Prescription onlyNo lower cost generic available


(Estradiol Gel)

  • Cream, gel, or ointment
  • Hot flashes and night sweats
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Relieves hot flashes due to menopause.

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Prescription onlyNo lower cost generic available

Our pharmacists’ bottom line

Elestrin (Estradiol Gel) is easy to use, absorbs well into your skin, and is a good option if you don’t want to use estrogen pills or patches.

  • Elestrin (Estradiol Gel) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, vaginal dryness).
  • Good for people who don't want to take daily pills.
  • The pre-measured packets are easy to use and can be taken anywhere.
  • Fewer side effects than pills since there are lower amounts of estrogen in topical gels.
  • In studies, when people used low doses of Elestrin (Estradiol Gel), their symptoms started to improve in 5 weeks and they felt continued improvement over 8 to 12 weeks. People using the highest doses of Elestrin (Estradiol Gel) felt better in just 2 weeks.
  • Elestrin (Estradiol Gel) is available in 3 strengths.
  • Very few women (less than 1%) had skin irritation from the medicine.
  • Can lower your risk of fractures by keeping your bones healthy. Make sure you also get enough calcium and Vitamin D.
  • Improves mood, energy, and mental alertness for some people.
  • Increases your risk of endometrial and breast cancer.
  • If you have your uterus, you have to use Elestrin (Estradiol Gel) with another hormone called progestin to lower your risk of uterine cancer.
  • Increases your risk of developing blood clots and stroke.
  • Can't be used in people with liver problems.
  • It's possible to expose other people to the estrogen before it's absorbed by your skin.
  • Can be expensive since it's only available as a brand name product.
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Side effects for Elestrin (Estradiol Gel)

From clinical trials of Elestrin / Postmenopausal estrogen replacement (1.7 g/day)  ( 279)

  • MetrorrhagiaMetrorrhagia9% for Elestrin gel vs.2% for placebo
  • Common coldCommon cold9% for Elestrin gel vs.7% for placebo
  • Breast tendernessBreast tenderness8% for Elestrin gel vs.4% for placebo
  • Ear, nose, or throat infectionEar, nose, or throat infection4% for Elestrin gel vs.4% for placebo

What to expect when you take Elestrin (Estradiol Gel)

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Tips from our pharmacists
  • Apply to your upper arm and shoulder area after a bath or shower.
  • Don't put it on your face, breasts, vagina, or irritated skin.
  • Don't rub it in. Let the gel dry before dressing, and don't get the application site wet for at least 2 hours.
  • Wash your hands well after applying the gel.
  • Can cause nausea, dizziness, bloating, and breast tenderness.
  • Tell your doctor about any unusual vaginal bleeding.
  • Get emergency care if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.

Risks and Warnings for Elestrin (Estradiol Gel)

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    • Higher risk if:
    • Using estrogen for more than one year

    Vaginal bleeding after menopause can be a warning sign of uterus (endometrial) cancer, so let your doctor know if you notice any unusual bleeding. When estrogen is prescribed to women after menopause who still have a uterus, progestin should be used with it to lower the risk of cancer. Low-dose vaginal estrogen products are often a better choice than oral pills for women 65 years or older who have vaginal symptoms.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Elestrin (Estradiol Gel)

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The FDA category for this medication is X. It is advised that you: Unsafe