Prescription onlyNo lower cost generic available

Estrace Vaginal Cream

(Estradiol Vaginal Cream)

  • Vaginal cream, gel, or ointment
  • Vaginal dryness and inflammation
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Relieves vaginal dryness due to menopause.

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Prescription onlyNo lower cost generic available

Our pharmacists’ bottom line

Estrace Vaginal Cream (Estradiol Vaginal Cream) works well for vaginal problems caused by menopause, and it has fewer side effects than estrogen pills.

  • Estrace Vaginal Cream (Estradiol Vaginal Cream) relieves vaginal dryness and irritation to make sex more enjoyable.
  • Works locally in the vagina and doesn't expose the rest of your body to estrogen like pills do.
  • Generally works well with few side effects.
  • Estrace Vaginal Cream (Estradiol Vaginal Cream) is a good choice for treating vaginal or urinary symptoms, especially if you're 65 or older.
  • No vaginal sex immediately after using Estrace Vaginal Cream (Estradiol Vaginal Cream) to prevent your partner from being exposed to the medicine.
  • The cream can weaken latex (rubber) condoms, cervical caps, and diaphrams. Don't use these within 72 hours after a dose.
  • Inserting the applicator can possibly cause discomfort or infection.
  • If you have your uterus, you might need to use Estrace Vaginal Cream (Estradiol Vaginal Cream) with another hormone called progestin to lower your risk of uterine cancer.
  • Can be expensive since it is only available as a brand name product.
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Side effects for Estrace Vaginal Cream (Estradiol Vaginal Cream)

Manufacturers don’t say how common these side effects are

  • Abdominal cramps
  • Abnormal jerking movements
  • Aggravation of porphyria
  • Anaphylactoid/anaplylactic reactions
  • Application site reactions of vulvovaginal discomfort including burning and irritation
  • Bloating
  • Blocked artery in lung
  • Breast cancer
  • Breast enlargement
  • Breast pain
  • Breast tenderness
  • Change in amount of cervical secretion
  • Changes in cervical ectropion
  • Changes in libido
  • Changes in vaginal bleeding pattern and abnormal withdrawal bleeding or flow
  • Chloasma or melasma that may persist when drug is discontinued
  • Cholestatic jaundice
  • Deep and superficial venous thrombosis
  • Deep skin swelling
  • Dementia
  • Dizziness
  • Endometrial cancer
  • Endometrial hyperplasia
  • Enlargement of hepatic hemangiomas
  • Erythema multiforme
  • Exacerbation of asthma
  • Exacerbation of epilepsy
  • Excessive hair growth
  • Fibrocystic breast changes
  • Genital pruritus
  • Hair loss
  • Headache
  • Heart attack
  • Hemorrhagic eruption
  • Hives
  • Hypersensitivity
  • Increase in blood pressure
  • Increase in size of uterine leiomyomata
  • Increase or decrease in weight
  • Increased incidence of gallbladder disease
  • Increased triglycerides
  • Intolerance to contact lenses
  • Irritability
  • Itching
  • Joint pain
  • Leaking fluid from nipples
  • Leg cramps
  • Low blood calcium
  • Low mood disorder
  • Menstrual cramps
  • Migraine
  • Mood disturbances
  • Nausea
  • Nervousness
  • Nipple discharge
  • Ovarian cancer
  • Pancreatitis
  • Rash
  • Reduced carbohydrate tolerance
  • Retinal vascular thrombosis
  • Spotting
  • Stroke
  • Swelling due to excess fluid
  • Tender red bumps under skin
  • Thrombophlebitis
  • Vaginitis
  • Vomiting
  • Yeast infection

What to expect when you take Estrace Vaginal Cream (Estradiol Vaginal Cream)

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Tips from our pharmacists
  • Apply Estrace Vaginal Cream (Estradiol Vaginal Cream) directly to your vagina once a day as instructed by your doctor.
  • Best used at bedtime to increase effectiveness.
  • Consider wearing a panty liner.
  • Attach the applicator to the tube and squeeze the tube to get your dose into the applicator. Insert the applicator deeply into your vagina and press the plunger to release all the medicine.
  • Clean the applicator with soap and warm water after each use.
  • Most people don't have many side effects, but temporary nausea, dizziness, bloating, and breast tenderness are possible.
  • Tell your doctor about any unusual vaginal bleeding.

Risks and Warnings for Estrace Vaginal Cream (Estradiol Vaginal Cream)

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    • Higher risk if:
    • Using estrogen for more than one year

    Vaginal bleeding after menopause can be a warning sign of uterus (endometrial) cancer, so let your doctor know if you notice any unusual bleeding. When estrogen is prescribed to women after menopause who still have a uterus, progestin should be used with it to lower the risk of cancer. Low-dose vaginal estrogen products are often a better choice than oral pills for women 65 years or older who have vaginal symptoms.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Estrace Vaginal Cream (Estradiol Vaginal Cream)

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The FDA category for this medication is X. It is advised that you: Unsafe
Pregnancy
Sex
  • Upsides and downsides from our pharmacists
  • No vaginal sex immediately after using Estrace Vaginal Cream (Estradiol Vaginal Cream) to prevent your partner from being exposed to the medicine.
  • Estrace Vaginal Cream (Estradiol Vaginal Cream) relieves vaginal dryness and irritation to make sex more enjoyable.