Prescription onlyLower-cost generic available

Evista Alternatives

(Raloxifene)

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Compare Evista (Raloxifene) to alternatives

These medications are comparable to Evista (Raloxifene) or used for similar purposes.

Evista
(Raloxifene)

Actonel
(Risedronate)

Boniva
(Ibandronate)

Fosamax
(Alendronate)

Forteo
(Teriparatide)

Prevents bone loss and lowers your risk of breast cancer. Evista (Raloxifene) is effective at reducing bone loss and lowering the risk of breast cancer in postmenopausal women, but does carry the risk of blood clots.Prevents bone loss. Actonel (Risedronate) is a first-choice treatment for osteoporosis and is available as a generic, but how you have to take it can be a hassle.Prevents bone loss. Boniva is a first-choice treatment for osteoporosis and is available as a generic, but how you have to take it can be a hassle. It's also only approved for women, not men.Prevents bone loss. Fosamax (Alendronate) is a first-choice treatment for osteoporosis and is available as a generic, but taking it can be a hassle.Prevents bone loss. Forteo (Teriparatide) is a good second-choice medication to treat bone loss, but it's only available as an injectable.
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Reviews & ratings
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Reviews for Actonel (Risedronate)
36%
64% vs. Evista (Raloxifene)
19%
81% vs. Evista (Raloxifene)
25%
25% vs. Evista (Raloxifene)
Reviews for Boniva (Ibandronate)
30%
70% vs. Evista (Raloxifene)
19%
81% vs. Evista (Raloxifene)
27%
27% vs. Evista (Raloxifene)
Reviews for Fosamax (Alendronate)
43%
57% vs. Evista (Raloxifene)
30%
70% vs. Evista (Raloxifene)
18%
18% vs. Evista (Raloxifene)

Not enough reviews for this drug. Help someone out, leave a review!

Side effects
EvistaActonelBonivaFosamaxForteo
  • Muscle spasms/leg cramps 4%
  • Leg cramps 3%
  • Sinus inflammation 3%
  • Leg or ankle swelling 2%
  • Muscle pain 2%
  • Sleep difficulty 2%
  • Rash 2%
  • Joint pain 2%
  • Weight gain 2%
  • Any side effect 1%
More Evista side effects »

We haven’t found good data for Actonel side effects.

FDA side effect reports for Actonel »
  • Any serious side effect 3%
More Boniva side effects »

We haven’t found good data for Fosamax side effects.

FDA side effect reports for Fosamax »
  • Dizziness 3%
  • Joint pain 2%
  • Fainting 2%
  • Leg cramps 2%
  • Muscle weakness 2%
  • Inflammation inside the nose 1%
  • Indigestion 1%
  • Vertigo 1%
  • Low mood disorder 1%
  • Tooth disorder 1%
More Forteo side effects »
How it works
EvistaActonelBonivaFosamaxForteo
Evista (Raloxifene) is a selective estrogen receptor modulator (SERM). It acts like estrogen to make your bones stronger and less likely to break, and also protects breast and uterus tissues from other estrogen effects.Actonel (Risedronate) is a bisphosphonate. It slows down osteoclasts, the cells that break down bone. This results in greater bone mass and lowers the possibility of fractures.Boniva (Ibandronate) is a bisphosphonate. It slows down osteoclasts, the cells that break down bone. This results in greater bone mass and lowers the possibility of fractures.Fosamax (Alendronate) is a bisphosphonate. It slows down osteoclasts, the cells that break down bone. This results in greater bone mass and lowers the possibility of fractures.Forteo (Teriparatide) works by stimulating cells that build up and strengthen your bones.
Type of medication
EvistaActonelBonivaFosamaxForteo
Osteoporosis
Selective estrogen receptor modulator
Prescription only
BisphosphonatePrescription only
BisphosphonatePrescription only
BisphosphonatePrescription only
Osteoporosis
Parathyroid hormone
Prescription only
Available as
EvistaActonelBonivaFosamaxForteo
  • Pill
  • Pill
  • Extended release
  • Pill
  • Injection
  • Pill
  • Effervescent tablet
  • Liquid
  • Injection
Used for (click to learn more)
EvistaActonelBonivaFosamaxForteo
Risk factors for serious side effects
EvistaActonelBonivaFosamaxForteo
  • History of stroke
  • Heart and blood vessel problems
  • History of mini stroke (TIA)
  • Atrial fibrillation
  • Smoking
  • High blood pressure
    • History of high triglycerides
      Detailed Evista (Raloxifene) risks & warnings »
      Coming soon.Coming soon.Coming soon.Coming soon.
      Pregnancy category
      EvistaActonelBonivaFosamaxForteo
      XFDA pregnancy category (Unsafe)

      Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

      See the FDA package insert
      CFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      CFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      CFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      CFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      Alcohol
      • Regular exercise, cutting back on smoking, and drinking less alcohol can also reduce your risk of bone loss.
      No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.
      Food
      • Take 1 tablet daily with or without food about the same time each day. It’s important to read the information you get with your medicine about how to take Evista (Raloxifene).
      • If you're taking the extended release medication, take it after your first meal of the day with at least a half cup of water.
      • Stay sitting or standing, and Don't take any other medications, vitamins or supplements for at least 60 minutes after you take the tablet until you've had your first food of the day.
      No specific food-related info.No specific food-related info.
      Kidneys and liver
      • Evista (Raloxifene) is processed by the kidney and liver. If you have kidney or liver problems, talk to your doctor because you may need a different dose.
      No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.
      Sex
      No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.
      Sleep
      No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.
      Weight
      No specific weight-related info.
      • Consider adding weight-bearing exercises as part of your exercise routine.
      • Consider adding weight-bearing exercises as part of your exercise routine.
      No specific weight-related info.No specific weight-related info.
      Upsides and benefits
      EvistaActonelBonivaFosamaxForteo
      • Evista (Raloxifene) doesn’t affect the breast or uterus the same way that estrogen does, so the risk of cancer is much lower.
      • Taking Evista (Raloxifene) with calcium and vitamin D improves spine and hip bone health and lowers the risk of fractures.
      • Lowers total cholesterol and low-density lipoprotein (LDL) cholesterol (the bad cholesterol).
      • Available in oral tablets that can be taken once or twice a month, once a week, or once a day.
      • Available in generic.
      • Available in oral tablets that can be given once a month or once a day.
      • Also available as shot given into your vein every 3 months.
      • Available in generic.
      • Lowers your risk of bone fractures.
      • Available as a generic medication.
      • Available in two forms: one that can be taken once a day or another that's taken once a week.
      • Comes as a regular tablet, an oral solution, or effervescent tablets meant to be dissolved in water.
      • If you're unable to use bisphosphonates or are still having fractures despite being on other medications, Forteo (Teriparatide) can be a good alternative.
      • You can start using Forteo (Teriparatide) as soon as you stop using bisphosphonates.
      Downsides and risks
      EvistaActonelBonivaFosamaxForteo
      • Can only take Evista (Raloxifene) once you’re in menopause. You can't take it if you're pregnant or breastfeeding.
      • Evista (Raloxifene) isn’t as effective as tamoxifen at lowering the risk of invasive breast cancer.
      • Shouldn’t take it with any other forms of estrogen (pills, patches, or injection).
      • It doesn’t increase bone strength as much as estrogen does and isn’t effective for treating hot flashes.
      • You have to remain upright for at least 30 minutes after you take the medication, which can be a problem if you have mobility issues.
      • You have to take it first thing in the morning with a full glass of water.
      • You have to remain upright for at least 60 minutes after you take the medication, which can be a problem if you have mobility issues.
      • Only approved to treat and prevent osteoporosis in women who have gone through menopause.
      • You have to take it first thing in the morning with a full glass of water.
      • You need to take it the first thing in the morning with a full glass of water.
      • Not good for people who can't sit or stand upright for at least 30 minutes in the morning.
      • The use of bisphosphonates increases your risk of other types of fractures not related to osteoporosis (called atypical fractures).
      • Can cause bad heartburn or stomach problems.
      • Only available as a brand medication, so it can be expensive.
