Prescription onlyNo lower cost generic available

Enbrel Alternatives

(Etanercept)

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Compare Enbrel (Etanercept) to alternatives

These medications are comparable to Enbrel (Etanercept) or used for similar purposes.

Enbrel
(Etanercept)

Cimzia
(Certolizumab)

Humira
(Adalimumab)

Otrexup
(Methotrexate)

Remicade
(Infliximab)

Calms down your immune system. Enbrel (Etanercept) is very effective at calming down your immune system, but it's expensive, you have to take into account the hassle of injections and traveling with the medication.Reduces inflammation. Cimzia (Certolizumab) is an effective medicine to calm down your immune system, but it can be expensive and it requires a lot of monitoring while you're taking it.Calms down your immune system. Humira (Adalimumab) is very effective at calming down your immune system, but it's expensive, you have to take into account the hassle of injections and traveling with the medication.Treats cancer and changes how your immune system works. Otrexup (Methotrexate) is a first line treatment for many autoimmune diseases and types of cancer. If you're taking it for a long time, you'll have to get routine blood tests.Calms down your immune system. Remicade (Infliximab) is very effective at calming down your immune system, but you have to get each dose at your doctor's office and watch out for serious side effects.
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Reviews & ratings
Button Group. All currently active
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4.924050632911392Enbrel
Reviews for Enbrel (Etanercept)
58%
of people say Enbrel (Etanercept) is worth it
52%
say it works well
19%
say it's a big hassle

Not enough reviews for this drug. Help someone out, leave a review!

Reviews for Humira (Adalimumab)
59%
+1% vs. Enbrel (Etanercept)
49%
3% vs. Enbrel (Etanercept)
26%
7% vs. Enbrel (Etanercept)

Not enough reviews for this drug. Help someone out, leave a review!

Reviews for Remicade (Infliximab)
77%
+19% vs. Enbrel (Etanercept)
65%
+13% vs. Enbrel (Etanercept)
13%
+6% vs. Enbrel (Etanercept)
Side effects
EnbrelCimziaHumiraMethotrexateRemicade
  • Injection site reactions 26%
  • Any infection 11%
  • Positive anti-double-stranded dna antibodies 11%
  • Upper respiratory infections 8%
  • Non-upper respiratory infections 6%
  • Positive ana 6%
  • Itching 1%
  • Rash 1%
More Enbrel side effects »
  • Upper respiratory infections 7%
  • Common cold 4%
  • Ear, nose, or throat infection 4%
  • High blood pressure 3%
  • Back pain 3%
  • Joint pain 2%
  • Acute bronchitis 2%
  • Rash 2%
  • Sore throat 2%
  • Urinary tract infections 1%
More Cimzia side effects »
  • Injection site reactions 6%
  • Rash 6%
  • Positive titers 5%
  • Upper respiratory infection 4%
  • Headache 4%
  • Abdominal pain 3%
  • Urinary tract infection 3%
  • High blood pressure 2%
  • Alkaline phosphatase increased 2%
  • High blood lipid levels 2%
More Humira side effects »

The Methotrexate FDA package insert doesn’t have numbers about how common side effects are.

