5.3/ 7 average rating with 15 reviewsforEstrace vaginal cream

Estrace vaginal cream
Alternatives

(Estradiol vaginal cream)

Estrace vaginal cream (Estradiol vaginal cream)

Prescription only

Premarin (Conjugated Estrogens)

Prescription only
1 of 8 alternatives
Relieves vaginal dryness due to menopause.

Estrace vaginal cream (Estradiol vaginal cream) works well to treat menopausal symptoms localized to the vagina.

Treats low estrogen, relieves menopause symptoms, and lowers your risk of osteoporosis.

Premarin (Conjugated Estrogens) relieves menopausal symptoms and prevents bone loss. It's an oral hormone replacement, so it can have a lot of side effects, and it's important to think through the benefits and potential hassles of this drug before using it.

Upsides
  • Side-effects are limited compared to estrogen pill since application is localized to the vagina only.
  • Premarin (Conjugated Estrogens) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, night sweats, vaginal dryness).
  • Lowers your risk of fractures by keeping your bones healthy. Make sure you also take enough calcium and Vitamin D.
  • Improves mood, energy, and mental alertness for some people.
  • Does not expose your partner to estrogen during sexual acitivities like vaginal estrogen creams.
  • Can help relieve symptoms of prostate cancer or advanced breast cancer in some people.
Downsides
  • Method of application can be difficult or uncomfortable compared to a pill that is taken by mouth.
  • It is not effective for hot flashes.
  • The cream is not compatible with certain birth control methods. It can weaken latex (rubber) condoms, cervical caps, and diaphrams so avoid use within 72 hours after a dose.
  • The applicator can be source of infection if not kept clean.
  • Available as a brand name product only.
  • More potential side effects than estrogen creams since it exposes your whole body to estrogen.
  • Increases your risk of uterine and breast cancer.
  • If you have your uterus, you have to take Premarin (Conjugated Estrogens) with another hormone called progestin to lower your risk of uterine cancer.
  • Increases your risk of developing blood clots and stroke.
  • Can't be used in people with liver problems.
  • Can be expensive since it's only available as a brand name product.
Used for
  • Vaginal dryness and inflammation
  • Hot flashes and night sweats
  • Vaginal dryness and inflammation
  • Low estrogen
  • Primary ovarian failure
  • Prevention of postmenopausal osteoporosis
  • Metastatic breast cancer
  • Advanced prostate cancer
Dosage forms
  • Cream
  • Pill
Price
No pricing information available
Lowest price near you
$165.77
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Reviews
15 
60%
think this treatment is worth it
73%
think this treatment works well
47%
think this treatment is a hassle

Have you used Estrace vaginal cream (Estradiol vaginal cream)?

Leave a review
154 
50%
think this treatment is worth it
43%
think this treatment works well
11%
think this treatment is a hassle

Have you used Premarin (Conjugated Estrogens)?

Leave a review
Side effects
The Estrace vaginal cream (Estradiol vaginal cream) FDA package insert doesn’t have numbers about how common side effects are.
10possible side effects
  • Headache
    13%
  • Abdominal pain
    9%
  • Breast pain
    7%
  • Nausea
    5%
  • Asthenia
    4%
  • Back pain
    4%
  • Pain
    4%
  • Flatulence
    4%
  • Insomnia
    4%
  • Leukorrhea
    4%
See more detailed side effects
Risks and warnings
  • Endometrial cancer

    Using estrogen for more than one year

  • Breast cancer

    Personal or family history of breast cancer

    ...and 1 more risk factors

  • Increased risk of blood clots and stroke

    Personal or family history of blood clots

    ...and 3 more risk factors

  • Increased risk of heart disease

    Smoking

    ...and 5 more risk factors

  • Dementia

    Age 65 or older

  • Inflammation of pancreas

    High levels of triglycerides

See more detailed risks and warnings
  • Endometrial cancer

    Using estrogen for more than one year

  • Breast cancer

    Personal or family history of breast cancer

    ...and 1 more risk factors

  • Increased risk of blood clots and stroke

    Personal or family history of blood clots

    ...and 2 more risk factors

  • Increased risk of heart disease

    Smoking

    ...and 5 more risk factors

  • Serious allergic reaction

    Prior severe allergic reaction to Premarin (Conjugated Estrogens)

  • Harm to fetus

    Women of childbearing age

  • Pancreas swelling (pancreatitis)

    High levels of triglycerides

See more detailed risks and warnings