Prescription onlyNo lower cost generic available

Eliquis Alternatives

(Apixaban)

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Compare Eliquis (Apixaban) to alternatives

These medications are comparable to Eliquis (Apixaban) or used for similar purposes.

Eliquis
(Apixaban)

Aspirin

Coumadin
(Warfarin)

Pradaxa
(Dabigatran)

Xarelto
(Rivaroxaban)

Prevents blood clots. Eliquis (Apixaban) is an easy to use and effective way to prevent blood clots from forming in your veins.Relieves pain, fever, and inflammation. Protects your heart and thins blood. A low dose of Aspirin (81mg) every day can protect your heart, but it's not the best medicine to take for pain, swelling, or fever.Prevents blood clots. Coumadin (Warfarin) is an old, cheap, and effective medicine to prevent blood clots, but it requires some monitoring, dose adjustments, and even lifestyle changes.Prevents blood clots. Pradaxa (Dabigatran) is a good medication for preventing blood clots. It doesn't require regular blood tests or changing doses often. It can be expensive and there's no way to reverse the medication's effects.Prevents blood clots. Xarelto (Rivaroxaban) is a good medication for preventing blood clots. It doesn't require regular blood tests or changing doses often. It can be expensive and there's no way to reverse the medication's effects.
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Reviews & ratings
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Reviews for Aspirin
76%
+16% vs. Eliquis (Apixaban)
41%
9% vs. Eliquis (Apixaban)
6%
+4% vs. Eliquis (Apixaban)
Reviews for Coumadin (Warfarin)
61%
+1% vs. Eliquis (Apixaban)
54%
+4% vs. Eliquis (Apixaban)
21%
11% vs. Eliquis (Apixaban)

Not enough reviews for this drug. Help someone out, leave a review!

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Side effects
EliquisAspirinCoumadinPradaxaXarelto
  • All bleeding 6%
  • Nosebleed 3%
  • Nonmajor bleeding 2%
  • Collection of blood 1%
More Eliquis side effects »

We haven’t found good data for Aspirin side effects.

FDA side effect reports for Aspirin »

The Coumadin FDA package insert doesn’t have numbers about how common side effects are.

More about Coumadin side effects »

The Pradaxa FDA package insert doesn’t have numbers about how common side effects are.

More about Pradaxa side effects »
  • Back pain 3%
More Xarelto side effects »
How it works
EliquisAspirinCoumadinPradaxaXarelto
Eliquis (Apixaban) is a factor Xa inhibitor anticoagulant and prevents the formation of blood clots in your veins.Aspirin is a salicylate and non-steroidal anti-inflammatory drug (NSAID). It blocks the inflammation process in your body, which relieves swelling and pain. It also prevents blood platelets from forming clots, which thins your blood.Coumadin (Warfarin) is an anticoagulant blood thinner. It lowers chemicals called clotting factors so that it's harder for your body to form blood clots.Pradaxa (Dabigatran) is an anticoagulant that stops the formation of blood clots.Xarelto (Rivaroxaban) is an anticoagulant that stops the formation of blood clots.
Type of medication
EliquisAspirinCoumadinPradaxaXarelto
Anticoagulant
Factor Xa inhibitor
Prescription only
Pain reliever
Salicylate
Anticoagulant
Anti-platelet
Over-the-counter
Anticoagulant
Vitamin K antagonist
Prescription only
Anticoagulant
Thrombin inhibitor
Prescription only
Anticoagulant
Factor Xa inhibitor
Prescription only
Available as
EliquisAspirinCoumadinPradaxaXarelto
  • Pill
  • Pill
  • Pill
  • Pill
  • Pill
Used for (click to learn more)
EliquisAspirinCoumadinPradaxaXarelto
Risk factors for serious side effects
EliquisAspirinCoumadinPradaxaXarelto
  • Stopping Eliquis (Apixaban) early
  • Spinal puncture (spinal tap)
  • Getting anesthesia in the spine (epidural anesthesia)
  • History of bleeding problems
  • Severe high blood pressure
  • Older age
  • Artificial heart valve
  • Current kidney problems
  • Current liver problems
Detailed Eliquis (Apixaban) risks & warnings »
Coming soon.Coming soon.Coming soon.Coming soon.
Pregnancy category
EliquisAspirinCoumadinPradaxaXarelto
BFDA pregnancy category (Probably safe)