More about Methotrexate side effects »
  • Infusion reaction 13%
  • Infections 11%
More Remicade side effects »
How it works
EnbrelCimziaHumiraMethotrexateRemicade
Enbrel (Etanercept) is a biologic response modifier. It works in the immune system to block a protein called TNF (tumor necrosis factor). Blocking TNF relieves symptoms and prevents disease progression.Cimzia (Certolizumab) is a monoclonal antibody. It lowers inflammation in the body by blocking a protein called TNF (tumor necrosis factor).Humira (Adalimumab) is a biologic response modifier. It works in the immune system to block a protein called TNF (tumor necrosis factor). Blocking TNF relieves symptoms and prevents disease progression.Otrexup (Methotrexate) is an anti-cancer and immunosuppressive medication that treats forms of cancer, arthritis, and psoriasis. For cancer, it helps your body destroy cancer cells by blocking building blocks that cancer cells need to grow. For rheumatoid arthritis and psoriasis, it lowers the body's normal immune response and prevents the body from attacking itself.Remicade (Infliximab) is a biologic response modifier. It works in the immune system to block a protein called TNF (tumor necrosis factor). Blocking TNF relieves symptoms and prevents disease progression.
Type of medication
EnbrelCimziaHumiraMethotrexateRemicade
Immunosuppressant
Immunomodulator
Antirheumatic
Biological response modifier
Prescription only
Immunosuppressant
Immunomodulator
Antirheumatic
Biological response modifier
Prescription only
Immunosuppressant
Immunomodulator
Antirheumatic
Biological response modifier
Prescription only
Immunosuppressant
Immunomodulator
Antirheumatic
Biological response modifier
Anticancer
Antimetabolite
Prescription only
Immunosuppressant
Immunomodulator
Antirheumatic
Biological response modifier
Prescription only
Available as
EnbrelCimziaHumiraMethotrexateRemicade
  • Injection
  • Injection
  • Injection
  • Pill
  • Injection
  • Injection
Used for (click to learn more)
EnbrelCimziaHumiraMethotrexateRemicade
Risk factors for serious side effects
EnbrelCimziaHumiraMethotrexateRemicade
    • History of heart failure
    • Taking other immunosuppressant drugs
    • Age 60 or older
    • Taking other immunosuppressant drugs
    • History of malignancy
    • History of neurologic condition
      Detailed Enbrel (Etanercept) risks & warnings »
      Coming soon.Coming soon.Coming soon.Coming soon.
      Pregnancy category
      EnbrelCimziaHumiraMethotrexateRemicade
      BFDA pregnancy category (Probably safe)

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      See the FDA package insert
      BFDA pregnancy category (Probably safe)

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      See the FDA package insert
      BFDA pregnancy category (Probably safe)

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      See the FDA package insert
      XFDA pregnancy category (Unsafe)

      Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

      See the FDA package insert
      BFDA pregnancy category (Probably safe)

