
Detailed Cymbalta (duloxetine) risks & warnings »
  • People under age 24
  • Tricyclic antidepressants
  • Fentanyl
  • Tramadol
  • Buspirone
Detailed Norpramin (desipramine) risks & warnings »
  • Age 24 years or younger
  • Using other medications that affect serotonin
  • History of bipolar disorder
  • At risk for bipolar disorder
  • Stopping Celexa (Citalopram) suddenly
Detailed Celexa (citalopram) risks & warnings »
  • Children ages 3 to 12
  • Taking with alcohol or drugs
  • Stopping Neurontin (Gabapentin) suddenly
Detailed Neurontin (gabapentin) risks & warnings »
  • Under 24 years old
  • Interactions with other medications
  • Stopping Zoloft (Sertraline) suddenly
  • Taking with blood-thinning drugs
  • Elderly
Detailed Zoloft (sertraline) risks & warnings »
  • Age 24 years or younger
  • Using other medications that affect serotonin
  • History of heart problems
  • History of liver problems
  • Higher dose
Detailed Remeron (mirtazapine) risks & warnings »
  • Age 24 years or younger
  • Age 65 years or older
  • Stopping Pamelor (Nortriptyline) suddenly
  • Using other medications that affect serotonin
  • History of heart disease
Detailed Pamelor (nortriptyline) risks & warnings »
  • Age 24 years or younger
  • History of seizures
  • Alcoholism
  • Eating disorder
  • Higher dose
Detailed Oleptro (trazodone) risks & warnings »
  • Age 24 years or younger
  • Using other medications that affect serotonin
  • Stopping Paxil (Paroxetine) suddenly
  • Taking other blood-thinning drugs
  • History of bipolar disorder
Detailed Paxil (paroxetine) risks & warnings »
  • Under age 24
  • History of heart disease
  • Overactive thyroid
  • High blood pressure
  • History of seizures
Detailed Tofranil (imipramine hydrochloride) risks & warnings »
  • Age 24 years or younger
  • Using other medications that affect serotonin
  • Stopping Effexor (Venlafaxine) suddenly
  • History of high blood pressure
  • Taking other blood-thinning drugs
Detailed Effexor (venlafaxine) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Interactions
ElavilCymbaltadesipramineCelexaNeurontinZoloftRemeronPamelorOleptroPaxilTofranilEffexor
No interactions related info.No interactions related info.No interactions related info.No interactions related info.No interactions related info.
  • It interacts with St. John's Wort and Tryptophan.
  • Prescription medications can interact with Remeron (mirtazapine). Let your doctor or pharmacist know if you're on prescription medications currently or within the past 14 days.
No interactions related info.No interactions related info.No interactions related info.No interactions related info.No interactions related info.
Alcohol
ElavilCymbaltadesipramineCelexaNeurontinZoloftRemeronPamelorOleptroPaxilTofranilEffexor
No alcohol related info.No alcohol related info.No alcohol related info.No alcohol related info.No alcohol related info.No alcohol related info.No alcohol related info.No alcohol related info.No alcohol related info.No alcohol related info.
  • Don't drink alcohol while taking Tofranil (imipramine hydrochloride).
No alcohol related info.
Food
ElavilCymbaltadesipramineCelexaNeurontinZoloftRemeronPamelorOleptroPaxilTofranilEffexor
No food related info.
  • Take with food to avoid upset stomach.
No food related info.
  • Take with food to avoid upset stomach.
  • Take the extended-release tablet with food.
No food related info.No food related info.
  • Take it with food and/or at bedtime to decrease the potential side effects.
No food related info.
  • Take with food to avoid upset stomach.
No food related info.No food related info.
Kidneys and liver
ElavilCymbaltadesipramineCelexaNeurontinZoloftRemeronPamelorOleptroPaxilTofranilEffexor
No kidneys and liver related info.
  • Not a good option if you're a heavy drinker, or if you have liver or kidney problems.
No kidneys and liver related info.
