Prescription onlyNo lower cost generic available



  • Injection
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Emergency injection for severe allergic reactions.

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Prescription onlyNo lower cost generic available

Our bottom line

Epipen (Epinephrine) is a life-saving medication for severe allergic reactions. Just make sure you know how to give an injection before it's needed.


  • Epipen (Epinephrine) is an easy-to-use automatic injector. Just place the injector on the upper/outer part of your thigh and press a button.
  • Can be used immediately to stop a life-threatening allergic reaction.
  • The Jr. dose is for children 33lbs to 66 lbs. Adults should use the standard Epipen (Epinephrine).


  • If you have heart disease or high blood pressure, you may a greater risk of having side effects from Epipen (Epinephrine).
  • You can only use 2 Epipen (Epinephrine) injections to treat a severe allergic reaction. If you need a 3rd dose, it'll have to be given by a doctor in a hospital or healthcare setting.
  • Injecting Epipen (Epinephrine) into body parts other than the upper/outer thigh can cause serious damage and may not treat your allergic reaction. Never, ever accidentally inject it into your hand.
  • You should keep two Epipen (Epinephrine) injectors that haven't expired yet with you at all times if you know you have severe allergies to insects, foods, drugs, or other products.
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What to expect when you take Epipen (Epinephrine)

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Tips from our pharmacists
  • Epipen (Epinephrine) comes in an adult dose and child dose autoinjector. Know how to use the injector before you need it by practicing with the sample injector in the Epipen (Epinephrine) kit.
  • When needed, inject the entire amount of medicine into the upper, outer part of the thigh, through clothing if necessary. If the severe allergic reaction doesn’t go away, the dose can be repeated with a second Epipen (Epinephrine) in 5 to 15 minutes.
  • It's best to get medical attention immediately, even though you gave the injection.
  • In overweight or obese people, including children, inject Epipen (Epinephrine) into the lower half of the thigh or calf.
  • Epipen (Epinephrine) is sensitive to light and air and will turn pink or brown if it goes bad. Don’t inject the solution if it’s discolored or contains solid particles.
  • Any additional doses will need to be given by a doctor in a healthcare setting.
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Side effects for Epipen (Epinephrine)

Manufacturers don’t say how common these side effects are

  • Angina (chest pain)
  • Anxiety
  • Apprehensiveness
  • Arrythmias
  • Cerebral hemorrhage
  • Dizziness
  • Headache
  • Heart pounding or racing sensation
  • Nausea and vomiting
  • Paleness
  • Respiratory difficulties
  • Restlessness
  • Sweating
  • Tremor
  • Weakness

Risks and Warnings for Epipen (Epinephrine)

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    • Higher risk if:
    • Heart condition
    • High blood pressure

    An injection of epinephrine can cause a significant increase in blood pressure.

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Epipen (Epinephrine)

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The FDA category for this medication is C. It is advised that you: Weigh risks vs. benefits
  • Upsides and downsides from our pharmacists
  • You should keep two Epipen (Epinephrine) injectors that haven't expired yet with you at all times if you know you have severe allergies to insects, foods, drugs, or other products.