Prescription onlyClass: Autoimmune

EnbrelAlternatives

(etanercept)

Prescription onlyClass: Autoimmune
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Compare Enbrel (etanercept) to alternatives

These medications are comparable to Enbrel (etanercept) or used for similar purposes.

Enbrel
(etanercept)

Cimzia
(certolizumab)

Humira
(adalimumab)

Otrexup
(methotrexate)

Remicade
(infliximab)

Calms down your immune system. Enbrel (Etanercept) is very effective at calming down your immune system, but it's expensive, you have to take into account the hassle of injections and traveling with the medication.Reduces inflammation. Cimzia (Certolizumab) is an effective medicine to calm down your immune system, but it can be expensive and it requires a lot of monitoring while you're taking it.Calms down the immune system. Humira (adalimumab) is good for treating many autoimmune conditions, but it can also cause serious side effects.Treats cancer and changes how your immune system works. Otrexup (Methotrexate) is a first line treatment for many autoimmune diseases and types of cancer. If you're taking it for a long time, you'll have to get routine blood tests.Calms down your immune system. Remicade (Infliximab) is very effective at calming down your immune system, but you have to get each dose at your doctor's office and watch out for serious side effects.
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Reviews & ratings
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4.99Enbrel
Reviews for Enbrel (etanercept)
62%
of people (All ages) say Enbrel (etanercept) is worth it
53%
say it works well
17%
say it's a big hassle
Have you used Enbrel (etanercept)?
Worth itNot sureNot worth it

Not enough reviews for this drug. Help someone out, leave a review!

Have you used Cimzia (certolizumab)?
Worth itNot sureNot worth it
Reviews for Humira (adalimumab)
60%
-2% worse vs. Enbrel (etanercept)
51%
-2% worse vs. Enbrel (etanercept)
26%
-9% worse vs. Enbrel (etanercept)
182 reviews
Have you used Humira (adalimumab)?
Worth itNot sureNot worth it

Not enough reviews for this drug. Help someone out, leave a review!

