Relieves hot flashes due to menopause.
Our bottom line
Evamist (Estradiol Spray) is easy to use, absorbs well into your skin without needing to rub it in, and is a good option if you don’t want to use estrogen pills or patches.
- Evamist (Estradiol Spray) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, vaginal dryness, low energy).
- Dries faster than topical estrogen gels.
- Good for people who don't want to take daily pills.
- Fewer side effects than pills since lower amounts of estrogen are used in topical sprays.
- Women in studies have seen the severity and number of hot flashes lower by half within 4 weeks of using Evamist (Estradiol Spray).
- Very few women had skin irritation from the medicine.
- Depending on your symptoms, your dose may change, but you can still use the same spray pump no matter what your dose is.
- Can lower your risk of fractures by keeping your bones healthy. Make sure you also get enough calcium and Vitamin D.
- Increases your risk of endometrial and breast cancer.
- If you have your uterus, you have to use Evamist (Estradiol Spray) with another hormone called progestin to lower your risk of uterine cancer.
- Increases your risk of developing blood clots and stroke.
- Can't be used in people with liver problems.
- It's possible to expose other people to the estrogen before it's absorbed by your skin.
- Can be expensive since it's only available as a brand name product.
What to expect when you take Evamist (Estradiol Spray)Skip what to expect section. Skip to Risks & Warnings section.
- Spray with the container upright and the cone flat against your skin on the inside of your forearm. If more than one spray is needed, always use a different area on your forearm.
- Don't put it on your face, breasts, vagina, or irritated skin.
- Don't rub it in. Let the spray dry for about 2 minutes before dressing, and don't get the application site wet for at least 1 hour.
- Can cause nausea, dizziness, bloating, and breast tenderness.
- Tell your doctor about any unusual vaginal bleeding.
- Get emergency care if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.
- The spray is alcohol-based and flammable, so you shouldn't smoke while applying it.
Side effects for Evamist (Estradiol Spray)
From clinical trials of Evamist / Hot flashes and night sweats (Any dose) ( 454)
- Application site reactionApplication site reaction1% for Evamist spray vs.0% for placebo
Risks and Warnings for Evamist (Estradiol Spray)Skip Risks and Warnings section. Skip to Tips section.
- Higher risk if:
- › Using estrogen for more than one year
Vaginal bleeding after menopause can be a warning sign of uterus (endometrial) cancer, so let your doctor know if you notice any unusual bleeding. When estrogen is prescribed to women after menopause who still have a uterus, progestin should be used with it to lower the risk of cancer. Low-dose vaginal estrogen products are often a better choice than oral pills for women 65 years or older who have vaginal symptoms.
This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.
Tips from pharmacists and people taking Evamist (Estradiol Spray)Final section. Do you want to return to drug navigation?
- Tips from our pharmacists
- › The spray is alcohol-based and flammable, so you shouldn't smoke while applying it.