Prescription onlyNo lower cost generic available


(Estradiol Spray)

  • Spray
  • Hot flashes and night sweats
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Relieves hot flashes due to menopause.

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Prescription onlyNo lower cost generic available

Our pharmacists’ bottom line

Evamist (Estradiol Spray) is easy to use, absorbs well into your skin without needing to rub it in, and is a good option if you don’t want to use estrogen pills or patches.

  • Evamist (Estradiol Spray) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, vaginal dryness, low energy).
  • Dries faster than topical estrogen gels.
  • Good for people who don't want to take daily pills.
  • Fewer side effects than pills since lower amounts of estrogen are used in topical sprays.
  • Women in studies have seen the severity and number of hot flashes lower by half within 4 weeks of using Evamist (Estradiol Spray).
  • Very few women had skin irritation from the medicine.
  • Depending on your symptoms, your dose may change, but you can still use the same spray pump no matter what your dose is.
  • Can lower your risk of fractures by keeping your bones healthy. Make sure you also get enough calcium and Vitamin D.
  • Increases your risk of endometrial and breast cancer.
  • If you have your uterus, you have to use Evamist (Estradiol Spray) with another hormone called progestin to lower your risk of uterine cancer.
  • Increases your risk of developing blood clots and stroke.
  • Can't be used in people with liver problems.
  • It's possible to expose other people to the estrogen before it's absorbed by your skin.
  • Can be expensive since it's only available as a brand name product.
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Side effects for Evamist (Estradiol Spray)

From clinical trials of Evamist / Hot flashes and night sweats (Any dose) ( 454)

  • Application site reactionApplication site reaction1% for Evamist spray vs.0% for placebo

Pharmacist tips

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  • Spray with the container upright and the cone flat against your skin on the inside of your forearm. If more than one spray is needed, always use a different area on your forearm.
  • Don't put it on your face, breasts, vagina, or irritated skin.
  • Don't rub it in. Let the spray dry for about 2 minutes before dressing, and don't get the application site wet for at least 1 hour.
  • Can cause nausea, dizziness, bloating, and breast tenderness.
  • Tell your doctor about any unusual vaginal bleeding.
  • Get emergency care if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.
  • The spray is alcohol-based and flammable, so you shouldn't smoke while applying it.

Risks and Warnings for Evamist (Estradiol Spray)

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    • Higher risk if:
    • Using estrogen for more than one year

    Vaginal bleeding after menopause can be a warning sign of uterus (endometrial) cancer, so let your doctor know if you notice any unusual bleeding. When estrogen is prescribed to women after menopause who still have a uterus, progestin should be used with it to lower the risk of cancer. Low-dose vaginal estrogen products are often a better choice than oral pills for women 65 years or older who have vaginal symptoms.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Evamist (Estradiol Spray)

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The FDA category for this medication is X. It is advised that you: Unsafe
  • Tips from our pharmacists
  • The spray is alcohol-based and flammable, so you shouldn't smoke while applying it.