Estrace vaginal cream

(Estradiol vaginal cream)

3.9/ 5 average rating with 15 reviewsforEstrace vaginal cream
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Relieves vaginal dryness due to menopause.

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Our bottom line

Estrace vaginal cream (Estradiol vaginal cream) works well to treat menopausal symptoms localized to the vagina.

Quick facts about Estrace vaginal cream
  • Drug class: Women's health
  • Rx status: Prescription only
  • Generic status: No lower cost generic available
Prices and discounts
Lowest price for 1 8-twice-weekly-patches-of-0.05mg-day cartons
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$129.41

Upsides

  • Side-effects are limited compared to estrogen pill since application is localized to the vagina only.

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What to expect from Estrace vaginal cream, on one page

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People’s experience with Estrace vaginal cream

15reviews so far. What do you think?

Downsides

  • Method of application can be difficult or uncomfortable compared to a pill that is taken by mouth.
  • It is not effective for hot flashes.
  • The cream is not compatible with certain birth control methods. It can weaken latex (rubber) condoms, cervical caps, and diaphrams so avoid use within 72 hours after a dose.
  • The applicator can be source of infection if not kept clean.
  • Available as a brand name product only.

Get the newsletter!

Sign up and get Pill Talk, the latest in health & medicine news from Iodine

Get our free fact sheet

What to expect from Estrace vaginal cream, on one page

Download Fact Sheet
Prices and discounts
Lowest price for 1 8-twice-weekly-patches-of-0.05mg-day cartons
Determining your location...
$129.41
How it works

Estrace vaginal cream (Estradiol vaginal cream) is a synthetic hormone called estradiol, which acts very similarly to estrogen. It replaces the estrogen lost during menopause to relieve vaginal dryness, soreness, irritation, and painful sex.

Quick facts about Estrace vaginal cream
  • Drug class: Women's health
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Used for

  • Vaginal dryness and inflammation

Dosage forms

  • Cream
People’s experience with Estrace vaginal cream

15reviews so far. What do you think?

What to expect when you take Estrace vaginal cream (Estradiol vaginal cream) for Vaginal dryness and inflammation

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Skip side effects section. Skip to risks and warnings section.

Side effect rates for Estrace vaginal cream (Estradiol vaginal cream)

Risks and Warnings for Estrace vaginal cream (Estradiol vaginal cream)

Skip risks section. Skip to common concerns section.
    • Higher risk if:
    • Using estrogen for more than one year

    Unusual vaginal bleeding during menopause can be a sign of cancer in the uterus. Let your doctor know if you notice any vaginal bleeding while on Estrace vaginal cream (Estradiol vaginal cream). The risk for cancer of the uterus increases the longer you're on this medicine. Talk to your doctor about other medicines you can take to protect yourself if you are worried.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect