Prescription onlyNo lower cost generic available

Elestrin Alternatives

(Estradiol Gel)

  • Cream, gel, or ointment
  • Hot flashes and night sweats
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Compare Elestrin (Estradiol Gel) to alternatives

These medications are comparable to Elestrin (Estradiol Gel) or used for similar purposes.

Elestrin
(Estradiol Gel)

Premarin
(Conjugated Estrogens)

Activella
(Estradiol / Norethindrone)

Prempro
(Conjugated Estrogens / Medroxyprogesterone Acetate)

Climara
(Estradiol Patch)

Provera
(Medroxyprogesterone)

Premarin Vaginal Cream
(Conjugated Estrogens)

Estring
(Estradiol Vaginal Ring)

Vivelle-Dot
(Estradiol Patch)

Relieves hot flashes due to menopause. Elestrin (Estradiol Gel) is easy to use, absorbs well into your skin, and is a good option if you don’t want to use estrogen pills or patches.Treats low estrogen, relieves menopause symptoms, and lowers your risk of osteoporosis. Premarin (Conjugated Estrogens) relieves menopausal symptoms and prevents bone loss. It's an oral hormone replacement, so it can have a lot of side effects, and it's important to think through the benefits and potential hassles of this drug before using it.Relieves menopause symptoms and lowers your risk of osteoporosis. Activella (Estradiol / Norethindrone) is effective at treating symptoms related to menopause and preventing bone loss. The estrogen/progestin combo is a good options for women with an intact uterus.Coming soon.Treats low estrogen, relieves menopause symptoms, and lowers your risk of osteoporosis. You only have to think about the Climara (Estradiol Patch) once a week, and it may have fewer side effects than oral estrogen pills.Regulates your menstrual cycle and supplements estrogen treatments for menopause. Provera (Medroxyprogesterone) works well to regulate your menstrual cycle and stop irregular bleeding. It also protects the uterus from estrogen's harmful effects.Relieves vaginal dryness and pain due to menopause. Premarin Vaginal Cream (Conjugated Estrogens) works well for vaginal problems caused by menopause, and it has fewer side effects than estrogen pills.Relieves vaginal dryness due to menopause. Estring (Estradiol Vaginal Ring) is a vaginal ring that may be less of a hassle than estrogen pills, gels, patches, or vaginal creams, but comes with the same side effects.Treats low estrogen, relieves menopause symptoms, and lowers your risk of osteoporosis. The Vivelle-Dot (Estradiol Patch) needs to be replaced twice a week, but it comes in more strengths than other patches. It may have fewer side effects than oral estrogen pills.
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Reviews & ratings
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Reviews for Premarin (Conjugated Estrogens)
50%
Same vs. Elestrin (Estradiol Gel)
43%
7% vs. Elestrin (Estradiol Gel)
11%
+39% vs. Elestrin (Estradiol Gel)

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Reviews for Estring (Estradiol Vaginal Ring)
62%
+12% vs. Elestrin (Estradiol Gel)
40%
10% vs. Elestrin (Estradiol Gel)
18%
+32% vs. Elestrin (Estradiol Gel)

Not enough reviews for this drug. Help someone out, leave a review!

Side effects
ElestrinPremarinEstradiol NorethindronePremproClimaraProveraPremarin Vaginal CreamEstringVivelle-Dot
  • Metrorrhagia 7%
  • Breast tenderness 4%
  • Common cold 3%
  • Ear, nose, or throat infection 2%
More Elestrin side effects »
  • Abdominal pain 5%
  • Back pain 4%
  • Muscle weakness 4%
  • Breast pain 4%
  • Passing gas 4%
  • Thick vaginal discharge 3%
  • Vaginal moniliasis 2%
  • Nervousness 2%
  • Itching 2%
  • Leg cramps 2%
More Premarin side effects »
  • Excessive vaginal bleeding 14%
  • Injury accidental 13%
  • Endometrial thickening 6%
  • Back pain 6%
  • Sinus inflammation 5%
  • Common cold 3%
  • Headache 3%
  • Weight increase 3%
  • "stomach flu" 2%
  • Other events 2%
More Estradiol Norethindrone side effects »

We haven’t found good data for Prempro side effects.