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      See the FDA package insert
      Alcohol
      No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.
      • You have to avoid alcohol and being in the sun too long.
      • Don't use alcohol, NSAIDs (anti-inflammatory medications), or stay in the sun too long.
      No specific alcohol-related info.
      Food
      No specific food-related info.No specific food-related info.No specific food-related info.No specific food-related info.No specific food-related info.
      Kidneys and liver
      No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.
      Sex
      No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.
      Sleep
      No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.
      Weight
      • Enbrel (Etanercept) can increase your risk of serious or life-threatening bacterial, fungal and viral infections. In some cases infections can be reactivated from an inactive virus in your body like tuberculosis (TB) or hepatitis B virus (HBV). You may need to take medicine for TB before you can begin taking Enbrel (Etanercept). If you develop symptoms of cough, fever, chills, muscle aches, feel very tired, or you notice dark urine, yellowing of skin/eyes, appetite/weight loss, vomiting, change in stool color, stomach discomfort, and skin rash, tell your doctor and get medical care right away.
      • Tell your doctor if you have night sweats, persistent fever, fatigue, weight loss, or swollen lymph nodes.
      No specific weight-related info.No specific weight-related info.No specific weight-related info.
      Upsides and benefits
      EnbrelCimziaHumiraMethotrexateRemicade
      • Treats certain types of arthritis conditions caused by an overactive immune system.
      • Enbrel is the first biologic approved for moderate to severe rheumatoid arthritis.
      • It has an established safety profile for treatment of rheumatoid arthritis (RA).
      • Available as a single-use syringe and SureClick auto-injector pen which may be more convenient and easier for some people to use.
      • People taking Enbrel for rheumatoid arthritis showed significant improvement and were able to reduce the dose or stop immunosuppressant medicines.
      • In studies, people with RA (rheumatoid arthritis) taking methotrexate had improved symptoms when Cimzia (Certolizumab) was added to methotrexate.
      • Cimzia (Certolizumab) is as effective as other similar medicines for Crohn's disease. It can be an option for people taking other RA medications that have too many side effects of don't work anymore.
      • Cimzia (Certolizumab) lasts longer in the body than other RA medications, letting it work longer.
      • Available in a prefilled syringe. This can make it easier to give yourself the injection.
      • Most people feel it's worth the hassle.
      • Once you've learned the correct way to use Humira, you can inject the medicine yourself without going to your doctor's office.
      • It's available in a single-use pen (Humira Pen) that may be more convenient and easier for some people to use.
      • It's an alternative for people with Crohn's disease who stopped getting better on other TNF-blockers or had side effects that made them switch.
      • Treats certain types of arthritis and gastrointestinal conditions caused by an overactive immune system.
      • Recommended as first line treatment for rheumatoid arthritis.
      • Available as a generic medication. Comes as a tablet, an injection that you give yourself weekly, and as an infusion that you get in your doctor's office or at an infusion center.
      • If you accidentally take too much, there's an antidote to help your body recover.
      • Remicade has almost two decades of clinical trial data and real-life experience with millions of people who have used it.
      • Initial dosing to introduce Remicade to your body might be a hassle, but then you only need to take it every 6-8 weeks depending on your condition.
      • Treats certain types of arthritis and gastrointestinal conditions caused by an overactive immune system.
      Downsides and risks
      EnbrelCimziaHumiraMethotrexateRemicade
      • Enbrel lowers your ability to fight infection and can cause serious life-threatening illness. The risk is greater if you take other drugs that lower your immune system, have an active infection, diabetes, or had tuberculosis (TB) in the past.
      • You're first dose of Enbrel will need to be given at your doctor's office. If you decide not to self-inject and don't have someone to do it for you, you'll need to continue to see your doctor for each dose.
      • It's an injection.
      • It's expensive because there's no generic available yet.
      • You'll need to properly dispose of the needle, syringes, or Pen in a special (FDA-approved) sharps container.
      • Because it needs to be refrigerated until you use it, if you're traveling, you'll need to carry it in a cooler with an ice pack.
      • Can lower your immune system's ability to fight infections. You can get serious infections such as TB (tuberculosis) and infections caused by viruses, fungi, or bacteria.
      • Can have a higher risk for causing bladder infections, rash, and upper respiratory infections (cold or flu) compared to other similar medicines.
      • Cimzia (Certolizumab) can increase the risk of lymphoma, leukemia, and other cancers.
      • Requires routine tests to check for infections.
      • Not a good choice if you have a history of heart failure, nervous system problems, or hepatitis B.
      • There's no generic available and it can be very expensive.
      • Humira lowers your ability to fight infection and can cause serious life-threatening illness. The risk is greater if you take other drugs that lower your immune system, have an active infection, diabetes, or had tuberculosis (TB) in the past.
      • You're first dose of Humira will need to be given at your doctor's office. If you decide not to self-inject and don't have someone to do it for you, you'll need to continue to see your doctor for each dose.
      • It's an injection.
      • It's expensive because there's no generic available yet.