  • Not a good option for you if you have heart or liver problems.
No kidneys and liver related info.No kidneys and liver related info.No kidneys and liver related info.No kidneys and liver related info.No kidneys and liver related info.No kidneys and liver related info.No kidneys and liver related info.No kidneys and liver related info.
Pain
ElavilCymbaltadesipramineCelexaNeurontinZoloftRemeronPamelorOleptroPaxilTofranilEffexor
  • Low doses work well to treat certain kinds of chronic pain. It can take 2 weeks to feel the full effects of the medication.
  • Full effects in 8 to 12 weeks for mood, 2 weeks for pain.
No pain related info.No pain related info.
  • Studies show it's most effective for nerve pain from diabetes, shingles, and fibromyalgia (a painful muscle condition).
No pain related info.No pain related info.No pain related info.No pain related info.No pain related info.No pain related info.No pain related info.
Sex
ElavilCymbaltadesipramineCelexaNeurontinZoloftRemeronPamelorOleptroPaxilTofranilEffexor
No sex related info.No sex related info.No sex related info.
  • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
No sex related info.
  • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
No sex related info.No sex related info.No sex related info.No sex related info.No sex related info.
  • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
Sleep
ElavilCymbaltadesipramineCelexaNeurontinZoloftRemeronPamelorOleptroPaxilTofranilEffexor
  • Can cause dizziness, drowsiness, constipation, and weight gain.
No sleep related info.No sleep related info.No sleep related info.
  • Neurontin (Gabapentin) is likely to cause some side effects, including memory problems, drowsiness, dizziness, or confusion.
  • Zoloft (Sertraline) may increase the risk of low sodium levels in the blood (hyponatremia). Watch out for symptoms including headache, difficulty concentrating, memory problems, confusion, weakness, and unsteadiness, which may lead to falls. Talk to a doctor right away before developing more serious symptoms, such as hallucination, fainting, coma, and death.
  • Causes less drowsiness than other antidepressants.
  • Remeron (mirtazapine) can make you sleepy. It is best to take at bedtime.
  • Can help you fall asleep if you have trouble sleeping.
  • Makes you more tired than other antidepressants.
No sleep related info.No sleep related info.
  • It causes drowsiness, so it's good for people who have trouble sleeping.
  • Tofranil (imipramine hydrochloride) can make you feel sleepy, so don't drive or do anything requiring concentration until you know how it affects you.
No sleep related info.
Weight
ElavilCymbaltadesipramineCelexaNeurontinZoloftRemeronPamelorOleptroPaxilTofranilEffexor
  • It's more likely to cause sleepiness, nausea, constipation, diarrhea, and weight gain (1 to 5 pounds) than other antidepressants.
No weight related info.No weight related info.
  • Can cause minor weight gain (1 to 5 pounds).
No weight related info.No weight related info.
  • Remeron (mirtazapine) can raise your appetite and cause you to gain weight. Remeron (mirtazapine) can also raise your cholesterol.
  • Remeron (mirtazapine) can increase your appetite and cause to you to gain weight.
  • Good option if you are underweight or frail, because it can help you gain weight.
  • More likely to cause minor weight gain (1-5 pounds) and raise cholesterol than any other antidepressant.
No weight related info.No weight related info.
  • Can cause weight gain, which can be helpful if you've recently lost weight or have a low appetite.
  • More likely to cause minor weight gain (1 to 5 pounds) or make you feel sick if you miss a dose than other antidepressants.
  • Compared to other medicines for depression, Tofranil (imipramine hydrochloride) can make you more likely to gain weight and have changes in blood sugar. If you have diabetes, your doctor might need to change the doses of your medications to make sure your blood sugar stays controlled. Talk to your doctor to see if you should take another medicine besides Tofranil (imipramine hydrochloride).
No weight related info.
Upsides and benefits
ElavilCymbaltadesipramineCelexaNeurontinZoloftRemeronPamelorOleptroPaxilTofranilEffexor
  • Low doses work well to treat certain kinds of chronic pain. It can take 2 weeks to feel the full effects of the medication.
