Prescription onlyClass: Women's health

Estrace Vaginal Cream 

(estradiol vaginal cream)

Prescription onlyClass: Women's health
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Relieves vaginal dryness due to menopause.

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Our bottom line

Estrace Vaginal Cream (Estradiol Vaginal Cream) works well for vaginal problems caused by menopause, and it has fewer side effects than estrogen pills.

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  • Estrace Vaginal Cream (Estradiol Vaginal Cream) relieves vaginal dryness and irritation to make sex more enjoyable.
  • Works locally in the vagina and doesn't expose the rest of your body to estrogen like pills do.
  • Generally works well with few side effects.
  • Estrace Vaginal Cream (Estradiol Vaginal Cream) is a good choice for treating vaginal or urinary symptoms, especially if you're 65 or older.
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  • No vaginal sex immediately after using Estrace Vaginal Cream (Estradiol Vaginal Cream) to prevent your partner from being exposed to the medicine.
  • The cream can weaken latex (rubber) condoms, cervical caps, and diaphrams. Don't use these within 72 hours after a dose.
  • Inserting the applicator can possibly cause discomfort or infection.
  • If you have your uterus, you might need to use Estrace Vaginal Cream (Estradiol Vaginal Cream) with another hormone called progestin to lower your risk of uterine cancer.
  • Can be expensive since it is only available as a brand name product.
How it works

Estrace Vaginal Cream (Estradiol Vaginal Cream) replaces estrogen hormones in your vagina that your body loses during menopause. Estrogen helps rebuild and maintain vaginal tissue, relieving symptoms of vaginal dryness, soreness, irritation, and painful sex.

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Side effect rates for Estrace Vaginal Cream (estradiol vaginal cream)

Risks and Warnings for Estrace Vaginal Cream (estradiol vaginal cream)

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    • Higher risk if:
    • Using estrogen for more than one year

    Vaginal bleeding after menopause can be a warning sign of uterus (endometrial) cancer, so let your doctor know if you notice any unusual bleeding. When estrogen is prescribed to women after menopause who still have a uterus, progestin should be used with it to lower the risk of cancer. Low-dose vaginal estrogen products are often a better choice than oral pills for women 65 years or older who have vaginal symptoms.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Estrace Vaginal Cream (estradiol vaginal cream)

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