Have you used Otrexup (methotrexate)?
Worth itNot sureNot worth it
Reviews for Remicade (infliximab)
76%
+14% better vs. Enbrel (etanercept)
62%
+9% better vs. Enbrel (etanercept)
15%
+2% better vs. Enbrel (etanercept)
Have you used Remicade (infliximab)?
Worth itNot sureNot worth it
Side effects
EnbrelCimziaHumiraMethotrexateRemicade
  • Positive anti-double-stranded dna antibodies 11%
  • Antibodies to etanercept 6%
  • Crithidia luciliae 3%
  • Anticardiolipin 3%
  • Mild or moderate skin reactions 15%
  • Any infection 11%
  • Upper respiratory infections 8%
  • Injection site reactions 26%
  • Non-upper respiratory infections 6%
  • Positive ana 6%
More Enbrel side effects »
  • Any side effect 1%
  • Upper respiratory infections 7%
  • Urinary tract infections 1%
  • Joint pain 2%
  • Ear, nose, or throat infection 4%
  • Headache 1%
  • High blood pressure 3%
  • Common cold 4%
  • Back pain 3%
  • Fever 1%
More Cimzia side effects »
  • Upper airway infection 4%
  • Rash 6%
  • Headache 4%
  • Sinus infection 2%
  • Nausea 1%
  • Injection site reactions 7%
  • Urinary tract infection 3%
  • Flu syndrome 1%
  • Stomach pain 3%
  • High cholesterol 2%
More Humira side effects »
  • Elevated liver function tests 15%
  • Nausea/vomiting 10%
  • Mouth and lip swelling 10%
  • Thrombocytopenia 10%
  • Rash/pruritus/dermatitis 3%
  • Diarrhea 3%
  • Hair loss or baldness 3%
  • Low white blood cells 3%
  • Low blood cell count 3%
  • Dizziness 3%
More Methotrexate side effects »
  • Infections 11%
  • Infusion reaction 13%
More Remicade side effects »
How it works
EnbrelCimziaHumiraMethotrexateRemicade
Enbrel (Etanercept) is a biologic response modifier. It works in the immune system to block a protein called TNF (tumor necrosis factor). Blocking TNF relieves symptoms and prevents disease progression.Cimzia (Certolizumab) is a monoclonal antibody. It lowers inflammation in the body by blocking a protein called TNF (tumor necrosis factor).Humira (adalimumab) is a TNF blocker which stops inflammation.Otrexup (Methotrexate) is an anti-cancer and immunosuppressive medication that treats forms of cancer, arthritis, and psoriasis. For cancer, it helps your body destroy cancer cells by blocking building blocks that cancer cells need to grow. For rheumatoid arthritis and psoriasis, it lowers the body's normal immune response and prevents the body from attacking itself.Remicade (Infliximab) is a biologic response modifier. It works in the immune system to block a protein called TNF (tumor necrosis factor). Blocking TNF relieves symptoms and prevents disease progression.
Type of medication
EnbrelCimziaHumiraMethotrexateRemicade
Prescription only
Prescription only
Prescription only
Prescription only
Prescription only
Available as
EnbrelCimziaHumiraMethotrexateRemicade
  • Injection
  • Injection
  • Injection
  • Pill
  • Injection
  • Injection
Used for
EnbrelCimziaHumiraMethotrexateRemicade
Risk factors for serious side effects
EnbrelCimziaHumiraMethotrexateRemicade
    • History of heart failure
    • Taking other immunosuppressant drugs
    • Age 60 or older
    • Taking other immunosuppressant drugs
    • History of malignancy
    • History of neurologic condition
      Detailed Enbrel (etanercept) risks & warnings »
      • Medications that lower immune system function
      • Younger age
          • History of heart failure
            Detailed Cimzia (certolizumab) risks & warnings »
            • Taking other immunosuppressant medications such as Kineret or Orencia
            • Age 65 or older
            • Active, chronic, or recurrent infection
            • Comorbidities
            • Taking other immunosuppressant medications, such as azathiprine or 6-mercaptopurine, at the same time as Humira (adalimumab)
            • History of malignancy
            • Adolescent age
            • COPD with significant smoking history
              • History of heart failure
              • Preexisting or recently acquired neurologic condition
                Detailed Humira (adalimumab) risks & warnings »
                • Women of childbearing age
                • Men of childbearing potential
                  • Reduced kidney function
                  • fluid in the abdomen (ascites)
                  • fluid in the lungs (pleural effusion)
                  • Long-term use
                  • Psoriasis
                    • Taking Otrexup (Methotrexate) with high-dose NSAIDs
                      • Taking Otrexup (Methotrexate) to treat cancer
                      • Rapidly growing tumors
                      Detailed Otrexup (methotrexate) risks & warnings »
                        • History of heart failure
                        • Taking other immunosuppressant drugs
                        • Age 60 or older
                        • Taking other immunosuppressant drugs
                        • History of malignancy
                        • History of neurologic condition
                            Detailed Remicade (infliximab) risks & warnings »
                            Pregnancy