FDA side effect reports for Prempro »
  • Breast pain 25%
  • Ear, nose, or throat infection 9%
  • Abdominal pain 8%
  • Headache 8%
  • Swelling due to excess fluid 7%
  • Thick vaginal discharge 6%
  • Passing gas 6%
  • Inflammation inside the nose 5%
  • Sore throat 4%
  • Pain 4%
More Climara side effects »

We haven’t found good data for Provera side effects.

FDA side effect reports for Provera »
  • Any side effect 8%
  • Abdominal pain 6%
  • Vaginitis 6%
  • Leg cramps 5%
  • Passing gas 4%
  • Thick vaginal discharge 4%
  • Vaginal moniliasis 4%
  • Sinus inflammation 4%
  • Headache 4%
  • Cough increased 3%
More Premarin Vaginal Cream side effects »

The Estring FDA package insert doesn’t have numbers about how common side effects are.

More about Estring side effects »
  • Headache 26%
  • Low mood disorder 7%
  • Weight increased 7%
  • Vaginal bleeding between periods 6%
  • Sinus headache 6%
  • Common cold 5%
  • Ear, nose, or throat infection 5%
  • Back pain 5%
  • Neck pain 5%
  • Constipation 4%
More Vivelle-Dot side effects »
How it works
ElestrinPremarinEstradiol NorethindronePremproClimaraProveraPremarin Vaginal CreamEstringVivelle-Dot
Elestrin (Estradiol Gel) replaces estrogen hormones in your vagina that your body loses during menopause. Estrogen helps relieve symptoms of menopause, such as hot flashes, night sweats, and vaginal problems.Premarin (Conjugated Estrogens) is an oral medication that replaces estrogen hormones during and after menopause. Higher levels of estrogen lower menopause-related hot flashes, flushing, night sweats, vaginal problems, and bone loss.Activella (Estradiol / Norethindrone) contains two hormones that work to balance hormone changes in your body during and after menopause. Estradiol (an estrogen) reduces hot flashes and night sweats and prevents bone loss, but can also harm cells in the uterus after menopause. Norethindrone (a progestin) protects the uterus from damage.Coming soon.The Climara (Estradiol Patch) replaces an estrogen hormone, estradiol, that your body loses during and after menopause. Higher levels of estradiol relieve symptoms of low estrogen and menopause and prevent bone loss.Provera (Medroxyprogesterone) contains medroxyprogesterone, a progesterone hormone that works to balance hormone changes in the body. In premenopausal women, it prevents thickening of the uterus lining and regulates your menstrual cycle. It's also added to hormone therapy to protect the uterus from the harmful effects of estrogen.Premarin Vaginal Cream (Conjugated Estrogens) is a topical medication that replaces estrogen hormones in the vagina to rebuild vaginal tissue and make vaginal sex more comfortable.Estring (Estradiol Vaginal Ring) is a vaginal ring that replaces estrogen hormones in your vagina that your body loses during menopause. Estrogen helps rebuild and maintain vaginal tissue, relieving symptoms of vaginal dryness, soreness, irritation, and painful sex.The Vivelle-Dot (Estradiol Patch) replaces an estrogen hormone, estradiol, that your body loses during and after menopause. Higher levels of estradiol relieve symptoms of low estrogen and menopause and prevent bone loss.
Type of medication
ElestrinPremarinEstradiol NorethindronePremproClimaraProveraPremarin Vaginal CreamEstringVivelle-Dot
Hormone replacement
Estrogen derivative
Prescription only
Hormone replacement
Estrogen derivative
Prescription only
Hormone replacement
Estrogen
Progestin
Prescription only
Coming soon.
Hormone replacement
Estrogen derivative
Prescription only
Hormone replacement
Progestin
Prescription only
Hormone replacement
Estrogen derivative
Prescription only
Hormone replacement
Estrogen derivative
Prescription only
Hormone replacement
Estrogen derivative
Prescription only
Available as
ElestrinPremarinEstradiol NorethindronePremproClimaraProveraPremarin Vaginal CreamEstringVivelle-Dot
  • Cream, gel, or ointment
  • Pill
  • Pill
  • Pill
  • Patch
  • Pill
  • Vaginal cream, gel, or ointment
  • Vaginal ring
  • Patch
Used for (click to learn more)
ElestrinPremarinEstradiol NorethindronePremproClimaraProveraPremarin Vaginal CreamEstringVivelle-Dot
  • Hot flashes and night sweats
  • Hot flashes and night sweats
  • Hot flashes and night sweats
  • Menopause - Moderate to severe abnormal vasomotor function Menopause - Moderate to severe vaginal atrophy - Moderate to severe vulvar atrophy Postmenopausal osteoporosis
  • Hot flashes and night sweats
  • Amenorrhea
  • Vaginal dryness and inflammation
  • Vaginal dryness and inflammation
  • Hot flashes and night sweats
Risk factors for serious side effects
ElestrinPremarinEstradiol NorethindronePremproClimaraProveraPremarin Vaginal CreamEstringVivelle-Dot
  • Using estrogen for more than one year
  • Personal or family history of breast cancer
  • Duration of use
  • Personal or family history of blood clots
  • Obesity
  • Systemic lupus erythematosus (SLE)
  • Smoking
  • Obesity
  • High blood pressure
  • High blood sugar
  • High cholesterol
  • Age 50 or older
  • Women of childbearing age
    Detailed Elestrin (Estradiol Gel) risks & warnings »
    Coming soon.Coming soon.Coming soon.Coming soon.Coming soon.Coming soon.Coming soon.Coming soon.
    Pregnancy category
    ElestrinPremarinEstradiol NorethindronePremproClimaraProveraPremarin Vaginal CreamEstringVivelle-Dot
    XFDA pregnancy category (Unsafe)

    Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

    See the FDA package insert
    XFDA pregnancy category (Unsafe)

    Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

    See the FDA package insert
    XFDA pregnancy category (Unsafe)

    Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

    See the FDA package insert
    XFDA pregnancy category (Unsafe)

    Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

    See the FDA package insert
    XFDA pregnancy category (Unsafe)

    Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

    See the FDA package insert
    XFDA pregnancy category (Unsafe)

    Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

    See the FDA package insert
    XFDA pregnancy category (Unsafe)

    Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

    See the FDA package insert
    XFDA pregnancy category (Unsafe)

    Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

    See the FDA package insert
    XFDA pregnancy category (Unsafe)

    Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

    See the FDA package insert
    Alcohol
    No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.
    Food
    No specific food-related info.No specific food-related info.No specific food-related info.No specific food-related info.No specific food-related info.No specific food-related info.No specific food-related info.No specific food-related info.No specific food-related info.
    Kidneys and liver
    No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.
    Sex
    No specific sex-related info.
    • Does not expose your partner to estrogen during sexual acitivities like vaginal estrogen creams.
    No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.
    • Some of the medicine can be absorbed into your partner's skin, so you can’t have vaginal sex right after using Premarin Vaginal Cream (Conjugated Estrogens).
    • Premarin Vaginal Cream (Conjugated Estrogens) relieves vaginal dryness and irritation to make sex more enjoyable.
    • For painful sex, it can work better than over-the-counter vaginal lubricants because Premarin Vaginal Cream (Conjugated Estrogens) treats the cause of the problem (low estrogen levels), not just the symptoms (dryness).
    • Estring (Estradiol Vaginal Ring) relieves vaginal dryness and irritation to make sex more enjoyable.
    • You don’t have to remove Estring (Estradiol Vaginal Ring) to treat a vaginal infection or have sex.
    No specific sex-related info.
    Sleep
    No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.
    Weight
    No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.
    • Can cause headache, weight gain, breast tenderness, or changes in mood.
    No specific weight-related info.No specific weight-related info.No specific weight-related info.
    Upsides and benefits
    ElestrinPremarinEstradiol NorethindronePremproClimaraProveraPremarin Vaginal CreamEstringVivelle-Dot
    • Elestrin (Estradiol Gel) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, vaginal dryness).
    • Good for people who don't want to take daily pills.
    • The pre-measured packets are easy to use and can be taken anywhere.
    • Fewer side effects than pills since there are lower amounts of estrogen in topical gels.
    • In studies, when people used low doses of Elestrin (Estradiol Gel), their symptoms started to improve in 5 weeks and they felt continued improvement over 8 to 12 weeks. People using the highest doses of Elestrin (Estradiol Gel) felt better in just 2 weeks.
    • Elestrin (Estradiol Gel) is available in 3 strengths.
    • Very few women (less than 1%) had skin irritation from the medicine.
    • Can lower your risk of fractures by keeping your bones healthy. Make sure you also get enough calcium and Vitamin D.
    • Improves mood, energy, and mental alertness for some people.
    • Premarin (Conjugated Estrogens) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, night sweats, vaginal dryness).
    • Lowers your risk of fractures by keeping your bones healthy. Make sure you also take enough calcium and Vitamin D.
    • Does not expose your partner to estrogen during sexual acitivities like vaginal estrogen creams.
    • Can help relieve symptoms of prostate cancer or advanced breast cancer in some people.
    • Improves mood, energy, and mental alertness for some people.
    • Activella (Estradiol / Norethindrone) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, night sweats, vaginal dryness).
    • Good choice for women with intact uterus. The norethindrone (a progestin) protects against the risk of cancer in the uterus from estrogen treatment.
    • Mimvey brand is less expensive than other estrogen/progestin combination medicines.
    • Lowers your risk of fractures by keeping your bones healthy. Make sure you also get enough calcium and Vitamin D.
    • Improves mood, energy, and mental alertness for some people.
    Coming soon.
    • The Climara (Estradiol Patch) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen, like hot flashes and vaginal dryness.
    • The patch is good for people who don't want to take daily pills.
    • Can be worn while swimming, bathing, and showering.
    • By using a patch instead of a pill, there's a lower risk of side effects such as blood clots and stroke since lower amounts of estrogen are used in patches.
    • Lowers your risk of fractures by keeping your bones healthy. Make sure you also get enough calcium and Vitamin D.
    • Improves mood, energy, and mental alertness for some people.
    • Provera (Medroxyprogesterone) can be used to treat multiple hormone problems in women.
    • After menopause, taking estrogen raises your risk of uterine cancer. However, taking progesterone, like in Provera (Medroxyprogesterone), along with estrogen gives you the positive effects of estrogen, but also prevents it from damaging your uterus.
    • Women taking an estrogen/progestin combination medications have a lower risk of uterine cancer.
    • Premarin Vaginal Cream (Conjugated Estrogens) relieves vaginal dryness and irritation to make sex more enjoyable.
    • Premarin Vaginal Cream (Conjugated Estrogens) doesn't need to be used forever, so you can work with your doctor to see how long you’ll need to continue treatment.
    • For painful sex, it can work better than over-the-counter vaginal lubricants because Premarin Vaginal Cream (Conjugated Estrogens) treats the cause of the problem (low estrogen levels), not just the symptoms (dryness).
    • Works locally in the vagina and doesn't expose the rest of your body to estrogen like pills do.
    • Estring (Estradiol Vaginal Ring) relieves vaginal dryness and irritation to make sex more enjoyable.
    • Good option for people who don't want to take oral pills.
    • Generally works well with fewer side effects.
    • Many women think Estring (Estradiol Vaginal Ring) is easy to insert and comfortable to use.
    • In a 12-week study, Estring (Estradiol Vaginal Ring) worked well to improve vaginal problems, reduced pain during urination, and sudden urges to urinate.
    • Estring (Estradiol Vaginal Ring) slowly releases estrogen over the 90 days the ring is in place, so you only have to remove and insert a new one every three months.
    • Works locally in the vagina and doesn't expose the rest of your body to estrogen like pills do.
    • Comes in 4 different strengths.
    • The Vivelle-Dot (Estradiol Patch) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen, like hot flashes and vaginal dryness.
    • The patch is good for people who don't want to take daily pills.
    • Can be worn while swimming, bathing, and showering.
    • By using a patch instead of a pill, there's a lower risk of side effects such as blood clots and stroke since lower amounts of estrogen are used in patches.
    • Lowers your risk of fractures by keeping your bones healthy. Make sure you also get enough calcium and Vitamin D.
    • Improves mood, energy, and mental alertness for some people.
    Downsides and risks
    ElestrinPremarinEstradiol NorethindronePremproClimaraProveraPremarin Vaginal CreamEstringVivelle-Dot
    • Increases your risk of endometrial and breast cancer.
    • If you have your uterus, you have to use Elestrin (Estradiol Gel) with another hormone called progestin to lower your risk of uterine cancer.
    • It's possible to expose other people to the estrogen before it's absorbed by your skin.
    • Increases your risk of developing blood clots and stroke.
    • Can't be used in people with liver problems.
    • Can be expensive since it's only available as a brand name product.
    • More potential side effects than estrogen creams since it exposes your whole body to estrogen.
    • If you have your uterus, you have to take Premarin (Conjugated Estrogens) with another hormone called progestin to lower your risk of uterine cancer.
