Prescription onlyLower-cost generic availableClass: Pain



Prescription onlyLower-cost generic availableClass: Pain
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Treats severe pain.

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Prescription opioids are used to treat several kinds of pain - but they carry significant risks, including addiction. Learn more about these drugs and be sure to discuss the risks with your doctor.

Our bottom line

Duragesic (Fentanyl) is an excellent pain reliever, but should only be used by people who've tried other opioid pain medications and still need more relief.

Price and discounts
Best available price for 2 (5 patches of 25mcg/hr) cartons of fentanyl


  • It's used for people who have tried other opioid medications, but still need stronger pain relief.
  • Duragesic (Fentanyl) is stronger than morphine, works quickly, and doesn't cause as many stomach problems.
  • It's available in many dosage forms, including a patch, injection, film, nasal spray, and lollipop.
  • The Duragesic (Fentanyl) patch provides long-term pain relief and lowers the number of times you need to take pain medications each day.
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  • Duragesic (Fentanyl) isn't for everyone. It's a really strong pain medication and taking too much can be deadly.
  • It doesn't provide quick pain relief.
  • Often causes drowsiness and constipation. If using it long-term, use a stool softener.
  • Like all opioids, don't use when pregnant, since the baby can become dependent on it and have withdrawal symptoms after birth.
  • Shouldn't be used for people with breathing problems (like asthma and COPD), a slow heart rate, or in the elderly.
  • If using the patch, you won't be able to get the medicine out of your body quickly in case of an overdose.
How it works

Duragesic (Fentanyl) is an opioid (narcotic) medicine that works in the brain to lower pain perception.

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Side effect rates for Duragesic (fentanyl)

254 From clinical trials of Fentanyl / Chronic pain
  • Vomiting
  • Nausea
  • Drowsiness
  • Dizziness
  • Headache
  • Diarrhea
  • Constipation
  • Itching
  • Headache
  • Vomiting

Risks and Warnings for Duragesic (fentanyl)

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    • Higher risk if:
    • Current use of medicine that affects liver enzyme CYP 3A4
    • Age 65 or greater
    • Higher dose
    • People with not enough thyroid hormones
    • History of lung problems

    Taking too much Duragesic (Fentanyl) can cause irregular or slow breathing that can put you in a coma and can cause death. Duragesic (Fentanyl) should be swallowed whole, don't ever crush or chew. If your lips and fingers start turning blue from low oxygen, see a doctor immediately. In the hospital, doctors can give you a medicine that reverses the effects of Duragesic (Fentanyl). Don't take more than your doctor prescribes. Always check with your doctor before starting any new medicines or supplements.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Duragesic (fentanyl)

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  • Never drink alcohol when using Duragesic (Fentanyl).
  • Duragesic (Fentanyl) isn't for everyone. It's a really strong pain medication and taking too much can be deadly.
  • For pain, the patch takes 12 hours to start working and all other forms start working in 30 minutes or less.
  • It works very well as for killing my pain, but it does not stick on my skin for 72 hours so my doctor gives me enough to change it every 24 hours.
  • Fentanyl did not work at all for me, the doctor switched me to another pain medication which worked very well.
  • Major Full body Nerve pain, In beginning 50mcg 72h w Oxycodone 10MG as needed for BT. After 5yrs BT GONE!! Only 50mcg 48h only kept BT's just in case needed 10yrs now 50mcg 48h CANCELED by PC BY Directive.
  • Often causes drowsiness and constipation. If using it long-term, use a stool softener.
  • It made me sleep the whole time I was on it . Nasty med. for me.