                            Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

                            Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

                            Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

                            Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

                            Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

                            Alcohol
                            EnbrelCimziaHumiraMethotrexateRemicade
                            No alcohol related info.No alcohol related info.No alcohol related info.
                            • You have to avoid alcohol and being in the sun too long.
                            • Don't use alcohol, NSAIDs (anti-inflammatory medications), or stay in the sun too long.
                            No alcohol related info.
                            Weight
                            EnbrelCimziaHumiraMethotrexateRemicade
                            No weight related info.No weight related info.No weight related info.No weight related info.
                            • Although rare, Remicade (Infliximab) can cause serious liver injury. You'll need to have your liver enzymes tested regularly. If liver enzymes are significantly elevated and you have appetite/weight loss, stomach discomfort, vomiting, and notice dark urine, yellowing of skin/eyes, change in stool color, and skin rash you should stop treatment with Remicade (Infliximab) until you can be completely assessed,
                            Upsides and benefits
                            EnbrelCimziaHumiraMethotrexateRemicade
                            • Treats certain types of arthritis conditions caused by an overactive immune system.
                            • Enbrel is the first biologic approved for moderate to severe rheumatoid arthritis.
                            • It has an established safety profile for treatment of rheumatoid arthritis (RA).
                            • Available as a single-use syringe and SureClick auto-injector pen which may be more convenient and easier for some people to use.
                            • People taking Enbrel for rheumatoid arthritis showed significant improvement and were able to reduce the dose or stop immunosuppressant medicines.
                            • In studies, people with RA (rheumatoid arthritis) taking methotrexate had improved symptoms when Cimzia (Certolizumab) was added to methotrexate.
                            • Cimzia (Certolizumab) is as effective as other similar medicines for Crohn's disease. It can be an option for people taking other RA medications that have too many side effects of don't work anymore.
                            • Cimzia (Certolizumab) lasts longer in the body than other RA medications, letting it work longer.
                            • Available in a prefilled syringe. This can make it easier to give yourself the injection.
                            • Humira (adalimumab) is effective in reducing symptoms in all of its approved indications.
                            • You can give yourself Humira (adalimumab) on your own at home rather than visiting a clinic or hospital.
                            • Humira (adalimumab) treats many different autoimmune conditions.
                            • Available in a single-use pen (Humira Pen) that may be more convenient and easier for some people to use.
                            • Recommended as first line treatment for rheumatoid arthritis.
                            • Available as a generic medication. Comes as a tablet, an injection that you give yourself weekly, and as an infusion that you get in your doctor's office or at an infusion center.
                            • If you accidentally take too much, there's an antidote to help your body recover.
                            • Treats certain types of arthritis and gastrointestinal conditions caused by an overactive immune system.
                            • Remicade has almost two decades of clinical trial data and real-life experience with millions of people who have used it.
                            • Initial dosing to introduce Remicade to your body might be a hassle, but then you only need to take it every 6-8 weeks depending on your condition.
                            Downsides and risks
                            EnbrelCimziaHumiraMethotrexateRemicade
                            • It's an injection.
                            • It's expensive because there's no generic available yet.
                            • Enbrel lowers your ability to fight infection and can cause serious life-threatening illness. The risk is greater if you take other drugs that lower your immune system, have an active infection, diabetes, or had tuberculosis (TB) in the past.
                            • You're first dose of Enbrel will need to be given at your doctor's office. If you decide not to self-inject and don't have someone to do it for you, you'll need to continue to see your doctor for each dose.
                            • You'll need to properly dispose of the needle, syringes, or Pen in a special (FDA-approved) sharps container.
                            • Because it needs to be refrigerated until you use it, if you're traveling, you'll need to carry it in a cooler with an ice pack.
                            • Can lower your immune system's ability to fight infections. You can get serious infections such as TB (tuberculosis) and infections caused by viruses, fungi, or bacteria.
                            • Can have a higher risk for causing bladder infections, rash, and upper respiratory infections (cold or flu) compared to other similar medicines.
                            • Cimzia (Certolizumab) can increase the risk of lymphoma, leukemia, and other cancers.
                            • Requires routine tests to check for infections.
                            • Not a good choice if you have a history of heart failure, nervous system problems, or hepatitis B.
                            • There's no generic available and it can be very expensive.
                            • Not first-choice treatment for rheumatoid arthritis.
                            • Humira (adalimumab) is an injection and not an oral medication.
                            • Humira (adalimumab) is expensive because there's no generic available yet.
                            • Humira (adalimumab) lowers your ability to fight infection and in some cases can cause serious life-threatening illness. The risk is greater if you take other drugs that lower your immune system, have an active infection, diabetes, or had tuberculosis (TB) in the past.
                            • You'll need to properly dispose of the needle, syringes, or Pen in a sharps container.
                            • Humira (adalimumab) needs to be refrigerated until you use it, so if you're traveling, you'll need to carry it in a cooler with an ice pack.
                            • You have to be on birth control for at least 2 to 3 months after you finish Otrexup (Methotrexate) since it can cause birth defects.
                            • You have to avoid alcohol and being in the sun too long.