    • Increases your risk of uterine and breast cancer.
    • Increases your risk of developing blood clots and stroke.
    • Can't be used in people with liver problems.
    • Can be expensive since it's only available as a brand name product.
    • More potential side effects since it exposes your whole body to two hormones, estrogen and norethindrone (a progestin).
    • You may get irregular bleeding and spotting that can last a few months to a year.
    • Increases your risk of developing blood clots and stroke.
    Coming soon.
    • If you have your uterus, you have to use the Climara (Estradiol Patch) with another hormone called progestin to lower your risk of uterine cancer.
    • Patch can fall off.
    • Increases your risk of uterine and breast cancer.
    • Increases your risk of developing blood clots and stroke.
    • Can worsen other health conditions, like high cholesterol, asthma, diabetes, fluid retention, and migraines.
    • Can't be used in people with liver problems.
    • You can't take Provera (Medroxyprogesterone) if you've had a hysterectomy (your uterus removed). You also can't take it if you're pregnant or breastfeeding, have unusual vaginal bleeding, or have a history of blood clots, certain kinds of cancer, stroke, heart attack, liver problems, or bleeding problems.
    • Vaginal estrogens can weaken latex (rubber) condoms, cervical caps, and diaphragms, so you can't rely on these for birth control for 72 hours after using Premarin Vaginal Cream (Conjugated Estrogens).
    • If you have severe vaginal dryness, you might have pain, bleeding, or infections from repeatedly inserting the applicator.
    • Some of the medicine can be absorbed into your partner's skin, so you can’t have vaginal sex right after using Premarin Vaginal Cream (Conjugated Estrogens).
    • Even though Premarin Vaginal Cream (Conjugated Estrogens) is used in the vagina, it's possible some of the estrogens will get into the rest of your body and cause side effects that happen more often with estrogen pills.
    • Estring (Estradiol Vaginal Ring) may not be the best estrogen product if you have a narrow vagina or frequent vaginal infections.
    • The ring can fall out without you noticing it.
    • Increases your risk of endometrial (uterine cancer).
    • If you have your uterus, you might need to use Estring (Estradiol Vaginal Ring) with another hormone called progestin to lower your risk of uterine cancer.
    • Can be expensive since it's only available as a brand name product.
    • You need to replace the Vivelle-Dot (Estradiol Patch) twice a week, compared to other patches that are once a week.
    • If you have your uterus, you have to use the Vivelle-Dot (Estradiol Patch) with another hormone called progestin to lower your risk of uterine cancer.
    • Patch can fall off.
    • Increases your risk of uterine and breast cancer.
    • Increases your risk of developing blood clots and stroke.
    • Can worsen other health conditions, like high cholesterol, asthma, diabetes, fluid retention, and migraines.
    • Can't be used in people with liver problems.
    Tips from our pharmacists for people taking the medication
    ElestrinPremarinEstradiol NorethindronePremproClimaraProveraPremarin Vaginal CreamEstringVivelle-Dot
    • Apply to your upper arm and shoulder area after a bath or shower.
    • Don't put it on your face, breasts, vagina, or irritated skin.
    • Don't rub it in. Let the gel dry before dressing, and don't get the application site wet for at least 2 hours.
    • Wash your hands well after applying the gel.
    • Can cause nausea, dizziness, bloating, and breast tenderness.
    • Get emergency care if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.
    • Take Premarin (Conjugated Estrogens) at the same time each day. If you miss a dose, take it as soon as possible, but if it’s almost time for your next dose, take only that dose.
    • Use the lowest dose possible of Premarin (Conjugated Estrogens) and take it only as long as needed. Talk to your doctor regularly to see if you still need treatment. If you’re taking Premarin (Conjugated Estrogens) only for vaginal symptoms or to prevent bone loss, there are other medicines that can work better with fewer side effects (like a vaginal cream for menopause symptoms, or non-estrogen medicine for bone loss).
    • Can cause nausea, dizziness, bloating and breast tenderness.
