Prescription onlyLower-cost generic availableClass: Musculoskeletal



Prescription onlyLower-cost generic availableClass: Musculoskeletal
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Prevents bone loss and lowers your risk of breast cancer.

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Our bottom line

Evista (Raloxifene) is effective at reducing bone loss and lowering the risk of breast cancer in postmenopausal women, but does carry the risk of blood clots.

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What is GoodRx?


  • Evista (Raloxifene) doesn’t affect the breast or uterus the same way that estrogen does, so the risk of cancer is much lower.
  • Taking Evista (Raloxifene) with calcium and vitamin D improves spine and hip bone health and lowers the risk of fractures.
  • Lowers total cholesterol and low-density lipoprotein (LDL) cholesterol (the bad cholesterol).


  • Can only take Evista (Raloxifene) once you’re in menopause. You can't take it if you're pregnant or breastfeeding.
  • Evista (Raloxifene) isn’t as effective as tamoxifen at lowering the risk of invasive breast cancer.
  • Shouldn’t take it with any other forms of estrogen (pills, patches, or injection).
  • It doesn’t increase bone strength as much as estrogen does and isn’t effective for treating hot flashes.
How it works

Evista (Raloxifene) is a selective estrogen receptor modulator (SERM). It acts like estrogen to make your bones stronger and less likely to break, and also protects breast and uterus tissues from other estrogen effects.

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Side effect rates for Evista (raloxifene)

10101 From clinical trials of Evista / Osteoporosis (60 mg)
  • Any side effect
  • Leg or ankle swelling
  • Muscle spasms/leg cramps
  • Hot flashes
  • Gallstones
  • Venous thromboembolic events

Risks and Warnings for Evista (raloxifene)

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    • Higher risk if:
    • History of stroke
    • Heart and blood vessel problems
    • History of mini stroke (TIA)
    • Atrial fibrillation
    • Smoking
    • High blood pressure

    Evista (Raloxifene) can cause increase the risk of stroke. The risk is greater in women with a history of stroke or TIA, who have heart disease, atrial fibrillation, high blood pressure and who smoke.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Evista (raloxifene)

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  • Regular exercise, cutting back on smoking, and drinking less alcohol can also reduce your risk of bone loss.
  • Take 1 tablet daily with or without food about the same time each day. It’s important to read the information you get with your medicine about how to take Evista (Raloxifene).
Kidneys and liver
  • Evista (Raloxifene) is processed by the kidney and liver. If you have kidney or liver problems, talk to your doctor because you may need a different dose.