                            • You'll have to get blood tests done if you're taking this long-term because it can cause harmful side effects.
                            • You have to get every dose through an IV infusion at your doctor's office.
                            • It's expensive because there's no generic available yet.
                            • Remicade has a higher risk of serious infusion-related side effects during or after it's given since it's injected right into your veins. Your doctor can prescribe medication before your dose that may lower this risk.
                            • Remicade lowers your ability to fight infection and can cause serious life-threatening illness. The risk is greater if you take other drugs that lower your immune system, have an active infection, diabetes, or had tuberculosis (TB) in the past.
                            • Not the best choice if you have heart failure.
                            • Talk to your baby's doctor if you're pregnant or breast-feeding. When women in a study took Remicade (Infliximab), the medicine was found in their breast milk 2 to 3 days after each dose, and in the baby's blood 6 months after they were born.
                            Tips from our pharmacists for people taking the medication
                            EnbrelCimziaHumiraMethotrexateRemicade
                            • Enbrel (Etanercept) is available as a single-use prefilled syringe, single-use prefilled SureClick Autoinjector, and multiple-use vial. You and your doctor can discuss which is best for you.
                            • The autoinjector can be stored at room temperature for up to 14 days and can't be refrigerated again.
                            • Enbrel (Etanercept) is a medication that's injected under the skin (subcutaneous). Your doctor can give you your first dose, then let you self-inject it once so you learn how to do it correctly.
                            • Enbrel (Etanercept) lowers the your immune system's ability to fight infections, so it's important to let your doctor know if you come down with a fever, cough, or notice flu-like symptoms.
                            • You'll need to have a TB test before you start using Enbrel (Etanercept).
                            • Tell your doctor if you have an allergy to latex since the syringe needle cover has latex in it.
                            • Don't inject Enbrel (Etanercept) into skin that's red, bruised, or irritated. Rotate your injection areas to avoid skin reactions.
                            • As with all injection medicines, store away from children and throw used syringes away in a protective container, and not in the trash.
                            • Cimzia (Certolizumab) is a medicine that's injected just under the skin (subcutaneous). It can be given in your doctor's office or you can do it yourself at home.
                            • It can take multiple doses before you start to see any effects, so don't change your dose without talking to your doctor.
                            • Tell your doctor if you have night sweats, persistent fever, fatigue, weight loss, or swollen lymph nodes.
                            • You'll need to have a TB (tuberculosis) test before you start Cimzia (Certolizumab) and periodically during treatment.
                            • Don't get any live vaccines while you're taking Cimzia (Certolizumab) since they may not work as well. Wait at least 3 months after you've stopped taking Cimzia (Certolizumab) before getting a live vaccine.
                            • Humira (adalimumab) is a medication that's injected under the skin. Your doctor can give you your first dose, then you can inject yourself at home once you feel comfortable doing so on your own.
                            • Humira (adalimumab) lowers your ability to fight infections, so it's important to let your doctor know if you have a fever, cough, or flu-like symptoms.
                            • Tell your doctor if you have an allergy to latex since the syringe needle cover has latex in it.
                            • Each time you use Humira (adalimumab), it's important to rotate the sites you chose to inject it in. Don't inject Humira (adalimumab) into skin that's red, bruised, or irritated.
                            • As with all injection medicines, store securely away from children and throw away used syringes in an FDA-approved sharps disposal container, and not in the trash.
                            • Don't use alcohol, NSAIDs (anti-inflammatory medications), or stay in the sun too long.
                            • Use birth control and avoid pregnancy for at least 2 months (for women) and 3 months (for men) after you finish Otrexup (Methotrexate).
                            • Drink plenty of liquids to stay hydrated while taking this.
                            • Take the medication exactly as your doctor or pharmacist tells you. Call your doctor or pharmacist if you're confused.
                            • Remicade (Infliximab) is a medication that's given as an infusion at your doctor's office or clinic.
                            • It's very important to read the patient Medication Guide when you first start using Remicade (Infliximab).
                            • It's possible to get an allergic reaction to Remicade (Infliximab) either immediately during the treatment or a several days after stopping it. Your doctor can give you medicines that'll lower this risk.
                            • You'll need to have a TB test before you start taking Remicade (Infliximab) and periodically during treatment.
                            • Remicade (Infliximab) lowers your immune system's ability to fight infections, so it's important to let your doctor know if you notice a fever, cough, or flu-like symptoms. Children seem to get more infections than adults, so keep a close eye on them.
                            • If you have a young child, let their doctor know if you were on Remicade (Infliximab) while pregnant or nursing. It can increase their risk of infections for several months after your last dose and can delay their vaccine schedule.
                            Learn more
                            More about EnbrelSide effectsReviews & ratingsAlternativesFDA package insert
                            Have you used Enbrel (etanercept)?
                            Worth itNot sureNot worth it
                            More about CimziaSide effectsReviews & ratingsFDA package insert
                            Have you used Cimzia (certolizumab)?
                            Worth itNot sureNot worth it
                            More about HumiraSide effectsReviews & ratingsFDA package insert
                            Have you used Humira (adalimumab)?
                            Worth itNot sureNot worth it
                            More about MethotrexateSide effectsReviews & ratingsFDA package insert
                            Have you used Otrexup (methotrexate)?
                            Worth itNot sureNot worth it
                            More about RemicadeSide effectsReviews & ratingsFDA package insert
                            Have you used Remicade (infliximab)?
                            Worth itNot sureNot worth it