Prescription onlyNo lower cost generic available


(Estradiol Topical)

  • Topical emulsion
  • Hot flashes and night sweats
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Relieves hot flashes due to menopause.

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Prescription onlyNo lower cost generic available

Our bottom line

Estrasorb (Estradiol Topical) comes in pre-dosed packets that can be convenient to use, but have the same side effects as other estrogen products.


  • Pre-measured packets can be easily transported.
  • Estrasorb (Estradiol Topical) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, vaginal dryness, low energy, irritability).
  • Good for people who don't want to take daily pills.
  • Fewer side effects than pills since lower amounts of estrogen are used in topical solutions.
  • Can lower your risk of fractures by keeping your bones healthy. Make sure you also get enough calcium and Vitamin D.


  • Increases your risk of endometrial and breast cancer.
  • If you have your uterus, you have to use Estrasorb (Estradiol Topical) with another hormone called progestin to lower your risk of uterine cancer.
  • Increases your risk of developing blood clots and stroke.
  • Can't be used in people with liver problems.
  • Possibily exposing other people to the estrogen before it is absorbed by your skin.
  • Can be expensive since it is only available as a brand name product.

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  • (1) 56 packets of 2.5mg/g carton
  • Cost for (1) 56 packets of 2.5mg/g carton of Estrasorb (Estradiol Topical) at pharmacies

What to expect when you take Estrasorb (Estradiol Topical)

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Tips from our pharmacists
  • Use 2 packets each time, one on each leg. Don't put them on your face, breasts, vagina, or irritated skin.
  • Massage the content of the packets onto dry, clean skin on your legs (thigh to calf) until it's absorbed (takes about 3 minutes).
  • Let the gel dry before dressing or letting anyone touch the areas where you put the medicine.
  • Wash your hands well after applying the gel.
  • Can cause nausea, dizziness, bloating, and breast tenderness.
  • Tell your doctor about any unusual vaginal bleeding.
  • Get emergency care if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.
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Side effects for Estrasorb (Estradiol Topical)

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These are side effects of Estrasorb (Estradiol Topical) reported to the FDA by people taking it, and by doctors and pharmacists.

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Risks and Warnings for Estrasorb (Estradiol Topical)

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    • Higher risk if:
    • Using estrogen for more than one year

    Vaginal bleeding after menopause can be a warning sign of uterus (endometrial) cancer, so let your doctor know if you notice any unusual bleeding. When estrogen is prescribed to women after menopause who still have a uterus, progestin should be used with it to lower the risk of cancer. Low-dose vaginal estrogen products are often a better choice than oral pills for women 65 years or older who have vaginal symptoms.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Estrasorb (Estradiol Topical)

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The FDA category for this medication is X. It is advised that you: Unsafe