      • You'll need to properly dispose of the needle, syringes, or Pen in a special (FDA-approved) sharps container.
      • Because it needs to be refrigerated until you use it, if you're traveling, you'll need to carry it in a cooler with an ice pack.
      • You have to be on birth control for at least 2 to 3 months after you finish Otrexup (Methotrexate) since it can cause birth defects.
      • You have to avoid alcohol and being in the sun too long.
      • You'll have to get blood tests done if you're taking this long-term because it can cause harmful side effects.
      • You have to get every dose through an IV infusion at your doctor's office.
      • Remicade has a higher risk of serious infusion-related side effects during or after it's given since it's injected right into your veins. Your doctor can prescribe medication before your dose that may lower this risk.
      • Remicade lowers your ability to fight infection and can cause serious life-threatening illness. The risk is greater if you take other drugs that lower your immune system, have an active infection, diabetes, or had tuberculosis (TB) in the past.
      • Not the best choice if you have heart failure.
      • Talk to your baby's doctor if you're pregnant or breast-feeding. When women in a study took Remicade (Infliximab), the medicine was found in their breast milk 2 to 3 days after each dose, and in the baby's blood 6 months after they were born.
      • It's expensive because there's no generic available yet.
      Tips from our pharmacists for people taking the medication
      EnbrelCimziaHumiraMethotrexateRemicade
      • Enbrel (Etanercept) is available as a single-use prefilled syringe, single-use prefilled SureClick Autoinjector, and multiple-use vial. You and your doctor can discuss which is best for you.
      • The autoinjector can be stored at room temperature for up to 14 days and can't be refrigerated again.
      • Enbrel (Etanercept) is a medication that's injected under the skin (subcutaneous). Your doctor can give you your first dose, then let you self-inject it once so you learn how to do it correctly.
      • Enbrel (Etanercept) lowers the your immune system's ability to fight infections, so it's important to let your doctor know if you come down with a fever, cough, or notice flu-like symptoms.
      • You'll need to have a TB test before you start using Enbrel (Etanercept).
      • Don't inject Enbrel (Etanercept) into skin that's red, bruised, or irritated. Rotate your injection areas to avoid skin reactions.
      • Tell your doctor if you have an allergy to latex since the syringe needle cover has latex in it.
      • As with all injection medicines, store away from children and throw used syringes away in a protective container, and not in the trash.
      • Cimzia (Certolizumab) is a medicine that's injected just under the skin (subcutaneous). It can be given in your doctor's office or you can do it yourself at home.
      • It can take multiple doses before you start to see any effects, so don't change your dose without talking to your doctor.
      • Tell your doctor if you have night sweats, persistent fever, fatigue, weight loss, or swollen lymph nodes.
      • You'll need to have a TB (tuberculosis) test before you start Cimzia (Certolizumab) and periodically during treatment.
      • Don't get any live vaccines while you're taking Cimzia (Certolizumab) since they may not work as well. Wait at least 3 months after you've stopped taking Cimzia (Certolizumab) before getting a live vaccine.
      • Humira (Adalimumab) is a medication that's injected under the skin (subcutaneous). Your doctor can give you your first dose, then let you self-inject it once so you learn how to do it correctly.
      • Humira (Adalimumab) lowers the your immune system's ability to fight infections, so it's important to let your doctor know if you come down with a fever, cough, or notice flu-like symptoms.
      • You'll need to have a TB test before you start using Humira (Adalimumab).
      • Don't inject Humira (Adalimumab) into skin that's red, bruised, or irritated. Rotate your injection areas to avoid skin reactions.
      • Tell your doctor if you have an allergy to latex since the syringe needle cover has latex in it.
      • As with all injection medicines, store away from children and throw used syringes away in a protective container, and not in the trash.
      • Don't use alcohol, NSAIDs (anti-inflammatory medications), or stay in the sun too long.
      • Use birth control and avoid pregnancy for at least 2 months (for women) and 3 months (for men) after you finish Otrexup (Methotrexate).
      • Drink plenty of liquids to stay hydrated while taking this.
      • Take the medication exactly as your doctor or pharmacist tells you. Call your doctor or pharmacist if you're confused.
      • Remicade (Infliximab) is a medication that's given as an infusion at your doctor's office or clinic.
      • It's very important to read the patient Medication Guide when you first start using Remicade (Infliximab).
      • It's possible to get an allergic reaction to Remicade (Infliximab) either immediately during the treatment or a several days after stopping it. Your doctor can give you medicines that'll lower this risk.
      • You'll need to have a TB test before you start taking Remicade (Infliximab) and periodically during treatment.
      • Remicade (Infliximab) lowers your immune system's ability to fight infections, so it's important to let your doctor know if you notice a fever, cough, or flu-like symptoms. Children seem to get more infections than adults, so keep a close eye on them.
      • If you have a young child, let their doctor know if you were on Remicade (Infliximab) while pregnant or nursing. It can increase their risk of infections for several months after your last dose and can delay their vaccine schedule.
      Learn more
      More about EnbrelSide effectsReviews & ratingsAlternativesFDA package insert
      More about CimziaSide effectsReviews & ratingsFDA package insert
      More about HumiraSide effectsReviews & ratingsFDA package insert
      More about MethotrexateSide effectsReviews & ratingsFDA package insert
      More about RemicadeSide effectsReviews & ratingsFDA package insert