Prescription onlyNo lower cost generic available

Epipen Alternatives


  • Injection
Back to: Full Site Navigation

Compare Epipen (Epinephrine) to alternatives

These medications are comparable to Epipen (Epinephrine) or used for similar purposes.


Sudafed Pe

Emergency injection for severe allergic reactions. Epipen (Epinephrine) is a life-saving medication for severe allergic reactions. Just make sure you know how to give an injection before it's needed.Clears your sinuses. Sudafed Pe (Phenylephrine) is a good medication for relieving stuffy nose. It doesn't work as well as pseudoephedrine (Sudafed), but it has fewer side effects.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
Loading pricing data...
Reviews & ratings
Button Group. All currently active
Button Group. All currently active

Not enough reviews for this drug. Help someone out, leave a review!

Reviews for Sudafed Pe (Phenylephrine)
6% vs. Epipen (Epinephrine)
27% vs. Epipen (Epinephrine)
+40% vs. Epipen (Epinephrine)
Side effects

The Epipen FDA package insert doesn’t have numbers about how common side effects are.

More about Epipen side effects »

We haven’t found good data for Phenylephrine side effects.

FDA side effect reports for Phenylephrine »
How it works
Epipen (Epinephrine) is like adrenaline. It relaxes muscles in your lungs and relieves spasm, wheezing, and shortness of breath that happens during a severe allergic reaction (anaphylaxis).Sudafed Pe (Phenylephrine) is a decongestant. It narrows blood vessels and reduces swelling in your nasal passages to make breathing easier.
Type of medication
Alpha agonist, Beta agonist
Prescription only
DecongestantPrescription or OTC
Available as
  • Injection
  • Pill
  • Nasal spray
  • Eye drops
  • Suppository
Used for (click to learn more)
Risk factors for serious side effects
  • Heart condition
  • High blood pressure
        Detailed Epipen (Epinephrine) risks & warnings »
        Coming soon.
        Pregnancy category
        No specific alcohol-related info.No specific alcohol-related info.
        • You should keep two Epipen (Epinephrine) injectors that haven't expired yet with you at all times if you know you have severe allergies to insects, foods, drugs, or other products.
        No specific food-related info.
        Kidneys and liver
        No specific kidneys and liver-related info.No specific kidneys and liver-related info.
        No specific sex-related info.No specific sex-related info.
        No specific sleep-related info.
        • Shouldn't use it before you want to sleep.
        No specific weight-related info.No specific weight-related info.
        Upsides and benefits
        • Epipen (Epinephrine) is an easy-to-use automatic injector. Just place the injector on the upper/outer part of your thigh and press a button.
        • Can be used immediately to stop a life-threatening allergic reaction.
        • The Jr. dose is for children 33lbs to 66 lbs. Adults should use the standard Epipen (Epinephrine).
        • Works to clear nasal congestion and helps you breathe better.
        • Helpful in relieving congestion-related headaches.
        • Has fewer side effects than other decongestants like pseudoephedrine.
        • It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
        • Doesn't give you rebound congestion (worse symptoms when you stop taking it) like nasal spray decongestants do.
        Downsides and risks
        • If you have heart disease or high blood pressure, you may a greater risk of having side effects from Epipen (Epinephrine).
        • You can only use 2 Epipen (Epinephrine) injections to treat a severe allergic reaction. If you need a 3rd dose, it'll have to be given by a doctor in a hospital or healthcare setting.
        • Injecting Epipen (Epinephrine) into body parts other than the upper/outer thigh can cause serious damage and may not treat your allergic reaction. Never, ever accidentally inject it into your hand.
        • You should keep two Epipen (Epinephrine) injectors that haven't expired yet with you at all times if you know you have severe allergies to insects, foods, drugs, or other products.
        • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine (Sudafed).
        • You shouldn't use it if you have high blood pressure.
        • Can make your heart race or make you feel anxious and restless.
        • Shouldn't use it before you want to sleep.
        • Not as effective after using it for 4 days in a row.
        Tips from our pharmacists for people taking the medication
        • Epipen (Epinephrine) comes in an adult dose and child dose autoinjector. Know how to use the injector before you need it by practicing with the sample injector in the Epipen (Epinephrine) kit.
        • When needed, inject the entire amount of medicine into the upper, outer part of the thigh, through clothing if necessary. If the severe allergic reaction doesn’t go away, the dose can be repeated with a second Epipen (Epinephrine) in 5 to 15 minutes.
        • It's best to get medical attention immediately, even though you gave the injection.
        • In overweight or obese people, including children, inject Epipen (Epinephrine) into the lower half of the thigh or calf.
        • Epipen (Epinephrine) is sensitive to light and air and will turn pink or brown if it goes bad. Don’t inject the solution if it’s discolored or contains solid particles.
        • Any additional doses will need to be given by a doctor in a healthcare setting.
        • Starts working in 30 minutes.
        • Phenylephrine can make you restless, so don't take it too close to bedtime.
        • It's in other cold and flu combination medicines. Read labels closely so you don't accidentally double up and take too much of it in a day.
        • Follow age-specific dosing instructions on how much to take.
        • Let your doctor know if your symptoms don't improve in a few days.
        Learn more
        More about EpipenSide effectsReviews & ratingsAlternativesFDA package insert
        More about PhenylephrineSide effectsReviews & ratingsFDA package insert