Prescription onlyClass: Women's health


(progesterone vaginal insert)

Prescription onlyClass: Women's health
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Supports fertility treatments.

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Our bottom line

Endometrin (Progesterone Vaginal Insert) is a vaginal insert used in fertility treatments, but you have to apply it more often than progesterone vaginal gel.

Price and discounts
Best available price for 21 (100mg) inserts of endometrin
What is GoodRx?


  • Helps increase your chances of getting pregnant.
  • Regulates your menstrual cycle.
  • Exposes your body to less hormone compared to progesterone pills or injections.
  • Endometrin (Progesterone Vaginal Insert) replaces low levels of progesterone to prepare the lining of your uterus to receive and nourish a fertilized egg.
  • Endometrin (Progesterone Vaginal Insert) comes with step-by-step instructions and is easy to use. Unlike some progesterone products that make you to lie down when inserting them, Endometrin (Progesterone Vaginal Insert) can be inserted while you are standing, sitting, or lying on your back with your knees bent.
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  • Endometrin (Progesterone Vaginal Insert) can cause vaginal irritation and burning.
  • Inserting the applicator can possibly cause discomfort or infection.
  • Endometrin (Progesterone Vaginal Insert) is dosed 2 to 3 times a day, compared to other progesterone products that are dosed 1 to 2 times a day.
  • You can't use tampons or other vaginal products for at least 6 hours before and 6 hours after taking Endometrin (Progesterone Vaginal Insert).
How it works

Endometrin (Progesterone Vaginal Insert) contains progesterone, one of the hormones essential for maintaining a pregnancy. Women on fertility treatment can take progesterone to prepare the lining of the uterus to receive and nourish a fertilized egg.

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Side effect rates for Endometrin (progesterone vaginal insert)

404 From clinical trials of Endometrin / Assisted Reproductive Technology treatment (100 mg)
  • Post-oocyte retrieval pain
  • Abdominal pain
  • Nausea
  • Ovarian hyperstimulation syndrome
  • Nausea
  • Headache
  • Abdominal distension
  • Uterine spasm
  • Vomiting
  • Vaginal bleeding

Risks and Warnings for Endometrin (progesterone vaginal insert)

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    • Higher risk if:
    • Personal or family history of breast cancer

    It is not completely clear if progestin, like as Endometrin (Progesterone Vaginal Insert), increases your risk of breast cancer. There may be a higher risk if you have a history of breast cancer, so make sure to get routine breast exams.

Common concerns from people taking Endometrin (progesterone vaginal insert)

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  • Endometrin (Progesterone Vaginal Insert) contains progestin. It could cause a higher risk of ovarian cancer, especially if you have a family history of it. Your doctor can help you weigh the risks versus the benefits of this medication.