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

See the FDA package insert
NFDA pregnancy category (Unknown)

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

See the FDA package insert
XFDA pregnancy category (Unsafe)

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

See the FDA package insert
CFDA pregnancy category (Weigh risks vs. benefits)

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

See the FDA package insert
CFDA pregnancy category (Weigh risks vs. benefits)

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

See the FDA package insert
Alcohol
No specific alcohol-related info.No specific alcohol-related info.
  • Many lifestyle factors can affect how well warfarin works, such as diet, alcohol, and activity level, so it's important that you try to stay consistent with your behaviors.
No specific alcohol-related info.No specific alcohol-related info.
Food
  • Take twice a day, with or without food, at the same time each day.
  • Take with food to lower the chance of an upset stomach.
  • Eat foods containing consistent amounts of Vitamin K.
No specific food-related info.
  • Xarelto (Rivaroxaban) doesn't have as many food interactions as compared to other anticoagulants like warfarin (Coumadin).
  • Take Xarelto (Rivaroxaban) with food and a full glass of water.
Kidneys and liver
  • Eliquis (Apixaban) is processed by the kidney and liver. If you have kidney or liver problems, talk to your doctor about possibly switching to a different medicine to prevent increased risk for side effects.
No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.
Sex
No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.
Sleep
No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.
Weight
No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.
Upsides and benefits
EliquisAspirinCoumadinPradaxaXarelto
  • Eliquis (Apixaban) is very effective in reducing the threat of stroke in people with Afib or other clotting disorders.
  • Eliquis (Apixaban) doesn't require regular blood testing and doesn't have dietary restrictions.
  • If you've had clots in your legs or lungs before, Eliquis (Apixaban) can lower the risk of these forming again.
  • When taking low doses (81 mg) every day, Aspirin provides protection for your heart and prevents heart attacks and stroke.
  • Used in higher doses to relieve pain, swelling, and fever.
  • Available over-the-counter in drugstores by itself and in combination with other cold and flu medications.
  • Oral blood-thinning medicine that prevents blood clots from forming or getting bigger.
  • Prevents complications of blood clots that can cause extreme discomfort or death. Examples include stroke (blood clots in the brain), pulmonary embolism (blood clots in the lungs causing trouble breathing), or deep vein thrombosis (blood clots in the legs causing pain and blood vessel damage).
  • Has an antidote, Vitamin K, in case of a major accidental bleeding.
  • Coumadin (Warfarin) has been around for a long time, so we know a lot about how well it works and what the risks are.
  • It's dirt cheap.
  • Clinical studies have shown that the risk of stroke and blood clots is lower than with warfarin, another popular "blood thinner" (anticoagulant).
  • Doesn't require regular blood tests or frequent dose changes.
  • In studies comparing Pradaxa (Dabigatran) to other "blood thinners", it worked just as well in preventing strokes and was better in lowering the risk of bleeding.
  • Studies have shown that Xarelto (Rivaroxaban) works just as well as other blood thinners (anticoagulants) in preventing strokes and reducing bleeding.
  • Xarelto (Rivaroxaban) doesn't require regular blood testing or frequent dose adjustments.
  • Xarelto (Rivaroxaban) doesn't have as many food interactions as compared to other anticoagulants like warfarin (Coumadin).
Downsides and risks
EliquisAspirinCoumadinPradaxaXarelto
  • You can bruise easier and if you cut yourself, it'll take longer to stop the bleeding. Always look for signs of internal bleeding, such as dark urine or blood in your stool.
  • Can't be used if you have artificial heart valves.
  • Never stop taking Eliquis (Apixaban) without talking to your doctor first.
  • Eliquis (Apixaban) isn't available as a generic, so it can be pricey.
  • Not a preferred medication for treating pain, swelling, or fever due to its high risk of bleeding.
  • NSAIDs (like ibuprofen and naproxen) and acetaminophen (Tylenol) are better for treating pain and fever thank Aspirin.
