Prescription onlyLower-cost generic available

Estrace

(Estradiol)

Prescription onlyLower-cost generic available
  • Pill
  • Hot flashes and night sweats
  • Vaginal dryness and inflammation
  • Low estrogen
  • Primary ovarian failure
  • Prevention of postmenopausal osteoporosis
  • Metastatic breast cancer
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Treats low estrogen, relieves menopause symptoms, and lowers your risk of osteoporosis.

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Our bottom line

Estrace (Estradiol) relieves menopausal symptoms and prevents bone loss. It's an oral hormone replacement, so it can have a lot of side effects, and it's important to think through the benefits and potential hassles of this drug before using it.

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Upsides

  • Estrace (Estradiol) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen, like hot flashes and vaginal dryness.
  • Lowers your risk of fractures by keeping your bones healthy. Make sure you also get enough calcium and Vitamin D.
  • Improves mood, energy, and mental alertness for some people.
  • Doesn't expose your partner to estrogen during sexual acitivities like the vaginal estrogen creams.
  • Can help relieve symptoms of advanced prostate or breast cancer in some people.

Downsides

  • More potential side effects than estrogen creams since it exposes your whole body to estrogen.
  • Increases your risk of uterine and breast cancer.
  • If you have your uterus, you have to take Estrace (Estradiol) with another hormone called progestin to lower your risk of uterine cancer.
  • Increases your risk of developing blood clots and stroke.
  • Can't be used in people with liver problems.
  • Can be expensive since it's only available as a brand name product.
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Side effect rates for Estrace (Estradiol)

Risks and Warnings for Estrace (Estradiol)

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    • Higher risk if:
    • Using estrogen for more than one year

    Vaginal bleeding after menopause can be a warning sign of uterus (endometrial) cancer, so let your doctor know if you notice any unusual bleeding. When estrogen is prescribed to women after menopause who still have a uterus, progestin should be used with it to lower the risk of cancer. Low-dose vaginal estrogen products are often a better choice than oral pills for women 65 years or older who have vaginal symptoms.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Estrace (Estradiol)

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Pregnancy
Pain
  • Estrogens like Estrace (Estradiol) can increase the risk of gallbladder disease, sometimes needing surgery. Let your doctor know if you have nausea, vomiting, bloating, or severe stomach pain that won't go away.
Weight
  • Can cause nausea, dizziness, bloating and breast tenderness.