    • Get emergency care if you notice swelling or pain in your lower legs, sudden shortness of breath, or an unexplained severe headache.
    • Shouldn't be used forever. Talk to your doctor regularly to see if you still need treatment.
    • Can cause nausea, dizziness, bloating, and breast tenderness.
    • Get emergency care if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.
    Coming soon.
    • Replace the patch every 7 days on a different area of your skin to lower your risk of skin irritation.
    • Remove the patch by tearing the package by hand and not with scissors. Never cut the patch.
    • Apply the sticky side of the patch to clean, dry, hairless skin below your waistline on areas as instructed by the manufacturer (never on your breast).
    • Fold together the sticky sides of used patches before throwing them away to avoid exposing others to the medicine. Don't flush them down the toilet.
    • Shouldn't be used forever. Talk to your doctor regularly to see if you still need treatment.
    • Can cause nausea, dizziness, bloating, and breast tenderness.
    • Get emergency care if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.
    • The dose of Provera (Medroxyprogesterone) will be different depending on what you’re using it for, so take it exactly the way your doctor tells you.
    • Talk to your doctor every few months about using the lowest possible dose of Provera (Medroxyprogesterone). Since there can be a lot of long-term side effects, take it only as long as you need it.
    • Can cause headache, weight gain, breast tenderness, or changes in mood.
    • If you're taking Provera (Medroxyprogesterone) to regulate your period, you'll get withdrawal bleeding 3 to 7 days after stopping Provera (Medroxyprogesterone).
    • Your doctor will tell you how often to use Premarin Vaginal Cream (Conjugated Estrogens). If you're taking Premarin Vaginal Cream (Conjugated Estrogens) regularly, use it around the same time each day.
    • Attach the applicator to the tube. Once the dose is measured, insert the applicator deeply into your vagina, and press the plunger to release all the medicine. Clean the applicator after each use.
    • More effective if you use it at bedtime.
    • Consider wearing a panty liner after use.
    • Most people don't have many side effects, but temporary nausea, dizziness, bloating, and breast tenderness are possible.
    • Insert the ring as deeply as possible into your vagina. You shouldn't feel the ring once it's inserted.
    • The ring is good for 90 days in your vagina. If it falls out before the 90 days are up, just clean it with warm water and reinsert.
    • You don’t have to remove Estring (Estradiol Vaginal Ring) to treat a vaginal infection or have sex.
    • It can take up to 2 to 3 weeks to feel the full benefits.
    • Most people don't have many side effects, but temporary nausea, dizziness, bloating, and breast tenderness are possible.
    • Replace the patch twice a week (every 3-4 days) on a different area of your skin to lower your risk of skin irritation.
    • Remove the patch by tearing the package by hand and not with scissors. Never cut the patch.
    • Apply the sticky side of the patch to clean, dry, hairless skin below your waistline on areas as instructed by the manufacturer (never on your breast).
    • Fold together the sticky sides of used patches before throwing them away to avoid exposing others to the medicine. Don't flush them down the toilet.
    • Shouldn't be used forever. Talk to your doctor regularly to see if you still need treatment.
    • Can cause nausea, dizziness, bloating, and breast tenderness.
    • Get emergency care if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.
    Learn more
    More about ElestrinSide effectsReviews & ratingsAlternativesFDA package insert
    More about PremarinSide effectsReviews & ratingsFDA package insert
    More about Estradiol NorethindroneSide effectsReviews & ratingsFDA package insert
    More about PremproSide effectsReviews & ratingsFDA package insert
    More about ClimaraSide effectsReviews & ratingsFDA package insert
    More about ProveraSide effectsReviews & ratingsFDA package insert
    More about Premarin Vaginal CreamSide effectsReviews & ratingsFDA package insert
    More about EstringSide effectsReviews & ratingsFDA package insert
    More about Vivelle-DotSide effectsReviews & ratingsFDA package insert