Prescription onlyLower-cost generic available

Activella

(Estradiol / Norethindrone)

Prescription onlyLower-cost generic available
  • Pill
  • Hot flashes and night sweats
  • Vaginal dryness and inflammation
  • Prevention of postmenopausal osteoporosis
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Relieves menopause symptoms and lowers your risk of osteoporosis.

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Our bottom line

Activella (Estradiol / Norethindrone) is effective at treating symptoms related to menopause and preventing bone loss. The estrogen/progestin combo is a good options for women with an intact uterus.

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Upsides

  • Activella (Estradiol / Norethindrone) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, night sweats, vaginal dryness).
  • Good choice for women with intact uterus. The norethindrone (a progestin) protects against the risk of cancer in the uterus from estrogen treatment.
  • Lowers your risk of fractures by keeping your bones healthy. Make sure you also get enough calcium and Vitamin D.
  • Improves mood, energy, and mental alertness for some people.
  • Mimvey brand is less expensive than other estrogen/progestin combination medicines.

Downsides

  • More potential side effects since it exposes your whole body to two hormones, estrogen and norethindrone (a progestin).
  • Increases your risk of developing blood clots and stroke.
  • You may get irregular bleeding and spotting that can last a few months to a year.
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Side effect rates for Activella (Estradiol / Norethindrone)

295 From clinical trials of Estradiol Norethindrone / Postmenopausal endometrial hyperplasia
  • Breast pain
  • Ear, nose, or throat infection
  • Headache
  • Sinus inflammation
  • Sleep difficulty
  • Back pain
  • Post-menopausal bleeding
  • Uterine fibroid
  • Infection viral
  • Moniliasis genital

Risks and Warnings for Activella (Estradiol / Norethindrone)

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    • Higher risk if:
    • Using estrogen for more than one year

    Vaginal bleeding after menopause can be a warning sign of uterus (endometrial) cancer, so let your doctor know if you notice any unusual bleeding. When estrogen is prescribed to women after menopause who still have a uterus, progestin should be used with it to lower the risk of cancer. Low-dose vaginal estrogen products are often a better choice than oral pills for women 65 years or older who have vaginal symptoms.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Activella (Estradiol / Norethindrone)

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Pregnancy
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  • Can cause nausea, dizziness, bloating, and breast tenderness.
  • Activella (Estradiol / Norethindrone) is a mixture of estrogen and progestin. It could cause a higher risk of ovarian cancer, especially if you have a family history of it. Your doctor can help you weigh the risks versus the benefits of this medication.