  • Low doses of Elavil (Amitriptyline) start working in 45 minutes to help you sleep better.
  • Six out of every ten people who use an antidepressant for the first time find that it works for them.
  • Effective at relieving depression and anxiety symptoms.
  • Lowers relapse rates for depression.
  • Can relieve some types of chronic pain. Might be particularly good at pain relief for people who are also depressed.
  • Six out of ten people who use an antidepressant for the first time find that it works for them.
  • Norpramin (desipramine) is available in generic and in many different strengths, so the dose can be more customized.
  • Norpramin (desipramine) has fewer side effects than similar tricyclic antidepressants.
  • Effective at relieving depression and anxiety symptoms.
  • Causes less sleepiness compared to other antidepressants.
  • Six out of ten people who use an antidepressant for the first time find that it works for them.
  • Originally used to treat epilepsy (partial seizures), but now it primarily treats neuropathic pain that's caused by nerve stimulation or damage.
  • Studies show it's most effective for nerve pain from diabetes, shingles, and fibromyalgia (a painful muscle condition).
  • It's available as a generic, so it's less expensive than similar medications.
  • Effective at lowering symptoms and relapse rates of depression and anxiety disorders.
  • Causes less drowsiness than other antidepressants.
  • Six out of ten people who use an antidepressant for the first time find that it works for them.
  • Effective at relieving some depression symptoms.
  • Starts to work more quickly than most antidepressants.
  • Can help you fall asleep if you have trouble sleeping.
  • Can also help relieve anxiety.
  • Good option if you are underweight or frail, because it can help you gain weight.
  • Available as a generic.
  • Helpful with treating certain types of pain, like migraines or nerve-related pain.
  • Generally well tolerated and has fewer side effects than other medicines in the same class of drugs.
  • Commonly used in lower doses to help treat sleep problems (insomnia).
  • Safer sleep medication than others (benzodiazepines or Unisom) for people age 65 and older.
  • Fewer sexual side effects than many other antidepressants.
  • Has been used for sleep and depression for a long time. There's a lot of information available about how it works and how safe it is.
  • Comes as a generic medication and is cheaper than many other sleep aides.
  • Six out of ten people who use an antidepressant for the first time find that it works for them.
  • Effective at relieving depression and anxiety symptoms.
  • Lowers relapse rates of depression and anxiety disorders, including OCD, panic disorder, social anxiety disorder, and generalized anxiety disorder.
  • It causes drowsiness, so it's good for people who have trouble sleeping.
  • Can cause weight gain, which can be helpful if you've recently lost weight or have a low appetite.
  • Six out of ten people who use an antidepressant for the first time find that it works for them.
  • Tofranil (imipramine hydrochloride) is part of the first choice of medicines used to treat depression.
  • Available in generic.
  • Tofranil (imipramine hydrochloride) is usually taken only once a day.
  • Available in 3 different strengths.
  • Effective at relieving depression and anxiety symptoms.
  • Lowers relapse rates of depression.
  • Causes more sleepiness than other antidepressants, so it's good for people who have trouble sleeping.
  • Six out of ten people who use an antidepressant for the first time find that it works for them.
  • Might work when other antidepressants haven't worked since it affects two chemicals in the brain that impact your mood. Many other antidepressants affect only serotonin, but not norepinephrine too.
Downsides and risks
ElavilCymbaltadesipramineCelexaNeurontinZoloftRemeronPamelorOleptroPaxilTofranilEffexor
  • When used for depression, Elavil (Amitriptyline) causes more side effects and has a higher risk of overdose than other antidepressants. It's usually used when other medications haven't worked.
  • It's more likely to cause sleepiness, nausea, constipation, diarrhea, and weight gain (1 to 5 pounds) than other antidepressants.
  • People age 65 and older have a higher risk for this medication's side effects.
  • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people age 24 and younger.
  • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
  • Not a good option if you're a heavy drinker, or if you have liver or kidney problems.
  • Not the best option for people with high blood pressure.
  • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
  • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
  • Norpramin (desipramine) isn't recommended if you or your family has heart disease, seizures, or glaucoma.
  • Norpramin (desipramine) isn't a first choice for depression because it has more side effects than other antidepressants.
  • In some people, Norpramin (desipramine) can make you sleepy. In other people, Norpramin (desipramine) can keep you awake.
  • If you have diabetes, Norpramin (desipramine) can make your blood sugar go up.
  • Not recommended in children under 12 years of age.
  • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
  • Can cause minor weight gain (1 to 5 pounds).
  • Celexa (Citalopram) can cause an irregular heartbeat if you take a high dose (40 mg a day, or more).
  • Not a good option for you if you have heart or liver problems.
  • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24 years.
  • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
  • Neurontin (Gabapentin) is likely to cause some side effects, including memory problems, drowsiness, dizziness, or confusion.
  • You can't skip or miss doses since suddenly stopping Neurontin (Gabapentin) can cause seizures. This is even more likely if you drink alcohol, so it might not be the best medication for heavy drinkers.
  • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
  • More likely to cause diarrhea than other antidepressants.
  • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
  • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
  • Makes you more tired than other antidepressants.
  • More likely to cause minor weight gain (1-5 pounds) and raise cholesterol than any other antidepressant.
  • Side effects are usually manageable, but can be annoying.
  • Increases the risk of falls, especially when used in the elderly.
  • There's an increased chance of it causing heart problems, especially in people with a history of heart problems.
  • Not as effective as other medications for depression.
  • More sedating than other antidepressants.
  • Causes more side effects when used at higher doses for depression. Includes sleepiness, dizziness, upset stomach, and irregular heartbeat.
  • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
  • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
  • Can cause more sexual side effects like low libido and an inability to orgasm or ejaculate than most antidepressants.
  • More likely to cause minor weight gain (1 to 5 pounds) or make you feel sick if you miss a dose than other antidepressants.
  • Can harm an unborn child, so you can't take it if you're pregnant.
  • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than age 24.
  • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
  • Tofranil (imipramine hydrochloride) can lower your sex drive and cause more weight gain than other similar medicines for depression.
  • You might be more sensitive to the sun and have a higher risk for heat stroke while taking Tofranil (imipramine hydrochloride).
  • If you have a history of heart conditions, your symptoms might get worse with Tofranil (imipramine hydrochloride). Talk to your doctor to see if Tofranil (imipramine hydrochloride) is right for you.
  • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
  • Not the best option for people with high blood pressure.
  • Overdosing on this medication could be fatal.
  • It's more likely to cause nausea and vomiting or make you feel sick if you miss a dose than other antidepressants. Also causes more sleepiness than others.
  • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
  • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
Tips from our pharmacists for people taking the medication
ElavilCymbaltadesipramineCelexaNeurontinZoloftRemeronPamelorOleptroPaxilTofranilEffexor
  • Take at bedtime to avoid some of its side effects.
  • Can cause dizziness, drowsiness, constipation, and weight gain.
  • Stop taking it slowly to avoid getting withdrawal symptoms.
  • Tell your doctor if you notice sudden mood changes or unusual thoughts.
  • Take with food to avoid upset stomach.
  • Full effects in 8 to 12 weeks for mood, 2 weeks for pain.
  • Stop taking slowly to avoid withdrawal symptoms.
  • Tell your doctor if you notice sudden mood changes or unusual thoughts.
  • Don't drive or do anything requiring concentration until you know how Norpramin (desipramine) affects you since it can make you feel sleepy.
  • Talk to your doctor right away if your mood suddenly darkens and you want to hurt yourself while taking Norpramin (desipramine).
  • If you're being switched to Norpramin (desipramine) from monoamine oxidase inhibitors, you'll need to wait 2 weeks before you can start it.
  • Don't stop taking Norpramin (desipramine) suddenly without talking to your doctor first.
  • Take with food to avoid upset stomach.
  • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
  • Stop taking it slowly to avoid getting withdrawal symptoms.
  • Tell your doctor if you notice sudden mood changes or unusual thoughts.
  • Side effects are common, but usually manageable.
  • Don't drive while taking Neurontin (Gabapentin) until you know how the medication affects you.
  • Neurontin and generic forms of Gabapentin have the same ingredients as Gralise and Horizant, but are dosed differently. Make sure you know which form you're taking since they are used for different purposes.
  • Take the extended-release tablet with food.
  • Stop taking Neurontin (Gabapentin) slowly over at least one week to avoid getting withdrawal symptoms.
  • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
  • It interacts with St. John's Wort and Tryptophan.
  • Stop taking it slowly to avoid getting withdrawal symptoms.
  • Tell your doctor if you notice sudden mood changes or unusual thoughts.
  • Remeron (mirtazapine) can make you sleepy. It is best to take at bedtime.
  • Remeron (mirtazapine) can increase your appetite and cause to you to gain weight.
  • You should not abruptly stop Remeron (mirtazapine) as this could cause serious side effects.
  • Prescription medications can interact with Remeron (mirtazapine). Let your doctor or pharmacist know if you're on prescription medications currently or within the past 14 days.
  • Remeron (mirtazapine) should be protected from light. Keep it in it's original package until ready to use.
  • Remeron (mirtazapine) can cause dry mouth. Try using sugar-free gum or candy to help with dry mouth.
  • Needs to be taken every day for 1 to 2 weeks to start feeling better, and for 6 to 8 weeks to see the full effect of the medication.
  • It's important to keep taking Pamelor (Nortriptyline) even when you feel your symptoms are getting better.
  • Take it with food and/or at bedtime to decrease the potential side effects.
  • Tell your doctor if you notice sudden mood changes or unusual thoughts.
  • If you decide to stop taking Pamelor (Nortriptyline), work with your doctor to slowly get off this medicine to avoid getting withdrawal symptoms.
  • Makes you sleepy. Take at bedtime.
  • Can cause temporary dry mouth and upset stomach.
  • Seek medical attention for unwanted, persistent erection.
  • Tell your doctor if you notice sudden mood changes or unusual thoughts.
  • Take with food to avoid upset stomach.
  • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
  • Stop taking it slowly to avoid getting withdrawal symptoms.
  • Tell your doctor if you notice sudden mood changes or unusual thoughts.
  • The controlled-release (CR) tablet can cause less nausea than other forms.
  • Don’t crush, break, or chew the Paxil (Paroxetine) controlled-release tablet or the Pexeva film-coated tablets.
  • It’s best to take Paxil (Paroxetine) in the morning, except Brisdelle, which can be taken at bedtime.
  • You might need to take Tofranil (imipramine hydrochloride) for a few weeks before you notice any changes in your mood.
  • Don't drink alcohol while taking Tofranil (imipramine hydrochloride).
  • If you miss your bedtime dose, skip it and take your regular dose the next evening. Don't take extra medicine to make up for the missed dose.
  • You might be more sensitive to the sun while taking Tofranil (imipramine hydrochloride). Make sure to drink plenty of liquids, wear sunscreen, or cover your skin if you'll be out in the sun.
  • Tofranil (imipramine hydrochloride) can make you feel sleepy, so don't drive or do anything requiring concentration until you know how it affects you.
  • Don't stop taking Tofranil (imipramine hydrochloride) without talking to your doctor first.
  • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
  • You can take the extended-release form once a day with food either in the morning or in the evening at about the same time each day.
  • Extended-release capsules should be swallowed whole. If you can’t swallow pills, open the capsule, sprinkle it on a spoonful of applesauce and then swallow it without chewing.
  • Stop taking it slowly to avoid getting withdrawal symptoms.
  • Tell your doctor if you notice sudden mood changes or unusual thoughts.
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