  • Aspirin raises your risk of bleeding, especially when used with other blood thinner medications like warfarin (Coumadin).
  • Studies show that using higher doses of Aspirin (162 mg or more) every day raises your risk of stomach bleeding and doesn't provide any additional heart protection.
  • Raises your risk of bleeding and bruising.
  • Requires routine blood testing (called an INR) to see how well the medicine is working for you and to make the dose just right for you.
  • Many lifestyle factors can affect how well warfarin works, such as diet, alcohol, and activity level, so it's important that you try to stay consistent with your behaviors.
  • Lots of interactions with other drugs or supplements. Always check with your doctor or pharmacist before starting any new meds.
  • Not available as generic.
  • There are no antidotes to stop bleeding caused by taking too much Pradaxa (Dabigatran).
  • Can't take during pregnancy.
  • Xarelto (Rivaroxaban) can increase your risk of bleeding. Call your doctor right away if there is blood in your phlegm, urine, or stool (look for black, tarry stools).
  • Xarelto (Rivaroxaban) isn't available as a generic medication.
  • There are no antidotes to stop bleeding caused by taking too much Xarelto (Rivaroxaban).
  • Can't take during pregnancy.
Tips from our pharmacists for people taking the medication
EliquisAspirinCoumadinPradaxaXarelto
  • Take twice a day, with or without food, at the same time each day.
  • Needs to be stopped prior to dental procedures or surgery.
  • You can bruise easier and if you have a cut, it can take longer for bleeding to stop.
  • Do not take with other drugs that affect your blood, like aspirin, ibuprofen, warfarin, or SSRIs.
  • Call a doctor immediately if you have dizziness, weakness, or a really bad headache.
  • Using low doses (81mg) of Aspirin every day can lower your risk of heart attack and stroke, but it isn't good for everyone. Only take Aspirin daily if your doctor recommends it.
  • Higher Aspirin doses can be used to treat occasional pain, swelling, and fever. Using ibuprofen or acetaminophen (Tylenol) instead can lower your risk of serious bleeding.
  • Take with food to lower the chance of an upset stomach.
  • Don't use for kids younger than 18 years old.
  • Stop taking this right away and tell your doctor if you have ringing in your ears, unusual bleeding, or nausea or vomiting that doesn't go away.
  • Thins your blood to prevent clots from forming or getting bigger. Doesn't break up existing clots.
  • The amount you need depends on your diet, other medical problems, and genes.
  • Take it exactly as instructed.
  • Can raise your risk of bleeding or bruising.
  • Requires regular blood tests to get your dose right.
  • Interacts with a lot of medicines and supplements. Don't start any new meds without talking to your doctor.
  • Eat foods containing consistent amounts of Vitamin K.
  • Tell your doctor immediately if you fell or if you have unusual bleeding, bruising, swelling, or changes in vision and coordination.
  • Get a medical bracelet so that people know you're on a blood thinner during an emergency situation.
  • Pradaxa (Dabigatran) is an anticoagulant, so it's important not to miss a dose. Don't stop taking this medication without talking to your doctor first.
  • When taking Pradaxa (Dabigatran), you can bleed more easily, so use a soft toothbrush and an electric razor to avoid cutting yourself.
  • Take this exactly as your doctor or pharmacist tells you to.
  • Take with a full glass of water. Swallow the capsule whole. Don't chew, break, or open the capsule.
  • Xarelto (Rivaroxaban) is an anticoagulant, so it's important not to miss a dose. Don't stop taking this medication without talking to your doctor first.
  • When taking Xarelto (Rivaroxaban), you can bleed more easily, so use a soft toothbrush and an electric razor to avoid cutting yourself.
  • Take Xarelto (Rivaroxaban) with food and a full glass of water.
  • You can crush the tablets and mix with applesauce.
Learn more
More about EliquisSide effectsReviews & ratingsAlternativesFDA package insert
More about AspirinSide effectsReviews & ratingsFDA package insert
More about CoumadinSide effectsReviews & ratingsFDA package insert
More about PradaxaSide effectsReviews & ratingsFDA package insert
More about XareltoSide effectsReviews & ratingsFDA package insert