Epipen (Epinephrine)

Prescription only

Sudafed Pe (Phenylephrine)

Prescription or OTC
1 of 1 alternatives
Emergency injection for severe allergic reactions.

Epipen (Epinephrine) is a life-saving medication for severe allergic reactions. Just make sure you know how to give an injection before it's needed.

Clears your sinuses.

Sudafed Pe (Phenylephrine) is a good medication for relieving stuffy nose. It doesn't work as well as pseudoephedrine (Sudafed), but it has fewer side effects.

  • Epipen (Epinephrine) is an easy-to-use automatic injector. Just place the injector on the upper/outer part of your thigh and press a button.
  • Can be used immediately to stop a life-threatening allergic reaction.
  • The Jr. dose is for children 33lbs to 66 lbs. Adults should use the standard Epipen (Epinephrine).
  • Works to clear nasal congestion and helps you breathe better.
  • Helpful in relieving congestion-related headaches.
  • Has fewer side effects than other decongestants like pseudoephedrine.
  • It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • Doesn't give you rebound congestion (worse symptoms when you stop taking it) like nasal spray decongestants do.
  • If you have heart disease or high blood pressure, you may a greater risk of having side effects from Epipen (Epinephrine).
  • You can only use 2 Epipen (Epinephrine) injections to treat a severe allergic reaction. If you need a 3rd dose, it'll have to be given by a doctor in a hospital or healthcare setting.
  • Injecting Epipen (Epinephrine) into body parts other than the upper/outer thigh can cause serious damage and may not treat your allergic reaction. Never, ever accidentally inject it into your hand.
  • You should keep two Epipen (Epinephrine) injectors that haven't expired yet with you at all times if you know you have severe allergies to insects, foods, drugs, or other products.
  • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine (Sudafed).
  • You shouldn't use it if you have high blood pressure.
  • Can make your heart race or make you feel anxious and restless.
  • Shouldn't use it before you want to sleep.
  • Not as effective after using it for 4 days in a row.
Used for
Dosage forms
  • Injection
  • Pill
  • Nasal spray
  • Eye drops
  • Suppository
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Side effects
The Epipen (Epinephrine) FDA package insert doesn’t have numbers about how common side effects are.
The Sudafed Pe (Phenylephrine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Severe allergic reaction

    Heart condition

    ...and 1 more risk factors

See more detailed risks and warnings
  • High blood pressure

    History of high blood pressure

    ...and 1 more risk factors

  • Heart problems

    History of heart problems

    ...and 1 more risk factors

  • Harm to fetus

    Women of childbearing age

See more detailed risks and warnings