      • You have to inject this every day, so it may not be a good option if you don't like needles.
      • Shouldn't take this longer than 18 to 24 months since it can increase the risk of bone cancers.
      Tips from our pharmacists for people taking the medication
      EvistaActonelBonivaFosamaxForteo
      • Take 1 tablet daily with or without food about the same time each day. It’s important to read the information you get with your medicine about how to take Evista (Raloxifene).
      • Your doctor may tell you to take calcium and vitamin D with Evista (Raloxifene) to prevent osteoporosis (bone thinning and loss), especially if you don’t get enough in your diet.
      • Regular exercise, cutting back on smoking, and drinking less alcohol can also reduce your risk of bone loss.
      • If you're taking the fast release medication, take it first thing when you wake up by swallowing the whole pill with a full glass of water.
      • Don't eat or drink anything for 30 minutes after you've taken the fast release medication.
      • If you're taking the extended release medication, take it after your first meal of the day with at least a half cup of water.
      • Stay sitting or standing and Don't take any other medications, vitamins or supplements for at least 30 minutes after you take the medication.
      • If you forget to take your dose, skip it and take it the following morning.
      • Some of these medications are only taken once or twice a month, others are taken once a week and others once a day. Talk to your pharmacist if you're not sure.
      • If you have pain with swallowing, around your chest or stomach, or new or worsening heartburn, talk to your doctor.
      • Call your doctor if you develop pain in your jaw, hips or thighs.
      • Keep taking your calcium and vitamin D.
      • Consider adding weight-bearing exercises as part of your exercise routine.
      • Can be taken as a tablet or as an intravenous infusion.
      • Take the tablet first thing when you wake up by swallowing the whole pill with a full glass of plain water.
      • Don't eat or drink anything for 60 minutes after you've taken the tablet.
      • Stay sitting or standing, and Don't take any other medications, vitamins or supplements for at least 60 minutes after you take the tablet until you've had your first food of the day.
      • Take the 150 mg tablet on the same day every month.
      • If you forget to take the 150mg tablet on your chosen day each month, take it on the next day in the morning.
      • Some of these medications are only taken once a month, others once a day. Talk to your pharmacist if you're not sure.
      • If you have pain with swallowing, around your chest or stomach, or new or worsening heartburn, talk to your doctor.
      • Call your doctor if you develop pain in your jaw, hips or thighs.
      • Keep taking your calcium and vitamin D.
      • Consider adding weight-bearing exercises as part of your exercise routine.
      • Take Fosamax (Alendronate) first thing in the morning with a full glass of water before eating or drinking anything else, including other medicines.
      • The pill must be swallowed whole.
      • Stay upright for at least 30 minutes after taking the medicine, and don't eat or drink anything except plain water during that time.
      • Make sure you take enough calcium and vitamin D to allow this medicine to work.
      • Can cause an upset stomach, joint pain, back pain, or heartburn.
      • Stop taking the medicine and let your doctor know if swallowing becomes painful, if you have chest pain, or if any of the side effects worsen.
      • If you have dental work coming up, get it done before starting this medicine since some people have experienced serious jaw problems while on Fosamax (Alendronate).
      • You should be sitting or lying down when you inject Forteo (Teriparatide) since it can make you dizzy.
      • You should inject Forteo (Teriparatide) under the skin in either your thigh or stomach.
      • Make sure the liquid in the vial of Forteo (Teriparatide) is clear and colorless before you inject it. Don't use it if it looks cloudy, colored, or if you see particles inside.
      Learn more
      More about EvistaSide effectsReviews & ratingsAlternativesFDA package insert
      More about ActonelSide effectsReviews & ratingsFDA package insert
      More about BonivaSide effectsReviews & ratingsFDA package insert
      More about FosamaxSide effectsReviews & ratingsFDA package insert
      More about ForteoSide effectsReviews & ratingsFDA package insert